Exposure study to examine chemosensory effects of formaldehyde on hyposensitive and hypersensitive males

International Archives of Occupational and Environmental Health

Volumn 86, Issue 1, 2013, Pages 107-117

  Mueller, Joerg U ^a   Bruckner, Thomas ^b   Triebig, Gerhard ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

Carbon dioxide; Chemosensory effect; Exposure; Formaldehyde; Hypersensitive; Sensitivity; Sensory irritation

Indexed keywords

FORMALDEHYDE; IRRITANT AGENT;

ADULT; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; EYE; FEMALE; HUMAN; MALE; NOSE; RANDOMIZED CONTROLLED TRIAL;

ADULT; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE; FEMALE; FORMALDEHYDE; HUMANS; IRRITANTS; MALE; NOSE;

EID: 84872338387     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-012-0745-9     Document Type: Article

References (59)

1. Alarie Y (1973) Sensory irritation by airborne chemicals. CRC Crit Rev Toxicol 2(3):299-363
2. Andersen I, Mølhave L (1983) Controlled human studies with formaldehyde. In: Gibson JE (ed) Formaldehyde toxicity. Hemisphere, Washington DC, pp 154-165
3. 2 pulses applied to the nasal mucosa. Pain 49(1):53-60
4. Arts JH, Rennen MA, de Heer C (2006a) Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity. Regul Toxicol Pharmacol 44(2):144-160
5. Arts JH, de Heer C, Woutersen RA (2006b) Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. Int Arch Occup Environ Health 79(4):283-298
6. Arts JH, Muijser H, Kuper CF, Woutersen RA (2008) Setting an indoor air exposure limit for formaldehyde: factors of concern. Regul Toxicol Pharmacol 52(2):189-194
7. Basu PK, Pimm PE, Shephard RJ, Silverman F (1978) The effect of cigarette smoke on the human tear film. Can J Ophthalmol 13(1):22-26
8. Baudouin C, Labbe A, Liang H, Pauly A, Brignole-Baudouin F (2010) Preservatives in eyedrops: the good, the bad and the ugly. Prog Retin Eye Res 29(4):312-334
9. Breivik EK, Bjornsson GA, Skovlund E (2000) A comparison of pain rating scales by sampling from clinical trial data. Clin J Pain 16(1):22-28
10. Carney AS, Bateman ND, Jones NS (2000) Reliable and reproducible anterior active rhinomanometry for the assessment of unilateral nasal resistance. Clin Otolaryngol Allied Sci 25(6):499-503
11. Cometto-Muniz JE, Noriega G (1985) Gender differences in the perception of pungency. Physiol Behav 34(3):385-389
12. Dalton P (2003) Upper airway irritation, odor perception and health risk due to airborne chemicals. Toxicol Lett 140-141:239-248
13. Doty RL, Cometto-Muniz JE, Jalowayski AA, Dalton P, Kendal-Reed M, Hodgson M (2004) Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit Rev Toxicol 34(2):85-142
14. 2 irritation in cigarette smokers. J Appl Toxicol 2(3):176-178
15. Emmen HH, Muijser H, Arts JH, Prinsen MK (2003) Human volunteer study with PGME: eye irritation during vapour exposure. Toxicol Lett 140-141:249-259
16. Gamberale F (1989) Critical issues in the study of the acute effects of solvent exposure. Neurotoxicol Teratol 11(6):565-570
17. Garcia Medina MR, Cain WS (1982) Bilateral integration in the common chemical sense. Physiol Behav 29(2):349-353
18. Holdgate A, Asha S, Craig J, Thompson J (2003) Comparison of a verbal numeric rating scale with the visual analogue scale for the measurement of acute pain. Emerg Med (Fremantle) 15(5-6):441-446
19. Hummel T, Livermore A (2002) Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfaction. Int Arch Occup Environ Health 75(5):305-313
20. Hummel T, Roscher S, Jaumann MP, Kobal G (1996) Intranasal chemoreception in patients with multiple chemical sensitivities: a double-blind investigation. Regul Toxicol Pharmacol 24(1 Pt 2):S79-S86
21. Iannilli E, Del Gratta C, Gerber JC, Romani GL, Hummel T (2008) Trigeminal activation using chemical, electrical, and mechanical stimuli. Pain 139(2):376-388
22. Ihrig A, Hoffmann J, Triebig G (2006) Examination of the influence of personal traits and habituation on the reporting of complaints at experimental exposure to ammonia. Int Arch Occup Environ Health 79(4):332-338
23. Iregren A, Gamberale F, Kjellberg A (1996) SPES: a psychological test system to diagnose environmental hazards. Swedish Performance Evaluation System. Neurotoxicol Teratol 18(4):485-491
24. Johanson G, Nihlen A, Lof A (1995) Toxicokinetics and acute effects of MTBE and ETBE in male volunteers. Toxicol Lett 82-83:713-718
25. Joyce CR, Zutshi DW, Hrubes V, Mason RM (1975) Comparison of fixed interval and visual analogue scales for rating chronic pain. Eur J Clin Pharmacol 8(6):415-420
26. Kiesswetter E, Thriel C, Schaper M, Blaszkewicz M, Seeber A (2005) Eye blinks as indicator for sensory irritation during constant and peak exposures to 2-ethylhexanol. Environ Toxicol Pharmacol 19(3):531-541
27. Kleinbeck S, Juran SA, Kiesswetter E, Schaper M, Blaszkewicz M, Bruning T, van Thriel C (2008) Evaluation of ethyl acetate on three dimensions: investigation of behaviorial, physiological and psychological indicators of adverse chemosensory effects. Toxicol Lett 182(1-3):102-109
28. Kobal G (1985) Pain-related electrical potentials of the human nasal mucosa elicited by chemical stimulation. Pain 22(2):151-163
29. Krohne HW, Egloff B, Kohlmann C-W, Tausch A (1996) Untersuchungen mit einer deutschen Version der "Positive and negative affect schedule" (PANAS). Diagnostica 42(2):139-156
30. Kulle TJ, Sauder LR, Hebel JR, Green DJ, Chatham MD (1987) Formaldehyde dose-response in healthy nonsmokers. JAPCA 37(8):919-924
31. Lang I, Bruckner T, Triebig G (2008) Formaldehyde and chemosensory irritation in humans: a controlled human exposure study. Regul Toxicol Pharmacol 50(1):23-36
32. Monster AW, Chan HC, O'Connor D (1978) Long-term trends in human eye blink rate. Biotelem Patient Monit 5(4):206-222
33. Nakamori K, Odawara M, Nakajima T, Mizutani T, Tsubota K (1997) Blinking is controlled primarily by ocular surface conditions. Am J Ophthalmol 124(1):24-30
34. Nihlen A, Walinder R, Lof A, Johanson G (1998) Experimental exposure to methyl tertiary-butyl ether. II. Acute effects in humans. Toxicol Appl Pharmacol 148(2):281-287
35. Nojgaard JK, Christensen KB, Wolkoff P (2005) The effect on human eye blink frequency of exposure to limonene oxidation products and methacrolein. Toxicol Lett 156(2):241-251
36. Norback D, Wieslander G (2002) Biomarkers and chemosensory irritations. Int Arch Occup Environ Health 75(5):298-304
37. Paustenbach D, Alarie Y, Kulle T, Schachter N, Smith R, Swenberg J, Witschi H, Horowitz SB (1997) A recommended occupational exposure limit for formaldehyde based on irritation. J Toxicol Environ Health 50(3):217-263
38. Price DD, Bush FM, Long S, Harkins SW (1994) A comparison of pain measurement characteristics of mechanical visual analogue and simple numerical rating scales. Pain 56(2):217-226
39. SCOEL (2008) (Scientific Committee on Occupational Exposure Limits). Recommendation from the Scientific Committee on Occupational Exposure Limits for formaldehyde 50-00-0; http://ec.europa.eu/social/keyDocuments.jsp?type= 0&policyArea=82&subCategory=153&country=0&year= 0&advSearchKey=formaldehyde&mode=advancedSubmit&langId=en. Accessed Jan 2012
40. Seeber A, Demes P, Golka K, Kiesswetter E, Schaper M, van Thriel C, Zupanic M (2000) Subjective symptoms due to solvent mixtures, dioxin, and toluene: impact of exposure versus personality factors. Neurotoxicology 21(5):677-684
41. Seeber A, van Thriel C, Haumann K, Kiesswetter E, Blaszkewicz M, Golka K (2002) Psychological reactions related to chemosensory irritation. Int Arch Occup Environ Health 75(5):314-325
42. Shusterman D, Avila PC (2003) Real-time monitoring of nasal mucosal pH during carbon dioxide stimulation: implications for stimulus dynamics. Chem Senses 28(7):595-601
43. Shusterman D, Balmes J (1997a) Measurement of nasal irritant sensitivity to pulsed carbon dioxide: a pilot study. Arch Environ Health 52(5):334-340
44. Shusterman D, Balmes J (1997b) A comparison of two methods for determining nasal irritant sensitivity. Am J Rhinol 11(5):371-378
45. Stevens JC, Cain WS (1986) Aging and the perception of nasal irritation. Physiol Behav 37(2):323-328
46. 2). Toxicol Lett 196(1):42-50
47. Watson D (1988) Intraindividual and interindividual analyses of positive and negative affect: their relation to health complaints, perceived stress, and daily activities. J Pers Soc Psychol 54(6):1020-1030
48. Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54(6):1063-1070
49. Weber-Tschopp A, Fischer T, Grandjean E (1977) Irritating effects of formaldehyde on man (author's transl). Int Arch Occup Environ Health 39(4):207-218
50. Wieslander G, Norback D, Nordstrom K, Walinder R, Venge P (1999) Nasal and ocular symptoms, tear film stability and biomarkers in nasal lavage, in relation to building-dampness and building design in hospitals. Int Arch Occup Environ Health 72(7):451-461
51. Wilson WS, Duncan AJ, Jay JL (1975) Effect of benzalkonium chloride on the stability of the precorneal tear film in rabbit and man. Br J Ophthalmol 59(11):667-669
52. Wolkoff P, Nielsen GD (2010) Non-cancer effects of formaldehyde and relevance for setting an indoor air guideline. Environ Int 36(7):788-799
53. Wolkoff P, Skov P, Franck C, Petersen LN (2003) Eye irritation and environmental factors in the office environment - hypotheses, causes and a physiological model. Scand J Work Environ Health 29(6):411-430
54. Wolkoff P, Nojgaard JK, Troiano P, Piccoli B (2005) Eye complaints in the office environment: precorneal tear film integrity influenced by eye blinking efficiency. Occup Environ Med 62(1):4-12
55. Wyon NM, Wyon DP (1987) Measurement of acute response to draught in the eye. Acta Ophthalmol (Copenh) 65(4):385-392
56. Yang X, Zhang YP, Chen D, Chen WG, Wang R (2001) Eye irritation caused by formaldehyde as an indoor air pollution-a controlled human exposure experiment. Biomed Environ Sci 14(3):229-236
57. Zeller J, Neuss S, Mueller JU, Kuhner S, Holzmann K, Hogel J, Klingmann C, Bruckner T, Triebig G, Speit G (2011a) Assessment of genotoxic effects and changes in gene expression in humans exposed to formaldehyde by inhalation under controlled conditions. Mutagenesis 26(4):555-561
58. Zeller J, Ulrich A, Mueller JU, Riegert C, Neuss S, Bruckner T, Triebig G, Speit G (2011b) Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity? Mutat Res 723(1):11-17
59. Ziegler AE, Zimmer H, Triebig G (2008) Exposure study on chemosensory effects of epsilon-caprolactam in the low concentration range. Int Arch Occup Environ Health 81(6):743-753