The multiple faces of proteinkinase R in antiviral defense

Virulence

Volumn 4, Issue 1, 2013, Pages 85-89

  Munir, Muhammad ^a   Berg, Mikael ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

IFN mRNA; Innate immunity; PKR; Virus infections

Indexed keywords

2', 5' OLIGOADENYLATE SYNTHETASE; ALPHA BETA INTERFERON RECEPTOR; ALPHA INTERFERON; BETA INTERFERON; CYTOKINE; GROWTH FACTOR; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN D; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR; INTERFERON REGULATORY FACTOR; MESSENGER RNA; PATTERN RECOGNITION RECEPTOR; PROTEIN KINASE; PROTEIN KINASE R; RETINOIC ACID INDUCIBLE PROTEIN I; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; AU RICH ELEMENT; CELL GROWTH; GENE EXPRESSION; HUMAN; IMMUNE RESPONSE; INNATE IMMUNITY; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PROTEIN SYNTHESIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; VIRUS TRANSCRIPTION;

EID: 84872851598     PISSN: 21505594     EISSN: 21505608     Source Type: Journal    
DOI: 10.4161/viru.23134     Document Type: Article

References (25)

1. Pichlmair A, Reis e Sousa C. Innate recognition of viruses. Immunity 2007; 27:370-83. PMID: 17892846; http://dx.doi.org/10.1016/j.immuni.2007.08.012
2. Metz DH, Esteban M. Interferon inhibits viral protein synthesis in L cells infected with vaccinia virus. Nature 1972; 238:385-388; PMID:4559581; http://dx.doi.org/10.1038/238385a0
3. Hovanessian AG, Kerr IM. The (2'-5') oligoadenylate (pppA2'-5'A2'-5'A) synthetase and protein kinase (s) from interferon-treated cells. Eur J Biochem 1979; 93:515-526; PMID:217683; http://dx.doi.org/10.1111/j.1432-1033.1979.tb12850.x
4. Williams BR. Signal integration via PKR. Sci STKE 2001; 2001:re2; PMID:11752661; http://dx.doi.org/10.1126/stke.2001.89.re2
5. Feng GS, Chong K, Kumar A, Williams BR. Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase. Proc Natl Acad Sci USA 1992; 89:5447-5451; PMID:1351683; http://dx.doi.org/10.1073/pnas.89.12.5447
6. García MA, Gil J, Ventoso I, Guerra S, Domingo E, Rivas C, et al. Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action. Microbiol Mol Biol Rev 2006; 70:1032-1060; PMID: 17158706; http://dx.doi.org/10.1128/MMBR.00027-06
7. McAllister CS, Taghavi N, Samuel CE. Protein Kinase PKR Amplification of Interferon β Induction Occurs through Initiation Factor eIF-2a-mediated Translational Control. J Biol Chem 2012; 287: 36384-36392; PMID:22948139; http://dx.doi.org/10.1074/jbc.M112.390039
8. Diebold SS, Montoya M, Unger H, Alexopoulou L, Roy P, Haswell LE, et al. Viral infection switches nonplasmacytoid dendritic cells into high interferon producers. Nature 2003; 424:324-322; PMID: 12819664; http://dx.doi.org/10.1038/nature01783
9. McAllister CS, Samuel CE. The RNA-activated protein kinase enhances the induction of interferon-beta and apoptosis mediated by cytoplasmic RNA sensors. J Biol Chem 2009; 284:1644-1651; PMID:19028691; http://dx.doi.org/10.1074/jbc.M807888200
10. Smith EJ, Marié I, Prakash A, García-Sastre A, Levy DE. IRF3 and IRF7 phosphorylation in virus-infected cells does not require double-stranded RNA-dependent protein kinase R or Ikappa B kinase but is blocked by Vaccinia virus E3L protein. J Biol Chem 2001; 276: 8951-8957; PMID:11124948; http://dx.doi.org/10.1074/jbc.M008717200
11. Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schäfer R, Kumar A, et al. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 1995; 14:6095-6106; PMID:8557029
12. Takeuchi O, Akira S. MDA5/RIG-I and virus recognition. Curr Opin Immunol 2008; 20:17-22; PMID:18272355; http://dx.doi.org/10.1016/j.coi.2008.01.002
13. Schulz O, Pichlmair A, Rehwinkel J, Rogers NC, Scheuner D, Kato H, et al. Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. Cell Host Microbe 2010; 7:354-361; PMID:20478537; http://dx.doi.org/10.1016/j.chom.2010.04.007
14. Zhu S, Romano PR, Wek RC. Ribosome targeting of PKR is mediated by two double-stranded RNA-binding domains and facilitates in vivo phosphorylation of eukaryotic initiation factor-2. J Biol Chem 1997; 272: 14434-14441; PMID:9162083; http://dx.doi.org/10.1074/jbc.272.22.14434
15. Jeffrey IW, Kadereit S, Meurs EF, Metzger T, Bachmann M, Schwemmle M, et al. Nuclear localization of the interferon-inducible protein kinase PKR in human cells and transfected mouse cells. Exp Cell Res 1995; 218:17-27; PMID:7737357; http://dx.doi.org/10.1006/excr.1995.1126
16. MacQuillan GC, Caterina P, de Boer B, Allan JE, Platten MA, Reed WD, et al. Ultra-structural localisation of hepatocellular PKR protein using immuno-gold labelling in chronic hepatitis C virus disease. J Mol Histol 2009; 40:171-176. PMID: 19642004; http://dx.doi.org/10.1007/s10735-009-9227-0
17. Ben-Asouli Y, Banai Y, Pel-Or Y, Shir A, Kaempfer R. Human interferon-gamma mRNA autoregulates its translation through a pseudoknot that activates the interferon-inducible protein kinase PKR. Cell 2002; 108:221-232; PMID:11832212; http://dx.doi.org/10.1016/S0092-8674(02)00616-5
18. Anderson P. Post-transcriptional control of cytokine production. Nat Immunol 2008; 9:353-359; PMID: 18349815; http://dx.doi.org/10.1038/ni1584
19. Pasté M, Huez G, Kruys V. Deadenylation of interferon-beta mRNA is mediated by both the AUrich element in the 3'-untranslated region and an instability sequence in the coding region. Eur J Biochem 2003; 270:1590-1597; PMID:12654014; http://dx.doi.org/10.1046/j.1432-1033.2003.03530.x
20. Langland JO, Cameron JM, Heck MC, Jancovich JK, Jacobs BL. Inhibition of PKR by RNA and DNA viruses. Virus Res 2006; 119:100-110; PMID:16704884; http://dx.doi.org/10.1016/j.virusres.2005.10.014
21. Barry G, Breakwell L, Fragkoudis R, Attarzadeh-Yazdi G, Rodriguez-Andres J, Kohl A, et al. PKR acts early in infection to suppress Semliki Forest virus production and strongly enhances the type I interferon response. J Gen Virol 2009; 90:1382-1391; PMID:19264662; http://dx.doi.org/10.1099/vir.0.007336-0
22. Carpentier PA, Williams BR, Miller SD. Distinct roles of protein kinase R and toll-like receptor 3 in the activation of astrocytes by viral stimuli. Glia 2007; 55: 239-252; PMID:17091495; http://dx.doi.org/10.1002/glia.20450
23. Gilfoy FD, Mason PW. West Nile virus-induced interferon production is mediated by the double stranded RNA-dependent protein kinase PKR. J Virol 2007; 81:11148-1158; PMID:17686861; http://dx.doi.org/10.1128/JVI.00446-07
24. Zamanian-Daryoush M, Mogensen TH, DiDonato JA, Williams BR. NF-kappaB activation by doublestranded-RNA-activated protein kinase (PKR) is mediated through NF-kappaB-inducing kinase and IkappaB kinase. Mol Cell Biol 2000; 20:1278-1290; PMID:10648614; http://dx.doi.org/10.1128/MCB.20.4.1278-1290.2000
25. Kumar A, Yang YL, Flati V, Der S, Kadereit S, Deb A, et al. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J 1997; 16:406-416; PMID:9029159; http://dx.doi.org/10.1093/emboj/16.2.406