The effect of COMT Val158 Met genotype on decision-making and preliminary findings on its interaction with the 5-HTTLPR in healthy females

Neuropharmacology

Volumn 56, Issue 2, 2009, Pages 493-498

  van den Bos, Ruud ^a,b   Homberg, Judith ^c,d   Gijsbers, Ellen ^a,d   den Heijer, Esther ^a,d   Cuppen, Edwin ^d  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

5 HTTLPR; COMT Val158 Met polymorphism; Decision making; Females; Iowa Gambling Task

Indexed keywords

CATECHOL METHYLTRANSFERASE; METHIONINE; SEROTONIN TRANSPORTER; SEROTONIN TRANSPORTER LENGTH POLYMORPHIC REGION; UNCLASSIFIED DRUG; VALINE;

ADULT; ALLELE; ARTICLE; DECISION MAKING; FEMALE; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; HUMAN EXPERIMENT; IOWA GAMBLING TASK; NEUROPSYCHOLOGICAL TEST; NORMAL HUMAN; PRIORITY JOURNAL; ANALYSIS OF VARIANCE; ATTENTION; GENETICS; PATHOLOGICAL GAMBLING; PHYSIOLOGY;

ADULT; ANALYSIS OF VARIANCE; ATTENTION; CATECHOL O-METHYLTRANSFERASE; DECISION MAKING; FEMALE; GAMBLING; GENOTYPE; HUMANS; METHIONINE; NEUROPSYCHOLOGICAL TESTS; POLYMORPHISM, GENETIC; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; VALINE; YOUNG ADULT;

EID: 58549114688     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2008.10.002     Document Type: Article

References (34)

1. Bechara A. Decision making, impulse control and loss of willpower to resist drugs: a neurocognitive perspective. Nature Neuroscience 8 (2005) 1458-1463
2. Bechara A., Damasio A.R., Damasio H., and Anderson S.W. Insensitivity to future consequences following damage to human prefrontal cortex. Cognition 50 (1994) 7-15
3. Bilder R.M., Volavka J., Lachman H.M., and Grace A.A. The catechol-O-methyltransferase polymorphism: relations to the tonic-phasic dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 29 (2004) 1943-1961
4. Brand M., Labudda K., and Markowitsch H.J. Neuropsychological correlates of decision-making in ambiguous and risky situations. Neural Networks 19 (2006) 1266-1276
5. Busemeyer J.R., and Stout J.C. A contribution of cognitive decision models to clinical assessment: decomposing performance on the Bechara Gambling Task. Psychological Assessment 14 3 (2002) 253-262
6. Chen J., Lipska B.K., Halim N., Ma Q.D., Matsumoto M., Melhem A., Kolachana S., Hyde T.M., Herman M.M., Apud J., Egan M.F., Kleinman J.E., and Weinberger D.R. Functional analysis of genetic variation in catechol-O-methyltransferase (COMT): effects on mRNA, protein, and enzyme activity in postmortem human brain. American Journal of Human Genetics 75 (2004) 807-821
7. 158 met genotype and neural mechanisms related to affective arousal and regulation. Archives of General Psychiatry 63 (2006) 1396-1406
8. 108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proceedings of the National Academy of Sciences of the United States of America 98 (2001) 6917-6922
9. Gogos J.A., Morgan M., Luine V., Santha M., Ogawa S., Pfaff D., and Karayiorgou M. Cathechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proceedings of the National Academy of Sciences of the United States of America 95 (1998) 9991-9996
10. Heinz A., Braus D.F., Smolka M.N., Wrase J., Puls I., Hermann D., Klein S., Grüsser S.M., Flor H., Schumann G., Mann K., and Büchel C. Amygdala-prefrontal coupling depends on a genetic variation of the 5-HT transporter. Nature Neuroscience 8 (2005) 20-21
11. Homberg J.R., Van den Bos R., den Heijer E., Suer R., and Cuppen E. Serotonin transporter dosage modulates long-term decision making in rat and human. Neuropharmacology 55 (2008) 80-84
12. Inglis I.R., Forkman B., and Lazarus J. Free food or earned food? A review and fuzzy model of contrafreeloading. Animal Behaviour 53 (1997) 1171-1191
13. Inglis I.R., Langton S., Forkman B., and Lazarus J. An information primacy model of exploratory and foraging behaviour. Animal Behaviour 62 (2001) 543-557
14. Jabbi M., Korf J., Kema I.P., Hartman C., van der Pompe G., Minderaa R.B., Ormel J., and den Boer J.A. Convergent genetic modulation of the endocrine stress response involves polymorphic variations of 5-HTT, COMT and MAOA. Molecular Psychiatry 12 (2007) 483-490
15. Karoum F., Chrapusta S.J., and Egan M.F. 3-Methoxytyramine is the major metabolite of released dopamine in the rat frontal cortex: reassessment of the effects of antipsychotics on the dynamics of dopamine release and metabolism in the frontal cortex, nucleus accumbens, and striatum by a simple two pool model. Journal of Neurochemistry 63 (1994) 972-979
16. Kahneman D., and Tversky A. Prospect theory: an analysis of decision making under risk. Econometrica 47 (1979) 263-291
17. Lachman H.M., Papolos D.F., Saito T., Yu Y.M., Szumlanski C.L., and Weinshilboum R.M. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 6 (1996) 243-250
18. Lotta T., Vidgren J., Tilgmann C., Ulmanen I., Melén K., Julkunen I., and Taskinen J. Kinetics of human soluble and membrane-bound catechol O-methyltransferase: a revised mechanism and description of the thermolabile variant of the enzyme. Biochemistry 34 (1995) 4202-4210
19. Malhotra A.K., Kestler L.J., Mazzanti C., Bates J.A., Goldberg T., and Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. American Journal of Psychiatry 159 (2002) 652-654
20. Pezawas L., Meyer-Lindenberg A., Drabant E.M., Verchinski B.A., Munoz K.E., Kolachana B.S., Egan M.F., Mattay V.S., Hariri A.R., and Weinberger D.R. 5-HTTLPR polymorphism impacts human cingulate-amygdala interactions: a genetic susceptibility mechanism for depression. Nature Neuroscience 8 (2005) 828-834
21. Rosa A., Peralta V., Cuesta M.J., Zarzuela A., Serrano F., Martínez-Larrea A., and Fañanás L. New evidence of association between COMT gene and prefrontal neurocognitive function in healthy individuals from sibling pairs discordant for psychosis. American Journal of Psychiatry 161 (2004) 1110-1112
22. Rotondo A., Mazzanti C., Dell'Osso L., Rucci P., Sullivan P., Bouanani S., Gonnelli C., Goldman D., and Cassano G.B. Catechol O-methyltransferase, serotonin transporter and tryptophan hydroxylase gene polymorphisms in bipolar disorder patients with and without comorbid panic disorder. American Journal of Psychiatry 159 (2002) 23-29
23. Roussos P., Giakoumaki S.G., Pavlakis S., and Bitsios P. Planning, decision-making and the COMT rs4818 polymorphism in healthy males. Neuropsychologia 46 (2008) 757-763
24. Sevy S., Hassoun Y., Bechara A., Yechiam E., Napolitano B., Burdick K., Delman H., and Malhotra A. Emotion-based decision-making in healthy subjects: short-term effects of reducing dopamine levels. Psychopharmacology 188 (2006) 228-235
25. 158 met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. The Journal of Neuroscience 25 (2005) 836-842
26. Smolka M.N., Bühler M., Schumann G., Klein S., Hu X.-Z., Moayer M., Zimmer A., Wrase J., Flor H., Mann K., Braus D.F., Goldman D., and Heinz A. Gene-gene effects on central processing of aversive stimuli. Molecular Psychiatry 12 (2007) 307-317
27. Stallen M. Excel Application of the Expectancy-Valence Model. Technical Report (2006), University of Amsterdam
28. Van den Bos R., Houx B.B., and Spruijt B.M. The effect of reward magnitude differences on choosing disadvantageous decks in the Iowa Gambling Task. Biological Psychology 71 (2006) 155-161
29. Van den Bos R., den Heijer E., Vlaar S., and Houx B.B. Exploring gender differences in decision-making using the Iowa Gambling Task. In: Elsworth J.E. (Ed). Psychology of Decision Making in Education, Behavior & High Risk Situations (2007), Nova Science Publishers, Inc 207-226
30. Wetzels, R., Vandekerckhove, J., Tuerlinckx, F., Wagenmakers, E.-J. Bayesian parameter estimation in the expectancy valence model of the Iowa Gambling Task, Journal of Mathematical Psychology, in press.
31. Winterer G., Musso F., Vucurevic G., Stoeter P., Konrad A., Seker B., Gallinat J., Dahmen N., and Weinberger D.R. COMT genotype predicts BOLD signal and noise characteristics in prefrontal circuits. NeuroImage 32 (2006) 172
32. Yavich L., Forsberg M.M., Karayiorgou M., Gogos J.A., and Männistö P.T. Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum. The Journal of Neuroscience 27 (2007) 10196-10202
33. Yechiam E., Busemeyer J.R., Stout J.C., and Bechara A. Using cognitive models to map relations between neuropsychological disorders and human decision-making deficits. Psychological Science 16 (2005) 973-978
34. Yechiam E., Kanz J.E., Bechara A., Stout J.C., Busemeyer J., Altmaier E.M., and Paulsen J.S. Neurocognitive deficits related to poor decision making in people behind bars. Psychonomic Bulletin & Review 15 1 (2008) 44-51