Effects of interleukin-6 blockade on the development of autoimmune thyroiditis in nonobese diabetic mice

Autoimmunity

Volumn 42, Issue 3, 2009, Pages 228-234

  Mori, Kouki ^a   Yoshida, Katsumi ^a   Mihara, Masahiko ^b   Ohsugi, Yoshiyuki ^b   Nakagawa, Yoshinori ^a   Hoshikawa, Saeko ^a   Ozaki, Hiroshi ^a   Ito, Sadayoshi ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Chugai Pharmaceutical Company Limited   (Japan)

Author keywords

Autoimmunity; Hashimoto's thyroiditis; Interleukin 6; NOD mouse

Indexed keywords

IMMUNOGLOBULIN G; INTERLEUKIN 6; INTERLEUKIN 6 ANTIBODY; INTERLEUKIN 6 RECEPTOR; IODIDE; THYROGLOBULIN; THYROGLOBULIN ANTIBODY; AUTOANTIBODY; CONCANAVALIN A; GAMMA INTERFERON; IMMUNOGLOBULIN CLASS; INTERLEUKIN 10; IODINE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOIMMUNE THYROIDITIS; CELL PROLIFERATION; CONTROLLED STUDY; DISEASE SEVERITY; HISTOPATHOLOGY; INCIDENCE; LYMPHOCYTIC INFILTRATION; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; ANIMAL; BLOOD; CYTOLOGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; HASHIMOTO DISEASE; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPLEEN; T LYMPHOCYTE; VACCINATION;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; CONCANAVALIN A; DISEASE MODELS, ANIMAL; HASHIMOTO DISEASE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN ISOTYPES; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-6; IODINE; MICE; MICE, INBRED NOD; RECEPTORS, INTERLEUKIN-6; SPLEEN; T-LYMPHOCYTES; THYROGLOBULIN; THYROIDITIS, AUTOIMMUNE; VACCINATION;

EID: 67649662376     PISSN: 08916934     EISSN: 1607842X     Source Type: Journal    
DOI: 10.1080/08916930802709141     Document Type: Article

References (34)

1. Yoshizaki, K., Nishimoto, N., Mihara, M. and Kishimoto, T. (1998) Therapy of rheumatoid arthritis by blocking IL-6 signal transduction with a humanized anti-IL-6 receptor antibody. Springer Semin Immunopathol, 20, pp. 247-259.
2. Kishimoto, T., Akira, S., Narazaki, M. and Taga, T. (1995) Interleukin-6 family of cytokines and gp130. Blood, 86, pp. 1243-1254.
3. Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimizu, M., Murashima, A., Tsunasawa, S., Sekiyama, F. and Kishimoto, T. (1988) Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis. Eur J Immunol, 18, pp. 1797-1801.
4. Yoshizaki, K., Matsuda, T., Nishimoto, N., Kuritani, T., Taeho, L., Aozasa, K., Nakahata, T., Kawai, H., Tagoh, H., Komori, T., Kishimoto, S., Hirano, T. and Kishimoto, T. (1989) Pathogenic significance of interleukin-6 (IL-6/BSF-2) in Castleman's disease. Blood, 74, pp. 1360-1367.
5. Gross, V., Andus, T., Caesar, I., Roth, M. and Scholmerich, J. (1992) Evidence for continuous stimulation of interleukin-6 production in Crohn's disease. Gastroenterology, 102, pp. 514-519.
6. Mihara, M., Nishimoto, N., Yoshizaki, K. and Suzuki, T. (2002) Influences of anti-mouse interleukin-6 receptor antibody on immune responses in mice. Immunol Lett, 84, pp. 223-229.
7. Okazaki, M., Yamada, Y., Nishimoto, N., Yoshizaki, K. and Mihara, M. (2002) Characterization of anti-mouse interleukin-6 receptor antibody. Immunol Lett, 84, pp. 231-240.
8. Takagi, N., Mihara, M., Moriya, Y., Nishimoto, N., Yoshizaki, K., Kishimoto, T., Takeda, Y. and Ohsugi, Y. (1998) Blockage of interleukin-6 receptor ameliorates joint disease in murine collagen-induced arthritis. Arthritis Rheum, 41, pp. 2117-2121.
9. Katsume, A., Saito, H., Yamada, Y., Yorozu, K., Ueda, O., Akamatsu, K-I, Nishimoto, N., Kishimoto, T., Yoshizaki, K. and Ohsugi, Y. (2002) Anti-interleukin 6 (IL-6) receptor antibody suppresses Castleman's disease like symptoms emerged in IL-6 transgenic mice. Cytokine, 20, pp. 304-311.
10. Yamamoto, M., Yoshizaki, K., Kishimoto, T. and Ito, H. (2000) IL-6 is required for the development of Th1 cell-mediated murine colitis. J Immunol, 164, pp. 4878-4882.
11. Champion, BR, Cooke, A. and Rayner, DC (1992) Thyroid autoimmunity. Curr Opin Immunol, 4, pp. 770-778.
12. Paschke, R., Schuppert, F., Taton, M. and Velu, T. (1994) Intrathyroidal cytokine gene expression profiles in autoimmune thyroiditis. J Endocrinol, 141, p. 309315.
13. Ajjan, RA, Watson, RF, McIntosh, RS and Weetman, AP (1996) Intrathyroidal cytokine gene expression in Hashimoto's thyroiditis. Clin Exp Immunol, 105, pp. 523-528.
14. Matsumura, M., Banba, N., Motohashi, S. and Hattori, Y. (1999) Interleukin-6 and transforming growth factor-β regulate the expression of monocyte chemoattractant protein-1 and colony-stimulating growth factors in human thyroid follicular cells. Life Sci, 65, pp. 129-135.
15. Yamazaki, K., Yamada, E., Kanaji, Y., Shizume, K., Wang, D-S, Maruo, N., Obara, T. and Sato, K. (1996) Interleukin-6 (IL-6) inhibits thyroid function in the presence of soluble IL-6 receptor in cultured human thyroid follicles. J Clin Endocrinol Metab, 137, pp. 4857-4863.
16. Tominaga, T., Yamashita, S., Nagayama, Y., Morita, S., Yokoyama, N., Izumi, M. and Nagataki, S. (1991) Interleukin 6 inhibits human thyroid peroxidase gene expression. Acta Endocrinol, 124, pp. 290-294.
17. Hashimoto, H., Igarashi, N., Miyawaki, T. and Sato, T. (1995) Effects of tumor necrosis factor-β, interleukin-1′, and interleukin-6 on type I iodothyronine 5′-deiodination in rat thyroid cell line, FRTL-5. J Interf Cytokine Res, 15, pp. 367-375.
18. Bartalena, L., Brogioni, S., Grasso, L. and Martino, E. (1995) Interleukin-6 and the thyroid. Eur J Endocrinol, 132, pp. 386-393.
19. Damotte, D., Colomb, E., Cailleau, C., Brousse, N., Charreire, J. and Carnaud, C. (1997) Analysis of susceptibility of NOD mice to spontaneous and experimentally induced thyroiditis. Eur J Immunol, 27, pp. 2854-2862.
20. Tani, J-I, Mori, K., Hoshikawa, S., Nakazawa, T., Satoh, J., Nakagawa, Y., Ito, S. and Yoshida, K. (2002) Prevention of lymphocytic thyroiditis in iodide-treated non-obese diabetic mice lacking interferon regulatory factor-1. Eur J Endocrinol, 147, pp. 809-814.
21. Jin, Z., Mori, K., Fujimori, K., Hoshikawa, S., Tani, J-I, Satoh, J., Ito, S., Satomi, S. and Yoshida, K. (2004) Experimental autoimmune thyroiditis in non-obese diabetic mice lacking interferon regulatory factor-1. Clin Immunol, 113, pp. 187-192.
22. Saboori, AM, Rose, NR, Butscher, WG and Burek, CL (1993) Modification of a nonincinerative method for determination of iodine in iodoproteins. Anal Biochem, 214, pp. 335-338.
23. Kong, Y., David, CS, Giraldo, AA, Elrehewy, M. and Rose, NR (1979) J Immunol, 123, pp. 15-18.
24. Kaiser, P., Rothwell, L., Vasicek, D. and Hala, K. (2002) A role for IL-15 in driving the onset of spontaneous autoimmune thyroiditis?. J Immunol, 168, pp. 4216-4220.
25. Mori, K., Yoshida, K., Tani, J-I, Nakagawa, Y., Hoshikawa, S., Ozaki, H. and Ito, S. (2008) Effects of angiotensin II blockade on the development of autoimmune thyroiditis in nonobese diabetic mice. Clin Immunol, 126, pp. 97-103.
26. Tada, Y., Ho, A., Matsuyama, T. and Mak, TW (1997) Reduced incidence and severity of antigen-induced autoimmune disease in mice lacking interferon regulatory factor-1. J Exp Med, 185, pp. 231-238.
27. Sagawa, K., Nagatani, K., Komagata, Y. and Yamamoto, K. (2005) Angiotensin receptor blockers suppress antigen-specific T cell responses and ameliorate collagen-induced arthritis in mice. Arthritis Rheum, 52, pp. 1920-1928.
28. Alonzi, T., Fattori, E., Lazzaro, D., Costa, P., Probert, L., Kollias, G., De Benedetti, F., Poli, V. and Ciliberto, G. (1998) Interleukin 6 is required for the development of collagen-induced arthritis. J Exp Med, 187, pp. 461-468.
29. Mendel, I., Katz, A., Kozak, N., Ben-Nun, A. and Revel, M. (1998) Interleukin-6 functions in autoimmune encephalomyelitis: A study in gene-targeted mice. Eur J Immunol, 28, pp. 1727-1737.
30. Tanaka, T., Katada, Y., Higa, S., Fujiwara, H., Wang, W., Saeki, Y., Ohshima, S., Okuda, Y., Suemura, M. and Kishimoto, T. (2001) Enhancement of T helper2 response in the absence of interleukin (IL-) 6; an inhibition of IL-4-mediated T helper2 cell differentiation by IL-6. Cytokine, 13, pp. 193-201.
31. Toyoda, H. and Formby, B. (1998) Contribution of T cells to the development of autoimmune diabetes in the NOD mouse model. BioEssays, 20, pp. 750-757.
32. Salvi, M., Girasole, G., Pedrazzoni, M., Passeri, M., Giuliani, N., Minelli, R., Braverman, LE and Roti, E. (1996) Increased serum concentrations of interleukin-6 (IL-6) and soluble IL-6 receptor in patients with Graves' disease. J Clin Endocrinol Metab, 81, pp. 2976-2979.
33. Minelli, R., Girasole, G., Pedrazzoni, M., Giuliani, N., Schianchi, C., Giuberti, T., Braverman, LE, Salvi, M. and Roti, E. (1996) Lack of increased interleukin-6 and soluble IL-6 receptor concentrations in patients with thyroid diseases following recombinant human interferon α therapy. J Invest Med, 44, pp. 370-374.
34. Bartalena, L., Brogioni, S., Grasso, L., Rago, T., Vitti, P., Pinchera, A. and Martino, E. (1994) Interleukin-6: A marker of thyroid-destructive processes?. J Clin Endocrinol Metab, 79, pp. 1424-1427.