Mere15, a novel polypeptide from Meretrix meretrix, inhibits adhesion, migration and invasion of human lung cancer A549 cells via down-regulating MMPs

Pharmaceutical Biology

Volumn 51, Issue 2, 2013, Pages 145-151

  Wang, Hui ^a,c   Wei, Jianteng ^a,c   Wu, Ning ^a   Liu, Ming ^a   Wang, Cuicui ^c   Zhang, Yuyan ^a   Wang, Fengxia ^a   Liu, Haizhou ^a   Lin, Xiukun ^a,b  

^a INSTITUTE OF OCEANOLOGY   (China)

^b CAPITAL MEDICAL UNIVERSITY   (China)

^c UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Anticancer; Cancer metastasis; Gelatin zymography; RT PCR; Transwell assay

Indexed keywords

ANTINEOPLASTIC AGENT; GELATIN; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; MERE15 POLYPEPTIDE; MESSENGER RNA; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL; CANCER INHIBITION; CELL ADHESION; CELL ASSAY; CELL INVASION; CELL MIGRATION; CELL STRUCTURE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; LUNG ADENOCARCINOMA; MATRIX METALLOPROTEINASE 2 GENE; MATRIX METALLOPROTEINASE 9 GENE; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZYMOGRAPHY;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL SHAPE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LUNG NEOPLASMS; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MOLLUSCA; NEOPLASM INVASIVENESS; PEPTIDES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

MERETRIX MERETRIX; VENERIDAE;

EID: 84872433058     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.3109/13880209.2012.715169     Document Type: Article

References (23)

1. Blunden G. (2001). Biologically active compounds from marine organisms. Phytother Res, 15, 89-94
2. Chen CJ, You SL, Lin LH, Hsu WL, Yang YW. (2002). Cancer epidemiology and control in Taiwan: A brief review. Jpn J Clin Oncol, 32 Suppl, S66-S81
3. Chen HY, Cong XQ, Zhang A, Zhu JM. (1980). The anticancer research of extraction from Mercenaria. Cancer Res Prev Treat, 4, 3-7 (in Chinese
4. Chien ST, Lin SS, Wang CK, Lee YB, Chen KS, Fong Y, Shih YW. (2011). Acacetin inhibits the invasion and migration of human nonsmall cell lung cancer A549 cells by suppressing the p38a MAPK signaling pathway. Mol Cell Biochem, 350, 135-148
5. Dou CH, Huang F, Huang LS, Li PZ, Xiao WD. (1999). An experimental study on the effects of Meretrix polysaccharide. J Marine Drugs, 2, 15-19 (in Chinese
6. Gebbia V, Galetta D, Caruso M, Verderame F, Pezzella G, Valdesi M, Borsellino N, Pandolfo G, Durini E, Rinaldi M, Loizzi M, Gebbia N, Valenza R, Tirrito ML, Varvara F, Colucci G; Gruppo Ocologico Italia Meridionale. (2003). Gemcitabine and cisplatin versus vinorelbine and cisplatin versus ifosfamide+gemcitabine followed by vinorelbine and cisplatin versus vinorelbine and cisplatin followed by ifosfamide and gemcitabine in stage IIIB-IV non small cell lung carcinoma: A prospective randomized phase III trial of the Gruppo Oncologico Italia Meridionale. Lung Cancer, 39, 179-189 (Pubitemid 36173619)
7. Huang CY, Lin CY, Tsai CW, Yin MC. (2011). Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines. Toxicol In Vitro, 25, 1274-1280
8. Hwang ES, Park KK. (2010). Magnolol suppresses metastasis via inhibition of invasion, migration, and matrix metalloproteinase-2/-9 activities in PC-3 human prostate carcinoma cells. Biosci Biotechnol Biochem, 74, 961-967
9. Kosacka M, Piesiak P, Kowal A, Gołecki M, Jankowska R. (2011). Galectin-3 and cyclin D1 expression in non-small cell lung cancer. J Exp Clin Cancer Res, 30, 101
10. Lee SH, Jaganath IB, Wang SM, Sekaran SD. (2011). Antimetastatic effects of Phyllanthus on human lung (A549) and breast (MCF-7) cancer cell lines. PLoS One, 6, 1-14
11. Leng B, Liu XD, Chen QX. (2005). Inhibitory effects of anticancer peptide from Mercenaria on the BGC-823 cells and several enzymes. FEBS Lett, 579, 1187-1190 (Pubitemid 40248685)
12. Li N, Zhang JP, Guo S, Min J, Liu LL, Su HC, Feng YM, Zhang HL. (2012
13. Down-regulation of β3-integrin inhibits bone metastasis of small cell lung cancer. Mol Biol Rep, 39, 3029-3035
14. Lu Z, Lu N, Li C, Li F, Zhao K, Lin B, Guo Q. (2012). Oroxylin A inhibits matrix metalloproteinase-2/9 expression and activation by up-regulating tissue inhibitor of metalloproteinase-2 and suppressing the ERK1/2 signaling pathway. Toxicol Lett, 209, 211-220
15. Mosmann T. (1983). Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods, 65, 55-63 (Pubitemid 14203433)
16. Ning X, Zhao J, Zhang Y, Cao S, Liu M, Ling P, Lin X. (2009). A novel antitumor protein extracted from Meretrix meretrix Linnaeus induces cell death by increasing cell permeability and inhibiting tubulin polymerization. Int J Oncol, 35, 805-812
17. Parkin DM, Bray F, Ferlay J, Pisani P. (2005). Global cancer statistics, 2002. CA Cancer J Clin, 55, 74-108 (Pubitemid 40372904)
18. Tiseo M, Franciosi V, Ardizzoni A. (2006). Multi-target inhibitors in nonsmall cell lung cancer (NSCLC). Ann Onco, 17 (Supplement 2), ii55-ii57
19. Wang CC, Liu M, Cheng LY, Wu N, Wei JT, Song YZ, Zheng LH, Lin XK. (2012). A novel polypeptide extracted from Meretrix meretrix Linnaeus, inhibits the growth of human lung adenocarcinoma via inducing G2/M phase arrest and apoptosis. Exp Biol Med, 237, 442-450
20. Wu CS, Chen YJ, Chen JJ, Shieh JJ, Huang CH, Lin PS, Chang GC, Chang JT, Lin CC. (2012). Terpinen-4-ol induces apoptosis in human nonsmall cell lung cancer in vitro and in vivo. Evid Based Complement Alternat Med, 2012, 818261
21. Xu K, Liang X, Gao F, Zhong JJ, Liu JW. (2010). Antimetastatic effect of ganoderic acid T in vitro through inhibition of cancer cell invasion. Process Biochem, 45, 1261-1267
22. Zhang JX, Xing YP. (1990). Studies on anticancer activity of Meretrix meretrix nucleic acid. Oceanol Et Limnol, 21, 88-91 (in Chinese
23. Zhu F, Zhang Z, Wu G, Li Z, Zhang R, Ren J, Nong L. (2011). Rho kinase inhibitor fasudil suppresses migration and invasion though downregulating the expression of VEGF in lung cancer cell line A549. Med Oncol, 28, 565-571