Transgenic overexpression of GATA-3 in T lymphocytes improves autoimmune glomerulonephritis in mice with a BXSB/MpJ-Yaa genetic background

Journal of the American Society of Nephrology

Volumn 14, Issue 10, 2003, Pages 2494-2502

  Yoh, Keigyou ^a   Shibuya, Kazuko ^c   Morito, Naoki ^a   Nakano, Takako ^a   Ishizaki, Kazusa ^a   Shimohata, Homare ^a   Nose, Masato ^d   Izui, Shozo ^e   Shibuya, Akira ^a,c,f   Koyama, Akio ^a   Engel, James Douglas ^g   Yamamoto, Masayuki ^a,b   Takahashi, Satoru ^a,b  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c RIKEN YOKOHAMA INSTITUTE   (Japan)

^d EHIME UNIVERSITY   (Japan)

^e UNIVERSITY OF GENEVA   (Switzerland)

^f JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^g NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G3; INTERLEUKIN 4; INTERLEUKIN 5; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GATA 3;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE DISEASE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOKINE PRODUCTION; DISEASE SEVERITY; GENE OVEREXPRESSION; GLOMERULONEPHRITIS; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; INCIDENCE; LYMPHOCYTE DIFFERENTIATION; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEINURIA; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; TRANSCRIPTION REGULATION; TRANSGENIC MOUSE;

EID: 0141566876     PISSN: 10466673     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.ASN.0000086473.23379.25     Document Type: Article

References (45)

1. Davidson A, Diamond B: Autoimmune diseases. N Engl J Med 345: 340-350, 2001
2. Mathisen PM, Tuohy VK: Gene therapy in the treatment of autoimmune disease. Immunol Today 19: 103-105, 1998
3. Mountz JD, Wu J, Cheng J, Zhou T: Autoimmune disease: A problem of defective apoptosis. Arthritis Rheum 37: 1415-1420, 1994
4. Marrack P, Kappler J, Kotzin BL: Autoimmune disease: Why and where it occurs. Nat Med 7: 899-905, 2001
5. + T cells in the pathogenesis of organ-specific autoimmune diseases. Immunol Today 16: 34-38, 1995
6. Abbas AK, Murphy KM, Sher A: Functional diversity of helper T lymphocytes. Nature 383: 787-793, 1996
7. + T-cell subsets in autoimmunity. Curr Opin Immunol 9: 872-883, 1997
8. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136: 2348-2357, 1986
9. Romagnani S: Human TH1 and TH2 subsets: Doubt no more. Immunol Today 12: 256-257, 1991
10. Farrar JD, Asnagli H, Murphy KM: T helper subset development: Roles of instruction, selection, and transcription. J Clin Invest 109: 431-435, 2002
11. Rengarajan J, Szabo SJ, Glimcher LH: Transcriptional regulation of Th1/Th2 polarization. Immunol Today 21: 479-483, 2000
12. Szabo SJ, Kim ST, Costa GL, Zhang X, Fathman CG, Glimcher c LH: A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100: 655-669, 2000
13. Yamamoto M, Ko LJ, Leonard MW, Beug H, Orkin SH, Engel JD: Activity and tissue-specific expression of the transcription factor NF-E1 mutigene family. Genes Dev 4: 1650-1662, 1990
14. Ko LJ, Yamamoto M, Leonard MW, George KM, Ting P, Engel JD: Murine and human T-lymphocyte GATA-3 factors mediate transcription through a cis-regulatory element within the human T-cell receptor δ gene enhancer. Mol Cell Biol 11: 2778-2784, 1991
15. Ting CN, Olson MC, Barton KP, Leiden JM: Transcription factor GATA-3 is required for development of the T-cell lineage. Nature 384: 474-478, 1996
16. Hendriks RW, Nawijn MC, Engel JD, van Doominck H, Grosveld F, Karis A: Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus. Eur J Immunol 29: 1912-1918, 1999
17. Hattori N, Kawamoto H, Fujimoto S, Kuno K, Katsura Y: Involvement of transcription factors TCF-1 and GATA-3 in the initiation of the earliest step of T cell development in the thymus. J Exp Med 184: 1137-1147, 1996
18. Zhang DH, Cohn L, Ray P, Bottomly K, Ray A: Transcription factor GATA-3 is differentially expressed in murine Th1 and Th2 cells and controls Th2-specific expression of the interleukin-5 gene. J Biol Chem 272: 21597-21603, 1997
19. Zheng W, Flavell RA: The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89: 587-596, 1997
20. Farrar JD, Ouyang W, Löhning M, Assenmacher M, Radbruch A, Kanagawa O, Murphy KM: An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3. J Exp Med 193: 643-650, 2001
21. Martin R, Ruddle NH, Reingold S, Hafler DA: T helper cell differentiation in multiple sclerosis and autoimmunity. Immunol Today 19: 495-498, 1998
22. Pisetsky DS: Tumor necrosis factor blockers in rheumatoid arthritis. N Engl J Med 342: 810-811, 2000
23. Day MJ, Tse AG, Puklavec M, Simmonds SJ, Mason DW: Targeting autoantigen to B cells prevents the induction of a cell-mediated autoimmune disease in rats. J Exp Med 175: 655-659, 1992
24. Khoury SJ, Hancock WW, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176: 1355-1364, 1992
25. Kaufman DL, Clare-Salzler M, Tian J, Forsthuber T, Ting GS, Robinson P, Atkinson MA, Sercarz EE, Tobin AJ, Lehmann PV: Spontaneous loss of T-cell tolerance to glutamic acid decarboxylase in murine insulin-dependent diabetes. Nature 366: 69-72, 1993
26. Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T, Izui S: Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest 97: 1597-1604, 1996
27. Izui S, Iwamoto M, Fossati L, Merino R, Takahashi S, Ibnou-Zekri N: The Yaa gene model of systemic lupus erythematosus. Immunol Rev 144: 137-156, 1995
28. Snapper CM, Mond JJ: Towards a comprehensive view of immunoglobulin class switching. Immunol Today 14: 15-17, 1993
29. Zhumabekov T, Corbella P, Tolaini M, Kioussis D: Improved version of a human CD2 minigene based vector for T cell-specific expression in transgenic mice. J Immunol Methods 185: 133-140, 1995
30. Yoh K, Itoh K, Enomoto A, Hirayama A, Yamaguchi N, Kobayashi M, Morito N, Koyama A, Yamamoto M, Takahashi S: Nrf2-deficient female mice develop lupus-like autoimmune nephritis. Kidney Int 60: 1343-1353, 2001
31. Andrews BS, Eisenberg RA, Theofilopoulos AN, Izui S, Wilson CB, McConahey PJ, Murphy ED, Roths JB, Dixon FJ: Spontaneous murine lupus-like syndromes: Clinical and immunopathological manifestations in several strains. J Exp Med 148: 1198-1215, 1978
32. 1 hybrid: A model of acute lupus and coronary vascular disease with myocardial infarction. J Exp Med 154: 216-221, 1981
33. Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K, Vassalli JD, Izui S: Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E α chain. J Exp Med 178: 1189-1197, 1993
34. Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ, Izui S: Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proc Natl Acad Sci USA 94: 14654-14659, 1997
35. Ferber IA, Lee HJ, Zonin F, Heath V, Mui A, Arai N, O'Garra A: GATA-3 significantly downregulates IFN-γ production from developing Th1 cells in addition to inducing IL-4 and IL-5 levels. Clin Immunol 91: 134-144, 1999
36. Ouyang W, Ranganath SH, Weindel K, Bhattacharya D, Murphy c TL, Sha WC, Murphy KM: Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity, 9: 745-755, 1998
37. Zhang DH, Yang L, Ray A: Differential responsiveness of the IL-5 and IL-4 genes to transcription factor GATA-3. J Immunol 161: 3817-3821, 1998
38. Ranganath S, Ouyang W, Bhattarcharya D, Sha WC, Grupe A, Peltz G, Murphy KM: GATA-3-dependent enhancer activity in IL-4 gene regulation. J Immunol 161: 3822-3826, 1998
39. Takemoto N, Kamogawa Y, Lee HJ, Kurata H, Arai K, O'Garra A, Arai N, Miyatake S: Chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster. J Immunol 165: 6687-6691, 2000
40. Lee GR, Fields PE, Flavell RA: Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14: 447-459, 2001
41. Zhang DH, Yang L, Cohn L, Parkyn L, Homer R, Ray P, Ray A: Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3. Immunity 11: 473-482, 1999
42. Ray A, Cohn L: Th2 cells and GATA-3 in asthma: New insights into the regulation of airway inflammation. J Clin Invest 104: 985-993, 1999
43. Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH: Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science 295: 336-338, 2002
44. Tarner IH, Fathman CG: Gene therapy in autoimmune disease. Curr Opin Immunol 13: 676-682, 2001
45. Mathisen PM, Yu M, Johnson JM, Drazba JA, Tuohy VK: Treatment of experimental autoimmune encephalomyelitis with genetically modified memory T cells. J Exp Med 186: 159-164, 1997