Tumor necrosis factor-α increases angiopoietin-like protein 2 gene expression by activating Foxo1 in 3T3-L1 adipocytes

Molecular and Cellular Endocrinology

Volumn 339, Issue 1-2, 2011, Pages 120-129

  Zheng, Jiao Yang ^a   Zou, Jun Jie ^a   Wang, Wen Zhao ^a   Feng, Xiao Yun ^a   Shi, Yong Yuan ^a   Zhao, Ying ^a   Jin, Gang ^b   Liu, Zhi Min ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Insulin resistance; Obesity; Proinflammatory cytokines; Promoter

Indexed keywords

ANGIOPOIETIN LIKE PROTEIN 2; GROWTH FACTOR; INSULIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR FKHR; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADIPOCYTE; ANGPTL2 GENE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE SEQUENCE; HUMAN; HUMAN CELL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; UPREGULATION;

3T3-L1 CELLS; 5' UNTRANSLATED REGIONS; ADIPOCYTES; ANGIOPOIETINS; ANIMALS; BASE SEQUENCE; CLONING, MOLECULAR; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; INSULIN; MICE; MOLECULAR SEQUENCE DATA; RESPONSE ELEMENTS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958026383     PISSN: 03037207     EISSN: 18728057     Source Type: Journal    
DOI: 10.1016/j.mce.2011.04.002     Document Type: Article

References (48)

1. Alikhani M., Alikhani Z., Graves D.T. FOXO1 functions as a master switch that regulates gene expression necessary for tumor necrosis factor-induced fibroblast apoptosis. J. Biol. Chem. 2005, 280:12096-12102.
2. Arden K. FOXO animal models reveal a variety of diverse roles for FOXO transcription factors. Oncogene 2008, 27:2345-2350.
3. Biggs W., Meisenhelder J., Hunter T., Cavenee W., Arden K. Protein kinase B/Akt-mediated phosphorylation promotes nuclear exclusion of the winged helix transcription factor FKHR1. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:7421-7426.
4. Brunet A., Bonni A., Zigmond M., Lin M., Juo P., Hu L., Anderson M., Arden K., Blenis J., Greenberg M. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999, 96:857-868.
5. Carlotti F., Bazuine M., Kekarainen T., Seppen J., Pognonec P., Maassen J.A., Hoeben R.C. Lentiviral vectors efficiently transduce quiescent mature 3T3-L1 adipocytes. Mol. Ther. 2004, 9:209-217.
6. Carlsson P., Mahlapuu M. Forkhead transcription factors: key players in development and metabolism. Dev. Biol. 2002, 250:1-23.
7. Chakrabarti P., Kandror K. FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes. J. Biol. Chem. 2009, 284:13296-13300.
8. Chow F., Ozols E., Nikolic-Paterson D., Atkins R., Tesch G. Macrophages in mouse type 2 diabetic nephropathy: correlation with diabetic state and progressive renal injury. Kidney Int. 2004, 65:116-128.
9. Daitoku H., Fukamizu A. FOXO transcription factors in the regulatory networks of longevity. J. Biochem. 2007, 141:769-774.
10. Eckel R., Grundy S., Zimmet P. The metabolic syndrome. Lancet 2005, 365:1415-1428.
11. Essers M., Weijzen S., de Vries-Smits A., Saarloos I., De Ruiter N., Bos J., Burgering B. FOXO transcription factor activation by oxidative stress mediated by the small GTPase Ral and JNK. EMBO J. 2004, 23:4802-4812.
12. Friedman J., Kaestner K. The Foxa family of transcription factors in development and metabolism. Cell. Mol. Life Sci. 2006, 63:2317-2328.
13. Galkina E., Ley K. Leukocyte recruitment and vascular injury in diabetic nephropathy. J. Am. Soc. Nephrol. 2006, 17:368-377.
14. Hong R., Harvey F.L. Insulin resistance in adipose tissue: direct and indirect effects of tumor necrosis factor-α. Cytokine Growth Factor Rev. 2003, 14:447-455.
15. Hosogai N., Fukuhara A., Oshima K., Miyata Y., Tanaka S., Segawa K., Furukawa S., Tochino Y., Komuro R., Matsuda M. Adipose tissue hypoxia in obesity and its impact on adipocytokine dysregulation. Diabetes 2007, 56:901-911.
16. Hotamisligil G. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
17. Hotamisligil G., Peraldi P., Budavari A., Ellis R., White M., Spiegelman B. IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha-and obesity-induced insulin resistance. Science 1996, 271:665-668.
18. Houstis N., Rosen E., Lander E. Reactive oxygen species have a causal role in multiple forms of insulin resistance. Nature 2006, 440:944-948.
19. Ito Y., Daitoku H., Fukamizu A. Foxo1 increases pro-inflammatory gene expression by inducing C/EBP [beta] in TNF-[alpha]-treated adipocytes. Biochem. Biophys. Res. Commun. 2009, 378:290-295.
20. Kamagate A., Dong H.H. Foxo1 integrates insulin signaling to VLDL production. Cell Cycle 2008, 7:3162-3170.
21. Kaufmann E., Knochel W. Five years on the wings of fork head. Mech. Dev. 1996, 57:3-20.
22. Kersten S., Mandard S., Tan N., Escher P., Metzger D., Chambon P., Gonzalez F., Desvergne B., Wahli W. Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene. J. Biol. Chem. 2000, 275:28488-28493.
23. Kim I., Moon S., Koh K., Kim H., Uhm C., Kwak H., Kim N., Koh G. Molecular cloning, expression, and characterization of angiopoietin-related protein. J. Biol. Chem. 1999, 274:26523-26528.
24. Koishi R., Ando Y., Ono M., Shimamura M., Yasumo H., Fujiwara T., Horikoshi H., Furukawa H. Angptl3 regulates lipid metabolism in mice. Nat. Genet. 2002, 30:151-157.
25. Kops G., De Ruiter N., De Vries-Smits A., Powell D., Bos J., Burgering B. Direct control of the Forkhead transcription factor AFX by protein kinase B. Nature 1999, 398:630-634.
26. Kubota Y., Oike Y., Satoh S., Tabata Y., Niikura Y., Morisada T., Akao M., Urano T., Ito Y., Miyamoto T. Cooperative interaction of angiopoietin-like proteins 1 and 2 in zebrafish vascular development. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13502-13507.
27. Lehtinen M., Yuan Z., Boag P., Yang Y., Villén J., Becker E., DiBacco S., de la Iglesia N., Gygi S., Blackwell T. A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span. Cell 2006, 125:987-1001.
28. Martinez S.C., Tanabe K., Cras-Méneur C., Abumrad N.A., Bernal-Mizrachi E., Permutt M.A. Inhibition of Foxo1 protects pancreatic islet β-Cells against fatty acid and endoplasmic reticulum stress-induced apoptosis. Diabetes 2008, 57:846-859.
29. Mokdad A., Ford E., Bowman B., Dietz W., Vinicor F., Bales V., Marks J. Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 2003, 289:76-79.
30. Nakae J., Kitamura T., Kitamura Y., Biggs W. The forkhead transcription factor Foxo1 regulates adipocyte differentiation. Dev. Cell 2003, 4:119-129.
31. Nishimura S., Manabe I., Nagasaki M., Seo K., Yamashita H., Hosoya Y., Ohsugi M., Tobe K., Kadowaki T., Nagai R. In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J. Clin. Invest. 2008, 118:710-721.
32. Oike Y., Yasunaga K., Ito Y., Matsumoto S., Maekawa H., Morisada T., Arai F., Nakagata N., Takeya M., Masuho Y. Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:9494-9499.
33. Oike Y., Akao M., Kubota Y., Suda T. Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy. Trends Mol. Med. 2005, 11:473-479.
34. Oike Y., Akao M., Yasunaga K., Yamauchi T., Morisada T., Ito Y., Urano T., Kimura Y., Kubota Y., Maekawa H. Angiopoietin-related growth factor antagonizes obesity and insulin resistance. Nat. Med. 2005, 11:400-408.
35. Okada T., Tsukano H., Endo M., Tabata M., Miyata K., Kadomatsu T., Miyashita K., Semba K., Nakamura E., Tsukano M., Mizuta H., Oike Y. Synoviocyte-derived angiopoietin-like protein 2 contributes to synovial chronic inflammation in rheumatoid arthritis. Am. J. Pathol. 2010, 176:2309-2319.
36. Rena G., Guo S., Cichy S., Unterman T., Cohen P. Phosphorylation of the transcription factor forkhead family member FKHR by protein kinase B. J. Biol. Chem. 1999, 274:17179-17183.
37. Salih D., Brunet A. FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr. Opin. Cell Biol. 2008, 20:126-136.
38. Samatar A.A., Wang L., Mirza A., Koseoglu S., Liu S., Kumar C.C. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor. J. Biol. Chem. 2002, 277:28118-28126.
39. Shoelson S.E., Herrero L., Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology 2007, 132:2169-2180.
40. Smale S.T., Baltimore D. The " initiator" as a transcription control element. Cell 1989, 57:103-113.
41. Su D., Coudriet G.M., Hyun Kim D., Lu Y., Perdomo G., Qu S., Slusher S., Tse H.M., Piganelli J., Giannoukakis N., Zhang J., Henry Dong H. Foxo1 links insulin resistance to proinflammatory cytokine IL-1β production in macrophages. Diabetes 2009, 58:2624-2633.
42. Sun H., Zheng J., Chen S., Zeng C., Liu Z., Li L. Enhanced expression of ANGPTL2 in the microvascular lesions of diabetic glomerulopathy. Nephron Exp. Nephrol. 2007, 105:e117-e123.
43. Tabata M., Kadomatsu T., Fukuhara S., Miyata K., Ito Y., Endo M., Urano T., Zhu H., Tsukano H., Tazume H. Angiopoietin-like protein 2 promotes chronic adipose tissue inflammation and obesity-related systemic insulin resistance. Cell Metab. 2009, 10:178-188.
44. Takaishi H., Konishi H., Matsuzaki H., Ono Y., Shirai Y., Saito N., Kitamura T., Ogawa W., Kasuga M., Kikkawa U. Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:11836-11841.
45. Tilg H., Moschen A. Inflammatory mechanisms in the regulation of insulin resistance. Mol. Med. 2008, 14:222-231.
46. Uysal K., Wiesbrock S., Marino M., Hotamisligil G. Protection from obesity-induced insulin resistance in mice lacking TNF-α function. Nature 1997, 389:610-614.
47. Wellen K.E., Hotamisligil G.S. Inflammation, stress, and diabetes. J. Clin. Invest. 2005, 115:1111-1119.
48. Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int. J. Obesity 2008, 33:54-66.