QSAR studies of macrocyclic diterpenes with P-glycoprotein inhibitory activity

European Journal of Pharmaceutical Sciences

Volumn 48, Issue 3, 2013, Pages 542-553

  Sousa, Iněs J ^a   Ferreira, Maria José U ^b   Molnár, Joseph ^c   Fernandes, Miguel X ^a  

^a CQM Centro de Química da Madeira   (Portugal)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c UNIVERSITY OF SZEGED   (Hungary)

Author keywords

Macrocyclic diterpenes; Multidrug resistance; Multiple linear regression; P glycoprotein; Quantitative structure activity relationship

Indexed keywords

DITERPENE; JATROPHANE; LATHYRANE; MULTIDRUG RESISTANCE PROTEIN; UNCLASSIFIED DRUG; VERAPAMIL; ABCB1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; FLUORESCENT DYE; MACROCYCLIC COMPOUND; RECOMBINANT PROTEIN; RHODAMINE 123; TUMOR PROTEIN;

ANIMAL CELL; ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; LIPOPHILICITY; LYMPHOMA CELL LINE; MOUSE; NONHUMAN; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; QUANTITATIVE STRUCTURE ACTIVITY RELATION; ANIMAL; ANTAGONISTS AND INHIBITORS; ARTIFICIAL INTELLIGENCE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; METABOLISM; MULTIDRUG RESISTANCE; OSMOLARITY; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE; VALIDATION STUDY;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ARTIFICIAL INTELLIGENCE; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DITERPENES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FLUORESCENT DYES; HUMANS; MACROCYCLIC COMPOUNDS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEOPLASM PROTEINS; OSMOLAR CONCENTRATION; P-GLYCOPROTEINS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RECOMBINANT PROTEINS; RHODAMINE 123;

EID: 84872528917     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2012.11.012     Document Type: Article

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