A Kinetic-Based Model of Radiation-Induced Intercellular Signalling

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  McMahon, Stephen J ^a   Butterworth, Karl T ^a   Trainor, Colman ^a   McGarry, Conor K ^a,b   O'Sullivan, Joe M ^a,b   Schettino, Giuseppe ^a   Hounsell, Alan R ^a,b   Prise, Kevin M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DNA;

ARTICLE; BYSTANDER EFFECT; CELL COMMUNICATION; CELL SURVIVAL; DNA DAMAGE; INTRACELLULAR SIGNALING; IONIZING RADIATION; KINETICS; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; RADIATION EXPOSURE; RADIATION RESPONSE; SIGNAL TRANSDUCTION;

BYSTANDER EFFECT; CELL COMMUNICATION; CELL SURVIVAL; DNA DAMAGE; HUMANS; KINETICS; MODELS, THEORETICAL; RADIATION; SIGNAL TRANSDUCTION;

EID: 84872765264     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0054526     Document Type: Article

References (40)

1. Mothersill C, Seymour C, (2001) Radiation-induced bystander effects: past history and future directions. Radiat Res 155: 759-767.
2. Mothersill C, Seymour CB, (1998) Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat Res 149: 256-262.
3. Schettino G, Folkard M, Prise KM, Vojnovic B, Held KD, et al. (2003) Low-dose studies of bystander cell killing with targeted soft X rays. Radiat Res 160: 505-511.
4. Suchowerska N, Ebert MA, Zhang M, Jackson M, (2005) In vitro response of tumour cells to non-uniform irradiation. Phys Med Biol 50: 3041-3051.
5. Butterworth KT, McGarry CK, O'Sullivan JM, Hounsell AR, Prise KM, (2010) A study of the biological effects of modulated 6 MV radiation fields. Phys Med Biol 55: 1607-1618.
6. Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, Hounsell AR, et al. (2011) Out-of-Field Cell Survival Following Exposure to Intensity-Modulated Radiation Fields. Int J Radiat Oncol Biol Phys 79: 1516-1522.
7. Butterworth KT, McGarry CK, Trainor C, McMahon SJ, O'Sullivan JM, et al. (2012) Dose, dose-rate and field size effects on cell survival following exposure to non-uniform radiation fields. Phys Med Biol 57: 3197-3206.
8. Hall EJ, Giaccia AJ (2006) Radiobiology for the Radiologist. Lippincott Williams & Wilkins. p.
9. Prise KM, O'Sullivan JM, (2009) Radiation-induced bystander signalling in cancer therapy. Nat Rev Cancer 9: 351-360.
10. Blyth B, Sykes P, (2011) Radiation-Induced Bystander Effects: What Are They, and How Relevant Are They to Human Radiation Exposures? Radiation Research 176: 139-157.
11. Brenner D, Little J, Sachs R, (2001) The bystander effect in radiation oncogenesis: II. A quantitative model. Radiat Res 408: 402-408.
12. Little MP, Wakeford R, (2001) The bystander effect in C3H 10T cells and radon-induced lung cancer. Radiat Res 156: 695-699.
13. Nikjoo H, Khvostunov IK, (2003) Biophysical model of the radiation-induced bystander effect. International Journal of Radiation Biology 79: 43-52.
14. Little MP, Filipe J a N, Prise KM, Folkard M, Belyakov OV, (2005) A model for radiation-induced bystander effects, with allowance for spatial position and the effects of cell turnover. J Theor Biol 232: 329-338.
15. Stewart RD, Ratnayake RK, Jennings K, (2006) Microdosimetric model for the induction of cell killing through medium-borne signals. Radiat Res 165: 460-469.
16. Shuryak I, Sachs RK, Brenner DJ, (2007) Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat Res 168: 741-749.
17. Fakir H, Hofmann W, Tan W, (2009) Triggering-response model for radiation-induced bystander effects. Radiat Res 331: 320-331.
18. Ebert M a, Suchowerska N, Jackson M a, McKenzie DR, (2010) A mathematical framework for separating the direct and bystander components of cellular radiation response. Acta Oncol (Madr) 49: 1334-1343.
19. Mothersill C, Seymour C, (1997) Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. International Journal of Radiation Biology 71: 421-427.
20. Ryan L a, Smith RW, Seymour CB, Mothersill CE, (2008) Dilution of irradiated cell conditioned medium and the bystander effect. Radiat Res 169: 188-196.
21. McMahon SJ, Butterworth KT, McGarry CK, Trainor C, O'Sullivan JM, et al. (2012) A Computational Model of Cellular Response to Modulated Radiation Fields. Int J Radiat Oncol Biol Phys 84: 250-256.
22. Carballo E, (1998) Feedback Inhibition of Macrophage Tumor Necrosis Factor-α Production by Tristetraprolin. Science (80-) 281: 1001-1005.
23. Harris SL, Levine AJ, (2005) The p53 pathway: positive and negative feedback loops. Oncogene 24: 2899-2908.
24. Vines AM, Lyng FM, McClean B, Seymour C, Mothersill CE, (2008) Bystander signal production and response are independent processes which are cell line dependent. Int J Radiat Biol 84: 83-90.
25. Trainor C, Butterworth KT, McGarry C, (2012) DNA Damage Responses following Exposure to Modulated Radiation Fields. PLoS ONE 7: e43326.
26. Schettino G, Folkard M, Michael BD, Prise KM, (2005) Low-dose binary behavior of bystander cell killing after microbeam irradiation of a single cell with focused c(k) x rays. Radiat Res 163: 332-336.
27. Burdak-Rothkamm S, Short SC, Folkard M, Rothkamm K, Prise KM, (2007) ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26: 993-1002.
28. Azzam EI, de Toledo SM, Little JB, (2003) Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect. Oncogene 22: 7050-7057.
29. Ponnaiya B, Jenkins-Baker G, Brenner DJ, Hall EJ, Randers-Pehrson G, et al. (2004) Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiat Res 162: 426-432.
30. Przybyszewski WM, Widel M, Szurko A, Lubecka B, Matulewicz L, et al. (2004) Multiple bystander effect of irradiated megacolonies of melanoma cells on non-irradiated neighbours. Cancer Lett 214: 91-102.
31. Partridge M, (2008) A radiation damage repair model for normal tissues. Phys Med Biol 53: 3595-3608.
32. Zhang Y, Zhou J, Baldwin J, Held KD, Prise KM, et al. (2009) Ionizing radiation-induced bystander mutagenesis and adaptation: quantitative and temporal aspects. Mutat Res 671: 20-25.
33. Belyakov OV, Mitchell S a, Parikh D, Randers-Pehrson G, Marino S a, et al. (2005) Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc Natl Acad Sci U S A 102: 14203-14208.
34. Mastro AM, Babich MA, Taylor WD, Keith AD, (1984) Diffusion of a small molecule in the cytoplasm of mammalian cells. Proc Natl Acad Sci U S A 81: 3414-3418.
35. Banerjee G, Gupta N, Kapoor A, Raman G, (2005) UV induced bystander signaling leading to apoptosis. Cancer Lett 223: 275-284.
36. Asur RS, Thomas R a, Tucker JD, (2009) Chemical induction of the bystander effect in normal human lymphoblastoid cells. Mutat Res 676: 11-16.
37. Purschke M, Laubach H-J, Anderson RR, Manstein D, (2010) Thermal injury causes DNA damage and lethality in unheated surrounding cells: active thermal bystander effect. J Invest Dermatol 130: 86-92.
38. Botchway S, Stevens D, Hill M, TJ J, O'Neill P, (1997) Induction and rejoining of DNA double-strand breaks in Chinese hamster V79-4 cells irradiated with characteristic aluminum K and copper L ultrasoft X rays. Radiation Research 148: 317-324.
39. Wang H, Zeng ZC, Bui T a, Sonoda E, Takata M, et al. (2001) Efficient rejoining of radiation-induced DNA double-strand breaks in vertebrate cells deficient in genes of the RAD52 epistasis group. Oncogene 20: 2212-2224.
40. Mackonis EC, Suchowerska N, Zhang M, Ebert M, McKenzie DR, et al. (2007) Cellular response to modulated radiation fields. Phys Med Biol 52: 5469-5482.