Structural characterization of de novo designed L5K5W model peptide isomers with potent antimicrobial and varied hemolytic activities

Molecules

Volumn 18, Issue 1, 2013, Pages 859-876

  Kim, Seo Jin ^a   Kim, Jae Seok ^a,e   Lee, Yoo Sup ^a   Sim, Dae Won ^a   Lee, Sung Hee ^a   Bahk, Young Yil ^a   Lee, Kwang Ho ^a   Kim, Eun Hee ^b   Park, Sung Jean ^c   Lee, Bong Jin ^d   Won, Hyung Sik ^a  

^a Konkuk University   (South Korea)

^b Korea Basic Science Institute (KBSI)   (South Korea)

^c Gachon University   (South Korea)

^d Seoul National University   (South Korea)

^e Animal Plant and Fisheries Quarantine and Inspection Agency   (South Korea)

Author keywords

Amphipathic helical peptides; Antimicrobial peptides; De novo design; Hemolytic activity; L5K5W isomers; Structure Activity relationships; Tryptophan

Indexed keywords

ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; HEMOLYTIC AGENT; OLIGOPEPTIDE; TRYPTOPHAN;

AMINO ACID SEQUENCE; ARTICLE; CELL MEMBRANE PERMEABILITY; CHEMICAL PHENOMENA; CHEMISTRY; DRUG DESIGN; DRUG EFFECT; ERYTHROCYTE; GRAM NEGATIVE BACTERIUM; HUMAN; ISOMERISM; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TEST; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; CELL MEMBRANE PERMEABILITY; DRUG DESIGN; ERYTHROCYTES; GRAM-NEGATIVE BACTERIA; HEMOLYTIC AGENTS; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; ISOMERISM; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; OLIGOPEPTIDES; PROTEIN STRUCTURE, SECONDARY; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPTOPHAN;

MLCS; MLOWN;

EID: 84872861325     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules18010859     Document Type: Article

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