Strategies towards injectable, load-bearing materials for the intervertebral disc: A review and outlook

Journal of Materials Science: Materials in Medicine

Volumn 24, Issue 1, 2013, Pages 1-10

  Persson, Cecilia ^a   Berg, Svante ^b  

^a UPPSALA UNIVERSITY   (Sweden)

^b Section North   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INJECTABILITY; INTERVERTEBRAL DISCS; INVASIVENESS; LOAD DISTRIBUTIONS; LOAD-BEARING; LOAD-BEARING MATERIALS; MINIMALLY INVASIVE; SETTING REACTIONS; SETTING TIME; WORKING TIME;

BIOCOMPATIBILITY; BONE CEMENT; MECHANICAL PROPERTIES;

MATERIALS PROPERTIES;

BIOMATERIAL; BONE CEMENT; MUSCLE RELAXANT AGENT;

BIOCOMPATIBILITY; HIP PROSTHESIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERVERTEBRAL DISK; KNEE PROSTHESIS; MATERIALS HANDLING; MECHANICS; NEEDLE; PERCUTANEOUS VERTEBROPLASTY; POROSITY; PRIORITY JOURNAL; PROSTHESIS FIXATION; REVIEW; SPONDYLOLYSIS; TEMPERATURE MEASUREMENT; TRABECULAR BONE; VISCOMETRY; WORKING TIME;

ANIMALS; BIOCOMPATIBLE MATERIALS; HUMANS; INTERVERTEBRAL DISC;

EID: 84872398952     PISSN: 09574530     EISSN: 15734838     Source Type: Journal    
DOI: 10.1007/s10856-012-4776-2     Document Type: Review

References (73)

1. Bjorck-van Dijken C, Fjellman-Wiklund A, Hildingsson C. Low back pain, lifestyle factors and physical activity: a population based-study. J Rehabil Med. 2008;40(10):864-9. doi: 10.2340/16501977-0273.
2. Brisby H. Pathology and possible mechanisms of nervous system response to disc degeneration. J Bone Joint Surg. 2006;88:68-71.
3. Adams MA, Roughley PJ. What is intervertebral disc degeneration, and what causes it? Spine (Phila Pa 1976). 2006;31(18):2151-61. doi: 10.1097/01.brs.0000231761.73859.2c.
4. Bouwmeester W, van Enst A, van Tulder M. Quality of low back pain guidelines improved. Spine (Phila Pa 1976). 2009;34(23):2562-7. doi: 10.1097/BRS.0b013e3181b4d50d.
5. Bao QB, McCullen GM, Higham PA, Dumbleton JH, Yuan HA. The artificial disc: theory, design and materials. Biomaterials. 1996;17(12):1157-67.
6. Shikinami Y, Kotani Y, Cunningham BW, Abumi K, Kaneda K. A biomimetic artificial disc with improved mechanical properties compared to biological intervertebral discs. Adv Funct Mater. 2004;14(11):1039-46. doi: 10.1002/adfm.200305038.
7. Gloria A, Causa F, De Santis R, Netti PA, Ambrosio L. Dynamic-mechanical properties of a novel composite intervertebral disc prosthesis. J Mater Sci Mater Med. 2007;18(11):2159-65. doi: 10.1007/s10856-007-3003-z.
8. Gloria A, Santis RD, Ambrosio L, Causa F, Tanner KE. A multi-component fiber-reinforced PHEMA-based hydrogel/HAPEXTM device for customized intervertebral disc prosthesis. J Biomater Appl. 2010;. doi: 10.1177/0885328209360933.
9. Ghiselli G, Wang JC, Bhatia NN, Hsu WK, Dawson EG. Adjacent segment degeneration in the lumbar spine. J Bone Joint Surg Am. 2004;86-A(7):1497-503.
10. Gillet P. The fate of the adjacent motion segments after lumbar fusion. J Spinal Disord Tech. 2003;16(4):338-45.
11. Park P, Garton HJ, Gala VC, Hoff JT, McGillicuddy JE. Adjacent segment disease after lumbar or lumbosacral fusion: review of the literature. Spine (Phila Pa 1976). 2004;29(17):1938-44.
12. Siepe CJ, Zelenkov P, Sauri-Barraza JC, Szeimies U, Grubinger T, Tepass A, et al. The fate of facet joint and adjacent level disc degeneration following total lumbar disc replacement: a prospective clinical, X-ray, and magnetic resonance imaging investigation. Spine (Phila Pa 1976). 2010;35(22):1991-2003. doi: 10.1097/BRS.0b013e3181d6f878.
13. Nyqvist C, Berg S, Tropp H, editors. Total disc replacement compared to lumbar fusion: a randomised controlled trial with five-year follow-up. ISASS 12; 2012; Barcelona.
14. Sakalkale DP, Bhagia SA, Slipman CW. A historical review and current perspective on the intervertebral disc prosthesis. Pain Physician. 2003;6(2):195-8.
15. Bao QB, Yuan HA. Artificial disc technology. Neurosurg Focus. 2000;9(4):e14.
16. van den Eerenbeemt KD, Ostelo RW, van Royen BJ, Peul WC, van Tulder MW. Total disc replacement surgery for symptomatic degenerative lumbar disc disease: a systematic review of the literature. Eur Spine J. 2010;19(8):1262-80. doi: 10.1007/s00586-010-1445-3.
17. van Ooij A, Oner FC, Verbout AJ. Complications of artificial disc replacement: a report of 27 patients with the SB charite disc. J Spinal Disord Tech. 2003;16(4):369-83.
18. Kurtz SM, Peloza J, Siskey R, Villarraga ML. Analysis of a retrieved polyethylene total disc replacement component. Spine J. 2005;5(3):344-50. doi: 10.1016/j.spinee.2004.11.011.
19. Guyer RD, Shellock J, MacLennan B, Hanscom D, Knight RQ, McCombe P, et al. Early failure of metal-on-metal artificial disc prostheses associated with lymphocytic reaction: diagnosis and treatment experience in four cases. Spine (Phila Pa 1976). 2011;36(7):E492-7. doi: 10.1097/BRS.0b013e31820ea9a2.
20. Cavanaugh DA, Nunley PD, Kerr EJ 3rd, Werner DJ, Jawahar A. Delayed hyper-reactivity to metal ions after cervical disc arthroplasty: a case report and literature review. Spine (Phila Pa 1976). 2009;34(7):E262-5. doi: 10.1097/BRS.0b013e318195dd60.
21. Berry MR, Peterson BG, Alander DH. A granulomatous mass surrounding a Maverick total disc replacement causing iliac vein occlusion and spinal stenosis: a case report. J Bone Joint Surg Am. 2010;92(5):1242-5. doi: 10.2106/jbjs.h.01625.
22. Kurtz SM, Edidin AA. Spine technology handbook. Amsterdam: Elsevier Academic Press; 2006.
23. Masuda K, Imai Y, Okuma M, Muehleman C, Nakagawa K, Akeda K, et al. Osteogenic protein-1 injection into a degenerated disc induces the restoration of disc height and structural changes in the rabbit anular puncture model. Spine (Phila Pa 1976). 2006;31(7):742-54. doi: 10.1097/01.brs.0000206358.66412.7b.
24. Bertram H, Kroeber M, Wang H, Unglaub F, Guehring T, Carstens C, et al. Matrix-assisted cell transfer for intervertebral disc cell therapy. Biochem Biophys Res Commun. 2005;331(4):1185-92. doi: 10.1016/j.bbrc.2005.04.034.
25. Vadala G, Sowa G, Hubert M, Gilbertson LG, Denaro V, Kang JD. Mesenchymal stem cells injection in degenerated intervertebral disc: cell leakage may induce osteophyte formation. J Tissue Eng Regen Med. 2011;. doi: 10.1002/term.433.
26. Scholz B, Kinzelmann C, Benz K, Mollenhauer J, Wurst H, Schlosshauer B. Suppression of adverse angiogenesis in an albumin-based hydrogel for articular cartilage and intervertebral disc regeneration. Eur Cell Mater. 2010;20:24-36; discussion-7.
27. Gloria A, Borzacchiello A, Causa F, Ambrosio L. Rheological characterization of hyaluronic acid derivatives as injectable materials toward nucleus pulposus regeneration. J Biomater Appl. 2012;26(6):745-59. doi: 10.1177/0885328210387174.
28. Revell PA, Damien E, Di Silvio L, Gurav N, Longinotti C, Ambrosio L. Tissue engineered intervertebral disc repair in the pig using injectable polymers. J Mater Sci Mater Med. 2007;18(2):303-8. doi: 10.1007/s10856-006-0693- 6.
29. Vernengo J, Fussell GW, Smith NG, Lowman AM. Synthesis and characterization of injectable bioadhesive hydrogels for nucleus pulposus replacement and repair of the damaged intervertebral disc. J Biomed Mater Res B Appl Biomater. 2010;93(2):309-17. doi: 10.1002/jbm.b.31547.
30. Berlemann U, Schwarzenbach O. An injectable nucleus replacement as an adjunct to microdiscectomy: 2 year follow-up in a pilot clinical study. Eur Spine J. 2009;18(11):1706-12. doi: 10.1007/s00586-009-1136-0.
31. Lindley EM, Jaafar S, Noshchenko A, Baldini T, Nair DP, Shandas R, et al. Nucleus replacement device failure: a case report and biomechanical study. Spine (Phila Pa 1976). 2010;35(22):E1241-7. doi: 10.1097/BRS.0b013e3181dfbc78.
32. Baumgartner W, inventor US Patent 5171280: intervertebral prosthesis. 1992.
33. Shimamura Y, Holding C, Haynes DR, Vernon-Roberts B, Blumbergs PC, Fraser RD, et al. The biologic response to particles from a potential disc prosthesis material. Spine (Phila Pa 1976). 2008;33(4):351-5. doi: 10.1097/BRS. 0b013e318163f323.
34. Zollner J, Eysel P, inventors; US6520992: utilization of an autopolymerizing organosiloxane-based compound. 2003.
35. Larraz E, Elvira C, Fernandez M, Parra J, Collia F, Lopez-Bravo A, et al. Self-curing acrylic formulations with applications in intervertebral disk restoration: drug release and biological behaviour. J Tissue Eng Regen Med. 2007;1(2):120-7. doi: 10.1002/term.10.
36. Larraz E, Elvira C, Roman JS. Design and properties of novel self-curing acrylic formulations for application in intervertebral disks restoration. Biomacromolecules. 2005;6(4):2058-66. doi: 10.1021/bm050055z.
37. 3 for intervertebral disk augmentation. J Biomed Mater Res B Appl Biomater. 2010;95(1):75-83.
38. Tsantrizos A, Ordway NR, Myint K, Martz E, Yuan HA. Mechanical and biomechanical characterization of a polyurethane nucleus replacement device injected and cured in situ within a balloon. SAS J. 2008;2(1):28-39.
39. Peebles DJ, Ellis RH, Stride SD, Simpson BR. Cardiovascular effects of methylmethacrylate cement. Br Med J. 1972;1(5796):349-51.
40. Nomura Y, Teshima W, Kawahara T, Tanaka N, Ishibashi H, Okazaki M, et al. Genotoxicity of dental resin polymerization initiators in vitro. J Mater Sci Mater Med. 2006;17(1):29-32. doi: 10.1007/s10856-006-6326-2.
41. Blattert TR, Jestaedt L, Weckbach A. Suitability of a calcium phosphate cement in osteoporotic vertebral body fracture augmentation: a controlled, randomized, clinical trial of balloon kyphoplasty comparing calcium phosphate versus polymethylmethacrylate. Spine (Phila Pa 1976). 2009;34(2):108-14. doi: 10.1097/BRS.0b013e31818f8bc1.
42. Li S, Chien S, Branemark PI. Heat shock-induced necrosis and apoptosis in osteoblasts. J Orthop Res. 1999;17(6):891-9. doi: 10.1002/jor.1100170614.
43. ISO10993. Biological evaluation of medical devices: international organization for standardization. 2001.
44. Ahrens M, Tsantrizos A, Donkersloot P, Martens F, Lauweryns P, Le Huec JC, et al. Nucleus replacement with the DASCOR disc arthroplasty device: interim two-year efficacy and safety results from two prospective, non-randomized multicenter European studies. Spine (Phila Pa 1976). 2009;34(13):1376-84. doi: 10.1097/BRS.0b013e3181a3967f.
45. Lewis G. Injectable bone cements for use in vertebroplasty and kyphoplasty: state-of-the-art review. J Biomed Mater Res B Appl Biomater. 2006;76(2):456-68. doi: 10.1002/jbm.b.30398.
46. Lewis G, Mladsi S. Effect of sterilization method on properties of Palacos R acrylic bone cement. Biomaterials. 1998;19(1-3):117-24.
47. del Valle S, Mino N, Munoz F, Gonzalez A, Planell JA, Ginebra MP. In vivo evaluation of an injectable macroporous calcium phosphate cement. J Mater Sci Mater Med. 2007;18(2):353-61. doi: 10.1007/s10856-006-0700-y.
48. Takagi S, Chow LC, Hirayama S, Sugawara A. Premixed calcium-phosphate cement pastes. J Biomed Mater Res B Appl Biomater. 2003;67(2):689-96.
49. Gbureck U, Dembski S, Thull R, Barralet JE. Factors influencing calcium phosphate cement shelf-life. Biomaterials. 2005;26(17):3691-7. doi: 10.1016/j.biomaterials.2004.09.036.
50. Eckel TS, Olan W. Vertebroplasty and vertebral augmentation techniques. Tech Vasc Interv Radiol. 2009;12(1):44-50.
51. Dang L, Wardlaw D, Hukins DW. Removal of nucleus pulposus from the intervertebral disc - the use of chymopapain enhances mechanical removal with rongeurs: a laboratory study. BMC Musculoskelet Disord. 2007;8:122. doi: 10.1186/1471-2474-8-122.
52. Sherman J, Horton C, Norton B, editors. Initial cadaver evaluation of a mechanical nucleus removal device. Annual Meeting of the Spine Arthroplasty Society; 2008; Miami Beach, FL.
53. Carrodeguas RG, Lasa BV, Del Barrio JS. Injectable acrylic bone cements for vertebroplasty with improved properties. J Biomed Mater Res B Appl Biomater. 2004;68(1):94-104. doi: 10.1002/jbm.b.20007.
54. Gbureck U, Spatz K, Thull R, Barralet JE. Rheological enhancement of mechanically activated alpha-tricalcium phosphate cements. J Biomed Mater Res B Appl Biomater. 2005;73(1):1-6. doi: 10.1002/jbm.b.30148.
55. Loeffel M, Heini PF, Bouduban N, Burger J, Nolte LP, Kowal J. Development of a computer-assisted high-pressure injection device for vertebroplasty. IEEE Trans Biomed Eng. 2007;54(11):2051-6. doi: 10.1109/TBME.2007.894964.
56. Unosson E. Mechanical properties and spreading characteristics of bone cement for spinal applications. Luleå: Luleå University of Technology; 2010.
57. ASTM F 451-08. Standard specification for acrylic bone cement. American Society for Testing and Materials; 2008.
58. ASTM C 266-99. Standard test method for time of setting of hydraulic-cement paste by Gillmore needles. American Society for Testing and Materials; 1999.
59. Morgan EF, Yetkinler DN, Constantz BR, Dauskardt RH. Mechanical properties of carbonated apatite bone mineral substitute: strength, fracture and fatigue behaviour. J Mater Sci Mater Med. 1997;8(9):559-70.
60. Scuderi GJ, Brusovanik GV, Campbell DR, Henry RP, Kwon B, Vaccaro AR. Evaluation of non-lead-based protective radiological material in spinal surgery. Spine J. 2006;6(5):577-82. doi: 10.1016/j.spinee.2005.09.010.
61. Boelen EJ, Lewis G, Xu J, Slots T, Koole LH, van Hooy-Corstjens CS. Evaluation of a highly-radiopaque iodine-containing acrylic bone cement for use in augmentation of vertebral compression fractures. J Biomed Mater Res A. 2008;86(1):76-88. doi: 10.1002/jbm.a.31601.
62. Lewis G, Towler MR, Boyd D, German MJ, Wren AW, Clarkin OM, et al. Evaluation of two novel aluminum-free, zinc-based glass polyalkenoate cements as alternatives to PMMA bone cement for use in vertebroplasty and balloon kyphoplasty. J Mater Sci Mater Med. 2009;. doi: 10.1007/s10856-009-3845-7.
63. López A, Montazerolghaem M, Ott M, Engqvist H, Persson C. Strontium halides as degradable radiopacifiers. GRIBOI; Uppsala: European Cells and Materials; 2012. S3, p. 45.
64. Johannessen W, Elliott DM. Effects of degeneration on the biphasic material properties of human nucleus pulposus in confined compression. Spine (Phila Pa 1976). 2005;30(24):E724-9.
65. Guerin HA, Elliott DM. Degeneration affects the fiber reorientation of human annulus fibrosus under tensile load. J Biomech. 2006;39(8):1410-8. doi: 10.1016/j.jbiomech.2005.04.007.
66. Wilke H-J, Neef P, Caimi M, Hoogland T, Claes LE. New in vivo measurements of pressures in the intervertebral disc in daily life. Spine. 1999;24(8):755-62.
67. ASTM F2423: Standard guide for functional, kinematic, and wear assessment of total disc prostheses; 2005.
68. ISO 18192. Implants for surgery - wear of total intervertebral spinal disc prostheses - part 1: loading and displacement parameters for wear testing and corresponding environmental conditions for test; 2008.
69. ASTM F2118-03. Standard test method for constant amplitude of force controlled fatigue testing of acrylic bone cement materials; 2009.
70. Hulme PA, Boyd SK, Ferguson SJ. Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone. 2007;41(6):946-57. doi: 10.1016/j.bone.2007.08.019.
71. ISO5833. Implants for surgery - acrylic resin cements. The International Organization for Standardization; 2002.
72. Zhang Z, Kuijer R, Bulstra SK, Grijpma DW, Feijen J. The in vivo and in vitro degradation behavior of poly(trimethylene carbonate). Biomaterials. 2006;27(9):1741-8. doi: 10.1016/j.biomaterials.2005.09.017.
73. Engstrand J, López A, Engqvist H, Persson C. Polyhedral oligomeric silsesquioxane (POSS) - poly(ethylene glycol) (PEG) hybrids as injectable biomaterials. Biomed Mater. 2012;7(3). doi: 10.1088/1748-6041/7/3/035013.