Angiopoietin-like protein 2, a chronic inflammatory mediator, is a new target induced by TGF-β1 through a Smad3-dependent mechanism

Biochemical and Biophysical Research Communications

Volumn 430, Issue 3, 2013, Pages 981-986

  Lee, Hee Jae ^a   Kim, Jun Hwan ^a   Kim, Joon Hyung ^a   Martinus, Ryan Dennis ^b   Park, Seok Hee ^a  

^a Sungkyunkwan University   (South Korea)

^b UNIVERSITY OF WAIKATO   (New Zealand)

Author keywords

Angptl2; Obesity; Smad3; TGF 1

Indexed keywords

ANGIOPOIETIN; ANGIOPOIETIN LIKE PROTEIN 2; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; SMAD BINDING ELEMENT; SMAD PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION; GENE TARGETING; IN VITRO STUDY; MACROPHAGE; MEDIATOR; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

3T3-L1 CELLS; ANGIOPOIETINS; ANIMALS; CELL LINE; CHRONIC DISEASE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPRECIPITATION; INFLAMMATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; OBESITY; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROMOTER REGIONS, GENETIC; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

RODENTIA;

EID: 84872493095     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.127     Document Type: Article

References (31)

1. Hato T., Tabata M., Oike Y. The role of angiopoietin-like proteins in angiogenesis and metabolism. Trends Cardiovasc. Med. 2008, 18:6-14.
2. Tabata M., Kadomatsu T., Fukuhara S., Miyata K., Ito Y., Endo M., et al. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 2009, 10:178-188.
3. Kadomatsu T., Tabata M., Oike Y. Angiopoietin-like proteins: emerging targets for treatment of obesity and related metabolic diseases. FEBS J. 2011, 278:559-564.
4. Hosogai N., Fukuhara A., Oshima K., Miyata Y., Tanaka S., Segawa K., et al. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56:901-911.
5. Nishimura S., Manabe I., Nagasaki M., Seo K., Yamashita H., Hosoya Y., et al. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J. Clin. Invest. 2008, 118:710-721.
6. Lebovitz H.E., Banerji M.A. Insulin resistance and its treatment by thiazolidinediones. Recent Prog. Horm. Res. 2001, 56:265-294.
7. Takano H., Komuro I. Peroxisome proliferator-activated receptor gamma and cardiovascular diseases. Circ. J. 2009, 73:214-220.
8. Blobe G.C., Schiemann W.P., Lodish H.F. Role of transforming growth factor beta in human disease. N. Engl. J. Med. 2000, 342:1350-1358.
9. Derynck R., Zhang Y.E. Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature 2003, 425:577-584.
10. Mu Y., Gudey S.K., Landstrom M. Non-Smad signaling pathways. Cell Tissue Res. 2012, 347:11-20.
11. Massague J., Wotton D. Transcriptional control by the TGF-beta/Smad signaling system. EMBO J. 2000, 19:1745-1754.
12. Hayashi H., Abdollah S., Qiu Y., Cai J., Xu Y.Y., Grinnell B.W., et al. The MAD-related protein Smad7 associates with the TGF-beta receptor and functions as an antagonist of TGF-beta signaling. Cell 1997, 89:1165-1173.
13. Imamura T., Takase M., Nishihara A., Oeda E., Hanai J., Kawabata M., Miyazono K. Smad6 inhibits signalling by the TGF-beta superfamily. Nature 1997, 389:622-626.
14. Zhang Y.E. Non-Smad pathways in TGF-beta signaling. Cell Res. 2009, 19:128-139.
15. Ignotz R.A., Massague J. Type beta transforming growth factor controls the adipogenic differentiation of 3T3 fibroblasts. Proc. Natl. Acad. Sci. USA 1985, 82:8530-8534.
16. Jeoung D.I., Tang B., Sonenberg M. Mitogenic response to TGF-beta in 3T3-F442A cells. Biochem. Biophys. Res. Commun. 1995, 216:964-969.
17. Corica F., Allegra A., Buemi M., Corsonello A., Bonanzinga S., Rubino F., et al. Reduced plasma concentrations of transforming growth factor beta1 (TGF-beta1) in obese women. Int. J. Obes. Relat. Metab. Disord. 1997, 21:704-707.
18. Alessi M.C., Bastelica D., Morange P., Berthet B., Leduc I., Verdier M., et al. Plasminogen activator inhibitor 1, transforming growth factor-beta1, and BMI are closely associated in human adipose tissue during morbid obesity. Diabetes 2000, 49:1374-1380.
19. Samad F., Yamamoto K., Pandey M., Loskutoff D.J. Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol. Med. 1997, 3:37-48.
20. Porreca E., Di Febbo C., Vitacolonna E., Baccante G., Di Castelnuovo A., Angelini A., et al. Transforming growth factor-beta1 levels in hypertensive patients: association with body mass index and leptin. Am. J. Hypertens. 2002, 15:759-765.
21. Choi K.C., Lee Y.S., Lim S., Choi H.K., Lee C.H., Lee E.K., et al. Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. Nat. Immunol. 2006, 7:1057-1065.
22. Ye F., Zhang H., Yang Y.X., Hu H.D., Sze S.K., Meng W., et al. Comparative proteome analysis of 3T3-L1 adipocyte differentiation using iTRAQ-coupled 2D LC-MS/MS. J. Cell. Biochem. 2011, 112:3002-3014.
23. Zheng J.Y., Zou J.J., Wang W.Z., Feng X.Y., Shi Y.Y., Zhao Y., et al. Tumor necrosis factor-alpha increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes. Mol. Cell. Endocrinol. 2011, 339:120-129.
24. Lee Y.S., Park J.S., Kim J.H., Jung S.M., Lee J.Y., Kim S.J., et al. Smad6-specific recruitment of Smurf E3 ligases mediates TGF-beta1-induced degradation of MyD88 in TLR4 signalling. Nat. Commun. 2011, 2:460.
25. Lee B.I., Park S.H., Kim J.W., Sausville E.A., Kim H.T., Nakanishi O., et al. MS-275, a histone deacetylase inhibitor, selectively induces transforming growth factor beta type II receptor expression in human breast cancer cells. Cancer Res. 2001, 61:931-934.
26. Kim I., Moon S.O., Koh K.N., Kim H., Uhm C.S., Kwak H.J., et al. Molecular cloning, expression, and characterization of angiopoietin-related protein. Angiopoietin-related protein induces endothelial cell sprouting. J. Biol. Chem. 1999, 274:26523-26528.
27. Okada T., Tsukano H., Endo M., Tabata M., Miyata K., Kadomatsu T., et al. Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis. Am. J. Pathol. 2010, 176:2309-2319.
28. Ogata A., Endo M., Aoi J., Takahashi O., Kadomatsu T., Miyata K., et al. The role of angiopoietin-like protein 2 in pathogenesis of dermatomyositis. Biochem. Biophys. Res. Commun. 2012, 418:494-499.
29. Endo M., Nakano M., Kadomatsu T., Fukuhara S., Kuroda H., Mikami S., et al. Tumor cell-derived angiopoietin-like protein ANGPTL2 is a critical driver of metastasis. Cancer Res. 2012, 72:1784-1794.
30. Aoi J., Endo M., Kadomatsu T., Miyata K., Nakano M., Horiguchi H., et al. Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis. Cancer Res. 2011, 71:7502-7512.
31. Padua D., Zhang X.H., Wang Q., Nadal C., Gerald W.L., Gomis R.R., et al. TGF-beta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008, 133:66-77.