2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 11, 2011, Pages 3399-3403

  Brown, Dean G ^a   Maier, Donna L ^a   Sylvester, Mark A ^a   Hoerter, Tiffany N ^a   Menhaji Klotz, Elnaz ^a   Lasota, Celina C ^a   Hirata, Lee T ^a   Wilkins, Deidre E ^a   Scott, Clay W ^a   Trivedi, Shephali ^a   Chen, Tongming ^a   McCarthy, Dennis J ^a   MacIag, Carla M ^a   Sutton, Evelynjeane J ^a   Cumberledge, Jerry ^a   Mathisen, Don ^a   Roberts, John ^a   Gupta, Anshul ^a   Liu, Frank ^a   Elmore, Charles S ^a   Alhambra, Cristobal ^a   Krumrine, Jennifer R ^a   Wang, Xia ^a   Ciaccio, Paul J ^a   Wood, Michael W ^a   Campbell, James B ^a   Johansson, Magnus J ^b   Xia, Jian ^c   Wen, Xiaotian ^c   Jiang, Ji ^c   Wang, Xiaoping ^c   Peng, Zuozhong ^c   Hu, Tao ^c   Wang, Jian ^c   more..

^a ASTRAZENECA   (United Kingdom)

^b ASTRAZENECA R AND D   (Sweden)

^c WUXI APPTEC   (China)

Author keywords

Anti depressant; NMDA antagonist; NR2B

Indexed keywords

2,6 DISUBSTITUTED PYRAZINE; AMINE; DIZOCILPINE; IFENPRODIL; IMIPRAMINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; PHENOL DERIVATIVE; POTASSIUM CHANNEL HERG; TRAXOPRODIL; UNCLASSIFIED DRUG;

ANTIDEPRESSANT ACTIVITY; ARTICLE; DEPRESSION; DRUG ACTIVITY; DRUG BINDING SITE; DRUG POTENCY; FORCED SWIMMING TEST; IC 50; NONHUMAN;

ANIMALS; ANTIDEPRESSIVE AGENTS; BINDING SITES; BINDING, COMPETITIVE; DOSE-RESPONSE RELATIONSHIP, DRUG; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; MOTOR ACTIVITY; PROTEIN BINDING; PYRAZINES; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 79956116531     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.117     Document Type: Article

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