Erratum: Hexa-D-Arginine Treatment Increases 7B2•PC2 Activity in hyp-Mouse Osteoblasts and Rescues the HYPPhenotype (Journal of Bone and Mineral Research (2013) 28: (56-72) DOI: 10.1002/jbmr.1738);Hexa-D-arginine treatment increases 7B2•PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype

Journal of Bone and Mineral Research

Volumn 28, Issue 1, 2013, Pages 56-72

  Yuan, Baozhi ^a   Feng, Jian Q ^b   Bowman, Stephen ^a   Liu, Ying ^b   Blank, Robert D ^a   Lindberg, Iris ^c   Drezner, Marc K ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b BAYLOR COLLEGE OF DENTISTRY   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

7B2; BONE; fgf 23; HEXA d ARGININE; hyp Mouse; OSTEOMALACIA; RICKETS; SPC2; X LINKED HYPOPHOSPHATEMIA

Indexed keywords

ARGININE DERIVATIVE; CHAPERONE; DENTIN MATRIX PROTEIN 1; FIBROBLAST GROWTH FACTOR 23; FURIN; HEXA D ARGININE; MESSENGER RNA; PROCOLLAGEN C PROTEINASE; PROPROTEIN CONVERTASE 2; SECRETOGRANIN V; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; GENETIC TRANSFECTION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOBLAST; PHENOTYPE; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; RNA INTERFERENCE; X LINKED HYPOPHOSPHATEMIC RICKETS;

EID: 84872857027     PISSN: 08840431     EISSN: 15234681     Source Type: Journal    
DOI: 10.1002/jbmr.1970     Document Type: Erratum

References (71)

1. Rasmussen H, Tenenhouse HS,. Mendelian hypophosphatemias. In:, Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular basis of inherited diseases. New York: Mc-Graw Hill Book Co; 1995. p. 3717-45.
2. [no authors listed]. A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium. Nat Genet. 1995; 11: 130-6.
3. Sabbagh Y, Tenenehouse HS,. PHEXdb: PHEX Locus Database Search Engine Site [Internet]. Debelle Data Group; 1999 [cited 2012 Aug 19]. Available from http://www.phexdb.mcgill.ca/.
4. Holm IA, Huang X, Kunkel LM,. Mutational analysis of the PEX gene in patients with X-linked hypophosphatemic rickets. Am J Hum Genet. 1997; 60 (4): 790-7.
5. Du L, Desbarats M, Viel J, Glorieux FH, Cawthorn C, Ecarot B,. cDNA cloning of the murine Pex gene implicated in X-linked hypophosphatemia and evidence for expression in bone. Genomics. 1996; 36 (1): 22-8.
6. Rowe PS, Oudet CL, Francis F, Sinding C, Pannetier S, Econs MJ, Strom TM, Meitinger T, Garabedian M, David A, Macher MA, Questiaux E, Popowska E, Pronicka E, Read AP, Mokrzycki A, Glorieux FH, Drezner MK, Hanauer A, Lehrach H, Goulding JN, O'Riordan JL,. Distribution of mutations in the PEX gene in families with X-linked hypophosphataemic rickets (HYP). Hum Mol Genet. 1997; 6: 539-49.
7. Beck L, Soumounou Y, Martel J, Krishnamurthy G, Gauthier C, Goodyer CG,. Pex/PEX tissue distribution and evidence for a deletion in the 3′ region of the Pex gene in X-linked hypophosphatemic mice. J Clin Invest. 1997; 99 (6): 1200-9.
8. The ADHR Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF-23. Nat Genet. 2000; 26: 345-8.
9. Bai XY, Miao D, Goltzman D, Karaplis AC,. The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency. J Biol Chem. 2003; 278: 9843-9.
10. White KE, Carn G, Lorenz-Depiereux B, Benet-Pages A, Strom TM, Econs MJ,. Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23. Kidney Int. 2001; 60: 2079-86.
11. Araya K, Fukumoto S, Backenroth R, Takeuchi Y, Nakayama K, Ito N, Yoshii N, Yamazaki Y, Yamashita T, Silver J, Igarashi T, Fujita T,. A novel mutation in fibroblast growth factor 23 gene as a cause of tumoral calcinosis. J Clin Endocrinol Metab. 2005; 90 (1): 5523-7.
12. Benet-Pages A, Orlik P, Strom TM, Lorenz-Depiereux B,. An FGF23 missense mutation causes familial tumoral calcinosis with hyperphosphatemia. Hum Mol Genet. 2005; 14 (3): 385-90.
13. Chefetz I, Heller R, Galli-Tsinopoulou A, Richard G, Wollnik B, Indelman M, Koerber F, Topaz O, Bergman R, Sprecher E, Schoenau E,. A novel homozygous missense mutation in FGF23 causes familial tumoral calcinosis associated with disseminated visceral calcification. Hum Genet. 2005; 118 (2): 261-6.
14. Larsson T, Yu X, Davis SI, Draman MS, Mooney SD, Cullen MJ, White KE,. A novel recessive mutation in fibroblast growth factor-23 causes familial tumoral calcinosis. J Clin Endocrinol Metab. 2005; 90 (4): 2424-7.
15. Larsson T, Davis SI, Garringer HJ, Mooney SD, Draman MS, Cullen MJ, White KE,. Fibroblast growth factor-23 mutants causing familial tumoral calcinosis are differentially processed. Endocrinology. 2005; 146 (9): 3883-91.
16. Garringer HJ, Malekpour M, Esteghamat F, Mortazavi SM, Davis SI, Farrow EG, Yu X, Arking DE, Dietz HC, White KE,. Molecular genetics and biochemical analyses of FGF23 mutations in familial tumoral calcinosis. Am J Physiol Endocrinol Metab. 2008; 295 (4): E929-37.
17. Larsson T, Marshll R, Schipani E, Ohlsson C, Ljunggren O, Tenenhouse HS, Juppner H, Jonsson KB,. Transgenic mice expressing fibroblast growth factor 23 under the control of the α1(I) collagen promoter exhibit growth retardation, osteomalacia, and disturbed phosphate homeostasis. Endocrinology. 2004; 145 (7): 3087-94.
18. Shimada T, Urakawa I, Yamazaki Y, Hasegawa H, Hino R, Yoneya T, Takeuchi Y, Fujita T, Fukumoto S, Yamashita, FGF-23 transgenic mice demonstrate hypophosphatemic rickets with reduced expression of sodium phosphate cotransporter type IIa. Biochem Biophys Res Commun. 2004; 314: 409-14.
19. Jonsson KB, Zahradnik R, Larsson T, White KE, Sugimoto T, Imanishi Y,. Fibrolast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia. N Engl J Med. 2003; 348: 1656-63.
20. Yamazaki Y, Okazaki R, Shibata M, Hasegawa Y, Satoh K, Tajima T,. Increased circulator level of biologically active full-length FGF-23 in patients with hypophosphatemic rickets/osteomalacia. J Clin Endocrinol Metab. 2002 Nov; 87 (11): 4957-60.
21. Liu S, Zhou J, Tang W, Jiang X, Rowe DW, Quarles LD,. Pathogenic role of Fgf23 in Hyp mice. Am J Physiol Endocrinol Metab. 2006; 291 (1): E38-49.
22. Yuan B, Takaiwa M, Clemens TL, Feng JQ, Kumar R, Rowe PS, Xie Y, Drezner MK,. Aberrant Phex function in osteoblast and osteocytes alone underlies murine X-linked hypophosphatemia. J Clin Invest. 2008; 118 (2): 722-34.
23. Yuan B, Xing Y, Horst RL, Drezner MK,. Evidence for abnormal translational regulation of renal 25-hydroxyvitamin D-1-α-hydroxylase activity in the Hyp-mouse. Endocrinology. 2004; 145 (8): 3804-12.
24. Liu S, Guo R, Tu Q, Quarles LD,. Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype. J Bio Chem. 2002; 277 (1): 3686-97.
25. Erben RG, Mayer D, Weber K, Jonsson K, Juppner H, Lanske B,. Overexpression of human PHEX under the human β-actin promoter does not fully rescue the Hyp mouse phenotype. J Bone Miner Res. 2005; 20 (7): 1149-60.
26. Bai X, Miao D, Panda D, Grady S, McKee MD, Goltzman D, Karaplis AC,. Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression. Mol Endocrinol. 2002; 16: 2913-25.
27. Yamazaki Y, Tamada T, Kasai N, Urakawa I, Aono Y, Hasegawa H, Fujita T, Kuroki R, Yamashita T, Fukumoto S, Shimada T,. Anti-FGF23 neutralizing antibodies show the physiological role and structural features of FGF23. J Bone Miner Res. 2008; 23: 1509-18.
28. Aono Y, Yamazaki Y, Yasutake J, Kawata T, Hasegawa H, Urakawa I, Fujita T, Wada M, Yamashita T, Fukumoto S, Shimada T,. Therapeutic effects of anti-FGF23 antibodies in hypophosphatemic rickets/osteomalacia. J Bone Miner Res. 2009; 24: 1879-88.
29. Liu S, Guo R, Simpson LG, Xiao ZS, Burnham CE, Quarles LD,. Regulation of fibroblastic growth factor 23 expression but not degradation by PHEX. J Biol Chem. 2003; 278: 37419-26.
30. Bai X, Miao D, Li J, Goltzman D, Karaplis AC,. Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders. Endocrinology. 2004; 145 (11): 5269-79.
31. Ichitawa S, Sorenson AH, Austin AM, Mackenzie DS, Fritz TA, Moh A, Hui SL, Econs MJ,. Ablation of the Galnt3 gene leads to low-circulating intact fibroblast growth factor 23 (Fgf23) concentrations and hyperphosphatemia despite increased Fgf23 expression. Endocrinology. 2009; 150 (6): 2543-50.
32. Kato K, Jeanneau C, Tarp MA, Benet-Pagès A, Lorenz-Depiereux B, Bennett EP, Mandel U, Strom TM, Clausen H,. Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation. J Biol Chem. 2006; 281 (27): 18370-7.
33. He G, Dahl T, Veis A, George A,. Dentin matrix protein 1 initiates hydroxyapatite formation in vitro. Connect Tissue Res. 2003; 44 (Suppl 1): 240-5.
34. Narayanan K, Ramachandran A, Hao J, He G, Park KW, Cho M, George A,. Dual functional roles of dentin matrix protein 1. J Biol Chem. 2003; 278 (19): 17500-8.
35. Feng JQ, Ward LM, Liu S, Lu Y, Xie Y, Yuan B, Yu X, Rauch F, Davis SI, Zhang S, Rios H, Drezner MK, Quarles LD, Bonewald LF, White KE,. Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism. Nat Genet. 2006; 38 (11): 1310-5.
36. Lorenz-Depiereux B, Bastepe M, Benet-Pagès A, Amyere M, Wagenstaller J, Müller-Barth U, Badenhoop K, Kaiser SM, Rittmaster RS, Shlossberg AH, Olivares JL, Loris C, Ramos FJ, Glorieux F, Vikkula M, Jüppner H, Strom TM,. DMP1 mutations in autosomal recessive hypophosphatemia implicate a bone matrix protein in the regulation of phosphate homeostasis. Nat Genet. 2006; 38: 1248-50.
37. Lu Y, Yuan B, Qin C, Cao Z, Xie Y, Dallas SL, McKee MD, Drezner MK, Bonewald LF, Feng JQ,. The biological function of DMP-1 in osteocyte maturation is mediated by its 57-kDa C-terminal fragment. J Bone Miner Res. 2011; 26 (2): 331-40.
38. Sun Y, Prasad M, Gao T, Wang X, Zhu Q, D'Souza R, Feng JQ, Qin C,. Failure to process dentin matrix protein 1 (DMP1) into fragments leads to its loss of function in osteogenesis. J Biol Chem. 2010; 285: 31713-22.
39. Lobaugh B, Drezner MK,. Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. J Clin Invest. 1983; 71 (2): 400-3.
40. Lu Y, Ye L, Yu S, Zhang S, Xie Y, McKee MD, Li YC, Kong J, Eick JD, Dallas SL, Feng JQ,. Rescue of odontogenesis in Dmp1-deficient mice by targeted re-expression of DMP1 reveals roles for DMP1 in early odontogenesis and dentin apposition in vivo. Dev Biol. 2007; 303 (1): 191-201.
41. Lu Y, Qin C, Xie Y, Bonewald LF, Feng JQ,. Studies of the DMP1 57-kDa functional domain both in vivo and in vitro. Cells Tissues Organs. 2009; 189 (1-4): 175-85.
42. Xiao ZS, Creshaw M, Guo R, Nesbitt T, Drezner MK, Quarles LD,. Intrinsic mineralization defect in Hyp mouse osteoblasts. Am J Physiol. 1998; 275 (4 Pt 1): E700-8.
43. Steiner DF,. On the discovery of precursor processing. Methods Mol Biol. 2011; 768: 3-11.
44. Seidah NG,. The proprotein convertases, 20 years later. Methods Mol Biol. 2011; 768: 23-57.
45. Zhu X, Lindberg I,. 7B2 facilitates the maturation of proPC2 in neuroendocrine cells and is required for the expression of enzymatic activity. J Cell Biol. 1995; 129 (6): 1641-50.
46. Leighton M, Kadler KE,. Paired basic/furin-like proprotein convertase cleavage of pro-BMP1 in the trans-Golgi network. J Biol Chem. 2003; 278: 18478-84.
47. Steiglitz BM, Ayala M, Narayanan K, George A, Greenspan DS,. Bone morphogenetic protein-1/tolloid-like proteinases process dentin matrix protein-1. J Biol Chem. 2004; 279: 980-6.
48. Westphal CH, Muller L, Zhou A, Zhu X, Bonner-Weir S, Schambelan M, Steiner DF, Lindberg I, Leder P,. The neuroendocrine protein 7B2 is required for peptide hormone processing in vivo and provides a novel mechanism for pituitary Cushing's disease. Cell. 1999; 96 (5): 689-700.
49. Cameron A, Appel J, Houghten RA, Lindberg I,. Polyarginines are potent furin inhibitors. J Biol Chem. 2000; 275 (47): 36741-9.
50. Petit-Turcotte C, Paquin J,. Coordinate regulation of neuroendocrine convertase PC2 and peptide 7B2 in P19 neurons. Peptides. 2000; 21 (3): 365-72.
51. Jansen E, Ayoubi TA, Meulemans SM, Van de Ven WJ,. Neuroendocrine- specific expression of the human prohormone convertase 1 gene. Hormonal regulation of transcription through distinct cAMP response elements. J Biol Chem. 1995; 270 (25): 15391-7.
52. Ohagi S, Sakaguchi H, Sanke T, Tatsuta H, Hanabusa T, Nanjo K,. Human prohormone convertase 3 gene: exon-intron organization and molecular scanning for mutations in Japanese subjects with NIDDM. Diabetes. 1996; 45 (7): 897-01.
53. Muller L, Cameron A, Fortenberry Y, Apletalina EV, Lindberg I,. Processing and sorting of the prohormone convertase 2 propeptide. J Biol Chem. 2000; 275 (50): 39213-22.
54. Braks JA, Martens GJ,. 7B2 is a neuroendocrine chaperone that transiently interacts with prohormone convertase PC2 in the secretory pathway. Cell. 1994; 78 (2): 263-73.
55. Seidel B, Dong W, Savaria D, Zheng M, Pintar JE, Day R,. Neuroendocrine protein 7B2 is essential for proteolytic conversion and activation of proprotein convertase 2 in vivo. DNA Cell Biol. 1998; 17 (12): 1017-29.
56. Benjannet S, Savaria D, Chretien M, Seidah NG,. 7B2 is a specific intracellular binding protein of the prohormone convertase PC2. J Neurochem. 1995; 64 (5): 2303-11.
57. Farber CR, Chitwood J, Lee SN, Verdugo RA, Islas-Trejo A, Rincon G, Lindberg I, Medrano JF,. Overexpression of Scg5 increases enzymatic activity of PCSK2 and is inversely correlated with body weight in congenic mice. BMC Genet. 2008; 9: 34-45.
58. Shimada T, Mizutani S, Muto T, Yoneya T, Hino R, Takeda S, Takeuchi Y, Fujita T, Fukomoto S, Yamashita T,. Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia. Proc Natl Acad Sci U S A. 2001; 98: 6500-5.
59. Benet-Pages A, Lorenz-Depiereux B, Zischka H, White KE, Econs MJ, Strom TM,. FGF23 is processed by proprotein convertases but not by PHEX. Bone. 2004; 35: 455-62.
60. Cameron A, Apletalina E, Lindberg I,. The enzymology of prohormone convertases PC1 and PC2. In:, Dalbey RE, editor. The enzymes. San Diego, CA, USA: Academic Press; p. 33-43. 2001.
61. Chaussain C, Eapen AS, Huet E, Floris C, Ravindran S, Hao J, Menashi S, George A,. MMP2-cleavage of DMP1 generates a bioactive peptide promoting differentiation of dental pulp stem/progenitor cell. Eur Cell Mater. 2009; 18: 84-95.
62. Helwig M, Lee SN, Hwang JR, Ozawa A, Medrano JF, Lindberg I,. Dynamic modulation of PC2-mediated precursor processing by 7B2: preferential effect on glucagon synthesis. J Biol Chem. 2011; 266 (4): 42504-13.
63. Schmidt G, Sirois F, Anini Y, Kauri LM, Gyamera-Acheampong C, Fleck E, Scott FW, Chretien M, Mbikay M,. Differences of pancreatic expression of 7B2 between C57BL/6J and C3H/HeJ mice and genetic polymorphisms at its locus (Sgne1). Diabetes. 2006; 55 (2): 452-9.
64. Tadros H, Schmidt G, Sirois F, Mbikay M,. Regulation of 7B2 mRNA translation: dissecting the role of its 5′-untranslated region. Methods Mol Biol. 2011; 768: 217-30.
65. Waha A, Koch A, Hartmann W, Milde U, Felsberg J, Hubner A, Mikeska T, Goodyer CG, Sorensen N, Lindberg I, Wiestler OD, Pietsch T, Waha A,. SGNE1/7B2 is epigenetically altered and transcriptionally downregulated in human medulloblastomas. Oncogene. 2007; 26 (38): 5662-8.
66. Waha A, Felsberg J, Hartmann W, Hammes J, von dem Knesebeck A, Endl E, Pietsch T, Waha A,. Frequent epigenetic inactivation of the chaperone SGNE1/7B2 in human gliomas. Int J Cancer. 2012; 131 (3): 612-22.
67. Lyles KW, Harrelson JM, Drezner MK,. The efficacy of vitamin D2 and oral phosphorus therapy in X-linked hypophosphatemic rickets and osteomalacia. J Clin Endocrinol Metab. 1982; 54: 307-15.
68. 3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia. J Clin Invest. 1980; 66: 1020-32.
69. Nakatani T, Ohnishi M, Razzaque MS,. Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model. FASEB J. 2009; 23: 3702-11.
70. Goetz R, Nakada Y, Hu MC, Kurosu H, Wang L, Nakatani T, Shi M, Eliseenkova AV, Razzaque MS, Moe OW, Kuro-o M, Mohammadi M,. Isolated C-terminal tail of FGF23 alleviates hypophosphatemia by inhibiting FGF23-FGFR-Klotho complex formation. Proc Natl Acad Sci U S A. 2010; 107: 407-12.
71. Qin C, Brunn JC, Cook RG, Orkiszewski RS, Malone JP, Veis A, Butler WT,. Evidence for the proteolytic processing of entin matrix protein 1. Identification and characterization of processed fragments and cleavage sites. J Biol Chem. 2003; 278: 34700-8.