MicroRNA-152 and -181a participate in human dermal fibroblasts senescence acting on cell adhesion and remodeling of the extracellular matrix

Aging

Volumn 4, Issue 11, 2012, Pages 843-853

  Mancini, Mara ^a   Saintigny, Gaelle ^b   Mahé, Christian ^b   Annicchiarico Petruzzelli, Margherita ^a   Melino, Gerry ^a,c   Candi, Eleonora ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b CHANEL Parfums Beauté   (France)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

Aging; MIR; miRNA; Senescence; Skin

Indexed keywords

EID: 84872508357     PISSN: 19454589     EISSN: None     Source Type: Journal    
DOI: 10.18632/aging.100508     Document Type: Editorial

References (87)

1. Serrano M, Lin AW, McCurrach ME, Beach D, and Lowe SW. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell. 1997; 88:593-602.
2. Campisi J. Cellular senescence as a tumor-suppressor mechanism. Trends Cell Biol. 2001; 11:S27-31.
3. Schmitt CA, Fridman JS, Yang M, Lee S, Baranov E, Hoffman RM, and Lowe SW. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell. 2002; 109:335-346.
4. Sharpless NE, and DePinho RA. Telomeres, stem cells, senescence, and cancer. J Clin Invest. 2004; 113:160-168.
5. Sommer M, Poliak N, Upadhyay S, Ratovitski E, Nelkin BD, Donehower LA, and Sidransky D. DeltaNp63alpha overexpression induces downregulation of Sirt1 and an accelerated aging phenotype in the mouse. Cell Cycle. 2006; 5:2005-2011.
6. Campisi J, and d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol. 2007; 8:729-740.
7. Fulco M, and Sartorelli V. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues. Cell Cycle. 2008; 7:3669-79.
8. Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN and Zhu C. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle. 2010; 9:3328-3336.
9. Narita M, Nunez S, Heard E, Narita M, Lin AW, Hearn SA, Spector DL, Hannon GJ, and Lowe SW. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell. 2003; 113:703-716.
10. Sharpless NE. Ink4a/Arf links senescence and aging. Exp Gerontol. 2004; 39:1751-1759.
11. Ryu SJ, Oh YS, and Park SC. Failure of stress-induced downregulation of Bcl-2 contributes to apoptosis resistance in senescent human diploid fibroblasts. Cell Death Differ. 2007; 14:1020-1028.
12. Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M, Pilpel Y, Nielsen FC, Oren M, Lund AH. p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ. 2010 Feb; 17:236-245.
13. Castro ME, del Valle Guijarro M, Moneo V, and Carnero A. Cellular senescence induced by p53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts. J Cell Biochem. 2004; 92:514-524.
14. Müller KC, Welker L, Paasch K, Feindt B, Erpenbeck VJ, Hohlfeld JM, Krug N, Nakashima M, Branscheid D, Magnussen H, Jörres RA, and Holz O. Lung fibroblasts from patients with emphysema show markers of senescence in vitro. Respir Res. 2006; 21:7:32.
15. Flanary BE, Sammons NW, Nguyen C, Walker D, and Streit WJ. Evidence that aging and amyloid promote microglial cell senescence. Rejuvenation Res. 2007; 10:61-74.
16. Marcel V, Dichtel-Danjoy ML, Sagne C, Hafsi H, Ma D, Ortiz-Cuaran S, Olivier M, Hall J, Mollereau B, Hainaut P, Bourdon JC. Biological functions of p53 isoforms through evolution: lessons from animal and cellular models. Cell Death Differ. 2011;18:1815-1824.
17. Nakamura T, Lipton SA. Redox modulation by S-nitrosylation contributes to protein misfolding, mitochondrial dynamics, and neuronal synaptic damage in neurodegenerative diseases. Cell Death Differ. 2011;18:1478-1486.
18. Hendel A, Hiebert PR, Boivin WA, Williams SJ, Granville DJ. Granzymes in age-related cardiovascular and pulmonary diseases. Cell Death Differ. 2010;17:596-606.
19. Darrah E, Rosen A. Granzyme B cleavage of autoantigens in autoimmunity. Cell Death Differ. 2010;17:624-632.
20. Cullen SP, Brunet M, Martin SJ. Granzymes in cancer and immunity. Cell Death Differ. 2010;17:616-623.
21. Melino G. p63 is a suppressor of tumorigenesis and metastasis interacting with mutant p53. Cell Death Differ. 2011; Sep;18(9):1487-1499.
22. Pinton P, Giorgi C, Pandolfi PP. The role of PML in the control of apoptotic cell fate: a new key player at ER-mitochondria sites. Cell Death Differ. 2011;18:1450-6.
23. Hofius D, Munch D, Bressendorff S, Mundy J, Petersen M. Role of autophagy in disease resistance and hypersensitive responseassociated cell death. Cell Death Differ. 2011;18:1257-1262.
24. Kang R, Zeh HJ, Lotze MT, Tang D. The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 2011;18:571-580.
25. Remijsen Q, Kuijpers TW, Wirawan E, Lippens S, Vandenabeele P, Vanden Berghe T. Dying for a cause: NETosis, mechanisms behind an antimicrobial cell death modality. Cell Death Differ. 2011;18:581-588.
26. Liang C. Negative regulation of autophagy. Cell Death Differ. 2010;17:1807-1815.
27. Geering B, Simon HU. Peculiarities of cell death mechanisms in neutrophils. Cell Death Differ. 2011;18:1457-1469.
28. Kelly PN, Strasser A. The role of Bcl-2 and its pro-survival relatives in tumourigenesis and cancer therapy. Cell Death Differ. 2011;18:1414-1424.
29. Füllgrabe J, Hajji N, Joseph B. Cracking the death code: apoptosis-related histone modifications. Cell Death Differ. 2010;17:1238-1243.
30. Candi E, Schmidt R, and Melino G. The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol. 2005; 6:328-340.
31. Candi E, Rufini A, Terrinoni A, Dinsdale D, Ranalli M, Paradisi A, De Laurenzi V, Spagnoli LG, Catani MV, Ramadan S, Knight RA, and Melino G. Differential roles of p63 isoforms in epidermal development: selective genetic complementation in p63 null mice. Cell Death Differ. 2006; 13:1037-1047.
32. Núñez R, Sancho-Martínez SM, Novoa JM, López-Hernández FJ. Apoptotic volume decrease as a geometric determinant for cell dismantling into apoptotic bodies. Cell Death Differ. 2010; 17:1665-1671.
33. Royer C, Lu X. Epithelial cell polarity: a major gatekeeper against cancer?. Cell Death Differ. 2011; 18:1470-1407.
34. Smertenko A, Franklin-Tong VE. Organisation and regulation of the cytoskeleton in plant programmed cell death. Cell Death Differ. 2011;18:1263-1270.
35. Leadsham JE, Kotiadis VN, Tarrant DJ, Gourlay CW. Apoptosis and the yeast actin cytoskeleton. Cell Death Differ. 2010; 17:754-762.
36. Carmona-Gutierrez D, Eisenberg T, Büttner S, Meisinger C, Kroemer G, Madeo F. Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ. 2010; 17:763-773.
37. El-Domyati M, Attia S, Saleh F, Brown D, Birk DE, Gasparro F, Ahmad H, and Uitto J. Intrinsic aging vs. photoaging: a comparative histopathological, immunohistochemical, and ultrastructural study of skin. Exp Dermatol. 2002; 11:398-405.
38. Lavker RM, Zheng PS, and Dong G. Aged skin: a study by light, transmission electron, and scanning electron microscopy. J Invest Dermatol. 1987; 88:44s-51s.
39. Carrino DA, Onnerfjord P, Sandy JD, Cs-Szabo G, Scott PG, Sorrell JM, Heinegård D, and Caplan AI. Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skin. J Biol Chem. 2003; 278:17566-17572.
40. Varani J. Epithelial cell invasion of the stroma in human skin organ culture. Front Biosci. 2004; 9:2989-2995.
41. Varani J, Dame MK, Rittie L, Fligiel SE, Kang S, Fisher GJ, and Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. Am J Pathol. 2006; 168:1861-1868.
42. Fisher GJ, Quan T, Purohit T, Shao Y, Cho MK, He T, Varani J, Kang S, and Voorhees JJ. Collagen fragmentation promotes oxidative stress and elevates matrix metalloproteinase-1 in fibroblasts in aged human skin. Am J Pathol. 2009; 174:101-114.
43. Goldstein S. Replicative senescence: the human fibroblast comes of age. Science. 1990; 249:1129-1133.
44. Cristofalo VJ, and Pignolo RJ. Replicative senescence of human fibroblast-like cells in culture. Physiol Rev. 1993; 73:617-638.
45. Manning JA, and Kumar S. A potential role for NEDD1 and the centrosome in senescence of mouse embryonic fibroblasts. Cell Death Dis. 2010;1:e35.
46. Gonzalez-Cano L, Herreros-Villanueva M, Fernandez-Alonso R, Ayuso-Sacido A, Meyer G, Garcia-Verdugo JM, Silva A, Marques MM, and Marin MC. p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53. Cell Death Dis. 2010;1:e109.
47. Giampietri C, Petrungaro S, Coluccia P, Antonangeli F, Giannakakis K, Faraggiana T, Filippini A, Cossu G, and Ziparo E. c-Flip overexpression affects satellite cell proliferation and promotes skeletal muscle aging. Cell Death Dis. 2010; 1:e38.
48. Drullion C, Trégoat C, Lagarde V, Tan S, Gioia R, Priault M, Djavaheri-Mergny M, Brisson A, Auberger P, Mahon FX, and Pasquet JM. Apoptosis and autophagy have opposite roles on imatinib-induced K562 leukemia cell senescence. Cell Death Dis. 2012; 3:e373.
49. Schneider EL. Aging and cultured human skin fibroblasts. J Invest Dermatol. 1979; 73:15-18.
50. Hayflick L. The cell biology of aging. J Invest Dermatol. 1979; 73:8-14.
51. West MD, Pereira-Smith OM, and Smith JR. Replicative senescence of human skin fibroblasts correlates with a loss of regulation and overexpression of collagenase activity. Exp Cell Res. 1989; 184:138-147.
52. Vilborg A, Bersani C, Wilhelm MT, Wiman KG. The p53 target Wig-1: a regulator of mRNA stability and stem cell fate? Cell Death Differ. 2011;18(9):1434-40.
53. Garofalo M, Condorelli GL, Croce CM, Condorelli G. MicroRNAs as regulators of death receptors signaling. Cell Death Differ. 2010;17(2):200-208.
54. Yi R, Fuchs E. MicroRNA-mediated control in the skin. Cell Death Differ. 2010; 17:229-35.
55. Godlewski J, Newton HB, Chiocca EA, Lawler SE. MicroRNAs and glioblastoma; the stem cell connection. Cell Death Differ. 2010; 17:221-228.
56. Aqeilan RI, Calin GA, Croce CM. miR-15a and miR-16-1 in cancer: discovery, function and future perspectives. Cell Death Differ. 2010; 17:215-220.
57. Lund AH. miR-10 in development and cancer. Cell Death Differ. 2010; 17:209-214. 58. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010; 17:193-199.
58. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ. 2010; 17:193-199.
59. Grillari J, and Grillari-Voglauer R. Novel modulators of senescence, aging, and longevity: Small non-coding RNAs enter the stage. Exp Gerontol. 2010; 45:302-311.
60. Hackl M, Brunner S, Fortschegger K, et al. miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging. Aging Cell. 2010; 9:291-296.
61. Faraonio R, Pane F, Intrieri M, Russo T, and Cimino F. In vitro acquired cellular senescence and aging-specific phenotype can be distinguished on the basis of specific mRNA expression. Cell Death Differ. 2002; 9:862-86.
62. Cufí S, Vazquez-Martin A, Oliveras-Ferraros C, Quirantes R, Segura-Carretero A, Micol V, Joven J, Bosch-Barrera J, Del Barco S, Martin-Castillo B, Vellon L, and Menendez JA. Metformin lowers threshold for stress-induced senescence: a role for microRNA-200 family and niR-205. Cell Cycle. 2012; 1:1235-1246.
63. Telgenhoff D, and Shroot B. Cellular senescence mechanisms in chronic wound healing. Cell Death Differ. 2005; 12:695-698.
64. Marasa BS, Srikantan S, Martindale JL, Kim MM, Lee EK, Gorospe M, and Abdelmohsen K. MicroRNA profiling in human diploid fibroblasts uncovers miR-519 role in replicative senescence. Aging (Albany NY). 2010; 2:333-343.
65. He L, He X, Lowe SW, and Hannon GJ. microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat Rev Cancer. 2007; 7:819-822.
66. Lafferty-Whyte K, Cairney CJ, Jamieson NB, Oien KA, and Keith WN. Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta. 2009; 1792:341-352.
67. Maes OC, Sarojini H, and Wang E. Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts. J Cell Physiol. 2009; 221:109-119.
68. Saunders LR, Sharma AD, Tawney J, Nakagawa M, Okita K, Yamanaka S, Willenbring H, and Verdin E. miRNAs regulate SIRT1 expression during mouse embryonic stem cell differentiation and in adult mouse tissues. Aging (Albany NY). 2010; 2:415-431.
69. Jun JI, and Lau LF. Cellular senescence controls fibrosis in wound healing. Aging (Albany NY). 2010; 2:627-631.
70. Gorospe M, and Abdelmohsen K. MicroRegulators come of age in senescence. Trends Genet. 2011; 27:233-241.
71. Smith SM, and Murray DW. An overview of microRNA methods: expression profiling and target identification. Methods Mol Biol. 2012; 823:119-138.
72. Fink LS, Roell M, Caiazza E, Lerner C, Stamato T, Hrelia S, Lorenzini A, and Sell C. 53BP1 contributes to a robust genomic stability in human fibroblasts. Aging (Albany NY). 2011; 3:836-845.
73. Mao Z, Ke Z, Gorbunova V, Seluanov A. Replicatively senescent cells are arrested in G1 and G2 phases. Aging (Albany NY). 2012; 4:431-435.
74. Lena AM, Mancini M, Rivetti di Val Cervo P, Saintigny G, Mahé C, Melino G, Candi E. MicroRNA-191 triggers keratinocytes senescence by SATB1 and CDK6 downregulation. Biochem Biophys Res Commun. 2012; 423:509-514.
75. Rivetti di Val Cervo P, Lena AM, Nicoloso M, Rossi S, Mancini M, Zhou H, Saintigny G, Dellambra E, Odorisio T, Mahé C, Calin GA, Candi E, and Melino G. p63-microRNA feedback in keratinocyte senescence. Proc Natl Acad Sci USA. 2012 ;109:1133-118.
76. Wang Y, Scheiber MN, Neumann C, Calin GA, and Zhou D. MicroRNA regulation of ionizing radiation-induced premature senescence. Int J Radiat Oncol Biol Phys. 2011; 81:839-848.
77. Dhahbi JM, Atamna H, Boffelli D, Magis W, Spindler SR, and Martin DI. Deep sequencing reveals novel microRNAs and regulation of microRNA expression during cell senescence. PLoS One. 2011;6:e20509.
78. Faraonio R, Salerno P, Passaro F, Sedia C, Iaccio A, Bellelli R, Nappi TC, Comegna M, Romano S, Salvatore G, Santoro M, and Cimino F. A set of miRNAs participates in the cellular senescence program in human diploid fibroblasts. Cell Death Differ. 2012; 19:713-721.
79. Hynes RO. Integrins: bidirectional, allosteric signaling machines. Cell. 2002; 110:673-687.
80. Luo BH, and Springer TA. Integrin structures and conformational signaling. Curr Opin Cell Biol. 2006; 18:579-586.
81. Leiss M, Beckmann K, Girós A, Costell M, and Fässler R. The role of integrin binding sites in fibronectin matrix assembly in vivo. Curr Opin Cell Biol. 2008; 20:502-507.
82. Desgrosellier JS, and Cheresh DA. Integrins in cancer: biological implications and therapeutic opportunities. Nat Rev Cancer. 2010; 10:9-22.
83. Watt FM, and Hodivala KJ. Cell adhesion. Fibronectin and integrin knockouts come unstuck. Curr Biol. 1994; 4:270-272.
84. Wang QY, Zhang Y, Shen ZH, and Chen HL. alpha1,3 fucosyltransferase-VII up-regulates the mRNA of alpha5 integrin and its biological function. J Cell Biochem. 2008; 104:2078-2090.
85. Grässel S, Unsöld C, Schäcke H, Bruckner-Tuderman L, and Bruckner P. Collagen XVI is expressed by human dermal fibroblasts and keratinocytes and is associated with the microfibrillar apparatus in the upper papillary dermis. Matrix Biol. 1999; 18:309-317.
86. Kassner A, Hansen U, Miosge N, Reinhardt DP, Aigner T, Bruckner-Tuderman L, Bruckner P, and Grässel S. Discrete integration of collagen XVI into tissue-specific collagen fibrils or beaded microfibrils. Matrix Biol. 2003; 22:131-143.
87. Lena AM, Shalom-Feuerstein R, Rivetti di Val Cervo P, Aberdam D, Knight RA, Melino G, and Candi E. miR-203 represses 'stemness' by repressing DeltaNp63. Cell Death Differ. 2008; 15:1187-1195.