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Volumn 73, Issue 2, 2013, Pages 595-604

High-avidity T cells are preferentially tolerized in the tumor microenvironment

Author keywords

[No Author keywords available]

Indexed keywords

DOPACHROME TAUTOMERASE; GAMMA INTERFERON; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PROGRAMMED DEATH 1 RECEPTOR; T LYMPHOCYTE RECEPTOR;

EID: 84872562269     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-1123     Document Type: Article
Times cited : (39)

References (46)
  • 1
    • 0036812718 scopus 로고    scopus 로고
    • Antigens derived from melanocyte differentiation proteins: Self-tolerance, autoimmunity, and use for cancer immunotherapy
    • Engelhard VH, Bullock TN, Colella TA, Sheasley SL, Mullins DW. Antigens derived from melanocyte differentiation proteins: self-tolerance, autoimmunity, and use for cancer immunotherapy. Immunol Rev 2002;188: 136-46.
    • (2002) Immunol Rev , vol.188 , pp. 136-146
    • Engelhard, V.H.1    Bullock, T.N.2    Colella, T.A.3    Sheasley, S.L.4    Mullins, D.W.5
  • 2
    • 34248550936 scopus 로고    scopus 로고
    • Expression of tumor-associated differentiation antigens,MUC1glycoforms and CEA, in human thymic epithelial cells: Implications for selftolerance and tumor therapy
    • Cloosen S, Arnold J, Thio M, Bos GM, Kyewski B, Germeraad WT. Expression of tumor-associated differentiation antigens,MUC1glycoforms and CEA, in human thymic epithelial cells: implications for selftolerance and tumor therapy. Cancer Res 2007;67: 3919-26.
    • (2007) Cancer Res , vol.67 , pp. 3919-3926
    • Cloosen, S.1    Arnold, J.2    Thio, M.3    Bos, G.M.4    Kyewski, B.5    Germeraad, W.T.6
  • 3
    • 0033565301 scopus 로고    scopus 로고
    • Identification of newHER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas
    • Rongcun Y, Salazar-Onfray F, Charo J, Malmberg KJ, Evrin K, Maes H, et al. Identification of newHER2/neu-derived peptide epitopes that can elicit specific CTL against autologous and allogeneic carcinomas and melanomas. J Immunol 1999;163: 1037-44.
    • (1999) J Immunol , vol.163 , pp. 1037-1044
    • Rongcun, Y.1    Salazar-Onfray, F.2    Charo, J.3    Malmberg, K.J.4    Evrin, K.5    Maes, H.6
  • 4
    • 0034507693 scopus 로고    scopus 로고
    • Impact of negative selection on the T cell repertoire reactive to a self-peptide: A large fraction of T cell clones escapes clonal deletion
    • Bouneaud C, Kourilsky P, Bousso P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 2000;13: 829-40.
    • (2000) Immunity , vol.13 , pp. 829-840
    • Bouneaud, C.1    Kourilsky, P.2    Bousso, P.3
  • 5
    • 0028839022 scopus 로고
    • Immunological function of a defined T-cell population tolerized to low-affinity self antigens
    • Kawai K, Ohashi PS. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature 1995;374: 68-9.
    • (1995) Nature , vol.374 , pp. 68-69
    • Kawai, K.1    Ohashi, P.S.2
  • 6
    • 0035903328 scopus 로고    scopus 로고
    • Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen
    • Hernandez J, Aung S, Redmond WL, Sherman LA. Phenotypic and functional analysis of CD8(+) T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J Exp Med 2001;194: 707-17.
    • (2001) J Exp Med , vol.194 , pp. 707-717
    • Hernandez, J.1    Aung, S.2    Redmond, W.L.3    Sherman, L.A.4
  • 7
    • 15444378924 scopus 로고    scopus 로고
    • Peripheral deletion of antigenspecific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells
    • Herndon JM, Stuart PM, Ferguson TA. Peripheral deletion of antigenspecific T cells leads to long-term tolerance mediated by CD8+ cytotoxic cells. J Immunol 2005;174: 4098-104.
    • (2005) J Immunol , vol.174 , pp. 4098-4104
    • Herndon, J.M.1    Stuart, P.M.2    Ferguson, T.A.3
  • 8
    • 15244355148 scopus 로고    scopus 로고
    • Peripheral tolerance of CD8 T lymphocytes
    • Redmond WL, Sherman LA. Peripheral tolerance of CD8 T lymphocytes. Immunity 2005;22: 275-84.
    • (2005) Immunity , vol.22 , pp. 275-284
    • Redmond, W.L.1    Sherman, L.A.2
  • 9
    • 22544450157 scopus 로고    scopus 로고
    • Provision of granulocyte-macrophage colony-stimulating factor converts an autoimmune response to a selfantigen into an antitumor response
    • Ji Q, Gondek D, Hurwitz AA. Provision of granulocyte-macrophage colony-stimulating factor converts an autoimmune response to a selfantigen into an antitumor response. J Immunol 2005;175: 1456-63.
    • (2005) J Immunol , vol.175 , pp. 1456-1463
    • Ji, Q.1    Gondek, D.2    Hurwitz, A.A.3
  • 10
    • 0034671292 scopus 로고    scopus 로고
    • Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model
    • Schreurs MW, Eggert AA, de Boer AJ, Vissers JL, van Hall T, Offringa R, et al. Dendritic cells break tolerance and induce protective immunity against a melanocyte differentiation antigen in an autologous melanoma model. Cancer Res 2000;60: 6995-7001.
    • (2000) Cancer Res , vol.60 , pp. 6995-7001
    • Schreurs, M.W.1    Eggert, A.A.2    De Boer, A.J.3    Vissers, J.L.4    Van Hall, T.5    Offringa, R.6
  • 11
    • 0035889923 scopus 로고    scopus 로고
    • Manipulation of avidity to improve effectiveness of adoptively transferred CD8(+) T cells for melanoma immunotherapy in human MHC class I-transgenic mice
    • Bullock TN, Mullins DW, Colella TA, Engelhard VH. Manipulation of avidity to improve effectiveness of adoptively transferred CD8(+) T cells for melanoma immunotherapy in human MHC class I-transgenic mice. J Immunol 2001;167: 5824-31.
    • (2001) J Immunol , vol.167 , pp. 5824-5831
    • Bullock, T.N.1    Mullins, D.W.2    Colella, T.A.3    Engelhard, V.H.4
  • 12
    • 0035253434 scopus 로고    scopus 로고
    • High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL
    • Derby M, Alexander-Miller M, Tse R, Berzofsky J. High-avidity CTL exploit two complementary mechanisms to provide better protection against viral infection than low-avidity CTL. J Immunol 2001;166: 1690-7.
    • (2001) J Immunol , vol.166 , pp. 1690-1697
    • Derby, M.1    Alexander-Miller, M.2    Tse, R.3    Berzofsky, J.4
  • 13
    • 0033556322 scopus 로고    scopus 로고
    • High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy
    • Zeh HJ III, Perry-Lalley D, Dudley ME, Rosenberg SA, Yang JC. High avidity CTLs for two self-antigens demonstrate superior in vitro and in vivo antitumor efficacy. J Immunol 1999;162: 989-94.
    • (1999) J Immunol , vol.162 , pp. 989-994
    • Zeh Iii, H.J.1    Perry-Lalley, D.2    Dudley, M.E.3    Rosenberg, S.A.4    Yang, J.C.5
  • 14
    • 70149114880 scopus 로고    scopus 로고
    • Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen
    • Johnson LA, Morgan RA, Dudley ME, Cassard L, Yang JC,HughesMS, et al. Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen. Blood 2009;114: 535-46.
    • (2009) Blood , vol.114 , pp. 535-546
    • Johnson, L.A.1    Morgan, R.A.2    Dudley, M.E.3    Cassard, L.4    Yang, J.C.5    Hughes, M.S.6
  • 15
    • 0037058993 scopus 로고    scopus 로고
    • Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: In vivo persistence, migration, and antitumor effect of transferred T cells
    • Yee C, Thompson JA, Byrd D, Riddell SR, Roche P, Celis E, et al. Adoptive T cell therapy using antigen-specific CD8+ T cell clones for the treatment of patients with metastatic melanoma: in vivo persistence, migration, and antitumor effect of transferred T cells. Proc Natl Acad Sci U S A 2002;99: 16168-73.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 16168-16173
    • Yee, C.1    Thompson, J.A.2    Byrd, D.3    Riddell, S.R.4    Roche, P.5    Celis, E.6
  • 16
    • 0037174674 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes
    • Dudley ME, Wunderlich JR, Robbins PF, Yang JC, Hwu P, Schwartzentruber DJ, et al. Cancer regression and autoimmunity in patients after clonal repopulation with antitumor lymphocytes. Science 2002; 298: 850-4.
    • (2002) Science , vol.298 , pp. 850-854
    • Dudley, M.E.1    Wunderlich, J.R.2    Robbins, P.F.3    Yang, J.C.4    Hwu, P.5    Schwartzentruber, D.J.6
  • 17
    • 20244366111 scopus 로고    scopus 로고
    • Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma
    • Dudley ME, Wunderlich JR, Yang JC, Sherry RM, Topalian SL, Restifo NP, et al. Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma. J Clin Oncol 2005;23: 2346-57.
    • (2005) J Clin Oncol , vol.23 , pp. 2346-2357
    • Dudley, M.E.1    Wunderlich, J.R.2    Yang, J.C.3    Sherry, R.M.4    Topalian, S.L.5    Restifo, N.P.6
  • 19
    • 68049118838 scopus 로고    scopus 로고
    • Immunity to murine prostatic tumors: Continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells
    • Shafer-Weaver KA, Watkins SK, Anderson MJ, Draper LJ, Malyguine A, Alvord WG, et al. Immunity to murine prostatic tumors: continuous provision of T-cell help prevents CD8 T-cell tolerance and activates tumor-infiltrating dendritic cells. Cancer Res 2009;69: 6256-64.
    • (2009) Cancer Res , vol.69 , pp. 6256-6264
    • Shafer-Weaver, K.A.1    Watkins, S.K.2    Anderson, M.J.3    Draper, L.J.4    Malyguine, A.5    Alvord, W.G.6
  • 20
    • 77954129034 scopus 로고    scopus 로고
    • Cutting edge: Tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells
    • Shafer-Weaver KA, Anderson MJ, Stagliano K, Malyguine A, Greenberg NM, Hurwitz AA. Cutting edge: tumor-specific CD8+ T cells infiltrating prostatic tumors are induced to become suppressor cells. J Immunol 2009;183: 4848-52.
    • (2009) J Immunol , vol.183 , pp. 4848-4852
    • Shafer-Weaver, K.A.1    Anderson, M.J.2    Stagliano, K.3    Malyguine, A.4    Greenberg, N.M.5    Hurwitz, A.A.6
  • 21
    • 33846506812 scopus 로고    scopus 로고
    • Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer
    • Anderson MJ, Shafer-Weaver K, Greenberg NM, Hurwitz AA. Tolerization of tumor-specific T cells despite efficient initial priming in a primary murine model of prostate cancer. J Immunol 2007;178: 1268-76.
    • (2007) J Immunol , vol.178 , pp. 1268-1276
    • Anderson, M.J.1    Shafer-Weaver, K.2    Greenberg, N.M.3    Hurwitz, A.A.4
  • 22
    • 42349112060 scopus 로고    scopus 로고
    • Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration
    • Janicki CN, Jenkinson SR, Williams NA, Morgan DJ. Loss of CTL function among high-avidity tumor-specific CD8+ T cells following tumor infiltration. Cancer Res 2008;68: 2993-3000.
    • (2008) Cancer Res , vol.68 , pp. 2993-3000
    • Janicki, C.N.1    Jenkinson, S.R.2    Williams, N.A.3    Morgan, D.J.4
  • 24
    • 77957744369 scopus 로고    scopus 로고
    • Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    • Sakuishi K, Apetoh L, Sullivan JM, Blazar BR, Kuchroo VK, Anderson AC. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J Exp Med 2010;207: 2187-94.
    • (2010) J Exp Med , vol.207 , pp. 2187-2194
    • Sakuishi, K.1    Apetoh, L.2    Sullivan, J.M.3    Blazar, B.R.4    Kuchroo, V.K.5    Anderson, A.C.6
  • 25
    • 63649127254 scopus 로고    scopus 로고
    • Melanoma progression despite infiltration by in vivo-primed TRP-2-specific T cells
    • Singh V, Ji Q, Feigenbaum L, Leighty RM, Hurwitz AA. Melanoma progression despite infiltration by in vivo-primed TRP-2-specific T cells. J Immunother 2009;32: 129-39.
    • (2009) J Immunother , vol.32 , pp. 129-139
    • Singh, V.1    Ji, Q.2    Feigenbaum, L.3    Leighty, R.M.4    Hurwitz, A.A.5
  • 26
    • 7444254052 scopus 로고    scopus 로고
    • Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanomaspecific CD8+ T lymphocytes
    • De Palma R, Marigo I, Del Galdo F, De Santo C, Serafini P, Cingarlini S, et al. Therapeutic effectiveness of recombinant cancer vaccines is associated with a prevalent T-cell receptor alpha usage by melanomaspecific CD8+ T lymphocytes. Cancer Res 2004;64: 8068-76.
    • (2004) Cancer Res , vol.64 , pp. 8068-8076
    • De Palma, R.1    Marigo, I.2    Del Galdo, F.3    De Santo, C.4    Serafini, P.5    Cingarlini, S.6
  • 27
    • 45149127888 scopus 로고    scopus 로고
    • Spectratype/immunoscope analysis of the expressed TCR repertoire
    • Chapter 10:Unit 10
    • Currier JR, Robinson MA. Spectratype/immunoscope analysis of the expressed TCR repertoire. Curr Protoc Immunol 2001;Chapter 10:Unit 10 28.
    • (2001) Curr Protoc Immunol , pp. 28
    • Currier, J.R.1    Robinson, M.A.2
  • 28
    • 0033118739 scopus 로고    scopus 로고
    • A kinetic basis for T cell receptor repertoire selection during an immune response
    • Savage PA, Boniface JJ, Davis MM. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 1999;10: 485-92.
    • (1999) Immunity , vol.10 , pp. 485-492
    • Savage, P.A.1    Boniface, J.J.2    Davis, M.M.3
  • 29
    • 0142106936 scopus 로고    scopus 로고
    • Caveats in the design of MHC class i tetramer/ antigen-specific T lymphocytes dissociation assays
    • Wang XL, Altman JD. Caveats in the design of MHC class I tetramer/ antigen-specific T lymphocytes dissociation assays. J Immunol Methods 2003;280: 25-35.
    • (2003) J Immunol Methods , vol.280 , pp. 25-35
    • Wang, X.L.1    Altman, J.D.2
  • 30
    • 33747803946 scopus 로고    scopus 로고
    • Bone marrow stromal cell antigen 2 is a specific marker of type i IFNproducing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation
    • Blasius AL, Giurisato E, Cella M, Schreiber RD, Shaw AS, Colonna M. Bone marrow stromal cell antigen 2 is a specific marker of type I IFNproducing cells in the naive mouse, but a promiscuous cell surface antigen following IFN stimulation. J Immunol 2006;177: 3260-5.
    • (2006) J Immunol , vol.177 , pp. 3260-3265
    • Blasius, A.L.1    Giurisato, E.2    Cella, M.3    Schreiber, R.D.4    Shaw, A.S.5    Colonna, M.6
  • 33
    • 0029029965 scopus 로고
    • Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity
    • Heath WR, Karamalis F, Donoghue J, Miller JF. Autoimmunity caused by ignorant CD8+ T cells is transient and depends on avidity. J Immunol 1995;155: 2339-49.
    • (1995) J Immunol , vol.155 , pp. 2339-2349
    • Heath, W.R.1    Karamalis, F.2    Donoghue, J.3    Miller, J.F.4
  • 34
    • 51349095229 scopus 로고    scopus 로고
    • Overcoming obstacles to the effective immunotherapy of human cancer
    • Rosenberg SA. Overcoming obstacles to the effective immunotherapy of human cancer. Proc Natl Acad Sci USA 2008;105: 12643-4.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 12643-12644
    • Rosenberg, S.A.1
  • 36
    • 0025755537 scopus 로고
    • Reduced tumorigenicity of murine tumor-cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class-I major histocompatibility complex expression
    • Esumi N, Hunt B, Itaya T, Frost P. Reduced tumorigenicity of murine tumor-cells secreting gamma-interferon is due to nonspecific host responses and is unrelated to class-I major histocompatibility complex expression. Cancer Res 1991;51: 1185-9.
    • (1991) Cancer Res , vol.51 , pp. 1185-1189
    • Esumi, N.1    Hunt, B.2    Itaya, T.3    Frost, P.4
  • 37
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005;5: 263-74.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 38
    • 41149119143 scopus 로고    scopus 로고
    • Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells
    • Marigo I, Dolcetti L, Serafini P, Zanovello P, Bronte V. Tumor-induced tolerance and immune suppression by myeloid derived suppressor cells. Immunol Rev 2008;222: 162-79.
    • (2008) Immunol Rev , vol.222 , pp. 162-179
    • Marigo, I.1    Dolcetti, L.2    Serafini, P.3    Zanovello, P.4    Bronte, V.5
  • 39
    • 33645286546 scopus 로고    scopus 로고
    • Regulatory T cells, tumour immunity and immunotherapy
    • Zou W. Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 2006;6: 295-307.
    • (2006) Nat Rev Immunol , vol.6 , pp. 295-307
    • Zou, W.1
  • 40
    • 70350529527 scopus 로고    scopus 로고
    • Functional plasticity of macrophages: In situ reprogramming of tumor-associated macrophages
    • Stout RD, Watkins SK, Suttles J. Functional plasticity of macrophages: in situ reprogramming of tumor-associated macrophages. J Leukoc Biol 2009;86: 1105-9.
    • (2009) J Leukoc Biol , vol.86 , pp. 1105-1109
    • Stout, R.D.1    Watkins, S.K.2    Suttles, J.3
  • 43
    • 13944278036 scopus 로고    scopus 로고
    • Simultaneous generation of CD8 +and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor
    • Roszkowski JJ, Lyons GE, Kast WM, Yee C, Van Besien K, Nishimura MI. Simultaneous generation of CD8 +and CD4+ melanoma-reactive T cells by retroviral-mediated transfer of a single T-cell receptor. Cancer Res 2005;65: 1570-6.
    • (2005) Cancer Res , vol.65 , pp. 1570-1576
    • Roszkowski, J.J.1    Lyons, G.E.2    Kast, W.M.3    Yee, C.4    Van Besien, K.5    Nishimura, M.I.6
  • 44
    • 38449104431 scopus 로고    scopus 로고
    • Highaffinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines
    • Zhao Y, Bennett AD, Zheng Z,WangQJ, Robbins PF, Yu LY, et al. Highaffinity TCRs generated by phage display provide CD4+ T cells with the ability to recognize and kill tumor cell lines. J Immunol 2007;179: 5845-54.
    • (2007) J Immunol , vol.179 , pp. 5845-5854
    • Zhao, Y.1    Bennett, A.D.2    Zheng, Z.3    Wang, Q.J.4    Robbins, P.F.5    Yu, L.Y.6
  • 45
    • 63049108160 scopus 로고    scopus 로고
    • Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain
    • Kuball J, Hauptrock B, Malina V, Antunes E, Voss RH, Wolfl M, et al. Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain. J Exp Med 2009;206: 463-75.
    • (2009) J Exp Med , vol.206 , pp. 463-475
    • Kuball, J.1    Hauptrock, B.2    Malina, V.3    Antunes, E.4    Voss, R.H.5    Wolfl, M.6
  • 46
    • 35349014587 scopus 로고    scopus 로고
    • Molecular signature of CD8+ T cell exhaustion during chronic viral infection
    • Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, et al. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity 2007;27: 670-84.
    • (2007) Immunity , vol.27 , pp. 670-684
    • Wherry, E.J.1    Ha, S.J.2    Kaech, S.M.3    Haining, W.N.4    Sarkar, S.5    Kalia, V.6


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