Lentivirus vector-mediated knockdown of erythropoietin-producing hepatocellular carcinoma receptors B4 inhibits laser-induced choroidal neovascularization

Journal of Ocular Pharmacology and Therapeutics

Volumn 29, Issue 1, 2013, Pages 14-22

  Du, Jing ^a   Zhao, Wei ^a   Wang, Yusheng ^a   Cai, Yan ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

EPHRIN RECEPTOR B4; LENTIVIRUS VECTOR; MESSENGER RNA; SHORT HAIRPIN RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; GENE EXPRESSION; GENE SILENCING; HISTOPATHOLOGY; IMMUNOFLUORESCENCE MICROSCOPY; IN VIVO STUDY; LASER COAGULATION; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RETINA FLUORESCEIN ANGIOGRAPHY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBRETINAL NEOVASCULARIZATION; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CHOROIDAL NEOVASCULARIZATION; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FLUORESCEIN ANGIOGRAPHY; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; INTRAVITREAL INJECTIONS; LASER COAGULATION; LENTIVIRUS; MALE; MICE; MICE, INBRED C57BL; NIH 3T3 CELLS; RECEPTOR, EPHB4; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

EID: 84872858730     PISSN: 10807683     EISSN: 15577732     Source Type: Journal    
DOI: 10.1089/jop.2012.0077     Document Type: Article

References (37)

1. McLeod, D.S., Grebe, R., Bhutto, I., Merges, C., Baba, T., and Lutty, G.A. Relationship between RPE and choriocapillaris in age-related macular degeneration. Invest. Ophthalmol. Vis. Sci. 50:4982-4991, 2009
2. Adams, R.H., and Klein, R. Eph receptors and ephrin ligands: Essential mediators of vascular development. Trends. Cardiovasc. Med. 10:183-188, 2000
3. Lopez, P.F., Sippy, B.D., Lambert, H.M., Thach, A.B., and Hinton, D.R. Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes. Invest. Ophthalmol. Vis. Sci. 37:855-868, 1996
4. Grossniklaus, H.E., and Green, W.R. Choroidal neovascularization. Am. J. Ophthalmol. 137:496-503, 2004
5. Troutbeck, R., Bunting, R., van Heerdon, A., Cain, M., and Guymer, R. Ranibizumab therapy for choroidal neovascularization secondary to non-Age-related macular degeneration causes. Clin. Exp. Ophthalmol. 40:67-72, 2012
6. Pfaff, D., Fiedler, U., and Augustin, H.G. Emerging roles of the Angiopoietin-Tie and the ephrin-Eph systems as regulators of cell trafficking. J. Leukoc. Biol. 80:719-726, 2006
7. Yuan, K., Hong, T.M., Chen, J.J.W., Tsai, W.H., and Lin, M.T. Syndecan-1 up-regulated by ephrinB2/EphB4 plays dual roles in inflammatory angiogenesis. Blood. 104:1025-1033, 2004
8. Martiny-Baron, G., Korff, T., Schaffner, F., Esser, N., Eggstein, S., Marmé, D., et al. Inhibition of tumor growth and angiogenesis by soluble EphB4. Neoplasia. 6:248-257, 2004
9. Flanagan, J.G., and Vanderhaeghen, P. The ephrins and Eph receptors in neural development. Annu. Rev. Neurosci. 21: 309-345, 1998
10. Noren, N.K., Lu, M., Freeman, A.L., Koolpe, M., and Pasquale, E.B. Interplay between EphB4 on tumor cells and vascular ephrin-B2 regulates tumor growth. Proc. Natl. Acad. Sci. U S A. 101:5583-5588, 2004
11. Davies, M.H., Stempel, A.J., Hubert, K.E., and Powers, M. Altered vascular expression of EphrinB2 and EphB4 in a model of oxygen-induced retinopathy. Dev. Dyn. 239:1695-1707, 2010
12. Kertesz, N., Kransnoperov, V., Reddy, R., et al. The soluble extracellular domain of EphB4 (sEphB4) antagonizes EphB4-EphrinB2 interaction, modulates angiogenesis, and inhibits tumor growth. Blood. 107:2330-2338, 2006
13. Ehlken, C., Martin, G., Lange, C., et al. Therapeutic interference with EphrinB2 signalling inhibits oxygen-induced angioproliferative retinopathy. Acta. Ophthalmol. 89:82-90, 2010
14. He, S., Ding, Y., Zhou, J., Krasnoperov, V., Zozulya, S., Kumar, S.R., et al. Soluble EphB4 regulates choroidal endothelial cell function and inhibits laser-induced choroidal neovascularization. Invest. Ophthalmol. Vis. Sci. 46:4772-4779, 2005
15. Liu, Z.J., Bian, J., Zhao, Y.L., Zhang, X., Zou, N., and Li, D. Lentiviral vector-mediated knockdown of SOCS3 in the hypothalamus protects against the development of dietinduced obesity in rats. Diabetes. Obes. Metab. 13:885-892, 2011
16. Feng, Y., Hu, J., Ma, J., Feng, K., Zhang, X., Yang, S., et al. RNAi-mediated silencing of VEGF-C inhibits non-small cell lung cancer progression by simultaneously down-regulating the CXCR4, CCR7, VEGFR-2 and VEGFR-3-dependent axesinduced ERK, p38 and AKT signalling pathways. Eur. J. Cancer. 47:2353-2363, 2011
17. Lin, Y., Peng, S., Yu, H., Teng, H., and Cui, M. RNAimediated downregulation of NOB1 suppresses the growth and colony-formation ability of human ovarian cancer cells. Med. Oncol. 29:311-317, 2011
18. Zhang, J., Liu, Q.S., and Dong, W.G. Blockade of proliferation and migration of gastric cancer via targeting CDH17 with an artificial microRNA. Med. Oncol. 28:494-501, 2011
19. Castilla, C., Flores, M.L., Conde, J.M., Medina, R., Torrubia, F.J., Japon, M.A., et al. Downregulation of protein tyrosine phosphatase PTPL1 alters cell cycle and upregulates invasion-related genes in prostate cancer cells. Clin. Exp. Metastasis. 29:349-358, 2012
20. Zhang, C., Wang, Y., Wu, H., Zhang, Z., Cai, Y., Hou, H., et al. Inhibitory efficacy of hypoxia-inducible factor 1a short hairpin RNA plasmid DNA-loaded poly (D, L-lactide-coglycolide) nanoparticles on choroidal neovascularization in a laser-induced rat model. Gene. Ther. 17:338-351, 2009
21. Lai, C.C., Wu, W.C., Chen, S.L., Xiao, X., Tsai, T.C., Huan, S.J., et al. Suppression of choroidal neovascularization by adeno-Associated virus vector expressing angiostatin. Invest. Ophthalmol. Vis. Sci. 42:2401-2407, 2001
22. Gu, L., Chen, H., Tuo, J., Gao, X., and Chen, L. Inhibition of experimental choroidal neovascularization in mice by anti-VEGFA/VEGFR2 or non-specific siRNA. Exp. Eye. Res. 91: 433-439, 2010
23. Shen, W.Y., Garrett, K.L., da Cruz, L., Constable, I.J., and Rakoczy, P.E. Dynamics of phosphorothioate oligonucleotides in normal and laser photocoagulated retina. Br. J. Ophthalmol. 83:852-861, 1999
24. Augustin, A.J., Scholl, S., and Kirchhof, J. Treatment of neovascular age-related macular degeneration: Current therapies. Clin. Ophthalmol. (Auckland, NZ). 3:175-182, 2009
25. Stalmans, I., Ng, Y.S., Rohan, R., et al. Arteriolar and venular patterning in retinas of mice selectively expressing VEGF isoforms. J. Clin. Invest. 109:327-336, 2002
26. Aiello, L.P. Angiogenic pathways in diabetic retinopathy. N. Engl. J. Med. 353:839-841, 2005
27. Ferrara, N., Gerber, H.P., and LeCouter, J. The biology of VEGF and its receptors. Nat. Med. 9:669-676, 2003
28. Cheng, N., Brantley, D.M., Liu, H., et al. Blockage of EphA receptor tyrosine kinase activation inhibits vascular endothelial cell growth factor-induced angiogenesis. Mol. Cancer. Res. 1:2-11, 2002
29. Zamora, D.O., Davies, M.H., Planck, S.R., et al. Soluble forms of EphrinB2 and EphB4 reduce retinal neovascularization in a model of proliferative retinopathy. Invest. Ophthalmol. Vis. Sci. 46:2175-2182, 2005
30. He, S., Kumar, S.R., Zhou, P., et al. Soluble EphB4 inhibition of PDGF-induced RPE migration in vitro. Invest. Ophthalmol. Vis. Sci. 51:543-552, 2010
31. Kim, D.H., and Rossi, J.J. Strategies for silencing human disease using RNA interference. Nat. Rev. Genet. 8:173-184, 2007
32. Noren, N.K., Yang, N.Y., Silldorff, M., et al. Ephrinindependent regulation of cell substrate adhesion by the EphB4 receptor. Biochem. J. 422:433-442, 2009
33. Wang, Z.H., Yang, Z.Q., He, X.J., Kamal, B.E., and Xing, Z. Lentivirus-mediated knockdown of aggrecanase-1 and -2 promotes chondrocyte-engineered cartilage formation in vitro. Biotechnol. Bioeng. 107:730-736, 2010
34. Gasperini, J.L., Fawzi, A.A., Khondkaryan, A., et al. Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroid neovascularisation. Br. J. Ophthalmol. 96:14-20, 2012
35. Cionni, D.A., Lewis, S.A., et al. Analysis of outcomes for intravitreal bevacizumab in the treatment of chorodial neovascularization secondary to ocular histoplasmosis. Ophthalmol. 119:327-332, 2012
36. Cheng, N., Brantley, D.M., and Chen J. The ephrins and Eph receptors in angiogenesis. Cytokine. Growth. Factor. Rev. 13: 75-85, 2002
37. Erber, R., Eichelsbacher, U., Powajbo, V., Korn, T., Djonov, V., Lin, J.H., et al. EphB4 controls blood vascular morphogenesis during postnatal angiogenesis. EMBO. J. 25:628-641, 2006