Time-of-flight secondary ion mass spectrometry (TOF-SIMS) imaging reveals cholesterol overload in the cerebral cortex of Alzheimer disease patients

Acta Neuropathologica

Volumn 125, Issue 1, 2013, Pages 133-144

  Lazar, Adina N ^a,b   Bich, Claudia ^c   Panchal, Maï ^a,b   Desbenoit, Nicolas ^c   Petit, Vanessa W ^d   Touboul, David ^c   Dauphinot, Luce ^b   Marquer, Catherine ^b   Laprévote, Olivier ^e   Brunelle, Alain ^c   Duyckaerts, Charles ^a,b  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^c CNRS   (France)

^d INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^e FACULTÉ DES SCIENCES PHARMACEUTIQUES ET BIOLOGIQUES   (France)

Author keywords

Alzheimer disease; Cholesterol; Neurofibrillary tangles; Senile plaques; TOF SIMS imaging

Indexed keywords

APOLIPOPROTEIN E; CHOLESTEROL;

AGED; ALZHEIMER DISEASE; ANIMAL TISSUE; APOLIPOPROTEIN E GENE; ARTICLE; BRAIN CORTEX; BRAIN LEVEL; CONTROLLED STUDY; FEMALE; GENE; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; LIPID ANALYSIS; LIPID STORAGE; MALE; MOLECULAR IMAGING; MOUSE; NEUROFIBRILLARY TANGLE; NONHUMAN; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; SENILE PLAQUE; SUPERIOR TEMPORAL GYRUS; TIME OF FLIGHT MASS SPECTROMETRY; TIME OF FLIGHT SECONDARY ION MASS SPECTROMETRY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; CEREBRAL CORTEX; CHOLESTEROL; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROFIBRILLARY TANGLES; NEUROIMAGING; PLAQUE, AMYLOID; SPECTROMETRY, MASS, SECONDARY ION;

EID: 84872340627     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-012-1041-1     Document Type: Article

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