Phagocytic uptake and ROS-mediated cytotoxicity in human hepatic cell line of amphiphilic polyphosphazene nanoparticles

Journal of Biomedical Materials Research - Part A

Volumn 101 A, Issue 1, 2013, Pages 285-297

  Qiu, Liyan ^a   Chen, Yue ^a   Gao, Menghua ^a   Zheng, Cheng ^a   Zhao, Qinghe ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Apoptosis; Biocompatibility; Nanotoxicity; Polymeric nanoparticles; Polyphosphazene

Indexed keywords

ACTIVE CHEMICALS; AMPHIPHILIC POLYPHOSPHAZENE; AMPHIPHILICS; ANTI-TUMORS; APOPTOTIC SIGNALING; BOVINE SERUM ALBUMINS; CASPASE-3; CELL VIABILITY; DOSE-DEPENDENT MANNER; FLUORESCENT LABELING AGENT; HEPATIC CELLS; METHYL ESTERS; MITOCHONDRIAL MEMBRANE POTENTIAL; NANOTOXICITY; NANOVEHICLES; NOVEL POLYMERS; PEGYLATION; PH-RESPONSIVE; POLYMERIC NANOPARTICLES; POLYPHOSPHAZENES; REACTIVE OXYGEN SPECIES; TOXIC EFFECT;

ADSORPTION; AMINO ACIDS; BEHAVIORAL RESEARCH; BIOCOMPATIBILITY; CELL CULTURE; CYTOTOXICITY; DRUG THERAPY; MITOCHONDRIA; NANOPARTICLES; POLYMERS;

CELL DEATH;

ADENOSINE TRIPHOSPHATE; AMINE; BOVINE SERUM ALBUMIN; CARBONYL DERIVATIVE; CASPASE 3; CASPASE 9; COPOLYMER; NANOCARRIER; POLYMER; POLYPHOSPHAZENE; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ACUTE MONOCYTIC LEUKEMIA; ADSORPTION; APOPTOSIS; ARTICLE; BIOCOMPATIBILITY; CELL LEVEL; CELL VIABILITY; CHEMICAL BINDING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; ELECTRIC POTENTIAL; ENZYME ACTIVITY; FLUORESCENCE ANALYSIS; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LEUKEMIA CELL; LIVER CELL; LIVER NECROSIS; LIVER TOXICITY; OXIDATIVE STRESS; PHAGOCYTOSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE PROPERTY;

ADENOSINE TRIPHOSPHATE; ADSORPTION; ANIMALS; BUFFERS; CASPASES; CATTLE; CELL DEATH; CELL LINE; CELL SURVIVAL; FLUORESCEIN-5-ISOTHIOCYANATE; FLUORESCENCE; HEPATOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIAL, MITOCHONDRIAL; NANOPARTICLES; ORGANOPHOSPHORUS COMPOUNDS; OXIDATIVE STRESS; PHAGOCYTOSIS; POLYMERS; REACTIVE OXYGEN SPECIES; SERUM ALBUMIN, BOVINE; STAINING AND LABELING; STATIC ELECTRICITY; SURFACE-ACTIVE AGENTS;

EID: 84872683578     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.34323     Document Type: Article

References (50)

1. Moghimi SM, Hunter AC, Murray JC. Nanomedicine: Current status and future prospects. FASEB J 2005;19:311-330.
2. De Jong WH, Borm PJA. Drug delivery and nanoparticles: Applications and hazards. Int J Nanomed 2008;3:133-149.
3. Flavell RA, Eisenbarth SC, Colegio OR, O'Connor W, Sutterwala FS. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 2008;453: 1122-1126.
4. Nohynek GJ, Dufour EK, Roberts MS. Nanotechnology, cosmetics and the skin: Is there a health risk? Skin Pharmacol Physiol 2008; 21:136-149.
5. Vallhov H, Qin J, Johansson SM, Ahlborg N, Muhammed MA, Scheynius A, Gabrielsson S. The importance of an endotoxin-free environment during the production of nanoparticles used in medical applications. Nano Lett 2006;6:1682-1686.
6. Dreher KL. Health and environmental impact of nanotechnology: Toxicological assessment of manufactured nanoparticles. Toxicol Sci 2004;77:3-5.
7. Chan WCW, Fischer HC. Nanotoxicity: The growing need for in vivo study. Curr Opin Biotechnol 2007;18:565-571.
8. Drezek R, Lewinski N, Colvin V. Cytotoxicity of nanoparticles. Small 2008;4:26-49.
9. Ma YF, Lin WS, Huang YW, Zhou XD. In vitro toxicity of silica nanoparticles in human lung cancer cells. Toxicol Appl Pharmacol 2006;217:252-259.
10. Labhasetwar V, Jain TK, Reddy MK, Morales MA, Leslie-Pelecky DL. Biodistribution, clearance, and biocompatibility of iron oxide magnetic nanoparticles in rats. Mol Pharm 2008;5:316-327.
11. Nel AE, Xia T, Kovochich M, Liong M, Madler L, Gilbert B, Shi HB, Yeh JI, Zink JI. Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. ACS Nano 2008;2:2121-2134.
12. Chonn A, Semple SC, Cullis PR. Association of blood proteins with large unilamellar liposomes in vivo - Relation to circulation lifetimes. J Biol Chem 1992;267:18759-18765.
13. Patel HM. Serum opsonins and liposomes - Their interaction and opsonophagocytosis. Crit Rev Ther Drug Carrier Syst 1992;9: 39-90.
14. Kiwada H, Miyajima T, Kato Y. Studies on the uptake mechanism of liposomes by perfused-rat-liver. II. An indispensable factor for liver uptake in serum. Chem Pharm Bull 1987;35:1189-1195.
15. Sadana A. Protein adsorption and inactivation on surfaces - Influence of heterogeneities. Chem Rev 1992;92:1799-1818.
16. He Q, Zhang J, Shi J, Zhu Z, Zhang L, Bu W, Guo L, Chen Y. The effect of PEGylation of mesoporous silica nanoparticles on non- specific binding of serum proteins and cellular responses. Biomaterials 2009;31:1085-1092.
17. Peppas NA, Owens DE. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006;307:93-102.
18. Veronese FM, Pasut G. PEGylation, successful approach to drug delivery. Drug Discov Today 2005;10:1451-1458.
19. Cabrini RL, Olmedo D, Guglielmotti MB. An experimental study of the dissemination of titanium and zirconium in the body. J Mater Sci Mater Med 2002;13:793-796.
20. Han CS, So SJ, Jang IS. Effect of micro/nano silica particle feeding for mice. J Nanosci Nanotechnol 2008;8:5367-5371.
21. Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006;311:622-627.
22. Xia T, Li N, Nel AE. Potential health impact of nanoparticles. Annu Rev Publ Health 2009;30:137-150.
23. Qiu LY, Zhang JX, Zhu KJ, Jin Y. Thermosensitive micelles selfassembled by novel N-isopropylacrylamide oligomer grafted polyphosphazene. Macromol Rapid Commun 2004;25:1563-1567.
24. Qiu LY, Zhang RX, Li XJ, Li XH, Yan MQ, Jin Y, Zhu KJ. Indomethacin-loaded polymeric nanocarriers based on amphiphilic polyphosphazenes with poly (N-isopropylacrylamide) and ethyl tryptophan as side groups: Preparation, in vitro and in vivo evaluation. J Control Release 2006;116:322-329.
25. Qiu LY, Zheng C, Xu J, Yao XP, Xu JA. Polyphosphazene nanoparticles for cytoplasmic release of doxorubicin with improved cytotoxicity against Dox-resistant tumor cells. J Colloid Interface Sci 2011;355:374-382.
26. Qiu LY, Zheng C, Zhu KJ. Novel polymersomes based on amphiphilic graft polyphosphazenes and their encapsulation of watersoluble anti-cancer drug. Polymer 2009;50:1173-1177.
27. Allcock HR, Singh A, Krogman NR, Sethuraman S, Nair LS, Sturgeon JL, Brown PW, Laurencin CT. Effect of side group chemistry on the properties of biodegradable L-alanine cosubstituted polyphosphazenes. Biomacromolecules 2006;7:914-918.
28. Klein J. Probing the interactions of proteins and nanoparticles. Proc Natl Acad Sci USA 2007;104:2029-2030.
29. Lynch I, Cedervall T, Lundqvist M, Cabaleiro-Lago C, Linse S, Dawson KA. The nanoparticle - protein complex as a biological entity; a complex fluids and surface science challenge for the 21st century. Adv Colloid Interface Sci 2007;134/135:167-174.
30. Gref R, Lemarchand C, Passirani C, Garcion E, Petri B, Muller R, Costantini D, Couvreur P. Influence of polysaccharide coating on the interactions of nanoparticles with biological systems. Biomaterials 2006;27:108-118.
31. Muller RH, Gessner A, Waicz R, Lieske A, Paulke BR, Mader K. Nanoparticles with decreasing surface hydrophobicities: Influence on plasma protein adsorption. Int J Pharm 2000;196:245-249.
32. Kim JH, Yoon JY, Kim WS. The relationship of interaction forces in the protein adsorption onto polymeric microspheres. Colloids Surf A: Physicochem Eng Aspects 1999;153:413-419.
33. Roser M, Fischer D, Kissel T. Surface-modified biodegradable albumin nano- and microspheres. II. Effect of surface charges on in vitro phagocytosis and biodistribution in rats. Eur J Pharm Biopharm 1998;46:255-263.
34. Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdorster G, McGrath JL. The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials 2009;30:603-610.
35. Holbrook NJ, Martindale JL. Cellular response to oxidative stress: Signaling for suicide and survival. J Cell Physiol 2002;192:1-15.
36. Jang J, Jeong YS, Oh WK, Kim S. Cellular uptake, cytotoxicity, and ROS generation with silica/conducting polymer core/shell nanospheres. Biomaterials 2011;32:7217-7225.
37. Sun JA, Liu X. Endothelial cells dysfunction induced by silica nanoparticles through oxidative stress via JNK/P53 and NF-kappa B pathways. Biomaterials 2010;31:8198-8209.
38. Rahman Q, Srivastava RK, Pant AB, Kashyap MP, Kumar V, Lohani M, Jonas L. Multi-walled carbon nanotubes induce oxidative stress and apoptosis in human lung cancer cell line-A549. Nanotoxicology 2011;5:195-207.
39. Marchetti P, Decaudin D, Macho A, Zamzami N, Hirsch T, Susin SA, Kroemer G. Redox regulation of apoptosis: Impact of thiol oxidation status on mitochondrial function. Eur J Immunol 1997;27: 289-296.
40. Kroemer G. Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution. Cell Death Differ 1997;4:443-456.
41. Hirsch T, Marzo I, Kroemer G. Role of the mitochondrial permeability transition pore in apoptosis. Biosci Rep 1997;17:67-76.
42. Simon U, Pan Y, Leifert A, Ruau D, Neuss S, Bornemann J, Schmid G, Brandau W, Jahnen-Dechent W. Gold nanoparticles of diameter 1.4 nm trigger necrosis by oxidative stress and mitochondrial damage. Small 2009;5:2067-2076.
43. Zhang SB, Lv HT, Wang B, Cui SH, Yan J. Toxicity of cationic lipids and cationic polymers in gene delivery. J Control Release 2006;114:100-109.
44. Monteiro-Riviere NA, Ryman-Rasmussen JP, Riviere JE. Surface coatings determine cytotoxicity and irritation potential of quantum dot nanoparticles in epidermal keratinocytes. J Invest Dermatol 2007;127:143-153.
45. Park TG, Lee K, Lee H, Lee KW. Optical imaging of intracellular reactive oxygen species for the assessment of the cytotoxicity of nanoparticles. Biomaterials 2011;32:2556-2565.
46. Thornberry NA, Ranon TA, Pieterson EP, Rasper DM, Timkey T, GarciaCalvo M, Houtzager VM, Nordstrom PA, Roy S, Vaillancourt JP, Chapman KT, Nicholson DW. A combinatorial approach defines specificities of members of the caspase family and granzyme B - Functional, relationships established for key mediators of apoptosis. J Biol Chem 1997;272:17907-17911.
47. Liu CS, Yuan Y, Qjan JC, Wang J, Zhang Y. Size-mediated cytotoxicity and apoptosis of hydroxyapatite nanoparticles in human hepatoma HepG2 cells. Biomaterials 2010;31:730-740.
48. Yoon HS, Choi BH, Kim W, Wang QC, Kim DC, Tan SN, Yong JWH, Kim KT. Kinetin riboside preferentially induces apoptosis by modulating Bcl-2 family proteins and caspase-3 in cancer cells. Cancer Lett 2008;261:37-45.
49. Magae J, Nakajima H, Tsuruga M, Sakaguchi K, Fujiwara I, Mizuta M, Sawai K, Yamagishi H, Mizuta N. Induction of mitochondriadependent apoptosis through the inhibition of mevalonate pathway in human breast cancer cells by YM529, a new third generation bisphosphonate. Cancer Lett 2007;253:89-96.
50. Qiu LY, Bae YH. Self-assembled polyethylenimine-graft-poly (ε-caprolactone) micelles as potential dual carriers of genes and anticancer drugs. Biomaterials 2007;28:4132-4142.