Increased serum hepcidin levels in patients with porphyria cutanea tarda

Journal of the European Academy of Dermatology and Venereology

Volumn 27, Issue 1, 2013, Pages

  Darwich, E ^a   To Figueras, J ^a   Molina Lopez R A ^b   Deulofeu, R ^a   Olbina, G ^c   Westerman, M ^c   Sanchez Tapias J M ^a   Munoz Santos C ^a   Herrero, C ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c Intrinsic LifeSciences LLC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; C REACTIVE PROTEIN; FERRITIN; GAMMA GLUTAMYLTRANSFERASE; HEPCIDIN; INTERLEUKIN 6; IRON;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FERRITIN BLOOD LEVEL; GENE FREQUENCY; HEPATITIS C; HUMAN; INFLAMMATION; IRON METABOLISM; MAJOR CLINICAL STUDY; MALE; OXIDATIVE STRESS; PORPHYRIA CUTANEA TARDA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SMOKING;

ADULT; ANTIMICROBIAL CATIONIC PEPTIDES; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; DISEASE PROGRESSION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FERRITINS; FOLLOW-UP STUDIES; HEMOCHROMATOSIS; HEPATITIS C, CHRONIC; HUMANS; MALE; MULTIVARIATE ANALYSIS; OXIDATIVE STRESS; PORPHYRIA CUTANEA TARDA; REGRESSION ANALYSIS; SENSITIVITY AND SPECIFICITY; SEVERITY OF ILLNESS INDEX;

EID: 84872854355     PISSN: 09269959     EISSN: 14683083     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2012.04511.x     Document Type: Article

References (40)

1. Thunell S, Harper P,. Porphyrins, porphyrin metabolism, porphyrias. III. Diagnosis, care and monitoring in porphyria cutanea tarda. Suggestions for a handling programme. Scand J Clin Lab Invest 2000; 60: 561-579.
2. Herrero C, Vicente A, Bruguera M, et al. Is hepatitis C virus infection a trigger of porphyria cutanea tarda? Lancet 1993; 27: 788-789. 341
3. Galossi A, Guarisco R, Bellis L, Puoti C,. Extrahepatic manifestations of chronic HCV infection. J Gastrointestin Liver Dis 2007; 16: 65-73.
4. Bonkovsky HL, Lambrecht RW, Shan Y,. Iron as a co-morbid factor in nonhemochromatotic liver disease. Alcohol 2003; 30: 137-144.
5. Alla V, Bonkovsky HL,. Iron in nonhemochromatotic liver disorders. Semin Liver Dis 2005; 25: 461-472.
6. Mascarõ JM, Herrero C,. New reasons for an archaic treatment: phlebotomy in sporadic porphyria cutanea tarda. Arch Dermatol 2003; 139: 379-380.
7. Sampietro M, Fiorelli G, Fargion S,. Iron overload in porphyria cutanea tarda. Haematologica 1999; 84: 248-253.
8. Berlin SO, Brante G,. Iron metabolisms in porhryria and hemochromatosis. Lancet 1962; 2: 729.
9. Lundvall O, Weinfeld A, Lundin P,. Iron storage in porphyria cutanea tarda. Acta Med Scand 1970; 188: 37-53.
10. Elder GH, Worwood M,. Mutations in the hemochromatosis gene, porphyria cutanea tarda, and iron overload. Hepatology 1998; 27: 289-291.
11. Mehrany K, Drage LA, Brandhagen DJ, Pittelkow MR,. Association of porphyria cutanea tarda with hereditary hemochromatosis. J Am Acad Dermatol 2004; 51: 205-211.
12. Roberts AG, Whatley SD, Morgan RR, et al. Increased frequency of the haemochromatosis Cys282Tyr mutation in sporadic porphyria cutanea tarda. Lancet 1997; 349: 321-323.
13. Toll A, Celis R, Ozalla MD, et al. The prevalence of HFE C282Y gene mutation is increased in Spanish patients with porphyria cutanea tarda without hepatitis C virus infection. J Eur Acad Dermatol Venereol 2006; 20: 1201-1206.
14. Gisbert JP, García-Buey L, Pajares JM, Moreno-Otero R,. Prevalence of hepatitis C virus infection in porphyria cutanea tarda: systematic review and meta-analysis. J Hepatol 2003; 39: 620-627.
15. Elder GH,. Alcohol intake and porphyria cutanea tarda. Clin Dermatol 1999; 17: 431-436.
16. Kohgo Y, Ohtake T, Ikuta K, et al. Iron accumulation in alcoholic liver diseases. Alcohol Clin Exp Res 2005; 29: 189S-193S.
17. Shan Y, Lambrecht RW, Bonkovsky HL,. Association of hepatitis C virus infection with serum iron status: analysis of data from the third National Health and Nutrition Examination Survey. Clin Infect Dis 2005; 40: 834-841.
18. Nemeth E, Ganz T,. Regulation of iron metabolism by hepcidin. Annu Rev Nutr 2006; 26: 323-342.
19. Trinder D, Ayonrinde OT, Olynik JK,. HCV, iron, and oxidative stress: the new choreography of hepcidin. Gastroenterology 2008; 134: 348-351.
20. Ganz T, Olbina G, Girelli D, et al. Immunoassay for human serum hepcidin. Blood 2008; 112: 4292-4297.
21. Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003; 361: 669-673.
22. Fujita N, Sugimoto R, Takeo M, et al. Hepcidin expression in the liver: relatively low level in patients with chronic hepatitis C. Mol Med 2007; 13: 97-104.
23. Bridle K, Cheung TK, Murphy T, et al. Hepcidin is down-regulated in alcoholic liver injury: implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res 2006; 30: 106-112.
24. Bansal SS, Abbate V, Bomford A, et al. Quantitation of hepcidin in serum using ultra-high-pressure liquid chromatography and a linear ion trap mass spectrometer. Rapid Commun Mass Spectrom 2010; 24: 1251-1259.
25. Koliaraki V, Marinou M, Vassilakopoulos TP, et al. A novel immunological assay for hepcidin quantification in human serum. PLoS ONE 2009; 4: e4581.
26. van Dijk BA, Laarakkers CM, Klaver SM, et al. Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels. Br J Haematol 2008; 142: 979-985.
27. Girelli D, Pasino M, Goodnough JB, et al. Reduced serum hepcidin levels in patients with chronic hepatitis C. J Hepatol 2009; 51: 845-852.
28. Iqbal T, Diab A, Ward DG, et al. Is iron overload in alcohol-related cirrhosis mediated by hepcidin? World J Gastroenterol 2009; 15: 5864-5866.
29. Konishi M, Iwasa M, Araki J, et al. Increased lipid peroxidation in patients with non-alcoholic fatty liver disease and chronic hepatitis C as measured by the plasma level of 8-isoprostane. J Gastroenterol Hepatol 2006; 21: 1821-1825.
30. Kohgo Y, Ikuta K, Ohtake T, et al. Iron overload and cofactors with special reference to alcohol, hepatitis C virus infection and steatosis/insulin resistance. World J Gastroenterol 2007; 13: 4699-4706.
31. Harrison-Findik DD, Schafer D, Klein E, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006; 281: 22974-22982.
32. Nishina S, Hino K, Korenaga M, et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology 2008; 134: 226-238.
33. Shearer MJ,. Vitamins: Vitamin E. HPLC of small molecules. A practical approach. In:, Lim CK, ed. The Practical Approach Series. IRL Press, Oxford, 1986: 177.
34. Fukunaga K, Yoshida M, Nakazono N,. A simple higly sensitive and reproducible quantification method for plasma malondialdehyde by high performance liquid chromatography. Biomed Chromatography 1998; 12: 300-303.
35. To-Figueras J, Ozalla D, Mateu CH,. Long-standing changes in the urinary profile of porphyrin isomers after clinical remission of porphyria cutanea tarda. Ann Clin Lab Sci 2003; 33: 251-256.
36. Badenas C, To-Figueras J, Phillips JD, et al. Identification and characterization of novel uroporphyrinogen decarboxylase gene mutations in a large series of porphyria cutanea tarda patients and relatives. Clin Genet 2009; 75: 346-353.
37. Wrighting DM, Andrews NC,. Interleukin-6 induces hepcidin expression through STAT3. Blood 2006; 108: 3204-3209.
38. Aoki CA, Rossaro L, Ramsamooj R, et al. Liver hepcidin mRNA correlates with iron stores, but not inflammation, in patients with chronic hepatitis C. J Clin Gastroenterol 2005; 39: 71-74.
39. Kaneko Y, Miyajima H, Piperno A, et al. Measurement of serum hepcidin-25 levels as a potential test for diagnosing hemochromatosis and related disorders. J Gastroenterol 2010; 45: 1163-1171.
40. Ajioka RS, Phillips JD, Weiss RB, et al., Down-regulation of hepcidin in porphyria cutanea tarda. Blood 2008; 112: 4723-4728.