Transcription factors GATA-3 and RORgt are important for determining the phenotype of allergic airway inflammation in a murine model of Asthma

Journal of Immunology

Volumn 190, Issue 3, 2013, Pages 1056-1065

  Ano, Satoshi ^a   Morishima, Yuko ^a   Ishii, Yukio ^a   Yoh, Keigyou ^a   Yageta, Yuichi ^a   Ohtsuka, Shigeo ^a   Matsuyama, Masashi ^a   Kawaguchi, Mio ^a   Takahashi, Satoru ^a   Hizawa, Nobuyuki ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 BROMOPHENYL) 3 (2 HYDROXY 4 NITROPHENYL)UREA; DEXAMETHASONE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 17 ANTIBODY; INTERLEUKIN 17F; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; INTERLEUKIN 22; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; KERATINOCYTE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 2; OVALBUMIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; TRANSCRIPTION FACTOR GATA 3; TRANSFORMING GROWTH FACTOR BETA;

ALLERGIC AIRWAY INFLAMMATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL HYPERPLASIA; CONTROLLED STUDY; CYTOKINE PRODUCTION; EOSINOPHILIA; FEMALE; GENE OVEREXPRESSION; GOBLET CELL; MOUSE; MUCUS SECRETION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT ALLERGY; RESPIRATORY TRACT INFLAMMATION; TH17 CELL; TH2 CELL;

ANIMALS; ASTHMA; CHEMOKINES; DISEASE MODELS, ANIMAL; FEMALE; GATA3 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; IMMUNOGLOBULIN E; INTERLEUKIN-17; LUNG; LYMPHOKINES; LYMPHOPOIESIS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; NEUTROPHILS; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; OVALBUMIN; PHENOTYPE; RECEPTORS, INTERLEUKIN-6; RECEPTORS, INTERLEUKIN-8B; RECOMBINANT FUSION PROTEINS; TH17 CELLS; TH2 CELLS;

EID: 84872710447     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1202386     Document Type: Article

References (41)

1. Gibeon, D., and K. F. Chung. 2012. The investigation of severe asthma to define phenotypes. Clin. Exp. Allergy 42: 678-692.
2. American Thoracic Society. 2000. Proceedings of the ATS workshop on refractory asthma: Current understanding, recommendations, and unanswered questions. Am. J. Respir. Crit. Care Med. 162: 2341-2351.
3. The ENFUMOSA Study Group. 2003. The ENFUMOSA cross-sectional European multicentre study of the clinical phenotype of chronic severe asthma. Eur. Respir. J. 22: 470-477.
4. Al-Ramli, W., D. Préfontaine, F. Chouiali, J. G. Martin, R. Olivenstein, C. Lemiere, and Q. Hamid. 2009. T(H)17-associated cytokines (IL-17A and IL-17F) in severe asthma. J. Allergy Clin. Immunol. 123: 1185-1187.
5. Wang, Y. H., and Y. J. Liu. 2008. The IL-17 cytokine family and their role in allergic inflammation. Curr. Opin. Immunol. 20: 697-702.
6. Zhu, J., H. Yamane, J. Cote-Sierra, L. Guo, and W. E. Paul. 2006. GATA-3 promotes Th2 responses through three different mechanisms: Induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cellspecific factors. Cell Res. 16: 3-10. (Pubitemid 43129303)
7. Lazarevic, V., and L. H. Glimcher. 2011. T-bet in disease. Nat. Immunol. 12: 597-606.
8. Ivanov, I. I., B. S. McKenzie, L. Zhou, C. E. Tadokoro, A. Lepelley, J. J. Lafaille, D. J. Cua, and D. R. Littman. 2006. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126: 1121-1133. (Pubitemid 44380299)
9. Korn, T., E. Bettelli, M. Oukka, and V. K. Kuchroo. 2009. IL-17 and Th17 Cells. Annu. Rev. Immunol. 27: 485-517.
10. Yoh, K., K. Shibuya, N. Morito, T. Nakano, K. Ishizaki, H. Shimohata, M. Nose, S. Izui, A. Shibuya, A. Koyama, et al. 2003. Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background. J. Am. Soc. Nephrol. 14: 2494-2502. (Pubitemid 37169335)
11. Yoh, K., N. Morito, M. Ojima, K. Shibuya, Y. Yamashita, Y. Morishima, Y. Ishii, M. Kusakabe, H. Nishikii, A. Fujita, et al. 2012. Overexpression of RORgt under control of the CD2 promoter induces polyclonal plasmacytosis and autoantibody production in transgenic mice. Eur. J. Immunol. 42: 1999-2009.
12. Ishii, M., K. Asano, H. Namkoong, S. Tasaka, K. Mizoguchi, T. Asami, H. Kamata, Y. Kimizuka, H. Fujiwara, Y. Funatsu, et al. 2012. CRTH2 is a critical regulator of neutrophil migration and resistance to polymicrobial sepsis. J. Immunol. 188: 5655-5664.
13. Mizutani, N., H. Goshima, T. Nabe, and S. Yoshino. 2012. Complement C3ainduced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice. J. Immunol. 188: 5694-5705.
14. Mori, K., K. Yoshida, M. Mihara, Y. Ohsugi, Y. Nakagawa, S. Hoshikawa, H. Ozaki, and S. Ito. 2009. Effects of interleukin-6 blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Autoimmunity 42: 228-234.
15. Pelletier, M., L. Maggi, A. Micheletti, E. Lazzeri, N. Tamassia, C. Costantini, L. Cosmi, C. Lunardi, F. Annunziato, S. Romagnani, and M. A. Cassatella. 2010. Evidence for a cross-talk between human neutrophils and Th17 cells. Blood 115: 335-343.
16. Nakamura, Y., O. Ghaffar, R. Olivenstein, R. A. Taha, A. Soussi-Gounni, D. H. Zhang, A. Ray, and Q. Hamid. 1999. Gene expression of the GATA-3 transcription factor is increased in atopic asthma. J. Allergy Clin. Immunol. 103: 215-222. (Pubitemid 29095824)
17. Caramori, G., S. Lim, K. Ito, K. Tomita, T. Oates, E. Jazrawi, K. F. Chung, P. J. Barnes, and I. M. Adcock. 2001. Expression of GATA family of transcription factors in T-cells, monocytes and bronchial biopsies. Eur. Respir. J. 18: 466-473. (Pubitemid 32895631)
18. Hamzaoui, A., H. Maalmi, A. Berraies, H. Abid, J. Ammar, and K. Hamzaoui. 2011. Transcriptional characteristics of CD4 T cells in young asthmatic children: RORC and FOXP3 axis. J Inflamm Res 4: 139-146.
19. Finotto, S., M. F. Neurath, J. N. Glickman, S. Qin, H. A. Lehr, F. H. Green, K. Ackerman, K. Haley, P. R. Galle, S. J. Szabo, et al. 2002. Development of spontaneous airway changes consistent with human asthma in mice lacking Tbet. Science 295: 336-338. (Pubitemid 34074365)
20. Kiwamoto, T., Y. Ishii, Y. Morishima, K. Yoh, A. Maeda, K. Ishizaki, T. Iizuka, A. E. Hegab, Y. Matsuno, S. Homma, et al. 2006. Transcription factors T-bet and GATA-3 regulate development of airway remodeling. Am. J. Respir. Crit. Care Med. 174: 142-151. (Pubitemid 44015387)
21. Bullens, D. M., E. Truyen, L. Coteur, E. Dilissen, P. W. Hellings, L. J. Dupont, and J. L. Ceuppens. 2006. IL-17 mRNA in sputum of asthmatic patients: Linking T cell driven inflammation and granulocytic influx? Respir. Res. 7: 135.
22. Wilson, R. H., G. S. Whitehead, H. Nakano, M. E. Free, J. K. Kolls, and D. N. Cook. 2009. Allergic sensitization through the airway primes Th17-dependent neutrophilia and airway hyperresponsiveness. Am. J. Respir. Crit. Care Med. 180: 720-730.
23. Zygmunt, B. M., F. Rharbaoui, L. Groebe, and C. A. Guzman. 2009. Intranasal immunization promotes th17 immune responses. J. Immunol. 183: 6933-6938.
24. Wang, Q., H. Li, Z. Zhang, Y. Yao, and J. Zhou. 2010. Prolonged ovalbumin challenge facilitates Th17 polarization in sensitized mice. Inflamm. Res. 59: 561-569.
25. Zhao, Y., J. Yang, Y. D. Gao, and W. Guo. 2010. Th17 immunity in patients with allergic asthma. Int. Arch. Allergy Immunol. 151: 297-307.
26. Zrioual, S., M. L. Toh, A. Tournadre, Y. Zhou, M. A. Cazalis, A. Pachot, V. Miossec, and P. Miossec. 2008. IL-17RA and IL-17RC receptors are essential for IL-17A-induced ELR+ CXC chemokine expression in synoviocytes and are overexpressed in rheumatoid blood. J. Immunol. 180: 655-663.
27. Fujie, H., K. Niu, M. Ohba, Y. Tomioka, H. Kitazawa, K. Nagashima, T. Ohrui, and M. Numasaki. 2012. A distinct regulatory role of Th17 cytokines IL-17A and IL-17F in chemokine secretion from lung microvascular endothelial cells. Inflammation 35: 1119-1131.
28. Pavord, I. D., C. E. Brightling, G. Woltmann, and A. J. Wardlaw. 1999. Noneosinophilic corticosteroid unresponsive asthma. Lancet 353: 2213-2214.
29. Berry, M., A. Morgan, D. E. Shaw, D. Parker, R. Green, C. Brightling, P. Bradding, A. J. Wardlaw, and I. D. Pavord. 2007. Pathological features and inhaled corticosteroid response of eosinophilic and non-eosinophilic asthma. Thorax 62: 1043-1049. (Pubitemid 350206195)
30. Saffar, A. S., H. Ashdown, and A. S. Gounni. 2011. The molecular mechanisms of glucocorticoids-mediated neutrophil survival. Curr. Drug Targets 12: 556-562.
31. Cox, G. 1995. Glucocorticoid treatment inhibits apoptosis in human neutrophils. Separation of survival and activation outcomes. J. Immunol. 154: 4719-4725.
32. McKinley, L., J. F. Alcorn, A. Peterson, R. B. Dupont, S. Kapadia, A. Logar, A. Henry, C. G. Irvin, J. D. Piganelli, A. Ray, and J. K. Kolls. 2008. TH17 cells mediate steroid-resistant airway inflammation and airway hyperresponsiveness in mice. J. Immunol. 181: 4089-4097.
33. Matsumoto, K., H. Aizawa, H. Inoue, H. Koto, H. Nakano, and N. Hara. 1999. Role of neutrophil elastase in ozone-induced airway responses in guinea-pigs. Eur. Respir. J. 14: 1088-1094.
34. O'Byrne, P. M., E. H. Walters, B. D. Gold, H. A. Aizawa, L. M. Fabbri, S. E. Alpert, J. A. Nadel, and M. J. Holtzman. 1984. Neutrophil depletion inhibits airway hyperresponsiveness induced by ozone exposure. Am. Rev. Respir. Dis. 130: 214-219. (Pubitemid 14055807)
35. Nishimoto, N., and T. Kishimoto. 2006. Interleukin 6: From bench to bedside. Nat. Clin. Pract. Rheumatol. 2: 619-626. (Pubitemid 44650950)
36. Linker, R. A., F. Luhder, K. J. Kallen, D. H. Lee, B. Engelhardt, S. Rose-John, and R. Gold. 2008. IL-6 transsignalling modulates the early effector phase of EAE and targets the blood-brain barrier. J. Neuroimmunol. 205: 64-72.
37. Ogura, H., M. Murakami, Y. Okuyama, M. Tsuruoka, C. Kitabayashi, M. Kanamoto, M. Nishihara, Y. Iwakura, and T. Hirano. 2008. Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction. Immunity 29: 628-636.
38. Tanaka, T., M. Narazaki, and T. Kishimoto. 2012. Therapeutic targeting of the interleukin-6 receptor. Annu. Rev. Pharmacol. Toxicol. 52: 199-219.
39. Yokoyama, A., N. Kohno, S. Fujino, H. Hamada, Y. Inoue, S. Fujioka, S. Ishida, and K. Hiwada. 1995. Circulating interleukin-6 levels in patients with bronchial asthma. Am. J. Respir. Crit. Care Med. 151: 1354-1358.
40. Broide, D. H., M. Lotz, A. J. Cuomo, D. A. Coburn, E. C. Federman, and S. I. Wasserman. 1992. Cytokines in symptomatic asthma airways. J. Allergy Clin. Immunol. 89: 958-967.
41. Doganci, A., T. Eigenbrod, N. Krug, G. T. De Sanctis, M. Hausding, V. J. Erpenbeck, B. Haddad, H. A. Lehr, E. Schmitt, T. Bopp, et al. 2005. The IL-6R alpha chain controls lung CD4+CD25+ Treg development and function during allergic airway inflammation in vivo. [Published erratum appears in 2005 J. Clin. Invest. 115: 1388.] J. Clin. Invest. 115: 313-325. (Pubitemid 40385473)