Aptamer-conjugated multifunctional nanoflowers as a platform for targeting, capture, and detection in laser desorption ionization mass spectrometry

ACS Nano

Volumn 7, Issue 1, 2013, Pages 417-427

  Ocsoy, Ismail ^a   Gulbakan, Basri ^a   Shukoor, Mohammed Ibrahim ^a   Xiong, Xiangling ^a,b   Chen, Tao ^a   Powell, David H ^a   Tan, Weihong ^a,b  

^a University of Florida   (United States)

^b HUNAN UNIVERSITY   (China)

Author keywords

aptamer; ATP; cancer cell; hybrid nanoparticles; mass spectrometry; nanoflower

Indexed keywords

APTAMERS; CANCER CELLS; FUNCTIONALIZED; HYBRID NANOPARTICLE; IONIZATION MASS SPECTROMETRY; LASER DESORPTION; LASER DESORPTION IONIZATION MASS SPECTROMETRY; METABOLITE EXTRACTION;

ADENOSINETRIPHOSPHATE; CELLS; IONIZATION; LASERS; MANGANESE OXIDE; MASS SPECTROMETRY; METABOLITES; NANOSTRUCTURED MATERIALS; SUBSTRATES;

NANOFLOWERS;

ADENOSINE TRIPHOSPHATE; APTAMER; NANOCAPSULE;

ARTICLE; CHEMISTRY; EXPERIMENTAL NEOPLASM; GENETICS; HUMAN; MASS SPECTROMETRY; METABOLISM; METHODOLOGY; MOLECULAR IMAGING; TUMOR CELL LINE;

ADENOSINE TRIPHOSPHATE; APTAMERS, NUCLEOTIDE; CELL LINE, TUMOR; HUMANS; MOLECULAR IMAGING; NANOCAPSULES; NEOPLASMS, EXPERIMENTAL; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

MLCS; MLOWN;

EID: 84872845976     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn304458m     Document Type: Article

References (77)

1. Ma, X.; Zhao, Y.; Liang, X.-J. Theranostic Nanoparticles Engineered for Clinic and Pharmaceutics Acc. Chem. Res. 2011, 44, 1114-1122
2. Wang, H.; Yang, R.; Yang, L.; Tan, W. Nucleic Acid Conjugated Nanomaterials for Enhanced Molecular Recognition ACS Nano 2009, 3, 2451-2460
3. Hu, R.; Zhang, X.-B.; Kong, R.-M.; Zhao, X.-H.; Jiang, J.; Tan, W. Nucleic Acid-Functionalized Nanomaterials for Bioimaging Applications J. Mater. Chem. 2011, 21, 16323-16334
4. Jain, P. K.; Huang, X.; El-Sayed, I. H.; El-Sayed, M. A. Noble Metals on the Nanoscale: Optical and Photothermal Properties and Some Applications in Imaging, Sensing, Biology, and Medicine Acc. Chem. Res. 2008, 41, 1578-1586
5. Dreaden, E. C.; Mackey, M. A.; Huang, X.; Kang, B.; El-Sayed, M. A. Beating Cancer in Multiple Ways Using Nanogold Chem. Soc. Rev. 2011, 40, 3391-3404
6. Dreaden, E. C.; Alkilany, A. M.; Huang, X.; Murphy, C. J.; El-Sayed, M. A. The Golden Age: Gold Nanoparticles for Biomedicine Chem. Soc. Rev. 2012, 41, 2740-2779
7. Veiseh, O.; Gunn, J. W.; Zhang, M. Design and Fabrication of Magnetic Nanoparticles for Targeted Drug Delivery and Imaging Adv. Drug Delivery Rev. 2010, 62, 284-304
8. Sun, C.; Lee, J. S. H.; Zhang, M. Magnetic Nanoparticles in MR Imaging and Drug Delivery Adv. Drug Delivery Rev. 2008, 60, 1252-1265
9. Gao, J.; Gu, H.; Xu, B. Multifunctional Magnetic Nanoparticles: Design, Synthesis, and Biomedical Applications Acc. Chem. Res. 2009, 42, 1097-1107
10. Das, M.; Mishra, D.; Dhak, P.; Gupta, S.; Maiti, T. K.; Basak, A.; Pramanik, P. Biofunctionalized, Phosphonate-Grafted, Ultrasmall Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Multimodal Imaging Small 2009, 5, 2883-2893
11. Pan, D.; Caruthers, S. D.; Hu, G.; Senpan, A.; Scott, M. J.; Gaffney, P. J.; Wickline, S. A.; Lanza, G. M. Ligand-Directed Nanobialys as Theranostic Agent for Drug Delivery and Manganese-Based Magnetic Resonance Imaging of Vascular Targets J. Am. Chem. Soc. 2008, 130, 9186-9187
12. Bae, K. H.; Lee, K.; Kim, C.; Park, T. G. Surface Functionalized Hollow Manganese Oxide Nanoparticles for Cancer Targeted SiRNA Delivery and Magnetic Resonance Imaging Biomaterials 2011, 32, 176-184
13. Kim, J.; Park, S.; Lee, J. E.; Jin, S. M.; Lee, J. H.; Lee, I. S.; Yang, I.; Kim, J.-S.; Kim, S. K.; Cho, M.-H. et al. Designed Fabrication of Multifunctional Magnetic Gold Nanoshells and Their Application to Magnetic Resonance Imaging and Photothermal Therapy Angew. Chem., Int. Ed. 2006, 118, 7918-7922
14. Hirsch, L. R.; Stafford, R. J.; Bankson, J. A.; Sershen, S. R.; Rivera, B.; Price, R. E.; Hazle, J. D.; Halas, N. J.; West, J. L. Nanoshell-Mediated Near-Infrared Thermal Therapy of Tumors under Magnetic Resonance Guidance Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 13549-13554
15. Sanvicens, N.; Marco, M. P. Multifunctional Nanoparticles-Properties and Prospects for Their Use in Human Medicine Trends Biotechnol. 2008, 26, 425-433
16. Lee, D.-E.; Koo, H.; Sun, I.-C.; Ryu, J. H.; Kim, K.; Kwon, I. C. Multifunctional Nanoparticles for Multimodal Imaging and Theragnosis Chem. Soc. Rev. 2012, 41, 2656-2672
17. 4 Nanoparticles Nano Lett. 2005, 5, 379-382
18. 4 Dumbbell Nanoparticles as Dual-Functional Probes Angew. Chem., Int. Ed. 2008, 47, 173-176
19. 4 Nanoparticles Angew. Chem., Int. Ed. 2010, 49, 1271-1274
20. 4 Optical Nanosensor for Imaging Protease Expressions in Vivo ACS Nano 2011, 5, 3043-3051
21. Schladt, T. D.; Shukoor, M. I.; Schneider, K.; Tahir, M. N.; Natalio, F.; Ament, I.; Becker, J.; Jochum, F. D.; Weber, S.; Köhler, O. et al. Au@MnO Nanoflowers: Hybrid Nanocomposites for Selective Dual Functionalization and Imaging Angew. Chem., Int. Ed. 2010, 49, 3976-3980
22. Song, H.-M.; Wei, Q.; Ong, Q. K.; Wei, A. Plasmon-Resonant Nanoparticles and Nanostars with Magnetic Cores: Synthesis and Magnetomotive Imaging ACS Nano 2010, 4, 5163-5173
23. 2/Graphene Composites for Selective Enrichment of Phosphopeptides Nanoscale 2012, 4, 1577-1580
24. Zenobi, R.; Knochenmuss, R. Ion Formation in MALDI Mass Spectrometry Mass Spectrom. Rev. 1998, 17, 337-366
25. Knochenmuss, R. Ion Formation Mechanisms in UV-MALDI Analyst 2006, 131, 966-986
26. Chiang, C.-K.; Chen, W.-T.; Chang, H.-T. Nanoparticle-Based Mass Spectrometry for the Analysis of Biomolecules Chem. Soc. Rev. 2011, 40, 1269-1281
27. Tanaka, K.; Waki, H.; Ido, Y.; Akita, S.; Yoshida, Y.; Yoshida, T.; Matsuo, T. Protein and Polymer Analyses up to m / z 100000 by Laser Ionization Time-of-Flight Mass Spectrometry Rapid Commun. Mass Spectrom. 1988, 2, 151-153
28. Harkness, K. M.; Cliffel, D. E.; McLean, J. A. Characterization of Thiolate-Protected Gold Nanoparticles by Mass Spectrometry Analyst 2010, 135, 868-874
29. Zhu, Z.-J.; Rotello, V. M.; Vachet, R. W. Engineered Nanoparticle Surfaces for Improved Mass Spectrometric Analyses Analyst 2009, 134, 2183-2188
30. Yan, B.; Zhu, Z.-J.; Miranda, O.; Chompoosor, A.; Rotello, V.; Vachet, R. Laser Desorption/Ionization Mass Spectrometry Analysis of Monolayer-Protected Gold Nanoparticles Anal. Bioanal. Chem. 2010, 396, 1025-1035
31. x J. Am. Chem. Soc. 2008, 130, 5940-5946
32. Tang, J.; Liu, Y.; Qi, D.; Yao, G.; Deng, C.; Zhang, X. On-Plate-Selective Enrichment of Glycopeptides Using Boronic Acid-Modified Gold Nanoparticles for Direct MALDI-QIT-TOF MS Analysis Proteomics 2009, 9, 5046-5055
33. Huang, Y.-F.; Chang, H.-T. Analysis of Adenosine Triphosphate and Glutathione through Gold Nanoparticles Assisted Laser Desorption/Ionization Mass Spectrometry Anal. Chem. 2007, 79, 4852-4859
34. 2+-Doped Carbon Nanotubes with CdS Nanoparticles as the Matrix, Preconcentrating and Accelerating Probes of Microwave Enzymatic Digestion of Peptides and Proteins for Direct MALDI-MS Analysis J. Mass Spectrom. 2010, 45, 1452-1460
35. Chang, S.; Zheng, N.-Y.; Chen, C.-S.; Chen, C.-D.; Chen, Y.-Y.; Wang, C. Analysis of Peptides and Proteins Affinity-Bound to Iron Oxide Nanoparticles by MALDI MS J. Am. Soc. Mass. Spectrom. 2007, 18, 910-918
36. Chiang, C.-K.; Chiang, M.-C.; Lin, Z.-H.; Lan, G.-Y.; Lin, Y.-W.; Chang, H.-T. Nanomaterial-Based Surface-Assisted Laser Desorption/Ionization Mass Spectrometry of Peptides and Proteins J. Am. Soc. Mass. Spectrom. 2010, 21, 1204-1207
37. Gulbakan, B.; Yasun, E.; Shukoor, M. I.; Zhu, Z.; You, M.; Tan, X.; Sanchez, H.; Powell, D. H.; Dai, H.; Tan, W. A Dual Platform for Selective Analyte Enrichment and Ionization in Mass Spectrometry Using Aptamer-Conjugated Graphene Oxide J. Am. Chem. Soc. 2010, 132, 17408-17410
38. Gulbakan, B.; Park, D.; Kang, M.; Kececi, K.; Martin, C. R.; Powell, D. H.; Tan, W. Laser Desorption Ionization Mass Spectrometry on Silicon Nanowell Arrays Anal. Chem. 2010, 82, 7566-7575
39. Chiang, C.-K.; Yang, Z.; Lin, Y.-W.; Chen, W.-T.; Lin, H.-J.; Chang, H.-T. Detection of Proteins and Protein-Ligand Complexes Using HgTe Nanostructure Matrixes in Surface-Assisted Laser Desorption/Ionization Mass Spectrometry Anal. Chem. 2010, 82, 4543-4550
40. Zhu, Z.-J.; Tang, R.; Yeh, Y.-C.; Miranda, O. R.; Rotello, V. M.; Vachet, R. W. Determination of the Intracellular Stability of Gold Nanoparticle Monolayers Using Mass Spectrometry Anal. Chem. 2012, 84, 4321-4326
41. Creran, B.; Yan, B.; Moyano, D. F.; Gilbert, M. M.; Vachet, R. W.; Rotello, V. M. Laser Desorption Ionization Mass Spectrometric Imaging of Mass Barcoded Gold Nanoparticles for Security Applications Chem. Commun. 2012, 48, 4543-4545
42. Zhu, Z.-J.; Ghosh, P. S.; Miranda, O. R.; Vachet, R. W.; Rotello, V. M. Multiplexed Screening of Cellular Uptake of Gold Nanoparticles Using Laser Desorption/Ionization Mass Spectrometry J. Am. Chem. Soc. 2008, 130, 14139-14143
43. Meng, J.-c.; Siuzdak, G.; Finn, M. G. Affinity Mass Spectrometry from a Tailored Porous Silicon Surface Chem. Commun. 2004, 2108-2109
44. Lowe, R. D.; Szili, E. J.; Kirkbride, P.; Thissen, H.; Siuzdak, G.; Voelcker, N. H. Combined Immunocapture and Laser Desorption/Ionization Mass Spectrometry on Porous Silicon Anal. Chem. 2010, 82, 4201-4208
45. Kausaite-Minkstimiene, A.; Ramanaviciene, A.; Kirlyte, J.; Ramanavicius, A. Comparative Study of Random and Oriented Antibody Immobilization Techniques on the Binding Capacity of Immunosensor Anal. Chem. 2010, 82, 6401-6408
46. Tajima, N.; Takai, M.; Ishihara, K. Significance of Antibody Orientation Unraveled: Well-Oriented Antibodies Recorded High Binding Affinity Anal. Chem. 2011, 83, 1969-1976
47. Alves, N. J.; Kiziltepe, T.; Bilgicer, B. Oriented Surface Immobilization of Antibodies at the Conserved Nucleotide Binding Site for Enhanced Antigen Detection Langmuir 2012, 28, 9640-9648
48. Song, H. Y.; Zhou, X.; Hobley, J.; Su, X. Comparative Study of Random and Oriented Antibody Immobilization As Measured by Dual Polarization Interferometry and Surface Plasmon Resonance Spectroscopy Langmuir 2011, 28, 997-1004
49. Tang, Z.; Shangguan, D.; Wang, K.; Shi, H.; Sefah, K.; Mallikratchy, P.; Chen, H. W.; Li, Y.; Tan, W. Selection of Aptamers for Molecular Recognition and Characterization of Cancer Cells Anal. Chem. 2007, 79, 4900-4907
50. Shangguan, D.; Cao, Z.; Meng, L.; Mallikaratchy, P.; Sefah, K.; Wang, H.; Li, Y.; Tan, W. Cell-Specific Aptamer Probes for Membrane Protein Elucidation in Cancer Cells J. Proteome Res. 2008, 7, 2133-2139
51. Shangguan, D.; Li, Y.; Tang, Z.; Cao, Z. C.; Chen, H. W.; Mallikaratchy, P.; Sefah, K.; Yang, C. J.; Tan, W. Aptamers Evolved From Live Cells as Effective Molecular Probes for Cancer Study Proc. Natl. Acad. Sci. U.S.A. 2006, 103, 11838-11843
52. Zhou, X.; Duan, R.; Xing, D. Highly Sensitive Detection of Protein and Small Molecules Based on Aptamer-Modified Electrochemiluminescence Nanoprobe Analyst 2012, 137, 1963-1969
53. Liu, J.; Lu, Y. Fast Colorimetric Sensing of Adenosine and Cocaine Based on a General Sensor Design Involving Aptamers and Nanoparticles Angew. Chem., Int. Ed. 2006, 45, 90-94
54. Miao, X.; Ling, L.; Shuai, X. Ultrasensitive Detection of Lead(II) with DNAzyme and Gold Nanoparticles Probes by Using a Dynamic Light Scattering Technique Chem. Commun. 2011, 47, 4192-4194
55. Lin, Y.-W.; Liu, C.-W.; Chang, H.-T. Fluorescence Detection of Mercury(II) and Lead(II) Ions Using Aptamer/Reporter Conjugates Talanta 2011, 84, 324-329
56. Rotem, D.; Jayasinghe, L.; Salichou, M.; Bayley, H. Protein Detection by Nanopores Equipped with Aptamers J. Am. Chem. Soc. 2012, 134, 2781-2787
57. Wang, J.; Zhu, G.; You, M.; Song, E.; Shukoor, M. I.; Zhang, K.; Altman, M. B.; Chen, Y.; Zhu, Z.; Huang, C. Z. et al. Assembly of Aptamer Switch Probes and Photosensitizer on Gold Nanorods for Targeted Photothermal and Photodynamic Cancer Therapy ACS Nano 2012, 6, 5070-5077
58. Yasun, E.; Gulbakan, B.; Ocsoy, I.; Yuan, Q.; Shukoor, M. I.; Li, C.; Tan, W. Enrichment and Detection of Rare Proteins with Aptamer-Conjugated Gold Nanorods Anal. Chem. 2012, 84, 6008-6015
59. Bamrungsap, S.; Chen, T.; Shukoor, M. I.; Chen, Z.; Sefah, K.; Chen, Y.; Tan, W. Pattern Recognition of Cancer Cells Using Aptamer-Conjugated Magnetic Nanoparticles ACS Nano 2012, 6, 3974-3981
60. Chen, T.; Shukoor, M. I.; Chen, Y.; Yuan, Q.; Zhu, Z.; Zhao, Z.; Gulbakan, B.; Tan, W. Aptamer-Conjugated Nanomaterials for Bioanalysis and Biotechnology Applications Nanoscale 2011, 3, 546-556
61. Fan, Z.; Shelton, M.; Singh, A. K.; Senapati, D.; Khan, S. A.; Ray, P. C. Multifunctional Plasmonic Shell-Magnetic Core Nanoparticles for Targeted Diagnostics, Isolation, and Photothermal Destruction of Tumor Cells ACS Nano 2012, 6, 1065-1073
62. Kim, Y.-K.; Na, H.-K.; Kwack, S.-J.; Ryoo, S.-R.; Lee, Y.; Hong, S.; Hong, S.; Jeong, Y.; Min, D.-H. Synergistic Effect of Graphene Oxide/MWCNT Films in Laser Desorption/Ionization Mass Spectrometry of Small Molecules and Tissue Imaging ACS Nano 2011, 5, 4550-4561
63. Kim, Y.-K.; Min, D.-H. Preparation of the Hybrid Film of Poly(allylamine hydrochloride)-Functionalized Graphene Oxide and Gold Nanoparticle and Its Application for Laser-Induced Desorption/Ionization of Small Molecules Langmuir 2012, 28, 4453-4458
64. Kim, Y.-K.; Min, D.-H. Fabrication of Alternating Multilayer Films of Graphene Oxide and Carbon Nanotube and Its Application in Mechanistic Study of Laser Desorption/Ionization of Small Molecules ACS Appl. Mater. Interfaces 2012, 4, 2088-2095
65. Sellick, C. A.; Hansen, R.; Stephens, G. M.; Goodacre, R.; Dickson, A. J. Metabolite Extraction from Suspension-Cultured Mammalian Cells for Global Metabolite Profiling Nat. Protoc. 2011, 6, 1241-1249
66. Chen, Y.; O'Donoghue, M. B.; Huang, Y.-F.; Kang, H.; Phillips, J. A.; Chen, X.; Estevez, M. C.; Yang, C. J.; Tan, W. A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces J. Am. Chem. Soc. 2010, 132, 16559-16570
67. Yanes, O.; Tautenhahn, R.; Patti, G. J.; Siuzdak, G. Expanding Coverage of the Metabolome for Global Metabolite Profiling Anal. Chem. 2011, 83, 2152-2161
68. Cutler, J. I.; Auyeung, E.; Mirkin, C. A. Spherical Nucleic Acids J. Am. Chem. Soc. 2012, 134, 1376-1391
69. Seferos, D. S.; Giljohann, D. A.; Hill, H. D.; Prigodich, A. E.; Mirkin, C. A. Nano-Flares: Probes for Transfection and mRNA Detection in Living Cells J. Am. Chem. Soc. 2007, 129, 15477-15479
70. Wang, Y.; Li, Z.; Hu, D.; Lin, C.-T.; Li, J.; Lin, Y. Aptamer/Graphene Oxide Nanocomplex for In Situ Molecular Probing in Living Cells J. Am. Chem. Soc. 2010, 132, 9274-9276
71. Tan, X.; Chen, T.; Xiong, X.; Mao, Y.; Zhu, G.; Yasun, E.; Li, C.; Zhu, Z.; Tan, W. Semiquantification of ATP in Live Cells Using Nonspecific Desorption of DNA from Graphene Oxide as the Internal Reference Anal. Chem. 2012, 84, 8622-8627
72. Tan, X.; Chen, W.; Lu, S.; Zhu, Z.; Chen, T.; Zhu, G.; You, M.; Tan, W. Molecular Beacon Aptamers for Direct and Universal Quantitation of Recombinant Proteins from Cell Lysates Anal. Chem. 2012, 84, 8272-8276
73. Zheng, D.; Seferos, D. S.; Giljohann, D. A.; Patel, P. C.; Mirkin, C. A. Aptamer Nano-Flares for Molecular Detection in Living Cells Nano Lett. 2009, 9, 3258-3261
74. Sellick, C. A.; Hansen, R.; Maqsood, A. R.; Dunn, W. B.; Stephens, G. M.; Goodacre, R.; Dickson, A. J. Effective Quenching Processes for Physiologically Valid Metabolite Profiling of Suspension Cultured Mammalian Cells Anal. Chem. 2008, 81, 174-183
75. El-Serag, H. B. Hepatocellular Carcinoma N. Engl. J. Med. 2011, 365, 1118-1127
76. Villanueva, A.; Minguez, B.; Forner, A.; Reig, M.; Llovet, J. M. Hepatocellular Carcinoma: Novel Molecular Approaches for Diagnosis, Prognosis, and Therapy Annu. Rev. Med. 2010, 61, 317-328
77. Chen, T.; Shukoor, M. I.; Wang, R.; Zhao, Z.; Yuan, Q.; Bamrungsap, S.; Xiong, X.; Tan, W. Smart Multifunctional Nanostructure for Targeted Cancer Chemotherapy and Magnetic Resonance Imaging ACS Nano 2011, 5, 7866-7873