Recent advances in the study of glycosphingolipids

Current Pharmaceutical Biotechnology

Volumn 13, Issue 14, 2012, Pages 2663-2668

  Yamashita, Tadashi ^a,b  

^a HOKKAIDO UNIVERSITY   (Japan)

^b Kyungpook National University   (South Korea)

Author keywords

Development; Embryonic lethality; Glycosphingolipids; Neuronal function

Indexed keywords

CHOLESTEROL; GANGLIOSIDE GD3; GANGLIOSIDE GM3; GANGLIOTETRAOSYLCERAMIDE; GLYCOSPHINGOLIPID; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; MESSENGER RNA; SPHINGOMYELIN;

ARTICLE; CELL MEMBRANE; CELL SURVIVAL; CENTRAL NERVOUS SYSTEM; EMBRYO DEVELOPMENT; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; LETHALITY; LIFESPAN; LIPID RAFT; NERVE CELL; NONHUMAN; PERIPHERAL NERVOUS SYSTEM; PHENOTYPE; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

EID: 84872505307     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920101314151120122928     Document Type: Article

References (43)

1. Kolter, T.; Sandhoff, K. Recent advance in the biochemistry of sphingolipidoses. Brain Pathol. Brain. Pathol., 1998, 8(1), 79-100.
2. Hakomori, S. Bifunctional role og glycosphingolipids. Modulation for transmembrane signaling and mediators for cellular interactions. J. Biol. Chem., 1990, 265(31), 18713-18716.
3. Hakomori, S.; Igarashi, Y. Functional role of glycosphingolipids in cell recognition and signaling. J. Biochem., 1995, 118(6), 1091-1103.
4. Nagai, Y.; Tsuji, S. Significance of ganglioside-mediated glycosignal transduction in neuronal differentiation and development. Prog. Brain Res., 1994, 101, 119-126.
5. Ichikawa, S.; Hirabayashi, Y. Glucosylceramide synthases and glycosphingolipid synthesis. Trends Cell Biol., 1998, 8(5), 198-202.
6. van Meer, G. Lipids of the Golgi membrane. Trends Cell Biol., 1998, 8(1), 29-33.
7. Varki, A. Biological roles of oligosaccharides: all of the theories are correct. Glycobiology, 1993, 3(2), 97-130.
8. Schnaar, R.L. Glycosphingolipids in cell surface recognition. Glycobiology, 1991, 1(5), 477-485.
9. Tettamanti, G.; Riboni, L. Gangliosides and modulation of the function of neural cells. Adv. Lipid Res., 1993, 25, 235-267.
10. Simons, K.; Ikonen, E. Functional rafts in cell membranes. Nature, 1997, 387(6633), 569-572.
11. Harder, T.; Simons, K. Caveolae, DIGs, and dynamics of sphingolipid-cholesterol microdomains. Curr. Opin. Cell Biol., 1997, 9(4), 534-542.
12. Anderson, R.G. The caveolae membrane system. Annu. Rev. Biochem., 1998, 67, 199-225.
13. Huang, C.; Hepler, J.R.; Chen, L.T.; Gilman, A.G.; Anderson, R.G.W.; Mumby, S.M. Organization of G proteins and adenylyl cyclase at the plasma membrane. Mol. Biol. Cell, 1997, 8(12), 2365-2378.
14. Hakomori, S.; Handa, K.; Iwabuchi, K.; Yamamura, S.; Prinetti, A. New insights in glycosphingolipid function: "glycosignaling domain, " a cell surface assembly of glycosphingolipids with signal transducer molecules, involved in cell adhesion coupled with signaling. Glycobiology, 1998, 8(10), xi-xix.
15. Iwabuchi, K.; Handa, K.; Hakomori, S. Separation of "glycosphingolipid signaling domain" from caveolin-containing membrane fraction in mouse melanoma B16 cells and its role in cell adhesion coupled with signaling. J. Biol. Chem., 1998, 273(50), 33766-33773.
16. Jeckel, D.; Karrenbauer, A.; Burger, K.N.; van Meer, G.; Wieland, F. Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions. J. Cell Biol., 1992, 117(2), 259-267.
17. Futerman, A.H.; Pagano, R.E. Determination of the intracellular sites and topology of glucosylceramide synthesis in rat liver. Biochem. J., 1991, 280(Pt2), 295-302.
18. Marks, D.L.; Wu, K.; Paul, P.; Kamisaka, Y.; Watanabe, R.; Pagano, R.E. Oligomerization and topology of the Golgi membrane protein glucosylceramide synthase. J. Biol. Chem., 1999, 274(1), 451-456.
19. Yamashita, T.; Wada, R.; Sasaki, T.; Deng, C.; Bierfreund, U.; Sandhoff, K.; Proia R.L. A vital role for glycosphingolipid synthesis during development and differentiation. Proc. Natl. Acad. Sci. USA, 1999, 96(16), 9142-9147.
20. Yamashita, T.; Wada, R.; Proia R.L. Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis. Biochim. Biophys. Acta, 2002, 1573(3), 236-240.
21. Chiavegatto, S.; Sun, J.; Nelson, R.J.; Schnaar, R.L. A functional role for complex gangliosides: motor deficits in GM2/GD2 synthase knockout mice. Exp. Neurol., 2000, 166(2), 227-234.
22. Inoue, M.; Fujii, Y.; Furukawa, K.; Okada, M.; Okumura, K.; Hayakawa, T.; Sugiura, Y. Refractory skin injury in complex knockout mice expressing only the GM3 ganglioside. J. Biol. Chem., 2002, 277(33), 29881-29888.
23. Kawai, H.; Allende, ML.; Wada, R.; Kono, M.; Sango, K.; Deng, C.; Miyakawa, T.; Crawley, J.N.; Werth, N.; Bierfreund, U.; Sandhoff, K.; Proia, R.L. Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures. J. Biol. Chem., 2001, 276(10), 6885-6888.
24. Sheikh, K.A.; Sun, J.; Liu, Y.; Kawai, H.; Crawford, T.O.; Proia, R.L.; Griffin, J.W.; Schnaar, R.L. Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects. Proc. Natl. Acad. Sci. USA, 1999, 96(13), 7532-7537.
25. Takamiya, K.; Yamamoto, A.; Furukawa, K.; Yamashiro, S.; Shin, M.; Okada, M.; Fukumoto, S.; Haraguchi, M.; Takeda, N.; Fujimura, K. Mice with disrupted GM2/GD2 synthase gene lack complex gangliosides but exhibit only dubtle defects in their nervous system. Proc. Natl. Acad. Sci. USA, 1996, 93(20), 10662-10667.
26. Yamashita, T.; Wu, Y.P.; Sandhoff, R.; Werth, N.; Mizukami, H.; Ellis, J.M.; Dupree, J.L.; Geyer, R.; Sandhoff, K.; Proia, R.L. Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions. Proc. Natl. Acad. Sci. USA, 2005, 102(8), 2725-2730.
27. Zhou, D.; Mattner, J.; Cantu, 3rd C.; Schrantz, N.; Yin, N.; Gao, Y.; Sagiv, Y.; Hudspeth, K.; Wu, Y.P.; Yamashita, T.; Teneberg, T.; Wang, D.; Proia, R.L.; Savage, P.B.; Teyton, L.; Bendelac, A. Lysosomal glysosphingolipid recognition by NKT calls. Science, 2004, 306(5702), 1786-1789.
28. Sandhoff, R.; Geyer, R.; Jennemann, R.; Paret, C.; Kiss, E.; Yamashita, T.; Gorgas, K.; Sijmonsma, T.P.; Iwamori, M.; Finaz, C.; Proia, R.L.; Wiegandt, H.; Grone, H.J. Novel class of glysosphingolipids involved in mice fertility. J. Biol. Chem., 2005, 280(29), 27310-27318.
29. Yamashita, T.; Hashiramoto, A.; Haluzik, M.; Mizukami, H.; Beck, S.; Norton, A.; Kono, M.; Tsuji, S.; Daniotti, J.L.; Werth, N.; Werth, N.; Sandhoff, R.; Sandhoff, K.; Proia, R.L. Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proc. Natl. Acad. Sci. USA, 2003, 100(6), 3445-3449.
30. Tagami, S.; Inokuchi, J.; Kabayama, K.; Yoshimura, H.; Kitamura, F.; Uemura, S.; Ogawa, C.; Ishii, A.; Saito, M.; Ohtsuka, Y.; Sakaue, S.; Igarashi, Y. Ganglioside GM3 participates in the pathological conditions of insulin resistance. J. Biol. Chem., 2002, 277(5), 3085-3092.
31. Dufort, D.; Schwartz, L.; Harpal, K.; Rossant, J. The transcription factor HNF3bera is required in visceral endoderm for normal primitive streak morphogenesis. Development, 1998, 125(16), 3015-3025.
32. Shawlot, W.; Deng, J.M.; Behringer, R.R. Expression of the mouse Cerberus-related gene, Cerr1, suggests a role in anterior neural induction and somatogenesis. Proc. Natl. Acad. Sci. USA, 1998, 95(11), 6198-6203.
33. Ang, S.L.; Conlon, R.A.; Jin, O.; Rossant, J. Positive and negative signals from mesoderm regulate the expression of mouse Otx2 in ectoderm explants. (1994) Development, 1994, 120(10), 2979-2989.
34. Kawai, H.; Sango, K.; Mullin, K.A.; Proia, R.L. Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides. J. Biol. Chem., 1998, 273(31), 19634-19638.
35. Gassmann, M.; Wartenberg, M.; McClanahan, T.; Fandrey, J.; Bichet, S.; Kreuter, R.; Acker, H.; Bauer, C. Differentiating embryonic stem cells as an in vitro model of early erythropoiesis. Toxicol. In Vitro, 1995, 9(4), 429-438.
36. Yin, X.; Crawford, T.O.; Griffin, J.W.; Tu, P.; Lee, V.Y.; Li, C.; Roder, J.; Trapp, B.D. Myelin-associated glycoprotein is a myelin signal that modulates the caliber of myelinated axons. J. Neurosci., 1998, 18(10), 1953-1962.
37. Fruttiger, M.; Montag, D.; Schachner, M.; Martini, R. Cruial role for the myelin-associated glycoprotein in the maintenance of axonmyelin integrity. Eur. J. Neurosci., 1995, 7(3), 511-515.
38. Yoshikawa, Ma.; Goa, S.; Takasaki, K.; Kakazu, Y.; Ohashi, M.; Nagafuku, M.; Kabayama, K.; Sekimoto, J.; Suzuki, S.; Takaiwa, K.; Kimitsuki, T.; Matsumoto, N.; Komune, S.; Kamei, D.; Saito, M.; Fujiwara, M.; Iwasaki, K.; Inokuchi, J. Mice lacking ganglioside GM3 synthase exhibit complete hearing loss due to selective degeneration of the organ of Corti. Proc. Natl. Acad. Sci. USA, 2009, 106(23), 9483-9488.
39. Tajima, O.; Egashira, N.; Ohmi, Y.; Fukue, Y.; Mishima, K.; Fujiwara, M.; Inokuchi, J.; Sugiuera, Y.; Furukawa, K.; Furukawa, K. Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behav. Brain Res., 2009, 198(1), 74-82.
40. Aicardi, J.; Castelein, P. Infantile neuroaxonal dystrophy. Brain, 1979, 102(4), 727-748.
41. Taniike, M.; Mohri, I.; Eguchi, N.; Beuckmann, C.T.; Suzuki, K.; Urade, Y. Perineuronal oligodendrocytes protect against neuronal apoptosis through the production of lipocalin-type prostaglandin D synthase in a genetic demyelinating model. J. Neurosci., 2002, 22(12), 4885-4896.
42. Poliak, S.; Peles, E. The local differentiation of myelinated axons at nodes of Ranvier. Nat. Rev. Neurosci., 2003, 4(12), 968-980.
43. Popko, B. Myelin galactolipids: mediators of axon-glial interactions? Glia, 2000, 29(2), 149-153.