The combined effects of the 5- HTTLPR and HTR1A rs6295 polymorphisms modulate decision making in schizophrenia patients

Genes, Brain and Behavior

Volumn 12, Issue 1, 2013, Pages 133-139

  Gu, H ^a   Liu, C ^b,c,d   Chen, M ^c   Zhang, Q ^d   Zhai, J ^d   Wang, K ^d   Ji, F ^d   Xu, Z ^a   Shen, Q ^a   Bao, X ^a   Chen, X ^a   Li, J ^a   Dong, Q ^a   Chen, C ^e  

^a BEIJING NORMAL UNIVERSITY   (China)

^b BEIJING HOSPITAL   (China)

^c SICHUAN UNIVERSITY   (China)

^d JINING MEDICAL UNIVERSITY   (China)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

5 HT1A; 5 HTTLPR; Decision making; Iowa Gambling Task (IGT); Polymorphism; Schizophrenia

Indexed keywords

GLYCINE; LYSINE; SEROTONIN RECEPTOR; SEROTONIN RECEPTOR HTR1A; SEROTONIN RECEPTOR HTTLPR; SEROTONIN TRANSPORTER; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CONTROLLED STUDY; DECISION MAKING; EMOTION; FEMALE; GENE FREQUENCY; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; HYPOTHESIS; MAJOR CLINICAL STUDY; MALE; NEUROMODULATION; PRIORITY JOURNAL; SCHIZOPHRENIA; TASK PERFORMANCE;

ADULT; CASE-CONTROL STUDIES; DECISION MAKING; FEMALE; GENOTYPE; HUMANS; MALE; POLYMORPHISM, GENETIC; RECEPTOR, SEROTONIN, 5-HT1A; SCHIZOPHRENIA; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 84872676264     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2012.00866.x     Document Type: Article

References (65)

1. Ase, A.R., Reader, T.A., Hen, R., Riad, M. & Descarries, L. (2001) Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout. J Neurochem 78, 619-630.
2. Barch, D.M., Carter, C.S., Arnsten, A., Buchanan, R.W., Cohen, J.D., Geyer, M., Green, M.F., Krystal, J.H., Nuechterlein, K., Robbins, T., Silverstein, S., Smith, E.E., Strauss, M., Wykes, T. & Heinssen, R. (2009) Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophr Bull 35, 109-114.
3. Bayliss, D.A., Li, Y.W. & Talley, E.M. (1997) Effects of serotonin on caudal raphe neurons: inhibition of N- and P/Q-type calcium channels and the afterhyperpolarization. J Neurophysiol 77, 1362-1374.
4. Bechara, A., Damasio, A.R., Damasio, H. & Anderson, S.W. (1994) Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50, 7-15.
5. Bechara, A., Damasio, H., Tranel, D. & Damasio, A.R. (1997) Deciding advantageously before knowing the advantageous strategy. Science 275, 1293-1295.
6. Bechara, A., Damasio, H., Tranel, D. & Damasio, A.R. (2005) The Iowa Gambling Task and the somatic marker hypothesis: some questions and answers. Trends Cogn Sci 9, 159-162 discussion 162-154.
7. Bechara, A., Tranel, D. & Damasio, H. (2000) Characterization of the decision-making deficit of patients with ventromedial prefrontal cortex lesions. Brain 123 (Pt 11), 2189-2202.
8. Beste, C., Heil, M., Domschke, K. & Konrad, C. (2010) The relevance of the functional 5-HT1A receptor polymorphism for attention and working memory processes during mental rotation of characters. Neuropsychologia 48, 1248-1254.
9. Brand, M., Labudda, K. & Markowitsch, H.J. (2006) Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Netw 19, 1266-1276.
10. Brand, M., Recknor, E.C., Grabenhorst, F. & Bechara, A. (2007) Decisions under ambiguity and decisions under risk: correlations with executive functions and comparisons of two different gambling tasks with implicit and explicit rules. J Clin Exp Neuropsychol 29, 86-99.
11. Cesarini, D., Dawes, C.T., Johannesson, M., Lichtenstein, P. & Wallace, B. (2009) Genetic variation in preferences for giving and risk taking. Q J Econ 124, 809.
12. Cools, R., Roberts, A.C. & Robbins, T.W. (2008) Serotoninergic regulation of emotional and behavioural control processes. Trends Cogn Sci 12, 31-40.
13. Crisan, L.G., Pana, S., Vulturar, R., Heilman, R.M., Szekely, R., Druga, B., Dragos, N. & Miu, A.C. (2009) Genetic contributions of the serotonin transporter to social learning of fear and economic decision making. Soc Cogn Affect Neurosci 4, 399-408.
14. David, S.P., Murthy, N.V., Rabiner, E.A., Munafo, M.R., Johnstone, E.C., Jacob, R., Walton, R.T. & Grasby, P.M. (2005) A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25, 2586-2590.
15. Dayan, P. & Huys, Q.J. (2008) Serotonin, inhibition, and negative mood. PLoS Comput Biol 4, e4.
16. Delbruck, S.J., Wendel, B., Grunewald, I., Sander, T., Morris-Rosendahl, D., Crocq, M.A., Berrettini, W.H. & Hoehe, M.R. (1997) A novel allelic variant of the human serotonin transporter gene regulatory polymorphism. Cytogenet Cell Genet 79, 214-220.
17. Fabre, V., Beaufour, C., Evrard, A., Rioux, A., Hanoun, N., Lesch, K.P., Murphy, D.L., Lanfumey, L., Hamon, M. & Martres, M.P. (2000) Altered expression and functions of serotonin 5-HT1A and 5-HT1B receptors in knock-out mice lacking the 5-HT transporter. Eur J Neurosci 12, 2299-2310.
18. Gelernter, J., Cubells, J.F., Kidd, J.R., Pakstis, A.J. & Kidd, K.K. (1999) Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 88, 61-66.
19. Grabe, H.J., Spitzer, C., Schwahn, C., Marcinek, A., Frahnow, A., Barnow, S., Lucht, M., Freyberger, H.J., John, U., Wallaschofski, H., Volzke, H. & Rosskopf, D. (2009) Serotonin transporter gene (SLC6A4) promoter polymorphisms and the susceptibility to posttraumatic stress disorder in the general population. Am J Psychiatry 166, 926-933.
20. Ha, R.Y., Namkoong, K., Kang, J.I., Kim, Y.T. & Kim, S.J. (2009) Interaction between serotonin transporter promoter and dopamine receptor D4 polymorphisms on decision making. Prog Neuropsychopharmacol Biol Psychiatry 33, 1217-1222.
21. He, Q., Xue, G., Chen, C., Lu, Z., Dong, Q., Lei, X., Ding, N., Li, J., Li, H., Moyzis, R.K. & Bechara, A. (2010) Serotonin transporter gene-linked polymorphic region (5-HTTLPR) influences decision making under ambiguity and risk in a large Chinese sample. Neuropharmacology 59, 518-526.
22. Heils, A., Teufel, A., Petri, S., Stober, G., Riederer, P., Bengel, D. & Lesch, K.P. (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66, 2621-2624.
23. Homberg, J.R., van den Bos, R., den Heijer, E., Suer, R. & Cuppen, E. (2008) Serotonin transporter dosage modulates long-term decision-making in rat and human. Neuropharmacology 55, 80-84.
24. Hsu, M., Bhatt, M., Adolphs, R., Tranel, D. & Camerer, C.F. (2005) Neural systems responding to degrees of uncertainty in human decision-making. Science 310, 1680-1683.
25. Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., Xu, K., Arnold, P.D., Richter, M.A., Kennedy, J.L., Murphy, D.L. & Goldman, D. (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78, 815-826.
26. Huang, Y.Y., Battistuzzi, C., Oquendo, M.A., Harkavy-Friedman, J., Greenhill, L., Zalsman, G., Brodsky, B., Arango, V., Brent, D.A. & Mann, J.J. (2004) Human 5-HT1A receptor C(-1019)G polymorphism and psychopathology. Int J Neuropsychopharmacol 7, 441-451.
27. Huettel, S.A., Song, A.W. & McCarthy, G. (2005) Decisions under uncertainty: probabilistic context influences activation of prefrontal and parietal cortices. J Neurosci 25, 3304-3311.
28. Jollant, F., Buresi, C., Guillaume, S., Jaussent, I., Bellivier, F., Leboyer, M., Castelnau, D., Malafosse, A. & Courtet, P. (2007) The influence of four serotonin-related genes on decision-making in suicide attempters. Am J Med Genet B Neuropsychiatr Genet 144B, 615-624.
29. Kawanishi, Y., Harada, S., Tachikawa, H., Okubo, T. & Shiraishi, H. (1998) Novel mutations in the promoter and coding region of the human 5-HT1A receptor gene and association analysis in schizophrenia. Am J Med Genet 81, 434-439.
30. Kester, H.M., Sevy, S., Yechiam, E., Burdick, K.E., Cervellione, K.L. & Kumra, S. (2006) Decision-making impairments in adolescents with early-onset schizophrenia. Schizophr Res 85, 113-123.
31. Kilpatrick, D.G., Koenen, K.C., Ruggiero, K.J., Acierno, R., Galea, S., Resnick, H.S., Roitzsch, J., Boyle, J. & Gelernter, J. (2007) The serotonin transporter genotype and social support and moderation of posttraumatic stress disorder and depression in hurricane-exposed adults. Am J Psychiatry 164, 1693-1699.
32. Kim, S., Choi, K.H., Baykiz, A.F. & Gershenfeld, H.K. (2007) Suicide candidate genes associated with bipolar disorder and schizophrenia: an exploratory gene expression profiling analysis of post-mortem prefrontal cortex. BMC Genomics 8, 413.
33. Kishi, T., Okochi, T., Tsunoka, T., Okumura, T., Kitajima, T., Kawashima, K., Yamanouchi, Y., Kinoshita, Y., Naitoh, H., Inada, T., Kunugi, H., Kato, T., Yoshikawa, T., Ujike, H., Ozaki, N. & Iwata, N. (2011) Serotonin 1A receptor gene, schizophrenia and bipolar disorder: An association study and meta-analysis. Psychiat Res 185, 20-26.
34. Koller, G., Preuss, U.W., Zill, P., Bondy, B. & Soyka, M. (2005) The C(-1019)G 5-HT1A promoter polymorphism and personality traits: no evidence for significant association in alcoholic patients. Pharmacopsychiatry 38, 256-256.
35. Kuhnen, C.M. & Chiao, J.Y. (2009) Genetic determinants of financial risk taking. PLoS One 4, e4362.
36. Lee, H.J., Lee, M.S., Kang, R.H., Kim, H., Kim, S.D., Kee, B.S., Kim, Y.H., Kim, Y.K., Kim, J.B., Yeon, B.K., Oh, K.S., Oh, B.H., Yoon, J.S., Lee, C., Jung, H.Y., Chee, I.S. & Paik, I.H. (2005) Influence of the serotonin transporter promoter gene polymorphism on susceptibility to posttraumatic stress disorder. Depress Anxiety 21, 135-139.
37. Lemonde, S., Turecki, G., Bakish, D., Du, L.S., Hrdina, P.D., Bown, C.D., Sequeira, A., Kushwaha, N., Morris, S.J., Basak, A., Ou, X.M. & Albert, P.R. (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23, 8788-8799.
38. Lemonde, S., Du, L., Bakish, D., Hrdina, P. & Albert, P.R. (2004) Association of the C(-1019)G 5-HT1A functional promoter polymorphism with antidepressant response. Int J Neuropsychopharmacol 7, 501-506.
39. Lesch, K.P., Bengel, D., Heils, A., Sabol, S.Z., Greenberg, B.D., Petri, S., Benjamin, J., Muller, C.R., Hamer, D.H. & Murphy, D.L. (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274, 1527-1531.
40. Lesch, K.P., Strobel, A., Gutknecht, L., Rothe, C., Reif, A., Mossner, R., Zeng, Y. & Brocke, B. (2003) Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110, 1445-1453.
41. Li, Q., Wichems, C., Heils, A., Van De Kar, L.D., Lesch, K.P. & Murphy, D.L. (1999) Reduction of 5-hydroxytryptamine (5-HT)(1A)-mediated temperature and neuroendocrine responses and 5-HT(1A) binding sites in 5-HT transporter knockout mice. J Pharmacol Exp Ther 291, 999-1007.
42. Li, Q., Wichems, C., Heils, A., Lesch, K.P. & Murphy, D.L. (2000) Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. J Neurosci 20, 7888-7895.
43. Little, K.Y., McLaughlin, D.P., Zhang, L., Livermore, C.S., Dalack, G.W., McFinton, P.R., DelProposto, Z.S., Hill, E., Cassin, B.J., Watson, S.J. & Cook, E.H. (1998) Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels. Am J Psychiatry 155, 207-213.
44. Miu, A.C., Crisan, L.G., Chis, A., Ungureanu, L., Druga, B. & Vulturar, R. (2012). Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task. Genes Brain Behav 1, 398-403.
45. Must, A., Juhasz, A., Rimanoczy, A., Szabo, Z., Keri, S. & Janka, Z. (2007) Major depressive disorder, serotonin transporter, and personality traits: why patients use suboptimal decision-making strategies? J Affect Disord 103, 273-276.
46. Parsey, R.V., Oquendo, M.A., Ogden, R.T., Olvet, D.M., Simpson, N., Huang, Y.Y., Van Heertum, R.L., Arango, V. & Mann, J.J. (2006) Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 59, 106-113.
47. Penington, N.J., Kelly, J.S. & Fox, A.P. (1993) Whole-cell recordings of inwardly rectifying K+currents activated by 5-HT1A receptors on dorsal raphe neurones of the adult rat. J Physiol 469, 387-405.
48. Ritter, L.M., Meador-Woodruff, J.H. & Dalack, G.W. (2004) Neurocognitive measures of prefrontal cortical dysfunction in schizophrenia. Schizophr Res 68, 65-73.
49. Serretti, A., Artioli, P., Lorenzi, C., Pirovano, A., Tubazio, V. & Zanardi, R. (2004) The C(-1019)G polymorphism of the 5-HT1A gene promoter and antidepressant response in mood disorders: preliminary findings. Int J Neuropsychopharmacol 7, 453-460.
50. Shurman, B., Horan, W.P. & Nuechterlein, K.H. (2005) Schizophrenia patients demonstrate a distinctive pattern of decision-making impairment on the Iowa Gambling Task. Schizophr Res 72, 215-224.
51. Si, T., Shu, L., Dang, W., Su, Y., Chen, J., Dong, W., Kong, Q. & Zhang, W. (2009) Evaluation of the reliability and validity of Chinese version of the Mini-International Neuropsychiatric Interview in patients with mental disorders. Chin Ment Health J 23, 493-497, 503.
52. Strobel, A., Gutknecht, L., Rothe, C., Reif, A., Mossner, R., Zeng, Y., Brocke, B. & Lesch, K.P. (2003) Allelic variation in 5-HT1A receptor expression is associated with anxiety- and depression-related personality traits. J Neural Transm 110, 1445-1453.
53. Sullivan, P.F., Konneker, T.I., Crowley, J.J., Quackenbush, C.R., Keefe, R.S.E., Perkins, D.O., Stroup, T.S., Lieberman, J.A. & van den Oord, E. (2010) No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition. Am J Med Genet B 153B, 1115-1117.
54. van den Bos, R., Homberg, J., Gijsbers, E., den Heijer, E. & Cuppen, E. (2009) The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females. Neuropharmacology 56, 493-498.
55. van den Bos, R., Houx, B.B. & Spruijt, B.M. (2006) The effect of reward magnitude differences on choosing disadvantageous decks in the Iowa Gambling Task. Biol Psychol 71, 151-161.
56. Wang, L., Fang, C., Zhang, A., Du, J., Yu, L., Ma, J., Feng, G., Xing, Q. & He, L. (2008) The -1019 C/G polymorphism of the 5-HT(1)A receptor gene is associated with negative symptom response to risperidone treatment in schizophrenia patients. J Psychopharmacol 22, 904-909.
57. Wendland, J.R., Martin, B.J., Kruse, M.R., Lesch, K.P. & Murphy, D.L. (2006) Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11, 224-226.
58. Williams, R.B. (1994) Neurobiology, cellular and molecular biology, and psychosomatic medicine. Psychosom Med 56, 308-315.
59. Williams, R.B. (1998) Lower socioeconomic status and increased mortality: early childhood roots and the potential for successful interventions. JAMA 279, 1745-1746.
60. Winstanley, C.A., Theobald, D.E., Dalley, J.W. & Robbins, T.W. (2005) Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 30, 669-682.
61. Woods, S.W. (2003) Chlorpromazine equivalent doses for the newer atypical antipsychotics. J Clin Psychiatry 64, 663-667.
62. Zhang, K., Xu, Q., Xu, Y., Yang, H., Luo, J., Sun, Y., Sun, N., Wang, S. & Shen, Y. (2009) The combined effects of the 5-HTTLPR and 5-HTR1A genes modulates the relationship between negative life events and major depressive disorder in a Chinese population. J Affect Disord 114, 224-231.
63. Zhang, Q., Shen, Q., Xu, Z., Chen, M., Cheng, L., Zhai, J., Gu, H., Bao, X., Chen, X., Wang, K., Deng, X., Ji, F., Liu, C., Li, J., Dong, Q. & Chen, C. (2011) The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder. Neuropsychopharmacology 37, 677-684.
64. Zhong, S., Chew, S.H., Set, E., Zhang, J., Xue, H., Sham, P.C., Ebstein, R.P. & Israel, S. (2009a) The heritability of attitude toward economic risk. Twin Res Hum Genet 12, 103-107.
65. Zhong, S., Israel, S., Xue, H., Ebstein, R.P. & Chew, S.H. (2009b) Monoamine oxidase A gene (MAOA) associated with attitude towards longshot risks. PLoS One 4, e8516.