A study of the biological effects of modulated 6 MV radiation fields

Physics in Medicine and Biology

Volumn 55, Issue 6, 2010, Pages 1607-1618

  Butterworth, Karl T ^a   McGarry, Conor K ^b   O'Sullivan, Joe M ^a,b   Hounsell, Alan R ^b   Prise, Kevin M ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ROYAL GROUP OF HOSPITALS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EFFECTS; CELL SURVIVAL; DOSE-RESPONSE CURVES; FIBROBLAST CELLS; IN-VITRO; MODULATED FIELD; MULTILEAF COLLIMATORS; NONUNIFORM; RADIATION FIELD; TUMOUR CELLS; UNIFORM FIELDS;

CELL CULTURE;

RADIATION EFFECTS;

ARTICLE; CELL CULTURE; CELL SURVIVAL; CYTOLOGY; FIBROBLAST; GLIOMA; HUMAN; INTENSITY MODULATED RADIATION THERAPY; MALE; METABOLISM; METHODOLOGY; PROSTATE TUMOR; RADIATION DOSE; RADIATION EXPOSURE; RADIATION RESPONSE; REPRODUCIBILITY; SCINTISCANNING; TIME;

CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, RADIATION; FIBROBLASTS; GLIOMA; HUMANS; MALE; PROSTATIC NEOPLASMS; RADIOTHERAPY DOSAGE; RADIOTHERAPY, INTENSITY-MODULATED; REPRODUCIBILITY OF RESULTS; TIME FACTORS;

EID: 77749307210     PISSN: 00319155     EISSN: 13616560     Source Type: Journal    
DOI: 10.1088/0031-9155/55/6/005     Document Type: Article

References (21)

1. Bewes J M, Suchowerska N, Jackson M, Zhang M and McKenzie D R 2008 The radiobiological effect of intra-fraction dose-rate modulation in intensity modulated radiation therapy (IMRT) Phys. Med. Biol. 53 3567-78
2. Claridge Mackonis E, Suchowerska N, McKenzie D R, Ebert M, Jackson M Morrell and Bewes J 2009 Reply to 'Comments on "Cellular response to modulated radiation fields"' Phys. Med. Biol. 54 L15-20
3. Claridge Mackonis E, Suchowerska N, Zhang M, Ebert M, McKenzie D R and Jackson M 2007 Cellular response to modulated radiation fields Phys. Med. Biol. 52 5469-82
4. Ezzell G A, Galvin J M, Low D, Palta J R, Rosen I, Sharpe M B, Xia P, Xiao Y, Xing L and Yu C X 2003 Guidance document on delivery, treatment planning, and clinical implementation of IMRT: report of the IMRT Subcommittee of the AAPM Radiation Therapy Committee Med. Phys. 30 2089-115
5. Fowler J F, Welsh J S and Howard S P 2004 Loss of biological effect in prolonged fraction delivery Int. J. Radiat. Oncol. Biol. Phys. 59 242-9
6. Garcia L M, Leblanc J, Wilkins D and Raaphorst G P 2006 Fitting the linear-quadratic model to detailed data sets for different dose ranges Phys. Med. Biol. 51 2813-23
7. Hall E J and Giaccia A J 2006 Radiobiology for the Radiologist 6th edn (Philadelphia, PA: Lippincott William & Wilkins)
8. IPSM 1990 Code of practice for high-energy photon therapy dosimetry based on the NPL absorbed dose calibration service Phys. Med. Biol. 35 1355-60
9. Kuperman V Y, Ventura A M and Sommerfeldt M 2008 Effect of radiation protraction in intensity-modulated radiation therapy with direct aperture optimization: a phantom study Phys. Med. Biol. 53 3279-92
10. Mogili N, Joiner M and Burmeister J 2006 Effects of IMRT treatment time progression on tumour cell survival Med. Phys. 33 2294
11. Moiseenko V, Duzenli C and Durand R E 2007 In vitro study of cell survival following dynamic MLC intensity-modulated radiation therapy dose delivery Med. Phys. 34 1514-20
12. Mu X, Löfroth P O, Karlsson M and Zackrisson B 2003 The effect of fraction time in intensity modulated radiotherapy: theoretical and experimental evaluation of an optimisation problem Radiother. Oncol. 68 181-7
13. Ogino H, Shibamoto Y, Sugie C and Ito M 2005 Biological effects of intermittent radiation in cultured tumor cells: influence of fraction number and dose per fraction J Radiat. Res (Tokyo) 46 401-6
14. Paganetti H 2005 Changes in tumor cell response due to prolonged dose delivery times in fractionated radiation therapy Int. J. Radiat. Oncol. Biol. Phys. 63 892-900
15. Prise K M and O'Sullivan J M 2009 Radiation-induced bystander signalling in cancer therapy Nat. Rev. Cancer 9 351-60
16. Puck T T and Marcus P I 1956 Action of x-rays on mammalian cells J. Exp. Med. 103 653-66
17. Ross C K and Klassen N V 2009 Comments on 'Cellular response to modulated radiation fields' Phys. Med. Biol. 54 L11-3
18. Shibamoto Y, Ito M, Sugie C, Ogino H and Hara M 2004 Recovery from sublethal damage during intermittent exposures in cultured tumor cells: implications for dose modification in radiosurgery and IMRT Int. J. Radiat. Oncol. Biol. Phys. 59 1484-90
19. Suchowerska N, Ebert M A, Zhang M and Jackson M 2005 In vitro response of tumour cells to non-uniform irradiation Phys. Med. Biol. 50 3041-51
20. Veldeman L, Madani I, Hulstaert F, De Meerleer G, Mareel M and De Neve W 2008 Evidence behind use of intensity-modulated radiotherapy: a systematic review of comparative clinical studies Lancet. Oncol. 9 367-75
21. Wang J Z, Li X A, D'Souza W D and Stewart R D 2003 Impact of prolonged fraction delivery times on tumor control: a note of caution for intensity-modulated radiation therapy (IMRT) Int. J. Radiat. Oncol. Biol. Phys. 57 543-52