Effects of intraperitoneal and intracerebroventricular injection of crocin on acute corneal pain in rats

Phytotherapy Research

Volumn 24, Issue 10, 2010, Pages 1463-1467

  Tamaddonfard, Esmaeal ^a   Hamzeh Gooshchi, Nasrin ^a  

^a URMIA UNIVERSITY   (Iran)

Author keywords

acute corneal pain; crocin; morphine; naloxone; rats

Indexed keywords

CROCIN; MORPHINE; NALOXONE; SODIUM CHLORIDE;

ACUTE CORNEAL PAIN; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; CORNEA; DRUG EFFECT; EYE PAIN; MALE; NONHUMAN; RAT;

ANALGESICS, OPIOID; ANIMALS; CAROTENOIDS; CORNEA; DRUG COMBINATIONS; INJECTIONS, INTRAPERITONEAL; INJECTIONS, INTRAVENTRICULAR; MALE; MORPHINE; NALOXONE; PAIN; PAIN MEASUREMENT; RATS; RATS, WISTAR;

RATTUS;

EID: 78649430493     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.3169     Document Type: Article

References (35)

1. Abdullaev FI., 1993. Biological effects of saffron stigma. Biofactors 4: 83-86.
2. Abdullaev FI., 2002. Cancer chemopreventive and tumoricidial properties of saffron (Crocus sativus L.). Exp Biol Med 227: 20-25.
3. Abebe W., 2002. Herbal medication: potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 27: 391-401.
4. Aung HH, Wang CZ, Ni M, et al,. 2007. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp Oncol 29: 175-180.
5. Carstens E, Kuenzier N, Handwerker HO., 1998. Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to the oral and ocular mucosa. J Neurophysiol 80: 465-492.
6. Dubner R, Bennet GJ., 1983. Spinal and trigeminal mechanisms of nociception. Annu Rev Neurosci 6: 384-418.
7. Enna SJ, McCarson KE., 2006. The role of GABA in the mediation and perception of pain. Adv Pharmacol 54: 1-27.
8. Farazifard R, Safapour F, Sheibani V, Javan M., 2005. Eye-wiping test: a sensitive animal model for acute trigeminal pain studies. Brain Res Brain Res Protoc 16: 44-49.
9. Felipe CD, Gonzalez GG, Gallar G, Belmonte C., 1999. Quantification and immunocytochemical characteristics of trigeminal ganglion neurons projecting to the cornea: effect of corneal wounding. Eur J Pain 3: 31-39.
10. Gupta RK, Tandon VR., 2005. Antinociceptive activity of Vitex-negundo Linn leaf extract. Indian J Physiol Pharmacol 49: 163-170.
11. Hirata H, Takeshita S, Hu JW, Bereiter DA., 2000. Cornea-responsive medullary dorsal horn neurons: modulation by local opioids and projection to thalamus and brain stem. J Neurophysiol 84: 1050-1061.
12. Hosseinzadeh H, Karami GH, Niapoor M., 2004. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranol, in mice. Acta Hort 650: 435-445.
13. Hosseinzadeh H, Khosravani V., 2002. Anticonvulsant effects of aqueous and ethanolic extracts of Crocus sativus L. stigma in mice. Arch Irn Med 5: 44-47. (Pubitemid 34591502)
14. Hosseinzadeh H, Sadeghnia HR., 2007. Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: involvement of GABAergic and opioids systems. Phytomedicine 14: 256-262.
15. Hosseinzadeh H, Younesi HM., 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol 2: 1-8.
16. Jones PG, Dunlop J., 2007. Targeting the cholinergic system as a therapeutic strategy for the treatment of pain. Neuropharmacology 53: 197-206.
17. Kogel B, Christoph T, Strassburger W, Friderichs F., 2005. Interaction of mu-opioid receptor agonists and antagonists with analgesic effect of buprenorphine in mice. Eur J Pain 9: 599-611.
18. Lee IA, Lee JH, Baek NI, Kim DH., 2005. Antihyperlipidemic effect of crocin isolated from the fructus of Gardenia jasminoides and its metabolite crocetin. Biol Pharm Bull 28: 2106-2110.
19. Muller IJ, Marfurt CF, Kruse F, Tervo TMT., 2003. Corneal nerves: structure, contents and functions. Exp Eye Res 76: 521-542.
20. Neubert JK, Rossi HL, Pogar J, Jenkins AC, Caudle RM., 2007. Effect of mu-and kappa-2 opioid receptor agonists on pain and rearing behaviors. Behav Brain Function 3: 49-59.
21. Ochiai T, Shimeno H, Mishima K, et al,. 2007. Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochim Biophys Acta 1770: 578-584.
22. Paxinos G, Watson C., 1997. The Rat Brain in Stereotaxic Coordinates. Compact Third Edition. Academic Press: San Diego.
23. Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis PA, Sakellaridis N., 2008. Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine 15: 1135-1139.
24. Pitsikas N, Sakellaridis N., 2006. Crocus sativa L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behav Brain Res 173: 112-115.
25. Pitsikas N, Zisopoulou S, Tarantilis PA, Kanakis CD, Polissiou MG, Sakellaridis N., 2007. Effects of active constituents of Crocus sativa L., crocins on recognition and spatial rats' memory. Behav Brain Res 183: 141-146. (Pubitemid 47348125)
26. Rios JL, Recio MC, Ginger RM, Manz S., 1996. An update review of saffron and its active constituents. Phytother Res 10: 189-193.
27. Saleem S, Ahmad M, Ahmad AS, et al,. 2006. Effect of saffron (Crocus sativus) on neurobehavioral and neurochemical changes in cerebral ischemia in rats. J Med Food 9: 246-253.
28. Schmidt M, Betti G, Hensen A., 2007. Saffron in phytotherapy: pharmacology and clinical uses. Wien Med Wochenschr 157: 315-319.
29. Sevostianova N, Zvartau E, Bespalov A, Danysz W., 2003. Effects of morphine on formalin-induced nociception in rats. Eur J Pharmacol 462: 109-113.
30. Sheth UK, Gupta K, Paul T, Pispati PK., 1980. Measurement of antipyretic activity of ibuprofen and paracetamol in children. J Clin Pharmacol 20: 672-675.
31. Smith HS., 2008. Peripherally-acting opioids. Pain Physician 11: S121-S132.
32. Tamaddonfard E, Hamzeh-Gooshchi N., 2010. Effect of crocin on the morphine-induced antinociception in the formalin test in rats. Phytother Res 24: 410-413.
33. Tamaddonfard E, Khalilzadeh E, Hamzeh-Gooshchi N, Seiednejhad-Yamchi S., 2008. Central effect of histamine in a rat model of acute trigeminal pain. Pharmacol Rep 60: 219-224.
34. Uchida S, Hirai K, Hatanaka J, Hanato J, Umegaki K, Yamada S., 2008. Antinociceptive effect of St John's wort, Harpagophytum procumbens extract and grape seed proanthocyanidins extract in mice. Biol Pharm Bull 31: 240-245.
35. Zheng YQ, Liu JX, Wang JN, Xu L., 2007. Effects of crocin on reperfusion-induced oxidative/nitrative injury to cerebral microvessels after global ischemia. Brain Res 1138: 86-94