Cytisine confers neuronal protection against excitotoxic injury by down-regulating GluN2B-containing NMDA receptors

NeuroToxicology

Volumn 34, Issue 1, 2013, Pages 219-225

  Li, Yu Jiao ^a   Yang, Qi ^a   Zhang, Kun ^a   Guo, Yan Yan ^a   Li, Xu Bo ^a   Yang, Le ^a   Zhao, Ming Gao ^a   Wu, Yu Mei ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bcl 2 family; Cytisine (CYT); GluN2B containing NMDA receptor; N Methyl d aspartate (NMDA); Neuron

Indexed keywords

CALCIUM; CYTISINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PROTEIN BAX; PROTEIN BCL 2;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN NERVE CELL; CALCIUM CELL LEVEL; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; EMBRYO; EXCITOTOXICITY; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ALKALOIDS; ANIMALS; APOPTOSIS; AZOCINES; BCL-2-ASSOCIATED X PROTEIN; CALCIUM; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GESTATIONAL AGE; MICE; MICE, INBRED C57BL; N-METHYLASPARTATE; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS C-BCL-2; QUINOLIZINES; RECEPTORS, N-METHYL-D-ASPARTATE; TIME FACTORS;

CYTISUS;

EID: 84872812388     PISSN: 0161813X     EISSN: 18729711     Source Type: Journal    
DOI: 10.1016/j.neuro.2012.09.009     Document Type: Article

References (41)

1. Abin-Carriquiry J.A., Costa G., Urbanavicius J., Cassels B.K., Rebolledo-Fuentes M., Wonnacott S., et al. In vivo modulation of dopaminergic nigrostriatal pathways by cytisine derivatives: implications for Parkinson's disease?. Eur J Pharmacol 2008, 589(1-3):80-84.
2. Antonsson B. Mitochondria and the Bcl-2 family proteins in apoptosis signaling pathways. Mol Cell Biochem 2004, 256-257(1-2):141-155.
3. Arundine M., Tymianski M. Molecular mechanisms of glutamate-dependent neurodegeneration in ischemia and traumatic brain injury. Cell Mol Life Sci 2004, 61(6):657-668.
4. Badanich K.A., Doremus-Fitzwater T.L., Mulholland P.J., Randall P.K., Delpire E., Becker H.C. NR2B-deficient mice are more sensitive to the locomotor stimulant and depressant effects of ethanol. Genes Brain Behav 2011, 10(7):805-816.
5. Birnbaumer L., Campbell K.P., Catterall W.A., Harpold M.M., Hofmann F., Horne W.A., et al. The naming of voltage-gated calcium channels. Neuron 1994, 13(3):505-506.
6. Brown D.G., Maier D.L., Sylvester M.A., Hoerter T.N., Menhaji-Klotz E., Lasota C.C., et al. 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity. Bioorg Med Chem Lett 2011, 21(11):3399-3403.
7. Bruce-Keller A.J., Begley J.G., Fu W., Butterfield D.A., Bredesen D.E., Hutchins J.B., et al. Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide. J Neurochem 1998, 70(1):31-39.
8. Cao X., Cui Z., Feng R., Tang Y.P., Qin Z., Mei B., et al. Maintenance of superior learning and memory function in NR2B transgenic mice during ageing. Eur J Neurosci 2007, 25(6):1815-1822.
9. Chang L.R., Liu J.P., Zhang N., Wang Y.J., Gao X.L., Wu Y. Different expression of NR2B and PSD-95 in rat hippocampal subregions during postnatal development. Microsc Res Tech 2009, 72(7):517-524.
10. Cho S.I., Park U.J., Chung J.M., Gwag B.J. Neu2000, an NR2B-selective, moderate NMDA receptor antagonist and potent spin trapping molecule for stroke. Drug News Perspect 2010, 23(9):549-556.
11. Collingridge G.L., Lester R.A. Excitatory amino acid receptors in the vertebrate central nervous system. Pharmacol Rev 1989, 41(2):143-210.
12. Cui Y., Jin J., Zhang X., Xu H., Yang L., Du D., et al. Forebrain NR2B overexpression facilitating the prefrontal cortex long-term potentiation and enhancing working memory function in mice. PLoS One 2011, 6(5):e20312.
13. D'Mello R., Marchand F., Pezet S., McMahon S.B., Dickenson A.H. Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain. Mol Ther 2011, 19(10):1780-1792.
14. Day D.E., Cooper M.A., Markham C.M., Huhman K.L. NR2B subunit of the NMDA receptor in the basolateral amygdala is necessary for the acquisition of conditioned defeat in Syrian hamsters. Behav Brain Res 2011, 217(1):55-59.
15. Erreger K., Geballe M.T., Kristensen A., Chen P.E., Hansen K.B., Lee C.J., et al. Subunit-specific agonist activity at NR2A-, NR2B-, NR2C-, and NR2D-containing N-methyl-d-aspartate glutamate receptors. Mol Pharmacol 2007, 72(4):907-920.
16. Etter J.F. Cytisine for smoking cessation: a literature review and a meta-analysis. Arch Intern Med 2006, 166(15):1553-1559.
17. Fitch R.W., Kaneko Y., Klaperski P., Daly J.W., Seitz G., Gundisch D. Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors. Bioorg Med Chem Lett 2005, 15(4):1221-1224.
18. Furukawa H., Singh S.K., Mancusso R., Gouaux E. Subunit arrangement and function in NMDA receptors. Nature 2005, 438(7065):185-192.
19. Gasic G.P., Hollmann M. Molecular neurobiology of glutamate receptors. Annu Rev Physiol 1992, 54:507-536.
20. Gu B., Nakamichi N., Zhang W.S., Nakamura Y., Kambe Y., Fukumori R., et al. Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-d-aspartate receptors composed of an NR1/NR2B subunit assembly. J Neurosci Res 2009, 87(9):2145-2156.
21. Guo H., Barrett T.M., Zhong Z., Fernandez J.A., Griffin J.H., Freeman R.S., et al. Protein S blocks the extrinsic apoptotic cascade in tissue plasminogen activator/N-methyl-d-aspartate-treated neurons via Tyro3-Akt-FKHRL1 signaling pathway. Mol Neurodegener 2011, 6:13.
22. Itoh N., Tsujimoto Y., Nagata S. Effect of bcl-2 on Fas antigen-mediated cell death. J Immunol 1993, 151(2):621-627.
23. Kew J.N., Kemp J.A. An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J Physiol 1998, 512(Pt 1):17-28.
24. Lipton S.A. Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond. Nat Rev Drug Discov 2006, 5(2):160-170.
25. Liu S., Lau L., Wei J., Zhu D., Zou S., Sun H.S., et al. Expression of Ca(2+)-permeable AMPA receptor channels primes cell death in transient forebrain ischemia. Neuron 2004, 43(1):43-55.
26. Liu S.B., Han J., Zhang N., Tian Z., Li X.B., Zhao M.G. Neuroprotective effects of oestrogen against oxidative toxicity through activation of G-protein-coupled receptor 30 receptor. Clin Exp Pharmacol Physiol 2011, 38(9):577-585.
27. Liu Y., Wong T.P., Aarts M., Rooyakkers A., Liu L., Lai T.W., et al. NMDA receptor subunits have differential roles in mediating excitotoxic neuronal death both in vitro and in vivo. J Neurosci 2007, 27(11):2846-2857.
28. MacDermott A.B., Mayer M.L., Westbrook G.L., Smith S.J., Barker J.L. NMDA-receptor activation increases cytoplasmic calcium concentration in cultured spinal cord neurones. Nature 1986, 321(6069):519-522.
29. + exchanger inhibitor, SM-20220, is protective against excitotoxicity in cultured cortical neurons. Stroke 2004, 35(1):185-190.
30. McInnis J., Wang C., Anastasio N., Hultman M., Ye Y., Salvemini D., et al. The role of superoxide and nuclear factor-kappaB signaling in N-methyl-d-aspartate-induced necrosis and apoptosis. J Pharmacol Exp Ther 2002, 301(2):478-487.
31. Meldrum B.S. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000, 130(4S (Suppl.)):1007S-1015S.
32. Mineur Y.S., Somenzi O., Picciotto M.R. Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice. Neuropharmacology 2007, 52(5):1256-1262.
33. Nizri E., Irony-Tur-Sinai M., Lavon I., Meshulam H., Amitai G., Brenner T. IBU-octyl-cytisine, a novel bifunctional compound eliciting anti-inflammatory and cholinergic activity, ameliorates CNS inflammation by inhibition of T-cell activity. Int Immunopharmacol 2007, 7(9):1129-1139.
34. Sattler R., Tymianski M. Molecular mechanisms of calcium-dependent excitotoxicity. J Mol Med (Berl) 2000, 78(1):3-13.
35. Sattler R., Tymianski M. Molecular mechanisms of glutamate receptor-mediated excitotoxic neuronal cell death?. Mol Neurobiol 2001, 24(1-3):107-129.
36. Shen H., Yuan Y., Ding F., Liu J., Gu X. The protective effects of Achyranthes bidentata polypeptides against NMDA-induced cell apoptosis in cultured hippocampal neurons through differential modulation of NR2A- and NR2B-containing NMDA receptors. Brain Res Bull 2008, 77(5):274-281.
37. Sheng M., Kim M.J. Postsynaptic signaling and plasticity mechanisms. Science 2002, 298(5594):776-780.
38. Simon R.P., Swan J.H., Griffiths T., Meldrum B.S. Blockade of N-methyl-d-aspartate receptors may protect against ischemic damage in the brain. Science 1984, 226(4676):850-852.
39. Soundarapandian M.M., Zhong X., Peng L., Wu D., Lu Y. Role of K(ATP) channels in protection against neuronal excitatory insults. J Neurochem 2007, 103(5):1721-1729.
40. Yang Q., Yang Z.F., Liu S.B., Zhang X.N., Hou Y., Li X.Q., et al. Neuroprotective effects of hydroxysafflor yellow A against excitotoxic neuronal death partially through down-regulation of NR2B-containing NMDA receptors. Neurochem Res 2010, 35(9):1353-1360.
41. Zhang X.N., Li J.M., Yang Q., Feng B., Liu S.B., Xu Z.H., et al. Anti-apoptotic effects of hyperoside via inhibition of NR2B-containing NMDA receptors. Pharmacol Rep 2010, 62(5):949-955.