Dose, dose-rate and field size effects on cell survival following exposure to non-uniform radiation fields

Physics in Medicine and Biology

Volumn 57, Issue 10, 2012, Pages 3197-3206

  Butterworth, Karl T ^a   McGarry, Conor K ^a,b   Trainor, Colman ^a   McMahon, Stephen J ^a   Osullivan, Joe M ^a,b   Schettino, Giuseppe ^a   Hounsell, Alan R ^a,b   Prise, Kevin M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELL POPULATIONS; CELL SURVIVAL; CLONOGENIC ASSAYS; DOSE DISTRIBUTIONS; DOSE-RATE; DOSE-RATE EFFECTS; FIELD SIZE; HUMAN PROSTATE CANCER; IN-FIELD; IN-VITRO; INTENSITY-MODULATED RADIATION THERAPY; IRRADIATION FIELDS; MATHEMATICAL MODELLING; MODULATED FIELD; NON-TARGETED; RADIATION FIELD; RADIOBIOLOGICAL EFFECTS; RADIOBIOLOGICAL PARAMETERS; X-RAY SOURCES;

CELL CULTURE; CELL PROLIFERATION; PHYSICAL THERAPY;

CELLS;

ARTICLE; CELL SURVIVAL; HUMAN; INTENSITY MODULATED RADIATION THERAPY; RADIATION DOSE; RADIATION EXPOSURE; TUMOR CELL LINE;

CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; RADIATION DOSAGE; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED;

EID: 84860653559     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/57/10/3197     Document Type: Article

References (15)

1. Butterworth K T, McGarry C K, OSullivan J M, Hounsell A R and Prise K M 2010 A study of the biological effects of modulated 6 MV radiation fields Phys. Med. Biol. 55 160718
2. Butterworth K T, McGarry C K, Trainor C, OSullivan J M, Hounsell A R and Prise K M 2011 Out-of-field cell survival following exposure to intensity-modulated radiation fields Int. J. Radiat. Oncol. Biol. Phys. 79 151622
3. Claridge Mackonis E C, Suchowerska N, Zhang M, Ebert M, McKenzie D R and Jackson M 2007 Cellular response to modulated radiation fields Phys. Med. Biol. 52 546982 (Pubitemid 350056678)
4. Hall E J and Giaccia A J 2006 Radiobiology for the Radiologist 6th edn (Philadelphia, PA: Lippincott William and Wilkins)
5. IPSM 1990 Code of practice for high-energy photon therapy dosimetry based on the NPL absorbed dose calibration service Phys. Med. Biol. 35 135560 (Pubitemid 20304104)
6. Kirkby C, Field C, MacKenzie M, Syme A and Fallone B G 2007 A Monte Carlo study of the variation of electron fluence in water from a 6 MV photon beam outside of the field Phys. Med. Biol. 52 356378 (Pubitemid 46830642)
7. Liu H H and Verhaegen F 2002 An investigation of energy spectrum and lineal energy variations in mega-voltage photon beams used for radiotherapy Radiat. Prot. Dosim. 99 4257
8. McGarry C K, Butterworth K T, Trainor C, OSullivan J M, Prise K M and Hounsell A R 2011 Temporal characterization and in vitro comparison of cell survival following the delivery of 3D-conformal, intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) Phys. Med. Biol. 56 244557
9. McMahon S J, Butterworth K T, McGarry C K, Trainor C, OSullivan J M, Hounsell A R and Prise K M 2012 A computational model of cellular response to modulated radiation fields Int. J. Radiat. Oncol. Biol. Phys. at press (doi: 10.1016/j.ijr.obp.2011.10.058)
10. Mothersill C and Seymour C 1997 Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells Int. J. Radiat. Biol. 71 4217 (Pubitemid 27187398)
11. Prise K M and OSullivan J M 2009 Radiation-induced bystander signalling in cancer therapy Nature Rev. Cancer 9 35160
12. Puck T T and Marcus P I 1956 Action of X-rays on mammalian cells J. Exp. Med. 103 65366
13. Suchowerska N, Ebert M A, Zhang M and Jackson M 2005 In vitro response of tumour cells to non-uniform irradiation Phys. Med. Biol. 50 304151 (Pubitemid 40905184)
14. Takam R, Bezak E, Marcu L G and Yeoh E 2011 Out-of-field neutron and leakage photon exposures and the associated risk of second cancers in high-energy photon radiotherapy: current status Radiat. Res. 176 50820
15. Trainor C T, Butterworth K T, McGarry C K, Liberante F, OSullivan J M, Hounsell A R and Prise K M 2012 Cell survival responses after exposure to modulated radiation fields Radiat. Res. 177 4451