Synthesis, cytotoxicity and antiplasmodial activity of novel ent-kaurane derivatives

European Journal of Medicinal Chemistry

Volumn 62, Issue , 2013, Pages 168-176

  Batista, Ronan ^a,b   García, Pablo A ^c   Castro, María Angeles ^c   Miguel Del Corral, José M ^c   Speziali, Nivaldo L ^d   De P Varotti, Fernando ^d,e   De Paula, Renata C ^d   García Fernández, Luis F ^f   Francesch, Andrés ^f   San Feliciano, Arturo ^c   De Oliveira, Alaíde B ^d  

^a UNIVERSIDADE ESTADUAL DO SUDOESTE DA BAHIA   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^c UNIVERSITY OF SALAMANCA   (Spain)

^d FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^e FEDERAL UNIVERSITY OF SÃO JOÃO DEL REI   (Brazil)

^f PHARMAMAR S A   (Spain)

Author keywords

Antineoplastic activity; ent Kaurane derivatives; In vitro antimalarial activity; Plasmodium falciparum; Wedelia paludosa D.C.

Indexed keywords

ANTIMALARIAL AGENT; ANTINEOPLASTIC AGENT; CHLOROQUINE; DITERPENOID; ENT 16 ALPHA EPOXY KAURAN 19 OIC ACID; ENT 16 BETA EPOXY KAURAN 19 OIC ACID; EPOXIDE; GRANDIFLORENIC ACID; KAURANE DERIVATIVE; KAURENOIC ACID; METHYL ENT 11 ALPHA 17 DIHYDROXY 16 ALPHA KAURAN 19 OATE; METHYL ENT 11 BETA 17 DIHYDROXY 9 EPI 16 ALPHA KAURAN 19 OATE; METHYL ENT 15 BETA HYDROXY 16 ALPHA KAURAN 19 OATE; METHYL ENT 15 BETA HYDROXY KAUR 16 EN 19 OATE; METHYL ENT 16 ALPHA 17 DIHYDROXY KAURAN 19 OATE; METHYL ENT 16 ALPHA(HEXAHYDROPYRIMIDIN 2 YL) 17 NOR KAURAN 19 OATE; METHYL ENT 17 HYDROXY 16 ALPHA KAUR 9 (11) EN 19 OATE; METHYL ENT 17 HYDROXY 16 BETA KAUR 9 (11) EN 19 OATE; METHYL ENT 17 HYDROXY KAUR 15 EN 19 OATE; METHYL ENT 9 BETA 11,16 ALPHA DIEPOXY KAURAN 19 OATE; METHYL ENT 9 BETA 11,16 BETA DIEPOXY KAURAN 19 OATE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CARBON NUCLEAR MAGNETIC RESONANCE; CRYSTALLOGRAPHY; CYTOTOXICITY; DRUG SYNTHESIS; EPOXIDATION; HUMAN; HUMAN CELL; HYDROBORATION; HYDROXYLATION; IC 50; IN VITRO STUDY; NONHUMAN; PLASMODIUM FALCIPARUM; PROTON NUCLEAR MAGNETIC RESONANCE; WEDELIA; WEDELIA PALUDOSA;

ANTIMALARIALS; ANTINEOPLASTIC AGENTS; CELL DEATH; CELL PROLIFERATION; DITERPENES, KAURANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872682775     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.12.010     Document Type: Article

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