Chemical, biochemical and microbiological properties of a brominated nitrovinylfuran with broad-spectrum antibacterial activity

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 3, 2013, Pages 795-804

  Scholz, Therese ^a   Heyl, Carina L ^a   Bernardi, Dan ^b   Zimmermann, Stefan ^c   Kattner, Lars ^b   Klein, Christian D ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Endotherm Life Science Molecules   (Germany)

^c UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Antibacterial agent; Degradation mechanism; Drug resistance; HPLC; Inhibition; MurA enzyme; Nitrovinylfuran; Stability

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL PROTEIN; BROMINATED NITROVINYLFURAN DERIVATIVE; CNICIN; CYSTEINE; FOSFOMYCIN; FURAN DERIVATIVE; METHIONYL AMINOPEPTIDASE; PROTEIN MURA; THIOL; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DISULFIDE BOND; DRUG CYTOTOXICITY; DRUG HALF LIFE; DRUG POTENCY; DRUG SELECTIVITY; EMBRYO; ENZYME INHIBITION; ESCHERICHIA COLI; HUMAN; HUMAN CELL; IC 50; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PSEUDOMONAS AERUGINOSA;

ANTI-BACTERIAL AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; NITROFURANS; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS); METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS;

EID: 84872355938     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.11.018     Document Type: Article

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