Halogenated and isosteric cytisine derivatives with increased affinity and functional activity at nicotinic acetylcholine receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 4, 2005, Pages 1221-1224

  Fitch, Richard W ^a,d   Kaneko, Yumika ^a   Klaperski, Paul ^b   Daly, John W ^a   Seitz, Gunther ^b   Gündisch, Daniela ^c  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d INDIANA STATE UNIVERSITY   (United States)

Author keywords

Acetylcholine; Cytisine; Nicotinic receptors; Structure activity relationships

Indexed keywords

CAULOPHYLLINE METHIODIDE; CYTISINE; HALOGEN; NICOTINIC RECEPTOR; QUINOLIZIDINE DERIVATIVE; RECEPTOR SUBTYPE; THIOCYTISINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; ELECTRON; HALOGENATION; HUMAN; HUMAN CELL; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

EID: 16244414874     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.073     Document Type: Article

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