Computational study of the covalent bonding of microcystins to cysteine residues - A reaction involved in the inhibition of the PPP family of protein phosphatases

FEBS Journal

Volumn 280, Issue 2, 2013, Pages 674-680

  Pereira, Susana R ^a   Vasconcelos, Vítor M ^a,b   Antunes, Agostinho ^a,b  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

Author keywords

computational study; covalent bond; microcystins; PPP family; protein phosphatases

Indexed keywords

ALANINE DERIVATIVE; ARGININE; CARBON; CARBONYL DERIVATIVE; CYSTEINE; GLUTATHIONE; HYDROGEN; MICROCYSTIN; MICROCYSTIN LR; N METHYLDEHYDROALANINE; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE 3; PHOSPHOPROTEIN PHOSPHATASE 4; PHOSPHOPROTEIN PHOSPHATASE 5; PHOSPHOPROTEIN PHOSPHATASE 6; PHOSPHOPROTEIN PHOSPHATASE 7; PHOSPHOPROTEIN PHOSPHATASE CATALYTIC SUBUNIT; SULFUR; THIOL; TYROSINE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL STRUCTURE; COMPUTER MODEL; COVALENT BOND; CRYSTAL STRUCTURE; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME SUBSTRATE; IC 50; MATHEMATICAL ANALYSIS; MICHAEL ADDITION; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTON TRANSPORT; QUANTUM MECHANICS; STRUCTURE ANALYSIS; THERMODYNAMICS;

CARCINOGENS; CATALYTIC DOMAIN; COMPUTER GRAPHICS; CYSTEINE; ENZYME INHIBITORS; ISOENZYMES; MICROCYSTINS; MICROCYSTIS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PHOSPHOPROTEIN PHOSPHATASES; PROTEIN BINDING; USER-COMPUTER INTERFACE;

CYANOBACTERIA; MAMMALIA;

EID: 84872823009     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08454.x     Document Type: Article

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