Clinically asymptomatic vascular brain injury: A potent cause of cognitive impairment among older individuals

Journal of Alzheimer's Disease

Volumn 33, Issue SUPPL. 1, 2013, Pages

  DeCarli, Charles ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cerebrovascular disease; magnetic resonance imaging; pathophysiology; white matter hyperintensities

Indexed keywords

APOLIPOPROTEIN E4;

AGING; BLOOD PRESSURE; BLOOD PRESSURE REGULATION; BRAIN ATROPHY; BRAIN FUNCTION; BRAIN INJURY; BRAIN SIZE; BRAIN VENTRICLE; CARDIOVASCULAR RISK; CEREBROVASCULAR ACCIDENT; COGNITIVE DEFECT; CORONARY ARTERY DISEASE; DIFFUSION TENSOR IMAGING; DISEASE ASSOCIATION; EARLY DIAGNOSIS; FOLLOW UP; FRAMINGHAM RISK SCORE; FUNCTIONAL NEUROIMAGING; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HYPERTENSION; MILD COGNITIVE IMPAIRMENT; MORTALITY; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIPHERAL VASCULAR DISEASE; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; WHITE MATTER; WHITE MATTER INJURY; WORKING MEMORY;

EID: 84872532002     PISSN: 13872877     EISSN: 18758908     Source Type: Journal    
DOI: 10.3233/JAD-2012-129004     Document Type: Review

References (111)

1. Kinsella K, Velkoff VA (2001) An AgingWorld: 2011. U.S Census Bureau, Washington, D.C., p. 190
2. Werner CA (2011) The older population: 2010, http://www. census.gov/prod/cen2010/briefs/c2010br-09.pdf
3. Cutler SJ, Grams AE (1988) Correlates of self-reported everyday memory problems. J Gerontol Social Sci 43, S82-S90
4. Wilson RS, Beckett LA, Barnes LL, Schneider JA, Bach J, EvansDA, BennettDA(2002) Individual differences in rates of change in cognitive abilities of older persons. Psychol Aging 17, 179-193
5. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2004) State-Specific projections through 2025 of Alzheimer disease prevalence. Neurology 62, 1645
6. Ferri CP, Prince M, Brayne C, Brodaty H, Fratiglioni L, Ganguli M, Hall K, Hasegawa K, Hendrie H, HuangY, Jorm A, Mathers C, Menezes PR, Rimmer E, Scazufca M (2005) Global prevalence of dementia: A Delphi consensus study. Lancet 366, 2112-2117
7. Ganguli M, Dodge HH, Chen P, Belle S, DeKosky ST (2000) Ten-Year incidence of dementia in a rural elderly US community population: The MoVIES project. Neurology 54, 1109-1116
8. Seshadri S, Beiser A, Kelly-Hayes M, Kase CS, Au R, Kannel WB, Wolf PA (2006) The lifetime risk of stroke: Estimates from the Framingham Study. Stroke 37, 345-350
9. Schneider JA, Arvanitakis Z, Bang W, Bennett DA (2007) Mixed brain pathologies account for most dementia cases in community-Dwelling older persons. Neurology 69, 2197-2204
10. Decarli C (2004)Vascular factors in dementia: An overview. J Neurol Sci 226, 19-23
11. Decarli C, Massaro J, Harvey D, Hald J, Tullberg M, Au R, Beiser A, D'Agostino R, Wolf PA (2005) Measures of brain morphology and infarction in the framingham heart study: Establishing what is normal. Neurobiol Aging 26, 491-510
12. Hachinski VC, Potter P, Merskey H (1986) Leuko-Araiosis: An ancient term for a new problem. Canad J Neurol Sci 13, 533-534
13. Steingart A, Lau K, Fox A, Diaz F, Fisman M, Hachinski V, Merskey H (1986) The significance of white matter lucencies on CT scan in relation to cognitive impairment. Canad J Neurol Sci 13, 383-384
14. Hachinski VC, Potter P, Merskey H (1987) Leuko-Araiosis. Arch Neurol 44, 21-23
15. Inzitari D, Diaz F, Fox A, Hachinski VC, Steingart A, Lau C, Donald A,Wade J, Mulic H, Merskey H (1987) Vascular risk factors and leuko-Araiosis. Arch Neurol 44, 42-47
16. Steingart A, Hachinski VC, Lau C, Fox AJ, Diaz F, Cape R, Lee D, Inzitari D, Merskey H (1987) Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-Araiosis). Arch Neurol 44, 32-35
17. Steingart A, Hachinski VC, Lau C, Fox AJ, Fox H, Lee D, Inzitari D, MerskeyH(1987) Cognitive and neurologic findings in demented patients with diffuse white matter lucencies on computed tomographic scan (leuko-Araiosis). Arch Neurol 44, 36-39
18. Janota I, Mirsen TR, Hachinski VC, Lee DH, Merskey H (1989) Neuropathologic correlates of leuko-Araiosis [published erratum appears in Arch Neurol 1990 Mar; 47(3): 281]. Arch Neurol 46, 1124-1128
19. Awad IA, Spetzler RF, Hodak JA,Awad CA, Carey R (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly I Correlation with age and cerebrovascular risk factors. Stroke 17, 1084-1089
20. Awad IA, Johnson PC, Spetzler RF, Hodak JA (1986) Incidental subcortical lesions identified on magnetic resonance imaging in the elderly. II. Postmortem pathological correlations. Stroke 17, 1090-1097
21. Lechner H, Schmidt R, Bertha G, Justich E, Offenbacher H, Schneider G (1988) Nuclear magnetic resonance image white matter lesions and risk factors for stroke in normal individuals. Stroke 19, 263-265
22. Fazekas F (1989) Magnetic resonance signal abnormaliaties in asymptomatic individuals: Their incidence and functional correlates. Eur Neurol 29, 164-168
23. Fukuda H, Kobayashi S, Koide H, Yamaguchi S, Okada K, Shimode K, Tsunematsu T, Komatsu A (1990) Age-related changes in cerebral white matter measured by computed cranial tomography. Comput Med Imaging Graph 14, 79-84
24. Kobari M, Meyer JS, Ichijo M, Oravez WT (1990) Leukoaraiosis: Correlation of MR and CT findings with blood flow, atrophy, and cognition. Am J Neuroradiol 11, 273-281
25. Mirsen TR, Lee DH, Wong CJ, Diaz JF, Fox AJ, Hachinski VC, Merskey H (1991) Clinical correlates of white-Matter changes on magnetic resonance imaging scans of the brain. Arch Neurol 48, 1015-1021
26. Schmidt R, Fazekas F, Offenbacher H, Lytwyn H, Blematl B, Niederkorn K, Horner S, Payer F, Freidl W (1991) Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals. Arch Neurol 48, 417-420
27. van Swieten JC, Geyskes GG, DerixMM,PeeckBM,Ramos LM, van Latum JC, van Gijn J (1991) Hypertension in the elderly is associated with white matter lesions and cognitive decline. Ann Neurol 30, 825-830
28. Fazekas F, Niederkorn K, Schmidt R, Offenbacher H, Horner S, Bertha G, Lechner H (1988) White matter signal abnormalities in normal individuals: Correlation with carotid ultrasonography, cerebral blood flow measurements, and cerebrovascular risk factors. Stroke 19, 1285-1288
29. DeCarli C, Maisog J, Murphy DG, Teichberg D, Rapoport SI, Horwitz B (1992) Method for quantification of brain, ventricular, and subarachnoid CSF volumes from MR images. J Comput Assist Tomogr 16, 274-284
30. Murphy DG, DeCarli C, Schapiro MB, Rapoport SI, Horwitz B (1992) Age-related differences in volumes of subcortical nuclei, brain matter, and cerebrospinal fluid in healthy men as measured with magnetic resonance imaging [published erratum appears in Arch Neurol 1994 Jan; 51(1): 60]. Arch Neurol 49, 839-845
31. Salerno JA, Murphy DG, Horwitz B, DeCarli C, Haxby JV, Rapoport SI, Schapiro MB (1992) Brain atrophy in hypertension. A volumetric magnetic resonance imaging study. Hypertension 20, 340-348
32. DeCarli C, Murphy DG, Tranh M, Grady CL, Haxby JV, Gillette JA, Salerno JA, Gonzales-Aviles A, Horwitz B, Rapoport SI, et al. (1995) The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults. Neurology 45, 2077-2084
33. Liao D, Cooper L, Cai J, Toole JF, Bryan NR, Hutchinson RG, Tyroler HA (1996) Presence and severity of cerebral white matter lesions and hypertension, its treatment, and its control. The ARIC study. Atherosclerosis risk in communities study. Stroke 27, 2262-2270
34. Liao D, Cooper L, Cai J, Toole J, Bryan N, Burke G, Shahar E, Nieto J, Mosley T, Heiss G (1997) The prevalence and severity of white matter lesions, their relationship with age, ethnicity, gender, and cardiovascular disease risk factors: The ARIC study. Neuroepidemiology 16, 149-162
35. Boone KB, Miller BL, Lesser IM, Mehringer CM, Hill-Gutierrez E, Goldberg MA, Berman NG (1992) Neuropsychological correlates of white-Matter lesions in healthy elderly subjects. A threshold effect. Arch Neurol 49, 549-554
36. Aronow WS, Fleg JL, Pepine CJ, Artinian NT, Bakris G, Brown AS, Ferdinand KC, Forciea MA, Frishman WH, Jaigobin C, Kostis JB, Mancia G, Oparil S, Ortiz E, Reisin E, Rich MW, Schocken DD, Weber MA, Wesley DJ, Harrington RA (2011) ACCF/AHA 2011 expert consensus document on hypertension in the elderly: A report of the American College of Cardiology Foundation Task force on clinical expert consensus documents. Circulation 123, 2434-2506
37. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J (2010) Heart disease and stroke statistics - 2010 update: A report from the American Heart Association. Circulation 121, e46-e215
38. Swan GE, DeCarli C, Miller BL, Reed T,Wolf PA, Jack LM, Carmelli D (1998) Association of midlife blood pressure to late-Life cognitive decline and brain morphology. Neurology 51, 986-993
39. Carmelli D, Swan GE, Reed T,Wolf PA, Miller BL, DeCarli C (1999) Midlife cardiovascular risk factors and brain morphology in identical older male twins [see comments]. Neurology 52, 1119-1124
40. DeCarli C, Miller BL, Swan GE, Reed T,Wolf PA, Garner J, Jack L, Carmelli D (1999) Predictors of brain morphology for the men of the NHLBI twin study. Stroke 30, 529-536
41. DeCarli C, Reed T, Miller BL,Wolf PA, Swan GE, Carmelli D (1999) Impact of apolipoprotein E epsilon4 and vascular disease on brain morphology in men from the NHLBI twin study. Stroke 30, 1548-1553
42. Carmelli D, DeCarli C, Swan GE, Kelly-Hayes M, Wolf PA, Reed T, Guralnik JM (2000) The joint effect of apolipoprotein E epsilon4 and MRI findings on lowerextremity function and decline in cognitive function. J Gerontol A Biol Sci Med Sci 55, M103-M109
43. Swan GE, DeCarli C, Miller BL, Reed T,Wolf PA, Carmelli D (2000) Biobehavioral characteristics of nondemented older adults with subclinical brain atrophy. Neurology 54, 2108-2114
44. Launer LJ, Masaki K, Petrovich H, Foley D, Havlik RJ (1995) The association between mid-Life blood pressure levels and late-Life cognitive function. The Honolulu-Asia aging study. JAMA 274, 1846-1851
45. DeCarli C, Miller BL, Swan GE, Reed T,Wolf PA, Carmelli D (2001) Cerebrovascular and brain morphologic correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol 58, 643-647
46. Lopez OL, Jagust WJ, DeKosky ST, Becker JT, Fitzpatrick A, Dulberg C, Breitner J, Lyketsos C, Jones B, Kawas C, Carlson M, Kuller LH (2003) Prevalence and classification of mild cognitive impairment in the cardiovascular health study cognition study: Part 1. Arch Neurol 60, 1385-1389
47. Lopez OL, Jagust WJ, Dulberg C, Becker JT, DeKosky ST, Fitzpatrick A, Breitner J, Lyketsos C, Jones B, Kawas C, Carlson M, Kuller LH (2003) Risk factors for mild cognitive impairment in the cardiovascular health study cognition study: Part 2. Arch Neurol 60, 1394-1399
48. Carmelli D, DeCarli C, Swan GE, Jack LM, Reed T, Wolf PA,Miller BL (1998) Evidence for genetic variance in white matter hyperintensity volume in normal elderly male twins. Stroke 29, 1177-1181
49. Reed T, Kirkwood SC, DeCarli C, Swan GE, Miller BL, Wolf PA, Jack LM, Carmelli D (2000) Relationship of family history scores for stroke and hypertension to quantitative measures of white-Matter hyperintensities and stroke volume in elderly males. Neuroepidemiology 19, 76-86
50. Carmelli D, Reed T, DeCarli C (2002) A bivariate genetic analysis of cerebral white matter hyperintensities and cognitive performance in elderly male twins. Neurobiol Aging 23, 413-420
51. Carmelli D, Swan GE, DeCarli C, Reed T (2002) Quantitative genetic modeling of regional brain volumes and cognitive performance in older male twins. Biol Psychol 61, 139-155
52. Geschwind DH, Miller BL, DeCarli C, Carmelli D (2002) Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness. Proc Natl Acad Sci U S A 99, 3176-3181
53. Lessov-Schlaggar CN, Hardin J, Decarli C, Krasnow RE, Reed T,Wolf PA, Swan GE, CarmelliD(2012) Longitudinal genetic analysis of brain volumes in normal elderly male twins. Neurobiol Aging 33, 636-644
54. Jeerakathil T, Wolf PA, Beiser A, Massaro J, Seshadri S, D'Agostino RB, DeCarli C (2004) Stroke risk profile predicts white matter hyperintensity volume: The Framingham Study. Stroke 35, 1857-1861
55. Seshadri S, Wolf PA, Beiser A, Elias MF, Au R, Kase CS, D'Agostino RB, DeCarli C (2004) Stroke risk profile, brain volume, and cognitive function: The Framingham Offspring Study. Neurology 63, 1591-1599
56. Au R, Massaro JM, Wolf PA, Young ME, Beiser A, Seshadri S, D'Agostino RB, DeCarli C (2006) Association of white matter hyperintensity volume with decreased cognitive functioning: The Framingham Heart Study. Arch Neurol 63, 246-250
57. Das RR, Seshadri S, Beiser AS, Kelly-Hayes M, Au R, Himali JJ, Kase CS, Benjamin EJ, Polak JF, O'Donnell CJ, Yoshita M, D'Agostino RB Sr, DeCarli C, Wolf PA (2008) Prevalence and correlates of silent cerebral infarcts in the Framingham offspring study. Stroke 39, 2929-2935
58. Seshadri S, Wolf PA, Beiser AS, Selhub J, Au R, Jacques PF, Yoshita M, Rosenberg IH, D'Agostino RB, DeCarli C (2008) Association of plasma total homocysteine levels with subclinical brain injury: Cerebral volumes, white matter hyperintensity, and silent brain infarcts at volumetric magnetic resonance imaging in the Framingham Offspring Study. Arch Neurol 65, 642-649
59. Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S (2009) Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 302, 2565-2572
60. Romero JR, Beiser A, Seshadri S, Benjamin EJ, Polak JF, Vasan RS, Au R, DeCarli C,Wolf PA (2009) Carotid artery atherosclerosis, MRI indices of brain ischemia, aging, and cognitive impairment: The Framingham study. Stroke 40, 1590-1596
61. Pikula A, Boger RH, Beiser AS, Maas R, DeCarli C, Schwedhelm E, Himali JJ, Schulze F, Au R, Kelly-Hayes M, Kase CS, Vasan RS,Wolf PA, Seshadri S (2009) Association of plasmaADMAlevels with MRI markers of vascular brain injury: Framingham offspring study. Stroke 40, 2959-2964
62. Stavitsky K, Du Y, Seichepine D, Laudate TM, Beiser A, Seshadri S, Decarli C, Wolf PA, Au R (2010) White matter hyperintensity and cognitive functioning in the racial and ethnic minority cohort of the Framingham Heart Study. Neuroepidemiology 35, 117-122
63. Tan ZS, Beiser AS, Fox CS, Au R, Himali JJ, Debette S, Decarli C, Vasan RS, Wolf PA, Seshadri S (2011) Association of metabolic dysregulation with volumetric brain magnetic resonance imaging and cognitive markers of subclinical brain aging in middle-Aged adults: The framingham offspring study. Diabetes Care 34, 1766-1770
64. Debette S, Seshadri S, Beiser A, Au R, Himali JJ, Palumbo C, Wolf PA, Decarli C (2011) Midlife vascular risk factor exposure accelerates structural brain aging and cognitive decline. Neurology 77, 461-468
65. Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: Prevalence estimates using the 2000 census. Arch Neurol 60, 1119-1122
66. Debette S, Beiser A, Decarli C, Au R, Himali JJ, Kelly-Hayes M, Romero JR, Kase CS,Wolf PA, Seshadri S (2010) Association of MRI markers of vascular brain injury with incident stroke, mild cognitive impairment, dementia, and mortality. The Framingham Offspring Study. Stroke 41, 600-606
67. Wright CB, Paik MC, Brown TR, Stabler SP, Allen RH, Sacco RL, Decarli C (2005) Total homocysteine is associated with white matter hyperintensity volume. The Northern Manhattan Study. Stroke 36, 1207-1211
68. Khatri M, Wright CB, Nickolas TL, Yoshita M, Paik MC, Kranwinkel G, Sacco RL, DeCarli C (2007) Chronic kidney disease is associated with white matter hyperintensity volume: The Northern Manhattan Study (NOMAS). Stroke 38, 3121-3126
69. Brickman AM, Schupf N, Manly JJ, Luchsinger JA, Andrews H, Tang MX, Reitz C, Small SA, Mayeux R, DeCarli C, Brown TR (2008) Brain morphology in older African Americans, Caribbean Hispanics, and whites from northern Manhattan. Arch Neurol 65, 1053-1061
70. Devanand DP, Tabert MH, Cuasay K, Manly JJ, Schupf N, Brickman AM, Andrews H, Brown TR, Decarli C, Mayeux R (2010) Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. Neurobiol Aging 31, 1593-1600
71. Prabhakaran S, Wright CB,Yoshita M, Delapaz R, Brown T, DeCarli C, Sacco RL (2008) Prevalence and determinants of subclinical brain infarction: The Northern Manhattan Study. Neurology 70, 425-430
72. Wright CB, Festa JR, Paik MC, Schmiedigen A, Brown TR, Yoshita M, DeCarli C, Sacco R, Stern Y (2008) White matter hyperintensities and subclinical infarction: Associations with psychomotor speed and cognitive flexibility. Stroke 39, 800-805
73. Wright CB, Moon Y, Paik MC, Brown TR, Rabbani L, Yoshita M, DeCarli C, Sacco R, Elkind MS (2009) Inflammatory biomarkers of vascular risk as correlates of leukoariosis. Stroke 40, 3466-3471
74. Brickman AM, Siedlecki KL, Muraskin J, Manly JJ, Luchsinger JA, Yeung LK, Brown TR, Decarli C, Stern Y (2011) White matter hyperintensities and cognition: Testing the reserve hypothesis. Neurobiol Aging 32, 1588-1598
75. Luchsinger JA, Brickman AM, Reitz C, Cho SJ, Schupf N, Manly JJ, Tang MX, Small SA, Mayeux R, DeCarli C, Brown TR (2009) Subclinical cerebrovascular disease in mild cognitive impairment. Neurology 73, 450-456
76. Reitz C, Brickman AM, Brown TR, Manly J, DeCarli C, Small SA, Mayeux R (2009) Linking hippocampal structure and function to memory performance in an aging population. Arch Neurol 66, 1385-1392
77. Aggarwal NT, Wilson RS, Bienias JL, De Jager PL, Bennett DA, Evans DA, DeCarli C (2010) The association of magnetic resonance imaging measures with cognitive function in a biracial population sample. Arch Neurol 67, 475-482
78. Brickman AM, Reitz C, Luchsinger JA, Manly JJ, Schupf N, Muraskin J, DeCarli C, Brown TR, Mayeux R (2010) Long-Term blood pressure fluctuation and cerebrovascular disease in an elderly cohort. Arch Neurol 67, 564-569
79. Devanand DP, Tabert MH, Cuasay K, Manly JJ, Schupf N, Brickman AM, Andrews H, Brown TR, DeCarli C, Mayeux R (2010) Olfactory identification deficits and MCI in a multi-ethnic elderly community sample. Neurobiol Aging 31, 1593-1600
80. Brickman AM, Siedlecki KL, Muraskin J, Manly JJ, Luchsinger JA, Yeung LK, Brown TR, Decarli C, Stern Y (2011) White matter hyperintensities and cognition: Testing the reserve hypothesis. Neurobiol Aging 32, 1588-1598
81. Marcus J, Gardener H, Rundek T, Elkind MS, Sacco RL, Decarli C, Wright CB (2011) Baseline and longitudinal increases in diastolic blood pressure are associated with greater white matter hyperintensity volume: The Northern Manhattan Study. Stroke 42, 2639-2641
82. Scarmeas N, Luchsinger JA, Stern Y, Gu Y, He J, DeCarli C, Brown T, Brickman AM (2011) Mediterranean diet and magnetic resonance imaging-Assessed cerebrovascular disease. Ann Neurol 69, 257-268
83. Willey JZ, Moon YP, Paik MC, Yoshita M, Decarli C, Sacco RL, Elkind MS, Wright CB (2011) Lower prevalence of silent brain infarcts in the physically active: The Northern Manhattan Study. Neurology 76, 2112-2118
84. Hudson BI, Moon YP, Kalea AZ, Khatri M, Marquez C, Schmidt AM, Paik MC, Yoshita M, Sacco RL, DeCarli C, Wright CB, Elkind MS (2011) Association of serum soluble receptor for advanced glycation end-Products with subclinical cerebrovascular disease: The Northern Manhattan Study (NOMAS). Atherosclerosis 216, 192-198
85. DeCarli C, Reed BR, Jagust W, Martinez O, Ortega M, Mungas D (2008) Brain behavior relationships among African Americans, whites, and Hispanics. Alzheimer Dis Assoc Disord 22, 382-391
86. Sacco RL, Boden-Albala B, Gan R, Chen X, Kargman DE, Shea S, Paik MC, Hauser WA (1998) Stroke incidence among white, black, and Hispanic residents of an urban community: The northern manhattan stroke study. Am J Epidemiol 147, 259-268
87. Manly JJ, Mayeux R (2004) Ethnic and racial differences in dementia and Alzheimer's disease. In. Critical Perspectives on Racial and Ethnic Differences in Health in Late Life, Anderson NB, Bulatao RA, Cohen B, eds. The National Academies Press Washington D.C., pp. 94-141
88. DeCarli C, Fletcher E, Ramey V, Harvey D, Jagust WJ (2005) Anatomical mapping of white matter hyperintensities (WMH): Exploring the relationships between periventricular WMH, deep WMH, and totalWMHburden. Stroke 36, 50-55
89. Tullberg M, Fletcher E, DeCarli C, Mungas D, Reed BR, Harvey DJ,WeinerMW, Chui HC, Jagust WJ (2004) White matter lesions impair frontal lobe function regardless of their location. Neurology 63, 246-253
90. Yoshita M, Fletcher E, Harvey D, Ortega M, Martinez O, Mungas DM, Reed BR, DeCarli CS (2006) Extent and distribution of white matter hyperintensities in normal aging, MCI, and AD. Neurology 67, 2192-2198
91. Nordahl CW, Ranganath C, Yonelinas AP, DeCarli C, Reed BR, Jagust WJ (2005) Different mechanisms of episodic memory failure in mild cognitive impairment. Neuropsychologia 43, 1688-1697
92. He J, Farias S, Martinez O, Reed B, Mungas D, Decarli C (2009) Differences in brain volume, hippocampal volume, cerebrovascular risk factors, and apolipoprotein E4 among mild cognitive impairment subtypes. Arch Neurol 66, 1393-1399
93. Carmichael O, Mungas D, Beckett L, Harvey D, Tomaszewski Farias S, Reed B, Olichney J,Miller J, Decarli C (2012) MRI predictors of cognitive change in a diverse and carefully characterized elderly population. Neurobiol Aging 33, 83-95
94. Carmichael O, Schwarz C, Drucker D, Fletcher E, Harvey D, Beckett L, Jack CR Jr, Weiner M, DeCarli C, Alzheimer's Disease Neuroimaging, Initiative (2010) Longitudinal changes in white matter disease and cognition in the first year of the Alzheimer Disease Neuroimaging Initiative. Arch Neurol 67, 1370-1378
95. Lee DY, Fletcher E, Martinez O, Ortega M, Zozulya N, Kim J, Tran J, Buonocore M, Carmichael O, Decarli C (2009) Regional pattern of white matter microstructural changes in normal aging, MCI, and AD. Neurology 73, 1722-1728
96. Lee DY, Fletcher E, Martinez O, Zozulya N, Kim J, Tran J, Buonocore M, Carmichael O, DeCarli C (2010) Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer's disease. Stroke 41, 1791-1797
97. Maillard P, Fletcher E, Harvey D, Carmichael O, Reed B, Mungas D, DeCarli C (2011) White matter hyperintensity penumbra. Stroke 42, 1917-1922
98. Nordahl CW, Ranganath C, Yonelinas AP, Decarli C, Fletcher E, Jagust WJ (2006) White matter changes compromise prefrontal cortex function in healthy elderly individuals. J Cogn Neurosci 18, 418-429
99. Mayda AB, Westphal A, Carter CS, DeCarli C (2011) Late life cognitive control deficits are accentuated by white matter disease burden. Brain 134, 1673-1683
100. Vannini P, O'Brien J, O'Keefe K, Pihlajamaki M, Laviolette P, Sperling RA (2011) What goes down must come up: Role of the posteromedial cortices in encoding and retrieval. Cereb Cortex 21, 22-34
101. West RL (1996) An application of prefrontal cortex function theory to cognitive aging. Psychol Bull 120, 272-292
102. Seshadri S, DeStefano AL, Au R, Massaro JM, Beiser AS, Kelly-Hayes M, Kase CS, D'Agostino RB, Decarli C, Atwood LD, Wolf PA (2007) Genetic correlates of brain aging on MRI and cognitive test measures: A genome-wide association and linkage analysis in the Framingham Study. BMC Med Genet 8 SUPPL1, S15
103. Atwood LD,Wolf PA, Heard-Costa NL, Massaro JM, Beiser A, D'Agostino RB, DeCarli C (2004) Genetic variation in white matter hyperintensity volume in the Framingham Study. Stroke 35, 1609-1613
104. DeStefano AL, Atwood LD, Massaro JM, Heard-Costa N, Beiser A, Au R, Wolf PA, DeCarli C (2006) Genome-wide scan for white matter hyperintensity: The Framingham Heart Study. Stroke 37, 77-81
105. Cuenco TK, Lunetta KL, Baldwin CT, McKee AC, Guo J, Cupples LA, Green RC, St George-Hyslop PH, Chui H, DeCarli C, Farrer LA (2008) Association of distinct variants in SORL1 with cerebrovascular and neurodegenerative changes related to Alzheimer disease. Arch Neurol 65, 1640-1648
106. Debette S, Bis JC, Fornage M, Schmidt H, Ikram MA, Sigurdsson S, Heiss G, Struchalin M, Smith AV, van der Lugt A, DeCarli C, Lumley T, Knopman DS, Enzinger C, Eiriksdottir G, Koudstaal PJ, DeStefano AL, Psaty BM, Dufouil C, Catellier DJ, Fazekas F, Aspelund T, Aulchenko YS, Beiser A, Rotter JI, Tzourio C, Shibata DK, Tscherner M, Harris TB, Rivadeneira F, Atwood LD, Rice K, Gottesman RF, van Buchem MA, Uitterlinden AG, Kelly-Hayes M, Cushman M, Zhu Y, Boerwinkle E, Gudnason V, Hofman A, Romero JR, Lopez O, van Duijn CM, Au R, Heckbert SR, Wolf PA, Mosley TH, Seshadri S, Breteler MM, Schmidt R, Launer LJ, Longstreth WT Jr (2010) Genomewide association studies of MRI-Defined brain infarcts: Meta-Analysis from the CHARGE Consortium. Stroke 41, 210-217
107. Fornage M, Debette S, Bis JC, Schmidt H, Ikram MA, Dufouil C, Sigurdsson S, Lumley T, DeStefano AL, Fazekas F, Vrooman HA, Shibata DK, Maillard P, Zijdenbos A, Smith AV, Gudnason H, de Boer R, Cushman M, Mazoyer B, Heiss G, Vernooij MW, Enzinger C, Glazer NL, Beiser A, Knopman DS, Cavalieri M, Niessen WJ, Harris TB, Petrovic K, Lopez OL, Au R, Lambert JC, Hofman A, Gottesman RF, Garcia M, Heckbert SR, Atwood LD, Catellier DJ, Uitterlinden AG, Yang Q, Smith NL, Aspelund T, Romero JR, Rice K, Taylor KD, Nalls MA, Rotter JI, Sharrett R, van Duijn CM, Amouyel P, Wolf PA, Gudnason V, van der Lugt A, Boerwinkle E, Psaty BM, Seshadri S, Tzourio C, Breteler MM, Mosley TH, Schmidt R, Longstreth WT, DeCarli C, Launer LJ (2011) Genomewide association studies of cerebral white matter lesion burden: The CHARGE consortium. Ann Neurol 69, 928-939
108. Hanon O, Forette F (2004) Prevention of dementia: Lessons from SYST-EUR and PROGRESS. J Neurol Sci 226, 71-74
109. Lytle LA (2012) Dealing with the childhood obesity epidemic: A public health approach. Abdom Imaging 37(5), 719-724
110. Whitmer RA, Gunderson EP, Barrett-Connor E, Quesenberry CP Jr,YaffeK(2005) Obesity in middle age and future risk of dementia: A 27 year longitudinal population based study. BMJ 330, 1360
111. Brookmeyer R, Gray S, Kawas C (1998) Projections of Alzheimer's disease in the United States and the public health impact of delaying disease onset. Am J Public Health 88, 1337-1342