메뉴 건너뛰기




Volumn 110, Issue 12, 2007, Pages 4086-4095

Proteinase 3, the Wegener autoantigen, is externalized during neutrophil apoptosis: Evidence for a functional association with phospholipid scramblase 1 and interference with macrophage phagocytosis

Author keywords

[No Author keywords available]

Indexed keywords

MYELOBLASTIN; NEUTROPHIL CYTOPLASMIC ANTIBODY; PHOSPHOLIPID SCRAMBLASE 1; SCRAMBLASE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 37049006778     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-03-080457     Document Type: Article
Times cited : (108)

References (49)
  • 1
    • 0024817730 scopus 로고
    • Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells
    • Bories D, Raynal MC, Solomon DH, Darzynkiewicz Z, Cayre YE. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell. 1989;59:959-968.
    • (1989) Cell , vol.59 , pp. 959-968
    • Bories, D.1    Raynal, M.C.2    Solomon, D.H.3    Darzynkiewicz, Z.4    Cayre, Y.E.5
  • 2
    • 0030997435 scopus 로고    scopus 로고
    • Granules of the human neutrophilic polymorphonuclear leukocyte
    • Borregaard N, Cowland JB. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood. 1997;89:3503-3521.
    • (1997) Blood , vol.89 , pp. 3503-3521
    • Borregaard, N.1    Cowland, J.B.2
  • 3
    • 0027968059 scopus 로고
    • Structure of the azurocidin, proteinase 3, and neutrophil elastase genes: Implications for inflammation and vasculitis
    • Jenne DE. Structure of the azurocidin, proteinase 3, and neutrophil elastase genes: implications for inflammation and vasculitis. Am J Respir Crit Care Med. 1994;150:S147-S154.
    • (1994) Am J Respir Crit Care Med , vol.150
    • Jenne, D.E.1
  • 4
    • 33745559712 scopus 로고    scopus 로고
    • Neutrophil serine proteases: Specific regulators of inflammation
    • Pham CT. Neutrophil serine proteases: specific regulators of inflammation. Nat Rev Immunol. 2006;6:541-550.
    • (2006) Nat Rev Immunol , vol.6 , pp. 541-550
    • Pham, C.T.1
  • 5
    • 84920235395 scopus 로고
    • Autoantibodies against neutrophils and monocytes: Tool for diagnosis and marker of disease activity in Wegener's granulomatosis
    • van der Woude FJ, Rasmussen N, Lobatto S, et al. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet. 1985;1:425-429.
    • (1985) Lancet , vol.1 , pp. 425-429
    • van der Woude, F.J.1    Rasmussen, N.2    Lobatto, S.3
  • 7
    • 33646381359 scopus 로고    scopus 로고
    • Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies
    • Jennette JC, Xiao H, Falk RJ. Pathogenesis of vascular inflammation by anti-neutrophil cytoplasmic antibodies. J Am Soc Nephrol. 2006;17:1235-1242.
    • (2006) J Am Soc Nephrol , vol.17 , pp. 1235-1242
    • Jennette, J.C.1    Xiao, H.2    Falk, R.J.3
  • 8
    • 0028307148 scopus 로고
    • Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo
    • Csernok E, Ernst M, Schmitt W, Bainton DF, Gross WL. Activated neutrophils express proteinase 3 on their plasma membrane in vitro and in vivo. Clin Exp Immunol. 1994;95:244-250.
    • (1994) Clin Exp Immunol , vol.95 , pp. 244-250
    • Csernok, E.1    Ernst, M.2    Schmitt, W.3    Bainton, D.F.4    Gross, W.L.5
  • 9
    • 0033214847 scopus 로고    scopus 로고
    • Presence of proteinase 3 in secretory vesicles: Evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules
    • Witko-Sarsat V, Cramer EM, Hieblot C, et al. Presence of proteinase 3 in secretory vesicles: evidence of a novel, highly mobilizable intracellular pool distinct from azurophil granules. Blood. 1999;94:2487-2496.
    • (1999) Blood , vol.94 , pp. 2487-2496
    • Witko-Sarsat, V.1    Cramer, E.M.2    Hieblot, C.3
  • 10
    • 0032991087 scopus 로고    scopus 로고
    • A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis
    • Witko-Sarsat V, Lesavre P, Lopez S, et al. A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J Am Soc Nephrol. 1999;10:1224-1233.
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1224-1233
    • Witko-Sarsat, V.1    Lesavre, P.2    Lopez, S.3
  • 11
    • 2442656372 scopus 로고    scopus 로고
    • Membrane proteinase 3 expression and ANCA-induced neutrophil activation
    • Schreiber A, Luft FC, Kettritz R. Membrane proteinase 3 expression and ANCA-induced neutrophil activation. Kidney Int. 2004;65:2172-2183.
    • (2004) Kidney Int , vol.65 , pp. 2172-2183
    • Schreiber, A.1    Luft, F.C.2    Kettritz, R.3
  • 12
    • 0036707876 scopus 로고    scopus 로고
    • Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis
    • Rarok AA, Stegeman CA, Limburg PC, Kallenberg CG. Neutrophil membrane expression of proteinase 3 (PR3) is related to relapse in PR3-ANCA-associated vasculitis. J Am Soc Nephrol. 2002;13:2232-2238.
    • (2002) J Am Soc Nephrol , vol.13 , pp. 2232-2238
    • Rarok, A.A.1    Stegeman, C.A.2    Limburg, P.C.3    Kallenberg, C.G.4
  • 13
    • 33746752715 scopus 로고    scopus 로고
    • Proteinase 3 expression on neutrophil membranes from patients with infectious disease
    • Matsumoto T, Kaneko T, Wada H, et al. Proteinase 3 expression on neutrophil membranes from patients with infectious disease. Shock. 2006;26:128-133.
    • (2006) Shock , vol.26 , pp. 128-133
    • Matsumoto, T.1    Kaneko, T.2    Wada, H.3
  • 14
    • 0037032544 scopus 로고    scopus 로고
    • Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation
    • Witko-Sarsat V, Canteloup S, Durant S, et al. Cleavage of p21waf1 by proteinase-3, a myeloid-specific serine protease, potentiates cell proliferation. J Biol Chem. 2002;277:47338-47347.
    • (2002) J Biol Chem , vol.277 , pp. 47338-47347
    • Witko-Sarsat, V.1    Canteloup, S.2    Durant, S.3
  • 15
    • 18644385928 scopus 로고    scopus 로고
    • Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: Potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils
    • Pederzoli M, Kantari C, Gausson V, Moriceau S, Witko-Sarsat V. Proteinase-3 induces procaspase-3 activation in the absence of apoptosis: potential role of this compartmentalized activation of membrane-associated procaspase-3 in neutrophils. J Immunol. 2005;174:6381-6390.
    • (2005) J Immunol , vol.174 , pp. 6381-6390
    • Pederzoli, M.1    Kantari, C.2    Gausson, V.3    Moriceau, S.4    Witko-Sarsat, V.5
  • 16
    • 0842304527 scopus 로고    scopus 로고
    • Apoptosis-induced proteinase 3 membrane expression is independent from degranulation
    • Durant S, Pederzoli M, Lepelletier Y, et al. Apoptosis-induced proteinase 3 membrane expression is independent from degranulation. J Leukoc Biol. 2004;75:87-98.
    • (2004) J Leukoc Biol , vol.75 , pp. 87-98
    • Durant, S.1    Pederzoli, M.2    Lepelletier, Y.3
  • 17
    • 0028942106 scopus 로고    scopus 로고
    • Homburg CH, de Haas M, von dem Borne AE, Verhoeven AJ, Reutelingsperger CP, Roos D. Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro. Blood. 1995;85:532-540.
    • Homburg CH, de Haas M, von dem Borne AE, Verhoeven AJ, Reutelingsperger CP, Roos D. Human neutrophils lose their surface Fc gamma RIII and acquire Annexin V binding sites during apoptosis in vitro. Blood. 1995;85:532-540.
  • 19
    • 0034911765 scopus 로고    scopus 로고
    • Unraveling the mysteries of phospholipid scrambling
    • Sims PJ, Wiedmer T. Unraveling the mysteries of phospholipid scrambling. Thromb Haemost. 2001;86:266-275.
    • (2001) Thromb Haemost , vol.86 , pp. 266-275
    • Sims, P.J.1    Wiedmer, T.2
  • 20
    • 0033547876 scopus 로고    scopus 로고
    • NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro
    • Ward C, Chilvers ER, Lawson MF, et al. NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro. J Biol Chem. 1999;274:4309-4318.
    • (1999) J Biol Chem , vol.274 , pp. 4309-4318
    • Ward, C.1    Chilvers, E.R.2    Lawson, M.F.3
  • 21
    • 0027989808 scopus 로고
    • Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis
    • Koopman G, Reutelingsperger CP, Kuijten GA, Keehnen RM, Pals ST, van Oers MH. Annexin V for flow cytometric detection of phosphatidylserine expression on B cells undergoing apoptosis. Blood. 1994;84:1415-1420.
    • (1994) Blood , vol.84 , pp. 1415-1420
    • Koopman, G.1    Reutelingsperger, C.P.2    Kuijten, G.A.3    Keehnen, R.M.4    Pals, S.T.5    van Oers, M.H.6
  • 22
    • 0026556554 scopus 로고
    • Dead cell discrimination with 7-aminoactinomycin D in combination with dual color immunofluorescence in single laser flow cytometry
    • Schmid I, Krall WJ, Uittenbogaart CH, Braun J, Giorgi JV. Dead cell discrimination with 7-aminoactinomycin D in combination with dual color immunofluorescence in single laser flow cytometry. Cytometry. 1992;13:204-208.
    • (1992) Cytometry , vol.13 , pp. 204-208
    • Schmid, I.1    Krall, W.J.2    Uittenbogaart, C.H.3    Braun, J.4    Giorgi, J.V.5
  • 23
    • 0032695198 scopus 로고    scopus 로고
    • Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies
    • Van Der Geld Y, Limburg P, Kallenberg C. Characterization of monoclonal antibodies to proteinase 3 (PR3) as candidate tools for epitope mapping of human anti-PR3 autoantibodies. Clin Exp Immunol. 1999;118:487-496.
    • (1999) Clin Exp Immunol , vol.118 , pp. 487-496
    • Van Der Geld, Y.1    Limburg, P.2    Kallenberg, C.3
  • 24
    • 0035827608 scopus 로고    scopus 로고
    • IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase
    • Pastorelli C, Veiga J, Charles N, et al. IgE receptor type I-dependent tyrosine phosphorylation of phospholipid scramblase. J Biol Chem. 2001;276:20407-20412.
    • (2001) J Biol Chem , vol.276 , pp. 20407-20412
    • Pastorelli, C.1    Veiga, J.2    Charles, N.3
  • 25
    • 0020513579 scopus 로고
    • Functional activity of enucleated human polymorphonuclear leukocytes
    • Roos D, Voetman AA, Meerhof LJ. Functional activity of enucleated human polymorphonuclear leukocytes. J Cell Biol. 1983;97:368-377.
    • (1983) J Cell Biol , vol.97 , pp. 368-377
    • Roos, D.1    Voetman, A.A.2    Meerhof, L.J.3
  • 26
    • 0036242552 scopus 로고    scopus 로고
    • Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain
    • Nicolas G, Fournier CM, Galand C, et al. Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain. Mol Cell Biol. 2002;22:3527-3536.
    • (2002) Mol Cell Biol , vol.22 , pp. 3527-3536
    • Nicolas, G.1    Fournier, C.M.2    Galand, C.3
  • 27
    • 0030849152 scopus 로고    scopus 로고
    • Molecular cloning of human plasma membrane phospholipid scramblase: A protein mediating transbilayer movement of plasma membrane phospholipids
    • Zhou Q, Zhao J, Stout JG, Luhm RA, Wiedmer T, Sims PJ. Molecular cloning of human plasma membrane phospholipid scramblase: a protein mediating transbilayer movement of plasma membrane phospholipids. J Biol Chem. 1997;272:18240-18244.
    • (1997) J Biol Chem , vol.272 , pp. 18240-18244
    • Zhou, Q.1    Zhao, J.2    Stout, J.G.3    Luhm, R.A.4    Wiedmer, T.5    Sims, P.J.6
  • 28
    • 2342436128 scopus 로고    scopus 로고
    • Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) colocalize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils
    • Frasch SC, Henson PM, Nagaosa K, Fessler MB, Borregaard N, Bratton DL. Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) colocalize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J Biol Chem. 2004;279:17625-17633.
    • (2004) J Biol Chem , vol.279 , pp. 17625-17633
    • Frasch, S.C.1    Henson, P.M.2    Nagaosa, K.3    Fessler, M.B.4    Borregaard, N.5    Bratton, D.L.6
  • 29
    • 24044553592 scopus 로고    scopus 로고
    • Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line: Molecular analysis of the cleavage site
    • Dublet B, Ruello A, Pederzoli M, et al. Cleavage of p21/WAF1/CIP1 by proteinase 3 modulates differentiation of a monocytic cell line: molecular analysis of the cleavage site. J Biol Chem. 2005;280:30242-30253.
    • (2005) J Biol Chem , vol.280 , pp. 30242-30253
    • Dublet, B.1    Ruello, A.2    Pederzoli, M.3
  • 30
    • 1842425635 scopus 로고    scopus 로고
    • p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells
    • Charles N, Monteiro RC, Benhamou M. p28, a novel IgE receptor-associated protein, is a sensor of receptor occupation by its ligand in mast cells. J Biol Chem. 2004 279:12312-12318.
    • (2004) J Biol Chem , vol.279 , pp. 12312-12318
    • Charles, N.1    Monteiro, R.C.2    Benhamou, M.3
  • 31
    • 0028233280 scopus 로고
    • Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils
    • Sengelov H, Kjeldsen L, Kroeze W, Berger M, Borregaard N. Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils. J Immunol. 1994;153:804-810.
    • (1994) J Immunol , vol.153 , pp. 804-810
    • Sengelov, H.1    Kjeldsen, L.2    Kroeze, W.3    Berger, M.4    Borregaard, N.5
  • 32
    • 0028806741 scopus 로고
    • Serum protects against azurophil granule dependent down-regulation of complement receptor type 1 (CR1) on human neutrophils
    • Lundahl J, Dahlgren C, Gustavsson K, Hed J. Serum protects against azurophil granule dependent down-regulation of complement receptor type 1 (CR1) on human neutrophils. Inflamm Res. 1995;44:438-446.
    • (1995) Inflamm Res , vol.44 , pp. 438-446
    • Lundahl, J.1    Dahlgren, C.2    Gustavsson, K.3    Hed, J.4
  • 33
    • 0034958883 scopus 로고    scopus 로고
    • Spectrin and ankyrin-based pathways: Metazoan inventions for integrating cells into tissues
    • Bennett V, Baines AJ. Spectrin and ankyrin-based pathways: metazoan inventions for integrating cells into tissues. Physiol Rev. 2001;81:1353-1392.
    • (2001) Physiol Rev , vol.81 , pp. 1353-1392
    • Bennett, V.1    Baines, A.J.2
  • 34
    • 22144435486 scopus 로고    scopus 로고
    • The presence of membrane proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558
    • David A, Fridlich R, Aviram I. The presence of membrane proteinase 3 in neutrophil lipid rafts and its colocalization with FcgammaRIIIb and cytochrome b558. Exp Cell Res. 2005;308:156-165.
    • (2005) Exp Cell Res , vol.308 , pp. 156-165
    • David, A.1    Fridlich, R.2    Aviram, I.3
  • 35
    • 12644283531 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming
    • Gilligan HM, Bredy B, Brady HR, et al. Antineutrophil cytoplasmic autoantibodies interact with primary granule constituents on the surface of apoptotic neutrophils in the absence of neutrophil priming. J Exp Med. 1996;184:2231-2241.
    • (1996) J Exp Med , vol.184 , pp. 2231-2241
    • Gilligan, H.M.1    Bredy, B.2    Brady, H.R.3
  • 36
    • 0033922343 scopus 로고    scopus 로고
    • Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils
    • Yang JJ, Tuttle RH, Hogan SL, et al. Target antigens for anti-neutrophil cytoplasmic autoantibodies (ANCA) are on the surface of primed and apoptotic but not unstimulated neutrophils. Clin Exp Immunol. 2000;121:165-172.
    • (2000) Clin Exp Immunol , vol.121 , pp. 165-172
    • Yang, J.J.1    Tuttle, R.H.2    Hogan, S.L.3
  • 37
    • 0033872054 scopus 로고    scopus 로고
    • Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages
    • Harper L, Ren Y, Savill J, Adu D, Savage CO. Antineutrophil cytoplasmic antibodies induce reactive oxygen-dependent dysregulation of primed neutrophil apoptosis and clearance by macrophages. Am J Pathol. 2000;157:211-220.
    • (2000) Am J Pathol , vol.157 , pp. 211-220
    • Harper, L.1    Ren, Y.2    Savill, J.3    Adu, D.4    Savage, C.O.5
  • 38
    • 0036151870 scopus 로고    scopus 로고
    • TNF-alpha-accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism
    • Kettritz R, Scheumann J, Xu Y, Luft FC, Haller H. TNF-alpha-accelerated apoptosis abrogates ANCA-mediated neutrophil respiratory burst by a caspase-dependent mechanism. Kidney Int. 2002;61:502-515.
    • (2002) Kidney Int , vol.61 , pp. 502-515
    • Kettritz, R.1    Scheumann, J.2    Xu, Y.3    Luft, F.C.4    Haller, H.5
  • 39
    • 0021244901 scopus 로고
    • Organelle-depleted human neutrophil cytoplasts used to study fmet-leu-phe receptor modulation and cell function
    • Gallin JI, Metcalf JA, Roos D, Seligmann B, Friedman MM. Organelle-depleted human neutrophil cytoplasts used to study fmet-leu-phe receptor modulation and cell function. J Immunol. 1984;133:415-421.
    • (1984) J Immunol , vol.133 , pp. 415-421
    • Gallin, J.I.1    Metcalf, J.A.2    Roos, D.3    Seligmann, B.4    Friedman, M.M.5
  • 40
    • 0037370784 scopus 로고    scopus 로고
    • Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils
    • Maianski NA, Roos D, Kuijpers TW. Tumor necrosis factor alpha induces a caspase-independent death pathway in human neutrophils. Blood. 2003;101:1987-1995.
    • (2003) Blood , vol.101 , pp. 1987-1995
    • Maianski, N.A.1    Roos, D.2    Kuijpers, T.W.3
  • 41
    • 0034665315 scopus 로고    scopus 로고
    • Bioactive proteinase 3 on the cell surface of human neutrophils: Quantification, catalytic activity, and susceptibility to inhibition
    • Campbell EJ, Campbell MA, Owen CA. Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition. J Immunol. 2000;165:3366-3374.
    • (2000) J Immunol , vol.165 , pp. 3366-3374
    • Campbell, E.J.1    Campbell, M.A.2    Owen, C.A.3
  • 42
    • 0033118875 scopus 로고    scopus 로고
    • Interaction of purified proteinase 3 (PR3) with reconstituted lipid bilayers
    • Goldmann WH, Niles JL, Arnaout MA. Interaction of purified proteinase 3 (PR3) with reconstituted lipid bilayers. Eur J Biochem. 1999;261:155-162.
    • (1999) Eur J Biochem , vol.261 , pp. 155-162
    • Goldmann, W.H.1    Niles, J.L.2    Arnaout, M.A.3
  • 43
    • 33846699482 scopus 로고    scopus 로고
    • Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils
    • Bauer S, Abdgawad M, Gunnarsson L, Segelmark M, Tapper H, Hellmark T. Proteinase 3 and CD177 are expressed on the plasma membrane of the same subset of neutrophils. J Leukoc Biol. 2007;81:458-464.
    • (2007) J Leukoc Biol , vol.81 , pp. 458-464
    • Bauer, S.1    Abdgawad, M.2    Gunnarsson, L.3    Segelmark, M.4    Tapper, H.5    Hellmark, T.6
  • 44
    • 34248385300 scopus 로고    scopus 로고
    • NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils
    • von Vietinghoff S, Tunnemann G, Eulenberg C, et al. NB1 mediates surface expression of the ANCA antigen proteinase 3 on human neutrophils. Blood. 2007;10:50-59.
    • (2007) Blood , vol.10 , pp. 50-59
    • von Vietinghoff, S.1    Tunnemann, G.2    Eulenberg, C.3
  • 45
    • 0036195343 scopus 로고    scopus 로고
    • Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis
    • Vandivier RW, Fadok VA, Hoffmann PR, et al. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002;109:661-670.
    • (2002) J Clin Invest , vol.109 , pp. 661-670
    • Vandivier, R.W.1    Fadok, V.A.2    Hoffmann, P.R.3
  • 46
    • 0034795821 scopus 로고    scopus 로고
    • Phagocyte receptors for apoptotic cells: Recognition, uptake, and consequences
    • Fadok VA, Bratton DL, Henson PM. Phagocyte receptors for apoptotic cells: recognition, uptake, and consequences. J Clin Invest. 2001;108:957-962.
    • (2001) J Clin Invest , vol.108 , pp. 957-962
    • Fadok, V.A.1    Bratton, D.L.2    Henson, P.M.3
  • 47
    • 27744556005 scopus 로고    scopus 로고
    • Hide and seek: The secret identity of the phosphatidylserine receptor
    • Williamson P, Schlegel RA. Hide and seek: the secret identity of the phosphatidylserine receptor. J Biol. 2004;3:14.
    • (2004) J Biol , vol.3 , pp. 14
    • Williamson, P.1    Schlegel, R.A.2
  • 48
    • 0036884424 scopus 로고    scopus 로고
    • A blast from the past: Clearance of apoptotic cells regulates immune responses
    • Savill J, Dransfield I, Gregory C, Haslett C. A blast from the past: clearance of apoptotic cells regulates immune responses. Nat Rev Immunol. 2002;2:965-975.
    • (2002) Nat Rev Immunol , vol.2 , pp. 965-975
    • Savill, J.1    Dransfield, I.2    Gregory, C.3    Haslett, C.4
  • 49
    • 0034528139 scopus 로고    scopus 로고
    • Opsonization of apoptotic neutrophils by antineutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha)
    • Moosig F, Csernok E, Kumanovics G, Gross WL. Opsonization of apoptotic neutrophils by antineutrophil cytoplasmic antibodies (ANCA) leads to enhanced uptake by macrophages and increased release of tumour necrosis factor-alpha (TNF-alpha). Clin Exp Immunol. 2000;122:499-503.
    • (2000) Clin Exp Immunol , vol.122 , pp. 499-503
    • Moosig, F.1    Csernok, E.2    Kumanovics, G.3    Gross, W.L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.