Development of tricyclic hydroxy-1H-pyrrolopyridine-trione containing HIV-1 integrase inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 10, 2011, Pages 2986-2990

  Zhao, Xue Zhi ^a   Maddali, Kasthuraiah ^b   Metifiot, Mathieu ^b   Smith, Steven J ^a   Christie Vu, B ^a   Marchand, Christophe ^b   Hughes, Stephen H ^a   Pommier, Yves ^b   Burke Jr , Terrence R ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cycloaddition; HIV 1 integrase; Inhibit; Raltegravir

Indexed keywords

7 HYDROXY 1H PYRROLO[3,4 C]PYRIDINE 1,3,6(2H,5H) TRIONE; INDOLE; INTEGRASE; INTEGRASE INHIBITOR; ISOINDOLEDIONE; PYRIDINE DERIVATIVE; RALTEGRAVIR; TRICYCLIC HYDROXY 1H PYRROLOPYRIDINETRIONE; UNCLASSIFIED DRUG;

ARTICLE; CYCLOADDITION; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GENE MUTATION; GENETIC SUSCEPTIBILITY; HUMAN; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

BIOLOGICAL ASSAY; CELLS, CULTURED; CYCLIZATION; HIV INTEGRASE; HIV INTEGRASE INHIBITORS; HIV-1; HUMANS; HYDROXYLATION; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRIMIDINONES; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 79955555398     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.03.047     Document Type: Article

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