Unexpected insensitivity of the cholinergic motor responses to morphine in the human small intestine

Pharmacology

Volumn 86, Issue 3, 2010, Pages 145-148

  Benko, Rita ^a   Molnár, Zsuzsanna ^a   Nemes, Dániel ^a   Dékány, András ^a   Kelemen, Dezsö ^a   Illényi, Lászlo ^a   Cseke, Lászlo ^a   Papp, András ^a   Varga, Gábor ^a   Bartho, Loránd ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

Acetylcholine; Cholinergic responses; Morphine; Neurogenic contraction; Opioid agonists; Small intestine

Indexed keywords

MORPHINE; PURINERGIC RECEPTOR BLOCKING AGENT;

ANIMAL TISSUE; ARTICLE; CHOLINERGIC SYSTEM; ELECTROSTIMULATION; GUINEA PIG; HUMAN; HUMAN TISSUE; INTESTINE CONTRACTION; INTESTINE MUSCLE; MYENTERIC PLEXUS; NONHUMAN; PRIORITY JOURNAL; SMALL INTESTINE;

ANALGESICS, OPIOID; ANIMALS; ELECTRIC STIMULATION; GUINEA PIGS; HUMANS; INTESTINE, SMALL; MORPHINE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; RECEPTORS, CHOLINERGIC;

EID: 77955286397     PISSN: 00317012     EISSN: None     Source Type: Journal    
DOI: 10.1159/000316637     Document Type: Article

References (16)

1. Holzer P: Opioid receptors in the gastrointestinal tract. Regul Pept 2009; 155:11-17.
2. Paton WDM: The action of morphine and related substances on contraction and on acetylcholine output of coaxially stimulated guinea-pig ileum. Br J Pharmacol Chemo-ther 1957; 12:119-127.
3. Schaumann W: Inhibition by morphine of the release of acetylcholine from the intestine of the guinea-pig. Br J Pharmacol Che-mother 1957; 12:115-118.
4. Cox BM, Weinstock M: The effect of analgesic drugs on the release of acetylcholine from electrically stimulated guinea-pig ileum. Br J Pharmacol Chemother 1966; 27: 81-9 2.
5. Vizi ES: Presynaptic modulation of neu-rochemical transmission. Prog Neurobiol 1979; 12:181-290.
6. Yuan CS, Foss JF, Moss J: Effects of methy l-naltrexone on morphine-induced inhibition of contraction in isolated guinea-pig ileum and human intestine. Eur J Pharmacol 1995; 276:107-111.
7. 2 pu-rinoceptor antagonist. Life Sci 2009; 84:871-875.
8. Burleigh DE, Trout SJ: Morphine attenuates cholinergic nerve activity in human isolated colonic muscle. Br J Pharmacol 1986; 88: 307-313.
9. Neumann PB, Henriksen H, Grosman N, Christensen CB: Plasma morphine concentrations during chronic oral administration in patients with cancer pain. Pain 1982; 13: 247-252.
10. Graves DA, Arrigo JM, Foster TS, Baumann TJ, Batenhorst RL: Relationship between plasma morphine concentrations and phar-macologic effects in postoperative patients using patient-controlled analgesia. Clin Pharm 1985; 4:41-47.
11. Halbsguth U, Rentsch KM, Eich-Höchli D, Diterich I, Fattinger K: Oral diacetylmor-phine (heroin) yields greater morphine bio-availability than oral morphine: bioavail-ability related to dosage and prior opioid exposure. Br J Clin Pharmacol 2008; 66:781-791.
12. Thomas JR, Yocum RC, Haller MF, Flam-ent JJ: The INFUSE-Morphine IIB study: use of recombinant human hyaluronidase (rHuPH20) to enhance the absorption of subcutaneous morphine in healthy volunteers. Pain Symptom Manage 2009; 38:673-682.
13. Cowie AL, Kosterlitz HW, Waterfield AA: Factors influencing the release of acetylcho-line from the myenteric plexus of the ileum of the guinea-pig and rabbit. Br J Pharmacol 1978; 64: 565-580.
14. Kitazawa T, Hoshi T, Temma K, Kondo H: Effects of morphine and methionine-en-kephalin on the smooth muscle tonus and the contraction induced by transmural stimulation in the carp (Cyprinus carpio) intestinal bulb. Comp Biochem Physiol C 1986; 84: 299-305.
15. Gillan MG, Pollock D: Acute effects of morphine and opioid peptides on the motility and responses of rat colon to electrical stimulation. Br J Pharmacol 1980; 68:381-392.
16. Coupar I M, De Luc a A: Opiate and opiate a nt idiar rhoea l d r ug ac t ion on r at isolated i ntes-tine. J Auton Pharmacol 1994; 14:69-78.