메뉴 건너뛰기




Volumn 168, Issue 1, 2013, Pages 28-43

Translational neuropharmacology: The use of human isolated gastrointestinal tissues

Author keywords

5 HT; gastrointestinal; human; motilin; neuropharmacology; translational sciences

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ATROPINE; CAMICINAL; CANNABINOID; CANNABINOID 1 RECEPTOR; CARBACHOL; ERYTHROMYCIN; HISTAMINE; HISTAMINE RECEPTOR; HORMONE RECEPTOR; MOTILIN; MOTILIN RECEPTOR; MOTILIN RECEPTOR AGONIST; NOLPITANTIUM; OPIATE; PROTEINASE ACTIVATED RECEPTOR; PRUCALOPRIDE; RIMONABANT; SEROTONIN 3 RECEPTOR; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG;

EID: 84872856753     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2012.02198.x     Document Type: Review
Times cited : (34)

References (109)
  • 1
    • 56749158003 scopus 로고    scopus 로고
    • Effects of excitatory and inhibitory neurotransmission on motor patterns of human sigmoid colon in vitro
    • Auli M, Martinez E, Gallego D, Opazo A, Espin F, Marti-Gallostra M, et al. (2008). Effects of excitatory and inhibitory neurotransmission on motor patterns of human sigmoid colon in vitro. Br J Pharmacol 155: 1043-1055.
    • (2008) Br J Pharmacol , vol.155 , pp. 1043-1055
    • Auli, M.1    Martinez, E.2    Gallego, D.3    Opazo, A.4    Espin, F.5    Marti-Gallostra, M.6
  • 2
    • 0036032261 scopus 로고    scopus 로고
    • Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle
    • Barthõ L, Benkõ R, Lázár Z, Illényi L, Horváth ÖP, (2002). Nitric oxide is involved in the relaxant effect of capsaicin in the human sigmoid colon circular muscle. Naunyn Schmiedebergs Arch Pharmacol 366: 496-500.
    • (2002) Naunyn Schmiedebergs Arch Pharmacol , vol.366 , pp. 496-500
    • Barthõ, L.1    Benkõ, R.2    Lázár, Z.3    Illényi, L.4    Horváth, Ö.5
  • 3
    • 0030871661 scopus 로고    scopus 로고
    • Neurochemical coding in the small intestine of patients with Crohn's disease
    • Belai A, Boulos PB, Robson T, Burnstock G, (1997). Neurochemical coding in the small intestine of patients with Crohn's disease. Gut 40: 767-774.
    • (1997) Gut , vol.40 , pp. 767-774
    • Belai, A.1    Boulos, P.B.2    Robson, T.3    Burnstock, G.4
  • 4
    • 77955286397 scopus 로고    scopus 로고
    • Unexpected insensitivity of the cholinergic motor responses to morphine in the human small intestine
    • Benko R, Molnár Z, Nemes D, Dekány A, Kelemen D, Illenyi L, et al. (2010). Unexpected insensitivity of the cholinergic motor responses to morphine in the human small intestine. Pharmacology 86: 145-148.
    • (2010) Pharmacology , vol.86 , pp. 145-148
    • Benko, R.1    Molnár, Z.2    Nemes, D.3    Dekány, A.4    Kelemen, D.5    Illenyi, L.6
  • 5
    • 0016517671 scopus 로고
    • The intrinsic innervation of the human alimentary tract and its relation to function
    • Bennett A, Stockley HL, (1975). The intrinsic innervation of the human alimentary tract and its relation to function. Gut 16: 443-453.
    • (1975) Gut , vol.16 , pp. 443-453
    • Bennett, A.1    Stockley, H.L.2
  • 6
    • 0017757917 scopus 로고
    • The contribution of prostaglandins in the muscle of human isolated small intestine to neurogenic responses
    • Bennett A, Stockley HL, (1977). The contribution of prostaglandins in the muscle of human isolated small intestine to neurogenic responses. Br J Pharmacol 61: 573-578.
    • (1977) Br J Pharmacol , vol.61 , pp. 573-578
    • Bennett, A.1    Stockley, H.L.2
  • 10
    • 0027526623 scopus 로고
    • Involvement of nitric oxide in the inhibitory innervation of the human isolated colon
    • Boeckxstaens GE, Pelckmans PA, Herman AG, Van Maercke YM, (1993). Involvement of nitric oxide in the inhibitory innervation of the human isolated colon. Gastroenterology 104: 690-697.
    • (1993) Gastroenterology , vol.104 , pp. 690-697
    • Boeckxstaens, G.E.1    Pelckmans, P.A.2    Herman, A.G.3    Van Maercke, Y.M.4
  • 11
    • 0030586730 scopus 로고    scopus 로고
    • Human colonic mucosa possesses a mixed population of 5-HT receptors
    • Borman RA, Burleigh DE, (1996). Human colonic mucosa possesses a mixed population of 5-HT receptors. Eur J Pharmacol 309: 271-274.
    • (1996) Eur J Pharmacol , vol.309 , pp. 271-274
    • Borman, R.A.1    Burleigh, D.E.2
  • 13
    • 84886800806 scopus 로고    scopus 로고
    • 4 receptor agonist prucalopride and the cholinesterase inhibitor donepezil in human isolated colon
    • Available at: http://www.pA2online.org /abstracts/Vol8Issue1abst071P.pdf (accessed 9 November 2012).
    • 4 receptor agonist prucalopride and the cholinesterase inhibitor donepezil in human isolated colon. Proc Br Pharmacol. Available at: http://www.pA2online.org/abstracts/Vol8Issue1abst071P. pdf (accessed 9 November 2012).
    • (2010) Proc Br Pharmacol
    • Broad, J.1    Mukherjee, S.2    Boundouki, G.3    Knowles, C.4    Sanger, G.J.5
  • 14
    • 84894661053 scopus 로고    scopus 로고
    • Reflex contraction of human isolated taenia coli induced by brief mucosal compression
    • Broad J, Knowles CH, Sanger G, (2011). Reflex contraction of human isolated taenia coli induced by brief mucosal compression. Gut 60 (Suppl. 3): A98.
    • (2011) Gut , vol.60 , Issue.SUPPL. 3
    • Broad, J.1    Knowles, C.H.2    Sanger, G.3
  • 15
    • 84866972210 scopus 로고    scopus 로고
    • Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists
    • Broad J, Mukherjee S, Samadi M, Martin JE, Dukes GE, Sanger GJ, (2012). Regional- and agonist-dependent facilitation of human neurogastrointestinal functions by motilin receptor agonists. Br J Pharmacol 167: 763-774.
    • (2012) Br J Pharmacol , vol.167 , pp. 763-774
    • Broad, J.1    Mukherjee, S.2    Samadi, M.3    Martin, J.E.4    Dukes, G.E.5    Sanger, G.J.6
  • 16
    • 0023204946 scopus 로고
    • Intracellular recordings from myenteric neurons in the human colon
    • Brookes SJH, Ewart WR, Wingate DL, (1987). Intracellular recordings from myenteric neurons in the human colon. J Physiol 390: 305-318.
    • (1987) J Physiol , vol.390 , pp. 305-318
    • Brookes, S.J.H.1    Ewart, W.R.2    Wingate, D.L.3
  • 17
    • 70349423402 scopus 로고    scopus 로고
    • Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome
    • Buhner S, Li Q, Vignali S, Barbara G, De Giorgio R, Stanghellini V, et al. (2009). Activation of human enteric neurons by supernatants of colonic biopsy specimens from patients with irritable bowel syndrome. Gastroenterology 137: 1425-1434.
    • (2009) Gastroenterology , vol.137 , pp. 1425-1434
    • Buhner, S.1    Li, Q.2    Vignali, S.3    Barbara, G.4    De Giorgio, R.5    Stanghellini, V.6
  • 18
    • 0018663486 scopus 로고
    • The effects of drugs and electrical field stimulation on the human lower oesophageal sphincter
    • Burleigh DE, (1979). The effects of drugs and electrical field stimulation on the human lower oesophageal sphincter. Arch Int Pharmacodyn Ther 240: 169-176.
    • (1979) Arch Int Pharmacodyn Ther , vol.240 , pp. 169-176
    • Burleigh, D.E.1
  • 20
    • 0018594192 scopus 로고
    • Responses of isolated human internal anal sphincter to drugs and electrical field stimulation
    • Burleigh DE, D'Mello A, Parks AG, (1979). Responses of isolated human internal anal sphincter to drugs and electrical field stimulation. Gastroenterology 77: 484-490.
    • (1979) Gastroenterology , vol.77 , pp. 484-490
    • Burleigh, D.E.1    D'Mello, A.2    Parks, A.G.3
  • 21
    • 0021680309 scopus 로고
    • A method for studying the actions of drugs on motility of vascularly perfused segments of human colon
    • Burleigh DE, Levine DF, Motson RW, (1984). A method for studying the actions of drugs on motility of vascularly perfused segments of human colon. Arch Int Pharmacodyn Ther 272: 118-128.
    • (1984) Arch Int Pharmacodyn Ther , vol.272 , pp. 118-128
    • Burleigh, D.E.1    Levine, D.F.2    Motson, R.W.3
  • 22
    • 0034234774 scopus 로고    scopus 로고
    • Gq-linked NK(2) receptors mediate neurally induced contraction of human sigmoid circular smooth muscle
    • Cao W, Pricolo VE, Zhang L, Behar J, Biancani P, Kirber MT, (2000). Gq-linked NK(2) receptors mediate neurally induced contraction of human sigmoid circular smooth muscle. Gastroenterology 119: 51-61.
    • (2000) Gastroenterology , vol.119 , pp. 51-61
    • Cao, W.1    Pricolo, V.E.2    Zhang, L.3    Behar, J.4    Biancani, P.5    Kirber, M.T.6
  • 23
  • 25
    • 78651419160 scopus 로고    scopus 로고
    • Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress
    • Chandrasekharan B, Anitha M, Blatt R, Shahnavaz N, Kooby D, Staley C, et al. (2011). Colonic motor dysfunction in human diabetes is associated with enteric neuronal loss and increased oxidative stress. Neurogastroenterol Motil 23: 131-138.
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 131-138
    • Chandrasekharan, B.1    Anitha, M.2    Blatt, R.3    Shahnavaz, N.4    Kooby, D.5    Staley, C.6
  • 26
    • 84862504708 scopus 로고    scopus 로고
    • Nerve activity recordings in routine human intestinal biopsies
    • doi: 10.1136/gutjnl-2011-301777.
    • Cirillo C, Tack J, Berghe PV, (2012). Nerve activity recordings in routine human intestinal biopsies. Gut doi: 10.1136/gutjnl-2011-301777.
    • (2012) Gut
    • Cirillo, C.1    Tack, J.2    Berghe, P.V.3
  • 27
    • 0031667279 scopus 로고    scopus 로고
    • Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans
    • Coulie B, Tack J, Peeters T, Janssens J, (1998). Involvement of two different pathways in the motor effects of erythromycin on the gastric antrum in humans. Gut 43: 395-400.
    • (1998) Gut , vol.43 , pp. 395-400
    • Coulie, B.1    Tack, J.2    Peeters, T.3    Janssens, J.4
  • 28
    • 0344010043 scopus 로고    scopus 로고
    • The rabbit motilin receptor: Molecular characterisation and pharmacology
    • Dass NB, Hill J, Muir A, Testa T, Wise A, Sanger GJ, (2003). The rabbit motilin receptor: molecular characterisation and pharmacology. Br J Pharmacol 140: 948-954.
    • (2003) Br J Pharmacol , vol.140 , pp. 948-954
    • Dass, N.B.1    Hill, J.2    Muir, A.3    Testa, T.4    Wise, A.5    Sanger, G.J.6
  • 29
    • 56949097757 scopus 로고    scopus 로고
    • Morphologic pattern of myenteric neural plexus in colonic diverticular disease. A whole-mount study emplying histochemical staining for acetylcholinesterase
    • Deduchovas O, Saladzinskas Z, Tamelis A, Pavalkis D, Pauziene N, Pauza DH, (2008). Morphologic pattern of myenteric neural plexus in colonic diverticular disease. A whole-mount study emplying histochemical staining for acetylcholinesterase. Ann Anat 190: 525-530.
    • (2008) Ann Anat , vol.190 , pp. 525-530
    • Deduchovas, O.1    Saladzinskas, Z.2    Tamelis, A.3    Pavalkis, D.4    Pauziene, N.5    Pauza, D.H.6
  • 30
    • 41949095497 scopus 로고    scopus 로고
    • Interstitial cells of Cajal in health and disease
    • Farrugia G, (2008). Interstitial cells of Cajal in health and disease. Neurogastroent Motil 20 (Suppl. S1): 54-63.
    • (2008) Neurogastroent Motil , vol.20 , Issue.SUPPL. S1 , pp. 54-63
    • Farrugia, G.1
  • 31
    • 0008196190 scopus 로고
    • Nicotine and colonic muscle
    • (letter).
    • Fishlock DJ, Parks AG, (1963). Nicotine and colonic muscle. Br Med J 2: L1528. (letter).
    • (1963) Br Med J , vol.2
    • Fishlock, D.J.1    Parks, A.G.2
  • 32
    • 0029830522 scopus 로고    scopus 로고
    • Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea-pig intestine
    • Foxx-Orenstein AE, Kuemmerle JF, Grider JR, (1996). Distinct 5-HT receptors mediate the peristaltic reflex induced by mucosal stimuli in human and guinea-pig intestine. Gastroenterology 111: 1281-1290.
    • (1996) Gastroenterology , vol.111 , pp. 1281-1290
    • Foxx-Orenstein, A.E.1    Kuemmerle, J.F.2    Grider, J.R.3
  • 34
    • 0015382035 scopus 로고
    • Excitatory effects of adrenaline upon isolated preparations of human colon
    • Gagnon DJ, Devroede G, Belisle S, (1972). Excitatory effects of adrenaline upon isolated preparations of human colon. Gut 13: 654-657.
    • (1972) Gut , vol.13 , pp. 654-657
    • Gagnon, D.J.1    Devroede, G.2    Belisle, S.3
  • 35
    • 65449118900 scopus 로고    scopus 로고
    • Constitutive basal and stimulated human small bowel contractility is enhanced in obesity
    • doi: 10.1186/1750-1164-3-4.
    • Gallagher TK, Baird AW, Winter DC, (2009). Constitutive basal and stimulated human small bowel contractility is enhanced in obesity. Ann Surg Innov Res 3: 4. doi: 10.1186/1750-1164-3-4.
    • (2009) Ann Surg Innov Res , vol.3 , pp. 4
    • Gallagher, T.K.1    Baird, A.W.2    Winter, D.C.3
  • 39
    • 3042647756 scopus 로고    scopus 로고
    • Different responsiveness of excitatory and inhibitory enteric motor neurons in the human esophagus to electrical field stimulation and to nicotine
    • González AA, Farré R, Clavé P, (2004). Different responsiveness of excitatory and inhibitory enteric motor neurons in the human esophagus to electrical field stimulation and to nicotine. Am J Physiol 287: G299-G306.
    • (2004) Am J Physiol , vol.287
    • González, A.A.1    Farré, R.2    Clavé, P.3
  • 40
    • 0028304329 scopus 로고
    • The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting the results
    • Goodman SN, Berlin JA, (1994). The use of predicted confidence intervals when planning experiments and the misuse of power when interpreting the results. Ann Intern Med 121: 200-206.
    • (1994) Ann Intern Med , vol.121 , pp. 200-206
    • Goodman, S.N.1    Berlin, J.A.2
  • 41
    • 80053307134 scopus 로고    scopus 로고
    • Translational neuropharmacology and the appropriate and effective use of animal models
    • Green AR, Gabrielsson J, Fone KCF, (2011). Translational neuropharmacology and the appropriate and effective use of animal models. Br J Pharmacol 164: 1041-1043.
    • (2011) Br J Pharmacol , vol.164 , pp. 1041-1043
    • Green, A.R.1    Gabrielsson, J.2    Fone, K.C.F.3
  • 42
    • 0024377435 scopus 로고
    • Identification of neurotransmitters regulating intestinal peristaltic reflex in humans
    • Grider JR, (1989). Identification of neurotransmitters regulating intestinal peristaltic reflex in humans. Gastroenterology 97: 1414-1419.
    • (1989) Gastroenterology , vol.97 , pp. 1414-1419
    • Grider, J.R.1
  • 43
    • 33747143081 scopus 로고    scopus 로고
    • Tolerance to cannabinoid response on the myenteric plexus of guinea-pig ileum and human small intestinal strips
    • Guagnini F, Cogliati P, Mukenge S, Ferla G, Croci T, (2006a). Tolerance to cannabinoid response on the myenteric plexus of guinea-pig ileum and human small intestinal strips. Br J Pharmacol 148: 1165-1173.
    • (2006) Br J Pharmacol , vol.148 , pp. 1165-1173
    • Guagnini, F.1    Cogliati, P.2    Mukenge, S.3    Ferla, G.4    Croci, T.5
  • 44
    • 33745500230 scopus 로고    scopus 로고
    • Neural contractions in colonic strips from patients with diverticular disease: Role of endocannabinoids and substance P
    • Guagnini F, Valenti M, Mukenge S, Matias I, Bianchetti A, Di Palo S, et al. (2006b). Neural contractions in colonic strips from patients with diverticular disease: role of endocannabinoids and substance P. Gut 55: 946-953.
    • (2006) Gut , vol.55 , pp. 946-953
    • Guagnini, F.1    Valenti, M.2    Mukenge, S.3    Matias, I.4    Bianchetti, A.5    Di Palo, S.6
  • 45
    • 74749106445 scopus 로고    scopus 로고
    • Stepwise loss of motilin and its specific receptor genes in rodents
    • He J, Irwin DM, Chen R, Zhang Y-P, (2010). Stepwise loss of motilin and its specific receptor genes in rodents. J Mol Endocrinol 44: 37-44.
    • (2010) J Mol Endocrinol , vol.44 , pp. 37-44
    • He, J.1    Irwin, D.M.2    Chen, R.3    Zhang, Y.-P.4
  • 46
    • 34247511138 scopus 로고    scopus 로고
    • Functional human tissue assays
    • Hillier C, Bunton D, (2007). Functional human tissue assays. Drug Discov Today 12: 382-388.
    • (2007) Drug Discov Today , vol.12 , pp. 382-388
    • Hillier, C.1    Bunton, D.2
  • 47
    • 33745042034 scopus 로고    scopus 로고
    • Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon
    • Hinds NM, Ullrich K, Smid SD, (2006). Cannabinoid 1 (CB1) receptors coupled to cholinergic motorneurones inhibit neurogenic circular muscle contractility in the human colon. Br J Pharmacol 148: 191-199.
    • (2006) Br J Pharmacol , vol.148 , pp. 191-199
    • Hinds, N.M.1    Ullrich, K.2    Smid, S.D.3
  • 49
    • 33847153056 scopus 로고    scopus 로고
    • Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro
    • Jarvie EM, North Laidler V, Corcoran S, Bassil A, Sanger GJ, (2007). Differences between the abilities of tegaserod and motilin receptor agonists to stimulate gastric motility in vitro. Br J Pharmacol 150: 455-462.
    • (2007) Br J Pharmacol , vol.150 , pp. 455-462
    • Jarvie, E.M.1    North Laidler, V.2    Corcoran, S.3    Bassil, A.4    Sanger, G.J.5
  • 50
    • 84856207917 scopus 로고    scopus 로고
    • Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent
    • Julio-Pieper M, O'Mahony CM, Clarke G, Bravo JA, Dinan TG, Cryan JF, (2012). Chronic stress-induced alterations in mouse colonic 5-HT and defecation responses are strain dependent. Stress 15: 218-226.
    • (2012) Stress , vol.15 , pp. 218-226
    • Julio-Pieper, M.1    O'Mahony, C.M.2    Clarke, G.3    Bravo, J.A.4    Dinan, T.G.5    Cryan, J.F.6
  • 52
    • 80052851950 scopus 로고    scopus 로고
    • Mouse genomic variation and its effect on phenotypes and gene regulation
    • Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, et al. (2011). Mouse genomic variation and its effect on phenotypes and gene regulation. Nature 477: 289-294.
    • (2011) Nature , vol.477 , pp. 289-294
    • Keane, T.M.1    Goodstadt, L.2    Danecek, P.3    White, M.A.4    Wong, K.5    Yalcin, B.6
  • 53
  • 56
    • 34548531961 scopus 로고    scopus 로고
    • Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve
    • Lang PM, Grafe P, (2007). Chemosensitivity of unmyelinated axons in isolated human gastric vagus nerve. Auton Neurosci 136: 100-104.
    • (2007) Auton Neurosci , vol.136 , pp. 100-104
    • Lang, P.M.1    Grafe, P.2
  • 57
  • 58
    • 1542379721 scopus 로고    scopus 로고
    • Why are taeniae, haustra, and semilunar folds differentiated in the gastrointestinal tract of mammals, including man?
    • Langer P, Takács A, (2004). Why are taeniae, haustra, and semilunar folds differentiated in the gastrointestinal tract of mammals, including man? J Morphol 259: 308-315.
    • (2004) J Morphol , vol.259 , pp. 308-315
    • Langer, P.1    Takács, A.2
  • 59
    • 0036152825 scopus 로고    scopus 로고
    • Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach
    • Leclere PG, Lefebvre RA, (2002). Presynaptic modulation of cholinergic neurotransmission in the human proximal stomach. Br J Pharmacol 135: 135-142.
    • (2002) Br J Pharmacol , vol.135 , pp. 135-142
    • Leclere, P.G.1    Lefebvre, R.A.2
  • 60
    • 84872867953 scopus 로고    scopus 로고
    • (-9). Java applets for power and sample size [computer software]. Available at: http://www.stat.uiowa.edu/~rlenth/Power (accessed 29/05/12).
    • Lenth RV, (2006 -9). Java applets for power and sample size [computer software]. Available at: http://www.stat.uiowa.edu/~rlenth/Power (accessed 29/05/12).
    • (2006)
    • Lenth, R.V.1
  • 61
    • 0024376707 scopus 로고
    • Direct effects of motilin on isolated smooth muscle from various regions of the human stomach
    • Lödtke FE, Möller H, Golenhofen K, (1989). Direct effects of motilin on isolated smooth muscle from various regions of the human stomach. Pflugers Arch 414: 558-563.
    • (1989) Pflugers Arch , vol.414 , pp. 558-563
    • Lödtke, F.E.1    Möller, H.2    Golenhofen, K.3
  • 62
    • 1242342927 scopus 로고    scopus 로고
    • Differential effect of nitric oxide synthase inhibition on sigmoid colon longitudinal and circular muscle responses to nicotine and nerve stimulation in vitro
    • McKirdy HC, Richardson CE, Green JT, Rhodes J, Williams GT, Marshall RW, (2004). Differential effect of nitric oxide synthase inhibition on sigmoid colon longitudinal and circular muscle responses to nicotine and nerve stimulation in vitro. Br J Surg 91: 229-234.
    • (2004) Br J Surg , vol.91 , pp. 229-234
    • McKirdy, H.C.1    Richardson, C.E.2    Green, J.T.3    Rhodes, J.4    Williams, G.T.5    Marshall, R.W.6
  • 64
    • 0019721059 scopus 로고
    • Two types of spike generation in human Auerbach's plexus cells in cultrure
    • Maruyama T, (1981). Two types of spike generation in human Auerbach's plexus cells in cultrure. Neurosci Lett 25: 143-148.
    • (1981) Neurosci Lett , vol.25 , pp. 143-148
    • Maruyama, T.1
  • 66
    • 79952454869 scopus 로고    scopus 로고
    • Gender- and age-related differences in muscular and nerve-mediated responses in human colon
    • Maselli MA, Trisolini P, Demma I, Pezzolla F, De Ponti F, (2011). Gender- and age-related differences in muscular and nerve-mediated responses in human colon. Dig Dis Sci 56: 352-358.
    • (2011) Dig Dis Sci , vol.56 , pp. 352-358
    • Maselli, M.A.1    Trisolini, P.2    Demma, I.3    Pezzolla, F.4    De Ponti, F.5
  • 67
    • 84863617798 scopus 로고    scopus 로고
    • Mechanosensitive enteric neurons in the myenteric plexus of the mouse intestine
    • Mazzuoli G, Schemann M, (2012). Mechanosensitive enteric neurons in the myenteric plexus of the mouse intestine. PLoS ONE 7: e39887.
    • (2012) PLoS ONE , vol.7
    • Mazzuoli, G.1    Schemann, M.2
  • 69
    • 54349103237 scopus 로고    scopus 로고
    • Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors
    • Morfis M, Tilakaratne N, Furness SGB, Christopoulos G, Werry TD, Christopoulos A, et al. (2008). Receptor activity-modifying proteins differentially modulate the G protein-coupling efficiency of amylin receptors. Endocrinology 149: 5423-5431.
    • (2008) Endocrinology , vol.149 , pp. 5423-5431
    • Morfis, M.1    Tilakaratne, N.2    Furness, S.G.B.3    Christopoulos, G.4    Werry, T.D.5    Christopoulos, A.6
  • 71
    • 81855185603 scopus 로고    scopus 로고
    • Parallel manifestations of neuropathologies in the enteric and central nervous systems
    • Natale G, Pasquali L, Paparelli A, Fornai F, (2011). Parallel manifestations of neuropathologies in the enteric and central nervous systems. Neurogastroenterol Motil 23: 1056-1065.
    • (2011) Neurogastroenterol Motil , vol.23 , pp. 1056-1065
    • Natale, G.1    Pasquali, L.2    Paparelli, A.3    Fornai, F.4
  • 72
    • 34347379300 scopus 로고    scopus 로고
    • Mechanism of abnormal intestinal motility in inflammatory bowel disease: How smooth muscle contraction is reduced?
    • Ohama T, Hori M, Ozaki H, (2007). Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced? J Smooth Muscle Res 43: 43-54.
    • (2007) J Smooth Muscle Res , vol.43 , pp. 43-54
    • Ohama, T.1    Hori, M.2    Ozaki, H.3
  • 75
    • 0036292096 scopus 로고    scopus 로고
    • Cholinergic and nitrergic interneurons in the myenteric plexus of the human colon
    • Porter AJ, Wattchow DA, Brookes SJH Costa M, (2002). Cholinergic and nitrergic interneurons in the myenteric plexus of the human colon. Gut 51: 70-75.
    • (2002) Gut , vol.51 , pp. 70-75
    • Porter, A.J.1    Wattchow, D.A.2    Brookes Sjh Costa, M.3
  • 76
    • 0028203516 scopus 로고
    • Nitric oxide mediates inhibitory nerve effects in human esophagus and lower esophageal sphincter
    • Preiksaitis HG, Tremblay L, Diamant NE, (1994). Nitric oxide mediates inhibitory nerve effects in human esophagus and lower esophageal sphincter. Dig Dis Sci 39: 770-775.
    • (1994) Dig Dis Sci , vol.39 , pp. 770-775
    • Preiksaitis, H.G.1    Tremblay, L.2    Diamant, N.E.3
  • 77
    • 0033709510 scopus 로고    scopus 로고
    • 4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle
    • 4 receptors on cholinergic nerves involved in contractility of canine and human large intestine longitudinal muscle. Br J Pharmacol 131: 927-932.
    • (2000) Br J Pharmacol , vol.131 , pp. 927-932
    • Prins, N.H.1    Akkermans, L.M.A.2    Lefebvre, R.A.3    Schuurkes, J.A.J.4
  • 81
    • 0026638048 scopus 로고
    • Benzimidazolone derivatives: A new class of 5-hydroxytryptamine4 receptor agonists with prokinetic and acetylcholine releasing properties in the guinea pig ileum
    • Rizzi CA, Coccini T, Onori L, Manzo L, Tonini M, (1992). Benzimidazolone derivatives: a new class of 5-hydroxytryptamine4 receptor agonists with prokinetic and acetylcholine releasing properties in the guinea pig ileum. J Pharmacol Exp Ther 261: 412-419.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 412-419
    • Rizzi, C.A.1    Coccini, T.2    Onori, L.3    Manzo, L.4    Tonini, M.5
  • 82
    • 0021838389 scopus 로고
    • Effects of metoclopramide and domperidone on cholinergically-mediated contractions of human isolated stomach muscle
    • Sanger GJ, (1985). Effects of metoclopramide and domperidone on cholinergically-mediated contractions of human isolated stomach muscle. J Pharm Pharmacol 37: 661-664.
    • (1985) J Pharm Pharmacol , vol.37 , pp. 661-664
    • Sanger, G.J.1
  • 83
    • 35748980586 scopus 로고    scopus 로고
    • Endocannabinoids and the gastrointestinal tract: What are the key questions?
    • Sanger GJ, (2007). Endocannabinoids and the gastrointestinal tract: what are the key questions? Br J Pharmacol 152: 663-670.
    • (2007) Br J Pharmacol , vol.152 , pp. 663-670
    • Sanger, G.J.1
  • 84
    • 40649105561 scopus 로고    scopus 로고
    • Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases
    • Sanger GJ, (2008). Motilin, ghrelin and related neuropeptides as targets for the treatment of GI diseases. Drug Discov Today 13: 234-239.
    • (2008) Drug Discov Today , vol.13 , pp. 234-239
    • Sanger, G.J.1
  • 85
    • 65949105077 scopus 로고    scopus 로고
    • GSK962040: A small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility
    • Sanger GJ, Westaway SM, Barnes AA, MacPherson DT, Muir AI, Jarvie EM, et al. (2009). GSK962040: a small molecule, selective motilin receptor agonist, effective as a stimulant of human and rabbit gastrointestinal motility. Neurogastroenterol Motil 21: 657-666.
    • (2009) Neurogastroenterol Motil , vol.21 , pp. 657-666
    • Sanger, G.J.1    Westaway, S.M.2    Barnes, A.A.3    MacPherson, D.T.4    Muir, A.I.5    Jarvie, E.M.6
  • 86
    • 79959778996 scopus 로고    scopus 로고
    • The translational value of rodent gastrointestinal functions: A cautionary tale
    • Sanger GJ, Holbrook JD, Andrews PLR, (2011). The translational value of rodent gastrointestinal functions: a cautionary tale. Trends Pharmacol Sci 32: 402-409.
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 402-409
    • Sanger, G.J.1    Holbrook, J.D.2    Andrews, P.L.R.3
  • 88
    • 72249102564 scopus 로고    scopus 로고
    • The β3-adrenoceptor agonist GW427353 (solabegron) decreases excitability of human enteric neurons via release of somatostatin
    • Schemann M, Hafsi N, Michel K, Kober O, Wollmann J, Li Q, et al. (2010). The β3-adrenoceptor agonist GW427353 (solabegron) decreases excitability of human enteric neurons via release of somatostatin. Gastroenterology 138: 266-274.
    • (2010) Gastroenterology , vol.138 , pp. 266-274
    • Schemann, M.1    Hafsi, N.2    Michel, K.3    Kober, O.4    Wollmann, J.5    Li, Q.6
  • 89
    • 78149472678 scopus 로고    scopus 로고
    • Regional differences of the effects of acetylcholine in the human gastric circular muscle
    • Sinn DH, Min B-H, Lee JY, Kim JJ, Rhee JC, et al. (2010). Regional differences of the effects of acetylcholine in the human gastric circular muscle. Am J Physiol 299: G1198-G1203.
    • (2010) Am J Physiol , vol.299
    • Sinn, D.H.1    Min, B.-H.2    Lee, J.Y.3    Kim, J.J.4    Rhee, J.C.5
  • 90
    • 0026352135 scopus 로고
    • Defect in colonic smooth muscle contraction in patients with ulcerative colitis
    • Snape WJ, Hyman PE, (1991). Defect in colonic smooth muscle contraction in patients with ulcerative colitis. Am J Physiol 261: G987-G991.
    • (1991) Am J Physiol , vol.261
    • Snape, W.J.1    Hyman, P.E.2
  • 91
    • 0026657240 scopus 로고
    • Decreased sensitivity of muscasrinic but not 5-hydroxytryptamine receptors of the internal anal sphincter in neurogenic faecal incontinence
    • Speakman CTM, Hoyle CHV, Kamm MA, Nicholls RJ, Burnstock G, (1992). Decreased sensitivity of muscasrinic but not 5-hydroxytryptamine receptors of the internal anal sphincter in neurogenic faecal incontinence. Br J Surg 79: 829-832.
    • (1992) Br J Surg , vol.79 , pp. 829-832
    • Speakman, C.T.M.1    Hoyle, C.H.V.2    Kamm, M.A.3    Nicholls, R.J.4    Burnstock, G.5
  • 92
    • 83755207115 scopus 로고    scopus 로고
    • Characterization of motor patterns in isolated human colon: Are there differences in patients with slow transit constipation?
    • Spencer NJ, Kyloh M, Wattchow DA, Thomas A, Sia TC, Brookes SJ, et al. (2012). Characterization of motor patterns in isolated human colon: are there differences in patients with slow transit constipation? Am J Physiol 302: G34-G43.
    • (2012) Am J Physiol , vol.302
    • Spencer, N.J.1    Kyloh, M.2    Wattchow, D.A.3    Thomas, A.4    Sia, T.C.5    Brookes, S.J.6
  • 93
    • 0029980999 scopus 로고    scopus 로고
    • Nitric oxide donating compounds stimulate human colonic ion transport in vitro
    • Stack WA, Filipowicz B, Hawkey CJ, (1996). Nitric oxide donating compounds stimulate human colonic ion transport in vitro. Gut 39: 93-99.
    • (1996) Gut , vol.39 , pp. 93-99
    • Stack, W.A.1    Filipowicz, B.2    Hawkey, C.J.3
  • 94
    • 79952440832 scopus 로고    scopus 로고
    • Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine
    • Sun X, Wang X, Wang G-D, Xia Y, Liu S, Qu M, et al. (2011). Lubiprostone reverses the inhibitory action of morphine on mucosal secretion in human small intestine. Dig Dis Sci 56: 330-338.
    • (2011) Dig Dis Sci , vol.56 , pp. 330-338
    • Sun, X.1    Wang, X.2    Wang, G.-D.3    Xia, Y.4    Liu, S.5    Qu, M.6
  • 95
    • 33846025894 scopus 로고    scopus 로고
    • Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract
    • Takeshita E, Matsuura B, Dong M, Miller LJ, Matsui H, Onji M, (2006). Molecular characterization and distribution of motilin family receptors in the human gastrointestinal tract. J Gastroenterol 41: 223-230.
    • (2006) J Gastroenterol , vol.41 , pp. 223-230
    • Takeshita, E.1    Matsuura, B.2    Dong, M.3    Miller, L.J.4    Matsui, H.5    Onji, M.6
  • 96
    • 0035502294 scopus 로고    scopus 로고
    • A robust method for evaluation of NANC transmission in human sigmoid colon muscle in vitro
    • Tavares IA, Rennie JA, (2001). A robust method for evaluation of NANC transmission in human sigmoid colon muscle in vitro. J Pharmacol Toxicol Methods 46: 153-161.
    • (2001) J Pharmacol Toxicol Methods , vol.46 , pp. 153-161
    • Tavares, I.A.1    Rennie, J.A.2
  • 98
    • 0036251177 scopus 로고    scopus 로고
    • Role of nitric oxide in the colon of patients with slow-transit constipation
    • Tomita R, Fujisaki S, Ikeda T, Fukuzawa M, (2002). Role of nitric oxide in the colon of patients with slow-transit constipation. Dis Colon Rectum 45: 593-600.
    • (2002) Dis Colon Rectum , vol.45 , pp. 593-600
    • Tomita, R.1    Fujisaki, S.2    Ikeda, T.3    Fukuzawa, M.4
  • 99
    • 34347359789 scopus 로고    scopus 로고
    • Regulation of enteric nervous system in the proximal and distal parts of the normal human pyloric sphincter - In vitro study
    • Tomita R, Igarashi S, Fijisaki S, Koshinaga T, Tanjoh K, (2007). Regulation of enteric nervous system in the proximal and distal parts of the normal human pyloric sphincter-in vitro study. Hepatogastroenterology 54: 1289-1292.
    • (2007) Hepatogastroenterology , vol.54 , pp. 1289-1292
    • Tomita, R.1    Igarashi, S.2    Fijisaki, S.3    Koshinaga, T.4    Tanjoh, K.5
  • 100
    • 0033980815 scopus 로고    scopus 로고
    • Role of nitric oxide- and vasoactive intestinal polypeptide-containing neurones in human gastric fundus strip relaxations
    • Tonini M, De Giorgio R, De Ponti F, Sternini C, Spelta V, Dionigi P, et al. (2000). Role of nitric oxide- and vasoactive intestinal polypeptide- containing neurones in human gastric fundus strip relaxations. Br J Pharmacol 129: 12-20.
    • (2000) Br J Pharmacol , vol.129 , pp. 12-20
    • Tonini, M.1    De Giorgio, R.2    De Ponti, F.3    Sternini, C.4    Spelta, V.5    Dionigi, P.6
  • 102
    • 55149097875 scopus 로고    scopus 로고
    • The role of positive selection in determining the molecular cause of species differences in disease
    • doi: 10.1186/1471-2148-8-273.
    • Vamathevan JJ, Hasan S, Emes RD, Amrine-Madsen H, Rajagopalan D, Topp SD, et al. (2008). The role of positive selection in determining the molecular cause of species differences in disease. BMC Evol Biol 8: 273. doi: 10.1186/1471-2148-8-273.
    • (2008) BMC Evol Biol , vol.8 , pp. 273
    • Vamathevan, J.J.1    Hasan, S.2    Emes, R.D.3    Amrine-Madsen, H.4    Rajagopalan, D.5    Topp, S.D.6
  • 104
    • 0001742909 scopus 로고
    • The muscularis mucosae of the human stomach
    • Walder DN, (1953). The muscularis mucosae of the human stomach. J Physiol 120: 365-372.
    • (1953) J Physiol , vol.120 , pp. 365-372
    • Walder, D.N.1
  • 105
    • 56549126380 scopus 로고    scopus 로고
    • Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation
    • Wattchow D, Brookes SD, Murphy E, Carbone S, de, Fontgalland D, Costa M, (2008). Regional variation in the neurochemical coding of the myenteric plexus of the human colon and changes in patients with slow transit constipation. Neurogastroenterol Motil 20: 1298-1305.
    • (2008) Neurogastroenterol Motil , vol.20 , pp. 1298-1305
    • Wattchow, D.1    Brookes, S.D.2    Murphy, E.3    De Carbone, S.4    Fontgalland, D.5    Costa, M.6
  • 106
    • 79960033349 scopus 로고    scopus 로고
    • The identification and rationale for drugs which act at the motilin receptor
    • Westaway SM, Sanger GJ, (2009). The identification and rationale for drugs which act at the motilin receptor. Prog Med Chem 48: 31-80.
    • (2009) Prog Med Chem , vol.48 , pp. 31-80
    • Westaway, S.M.1    Sanger, G.J.2
  • 107
    • 77956302687 scopus 로고    scopus 로고
    • Tonic inhibition of human small intestinal motility by nitric oxide in children but not in adults
    • Wittmeyer V, Merrot T, Mazet B, (2010). Tonic inhibition of human small intestinal motility by nitric oxide in children but not in adults. Neurogastroenterol Motil 22: 1078-1282.
    • (2010) Neurogastroenterol Motil , vol.22 , pp. 1078-1282
    • Wittmeyer, V.1    Merrot, T.2    Mazet, B.3
  • 109
    • 0027743378 scopus 로고
    • Preservation of human small intestine: Function of smooth muscle and nerve
    • Zorychta E, Lubin A, Guttman FM, (1993). Preservation of human small intestine: function of smooth muscle and nerve. Transplant Proc 25: 3034-3035.
    • (1993) Transplant Proc , vol.25 , pp. 3034-3035
    • Zorychta, E.1    Lubin, A.2    Guttman, F.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.