Coordinated Dynamic Gene Expression Changes in the Central Nucleus of the Amygdala During Alcohol Withdrawal

Alcoholism: Clinical and Experimental Research

Volumn 37, Issue SUPPL.1, 2013, Pages

  Freeman, Kate ^a   Staehle, Mary M ^a,b,c   Vadigepalli, Rajanikanth ^a   Gonye, Gregory E ^a   Ogunnaike, Babatunde A ^c   Hoek, Jan B ^a   Schwaber, James S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b Rowan University   (United States)

^c University of Delaware   (United States)

Author keywords

Alcohol withdrawal; Central nucleus of the amygdala; Gene expression; Gene regulatory network; Time series

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; CHEMOKINE; G PROTEIN COUPLED RECEPTOR; IONOTROPIC RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPEPTIDE; RAF PROTEIN; RAS PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP2; TRANSCRIPTION FACTOR C ETS; TRANSCRIPTION FACTOR CEBP; UNCLASSIFIED DRUG; UPSTREAM STIMULATORY FACTOR 1;

ALCOHOL WITHDRAWAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CENTRAL NUCLEUS (AMYGDALA); CONTROLLED STUDY; EPIGENETICS; GENE CLUSTER; GENE EXPRESSION; GENETIC TRANSCRIPTION; MALE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

AMYGDALA; ANIMALS; DOWN-REGULATION; ETHANOL; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; MALE; MOLECULAR DYNAMICS SIMULATION; RATS; RATS, SPRAGUE-DAWLEY; SUBSTANCE WITHDRAWAL SYNDROME;

RATTUS;

EID: 84872497073     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2012.01910.x     Document Type: Article

References (57)

1. Bajo M, Cruz MT, Siggins GR, Messing R, Roberto M (2008) Protein kinase C epsilon mediation of CRF- and ethanol-induced GABA release in central amygdala. Proc Natl Acad Sci USA 105:8410-8415.
2. Bolstad BM, Irizarry RA, Astrand M, Speed TP (2003) A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 19:2185-2193.
3. Chen K, Ou XM, Wu JB, Shih JC (2011) Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B. Mol Pharmacol 79:2308-2317.
4. Chen YH, Yang CM, Chang SP, Hu ML (2009) C/EBP beta and C/EBP delta expression is elevated in the early phase of ethanol-induced hepatosteatosis in mice. Acta Pharmacol Sin 30:1138-1143.
5. Clapp P, Bhave SV, Hoffman PL (2008) How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective. Alcohol Res Health 31:310-339.
6. Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD (2007) Integration of biological networks and gene expression data using Cytoscape. Nat Protoc 2:2366-2382.
7. Cruz MT, Herman MA, Kallupi M, Roberto M (2012) Nociceptin/orphanin FQ blockade of corticotropin-releasing factor-induced gamma-aminobutyric acid release in central amygdala is enhanced after chronic ethanol exposure. Biol Psychiatry 8:666-676.
8. D'Aversa TG, Eugenin EA, Berman JW (2008) CD40-CD40 ligand interactions in human microglia induce CXCL8 (interleukin-8) secretion by a mechanism dependent on activation of ERK1/2 and nuclear translocation of nuclear factor-kappaB (NFkappaB) and activator protein-1 (AP-1). J Neurosci Res 86:630-639.
9. Eidson M, Wahlstrom J, Beaulieu AM, Zaidi B, Carsons SE, Crow PK, Yuan J, Wolchok JD, Horsthemke B, Wieczorek D, Sant'Angelo DB (2011) Altered development of NKT cells, γδ T cells, CD8 T cells and NK cells in a PLZF deficient patient. PLoS One 6:e24441.
10. Ernst J, Bar-Joseph Z (2006) STEM: a tool for the analysis of short time series gene expression data. BMC Bioinformatics 7:191.
11. Freeman K, Brureau A, Vadigepalli R, Staehle MM, Brureau MM, Gonye GE, Hoek JB, Hooper DC, Schwaber JS (2012a) Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei. J Neuroinflammation 9:97.
12. Freeman K, Staehle MM, Gümüş ZH, Vadigepalli R, Gonye GE, Nichols CN, Ogunnaike BA, Hoek JB, Schwaber JS (2012b) Rapid temporal changes in the expression of a set of neuromodulatory genes during alcohol withdrawal in the dorsal vagal complex: molecular evidence of homeostatic disturbance. Alcohol Clin Exp Res doi: 10.1111/j.1530-0277.2012.01791.x [Epub ahead of print].
13. Geisler RF, Hunter BE, Walker DW (1978) Ethanol dependence in the rat: temporal changes in neuroexcitability following withdrawal. Psychopharmacology 56:287-292.
14. Giese K, Kingsley C, Kirshner JR, Grosschedl R (1995) Assembly and function of a TCR alpha enhancer complex is dependent on LEF-1-induced DNA bending and multiple protein-protein interactions. Genes Dev 9:995-1008.
15. Golding I, Paulsson J, Zawilski SM, Cox EC (2005) Real-time kinetics of gene activity in individual bacteria. Cell 123:1025-1036.
16. Hansson AC, Rimondini R, Neznanova O, Sommer WH, Heilig M (2008) Neuroplasticity in brain reward circuitry following a history of ethanol dependence. Eur J Neurosci 27:1912-1922.
17. Ho AM, MacKay RK, Dodd PR, Lewohl JM (2010) Association of polymorphisms in RGS4 and expression of RGS transcripts in the brains of human alcoholics. Brain Res 1340:1-9.
18. Hong SJ, Lardaro T, Oh MS, Huh Y, Ding Y, Kang UJ, Kirfel J, Buettner R, Kim KS (2008) Regulation of the noradrenaline neurotransmitter phenotype by the transcription factor AP-2beta. J Biol Chem 283:16860-16867.
19. Huang da W, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC, Lempicki RA (2007) DAVID Bioinformatics Resources: expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res 35:169-175.
20. Hunter BE, Riley JN, Walker DW (1975) Ethanol dependence in the rat: a parametric analysis. Pharmacol Biochem Behav 3:619-629.
21. Jeon GS, Byun HJ, Park SK, Park SW, Kim DW, Seo JH, Cha CI, Cho SS (2006) Induction of transcription factor A-myb expression in reactive astrocytes following an excitotoxic lesion in the mouse hippocampus. Neurochem Res 31:1371-1374.
22. Karaa A, Thompson KJ, McKillop IH, Clemens MG, Schrum LW (2008) S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock 30:197-205.
23. Kim CH, Ardayfio P, Kim KS (2001a) An E-box motif residing in the exon/intron 1 junction regulates both transcriptional activation and splicing of the human norepinephrine transporter gene. J Biol Chem 276:24797-24805.
24. Kim HS, Hong SJ, LeDoux MS, Kim KS (2001b) Regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor AP-2. J Neurochem 76:280-294.
25. Kitanaka N, Kitanaka J, Hall FS, Tatsuta T, Morita Y, Takemura M, Wang XB, Uhl GR (2008) Alterations in the levels of heterotrimeric G protein subunits induced by psychostimulants, opiates, barbiturates, and ethanol: implications for drug dependence, tolerance, and withdrawal. Synapse 62:689-699.
26. Koob GF (in press) Theoretical frameworks and mechanistic aspects of alcohol addiction: alcohol addiction as a reward deficit disorder. Curr Top Behav Neurosci doi: 10.1007/7854_2011_129 [Epub ahead of print].
27. Lieber CS, DeCarli LM (1994) Animal models of chronic ethanol toxicity. Methods Enzymol 233:585-594.
28. Liu W, Yuen EY, Allen PB, Feng J, Greengard P, Yan Z (2006) Adrenergic modulation of NMDA receptors in prefrontal cortex is differentially regulated by RGS proteins and spinophilin. Proc Natl Acad Sci USA 103:18338-18343.
29. Logan RW, McCulley WD, Seggio JA, Rosenwasser AM (2012) Effects of withdrawal from chronic intermittent ethanol vapor on the level and circadian periodicity of running-wheel activity in C57BL/6J and C3H/HeJ mice. Alcohol Clin Exp Res 36:467-476.
30. Macey DJ, Schulteis G, Heinrichs SC, Koob GF (1996) Time-dependent quantifiable withdrawal from ethanol in the rat: Effect of method of dependence induction. Alcohol 13:163-170.
31. Mar JC, Kimura Y, Schroder K, Irvine KM, Hayashizaki Y, Suzuki H, Hume D, Quackenbush J (2009) Data-driven normalization strategies for high-throughput quantitative RT-PCR. BMC Bioinformatics 10:1-10.
32. McBride WJ (2002) Central nucleus of the amygdala and the effects of alcohol and alcohol-drinking behavior in rodents. Pharmacol Biochem Behav 71:509-515.
33. McBride WJ, Kimpel MW, Schultz JA, McClintick JN, Edenberg HJ, Bell RL (2010) Changes in gene expression in regions of the extended amygdala of alcohol-preferring rats after binge-like alcohol drinking. Alcohol 44:171-183.
34. McCool BA, Christian DT, Diaz MR, Lack AK (2010) Glutamate plasticity in the drunken amygdala: the making of an anxious synapse. Int Rev Neurobiol 91:205-233.
35. Nie Z, Schweitzer P, Roberts AJ, Madamba SG, Moore SD, Siggins GR (2004) Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. Science 303:1512-1514.
36. Obara I, Bell R, Goulding SP, Reyes CM, Larson L, Ary A, Truitt W, Szumlinski K (2009) Differential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P rats. Alcohol Clin Exp Res 33:1924-1934.
37. Pandey SC (2004) The gene transcription factor cyclic AMP-responsive element binding protein: role in positive and negative affective states of alcohol addiction. Pharmacol Ther 104:47-58.
38. Pandey SC, Chartoff EH, Carlezon WA Jr, Zou J, Zhang H, Kreibich AS, Blendy JA, Crews FT (2005) CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. Alcohol Clin Exp Res 29:176-184.
39. Potter JJ, Rennie-Tankersley L, Mezey E (2003) Endotoxin enhances liver alcohol dehydrogenase by action through upstream stimulatory factor but not by nuclear factor-kappa B. J Biol Chem 278:4353-4357.
40. Pradervand S, Weber J, Thomas J, Bueno M, Wirapati P, Lefort K, Dotto GP, Harshman K (2009) Impact of normalization on miRNA microarray expression profiling. RNA 15:493-501.
41. Prosser HM, Wotton D, Gegonne A, Ghysdael J, Wang S, Speck NA, Owen MJ (1992) A phorbol ester response element within the human T-cell receptor beta-chain enhancer. Proc Natl Acad Sci USA 89:9934-9938.
42. Puig-Kroger A, Lopez-Rodriguez C, Relloso M, Sanchez-Elsner T, Nueda A, Munoz E, Bernabeu C, Corbi AL (2000) Polyomavirus enhancer-binding protein 2/core binding factor/acute myeloid leukemia factors contribute to the cell type-specific activity of the CD11a integrin gene promoter. J Biol Chem 275:28507-28512.
43. Radwanska K, Wrobel E, Korkosz A, Rogowski A, Kostowski W, Bienkowski P, Kaczmarek L (2008) Alcohol relapse induced by discrete cues activates components of AP-1 transcription factor and ERK pathway in the rat basolateral and central amygdala. Neuropsychopharmacology 33:1835-1846.
44. Raj A, van Oudenaarden A (2008) Nature, nurture, or chance: stochastic gene expression and its consequences. Cell 135:216-226.
45. Roberto M, Bajo M, Crawford E, Madamba SG, Siggins GR (2006) Chronic ethanol exposure and protracted abstinence alter NMDA receptors in central amygdala. Neuropsychopharmacology 31:988-996.
46. Roberto M, Schweitzer P, Madamba SG, Stouffer DG, Parsons L, Siggins GR (2004) Acute and chronic ethanol alter glutamatergic transmission in rat central amygdala: an in vitro and in vivo analysis. J Neurosci 24:1594-1603.
47. Rodd ZA, Kimpel MW, Edenberg HJ, Bell RL, Strother WN, McClintick JN, Carr LG, Liang T, McBride WJ (2008) Differential gene expression in the nucleus accumbens with ethanol self-administration in inbred alcohol-preferring rats. Pharmacol Biochem Behav 89:481-498.
48. Sanna PP, Simpson C, Lutjens R, Koob G (2002) ERK regulation in chronic ethanol exposure and withdrawal. Brain Res 948:186-191.
49. Schmidt M, Huber L, Majdazari A, Schutz G, Williams T, Rohrer H (2011) The transcription factors AP-2beta and AP-2alpha are required for survival of sympathetic progenitors and differentiated sympathetic neurons. Dev Biol 355:89-100.
50. Spicuglia S, Vincent-Fabert C, Benoukraf T, Tiberi G, Saurin AJ, Zacarias-Cabeza J, Grimwade D, Mills K, Calmels B, Bertucci F, Sieweke M, Ferrier P, Duprez E (2011) Characterisation of genome-wide PLZF/RARA target genes. PLoS One 6:e24176.
51. Spurgeon SL, Jones RC, Ramakrishnan R (2008) High throughput gene expression measurement with real time PCR in a microfluidic dynamic array. PLoS One 3:e1662.
52. Storey JD, Tibshirani R (2003) Statistical significance for genomewide studies. Proc Natl Acad Sci USA 100:9440-9445.
53. Vadigepalli R, Chakravarthula P, Zak DE, Schwaber JS, Gonye GE (2003) PAINT: a promoter analysis and interaction network generation tool for gene regulatory network identification. OMICS 7:3235-3252.
54. Vilpoux C, Warnault V, Pierrefiche O, Daoust M, Naassila M (2009) Ethanol-sensitive brain regions in rat and mouse: a cartographic review, using immediate early gene expression. Alcohol Clin Exp Res 33:945-969.
55. Walker DW, Hunter BE, Riley J (1975) A behavioral and electrophysiological analysis of ethanol dependence in the rat. Adv Exp Med Biol 59:353-372.
56. Wilson JS, Korsten MA, Lieber CS (1986) The combined effects of protein deficiency and chronic ethanol administration on rat ethanol metabolism. Hepatology 6:823-829.
57. Yang CM, Lin CC, Lee IT, Lin YH, Yang CM, Chen WJ, Jou MJ, Hsiao LD (2012) Japanese encephalitis virus induces matrix metalloproteinase-9 expression via a ROS/c-Src/PDGFR/PI3K/Akt/MAPKs-dependent AP-1 pathway in rat brain astrocytes. J Neuroinflammation 9:12.