Intranasal chemosensory function of the trigeminal nerve and aspects of its relation to olfaction

International Archives of Occupational and Environmental Health

Volumn 75, Issue 5, 2002, Pages 305-313

  Hummel, Thomas ^a   Livermore, Andrew ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b CHARLES STURT UNIVERSITY   (Australia)

Author keywords

Chemosensory; Electrophysiology; Human; Irritation; Psychophysiology

Indexed keywords

CAPSAICIN; CHEMICAL AGENT; LIDOCAINE; NICOTINE DERIVATIVE;

AGING; ANATOMY; CHEMOSENSITIVITY; DRUG EFFECT; ELECTROPHYSIOLOGY; GENDER; HEALTH STATUS; HUMAN; NEUROPHYSIOLOGY; NONHUMAN; ODOR; OLFACTORY RECEPTOR; OLFACTORY SYSTEM; PERCEPTION; PHYSIOLOGY; PREDICTION; REVIEW; SEX DIFFERENCE; SMELLING; TRIGEMINAL NERVE;

AGING; FEMALE; HUMANS; MALE; NOSE; ODORS; SEX FACTORS; SMELL; TRIGEMINAL NERVE;

EID: 0036626661     PISSN: 03400131     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00420-002-0315-7     Document Type: Review

References (118)

1. Adriaensen H, Gybels J, Handwerker HO, Van Hees J (1983) Response properties of thin myelinated (A-delta) fibers in human skin nerves. J Neurophysiol 49:111-122
2. Alimohammadi H, Silver WL (2000) Evidence for nicotinic acetylcholine receptors on nasal trigeminal nerve endings of the rat. Chem Senses 25:61-66
3. Anton F, Peppel P (1991) Central projections of trigeminal primary afferents innervating the nasal mucosa: A horseradish peroxidase study in the rat. Neuroscience 41:617-628
4. 2 pulses applied to the nasal mucosa. Neurosci Lett 123:208-211
5. 2 pulses applied to the nasal mucosa. Pain 49:53-60
6. Barnett EM, Evans GD, Sun N, Perlman S, Cassell MD (1995) Anterograde tracing of trigeminal afferent pathways from the murine tooth pulp to cortex using herpes simplex virus type I. J Neuroscience 15:2972-2984
7. Bernard JF, Peschanski M, Besson JM (1989) A possible spino (trigemino)-ponto-amygdaloid pathway for pain. Neurosci Lett 100:83-88
8. Bevan S, Yeats J (1991) Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones. J Physiol 433:145-161
9. Bevan S, Forbes CA, Winter J (1993) Protons and capsaicin activate the same ion channels in rat isolated ganglion neurones. J Physiol 459:401P
10. Bouvet JF, Delaleu JC, Holley A (1987) Olfactory receptor cell function is affected by trigeminal nerve activity. Neurosci Lett 77:181-186
11. Bouvet JF, Delaleu JC, Holley A (1988) The activity of olfactory receptor cells is affected by acetylcholine and substance P. Neurosci Res 5:214-223
12. Cain WS (1976) Olfaction and the common chemical sense: Some psychophysical contrasts. Sens Process 1:57-67
13. Cain WS (1977) Bilateral interaction in olfaction. Nature 268:50-53
14. Cain WS (1982) Odor identification by males and females: Prediction vs. performance. Chem Senses 7:129-142
15. Cain WS, Murphy C (1980) Interaction between chemoreceptive modalities of odor and irritation. Nature 284:255-257
16. Caterina MJ, Julius D (1999) Sense and specificity: A molecular identity for nociceptors. Curr Opin Neurobiol 9:525-930
17. Caterina MJ, Leffler A, Malmberg AB, Martin WJ, Trafton J, Petersen-Zeitz KR, Koltzenburg M, Basbaum AI, Julius D (2000) Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288:306-313
18. Chakour MC, Gibson SJ, Bradbeer M, Helme RD (1996) The effect of age on A delta- and C-fibre thermal pain perception. Pain 64:143-152
19. Chen X, Belmonte C, Rang HP (1997) Capsaicin and carbon dioxide act by distinct mechanisms on sensory nerve terminals in the cat cornea. Pain 70:23-29
20. Chudler EH, Dong WK, Kawakami Y (1985) Tooth pulp evoked potentials in the monkey: Cortical surface and intracortical distribution. Pain 22:221-223
21. Cometto-Muñiz E, Cain WS (1984) Temporal integration of pungency. Chem Senses 8:315-327
22. Cometto-Muñiz JE, Cain WS, Abraham MH (1998) Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp Brain Res 118:180-188
23. Cometto-Muñiz JE, Cain WS, Abraham MH, Kumarsingh R (1998) Sensory properties of selected terpenes. Thresholds for odor, nasal pungency, nasal localization, and eye irritation. Ann N Y Acad Sci 855:648-651
24. Cometto-Muñiz JE, Cain WS, Hudnell HK (1997) Agonistic effects of airborne chemicals in mixtures: Odor, nasal pungency, and eye irritation. Percept Psychophys 59:665-674
25. 2 pungency and taste. Perception 16:629-640
26. Cometto-Muñiz JE, Hernandez SM (1990) Odorous and pungent attributes of mixed and unmixed odorants. Percept Psychophys 47:391-399
27. Doty RL (1995) The Smell Identification Test Administration Manual, 3rd edn. Sensonics Inc, Haddon Heights, New Jersey, USA
28. Doty RL, Bromley SM, Moberg PJ, Hummel T (1997) Laterality in human nasal chemoreception. In: Christman S (ed) Cerebral Asymmetries in Sensory and Perceptual Processing. North Holland Publishing, Amsterdam, pp 497-542
29. Doty RL, Brugger WPE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD (1978) Intranasal trigeminal stimulation from odorous volatiles: Psychometric responses from anosmic and normal humans. Physiol Behav 20:175-185
30. 2 irritation in cigarette smokers. J Appl Toxicol 2:176-178
31. Elsberg CA, Levy O, Brewer ED (1935) The sense of smell VI. The trigeminal effects of odorous substances. Bull Neurol Inst N Y 4:270-285
32. Finger TE, Getchell ML, Getchell TV, Kinnamon JC (1990) Affector and effector functions of peptidergic innervation of the nasal cavity. In: Green BG, Mason JR, Kare MR (eds) Chemical Senses: Irritation. Marcell Dekker, New York, pp 1-20
33. Fröhlich R (1851) Ueber einige Modificationen des Geruchsinnes. Akad Wiss Wien, Math-Nat CL 6:322-328
34. Garcia Medina MR, Cain WS (1982) Bilateral integration in the common chemical sense. Physiol Behav 29:349-353
35. Getchell ML, Bouvet JF, Finger TE, Holley A, Getchell TV (1989) Peptidergic regulation of secretory activity in the amphibian olfactory mucosa: Immunohistochemistry, neural stimulation and pharmacology. Cell Tissue Res 256:381-389
36. Green BG, Lawless HT (1991) The psychophysics of somatosensory chemoreception in the nose and mouth. In: Getchell TV, R.L. D, Bartoshuk LM, Snow JBJ (eds) Smell and Taste in Health and Disease. Raven Press, New York, pp 235-253
37. Gudziol H, Gramowski KH (1987) Respirations-olfakto-metrie-eine objektivierende method zur quantitativen bewertung einer hyposmie. Laryngol Rhinol Otol 66:570-572
38. Gudziol H, Schubert M, Hummel T (2001) Decreased trigeminal sensitivity in anosmia. ORL J Otorhinolaryngol Relat Spec 63:72-75
39. Handwerker H, Kobal G (1993) Psychophysiology of experimentally induced pain. Physiol Rev 73:639-671
40. Handwerker HO, Anton F, Reeh PW (1987) Discharge patterns of afferent cutaneous nerve fibers from the rat's tail during prolonged noxious mechanical stimulation. Brain Res 65:493-504
41. Handwerker HO, Iggo A, Zimmermann M (1975) Segmental and supraspinal actions on dorsal horn neurons responding to noxious and non-noxious skin stimuli. Pain 1:147-165
42. 4 irrigation on olfactory and trigeminal cues. Physiol Behav 55:699-704
43. 2 stimulation of the human nasal mucosa. Pain 72:145-151
44. Harkins SW, Davis MD, Bush FM, Kasberger J (1996) Suppression of first pain and slow temporal summation of second pain in relation to age. J Gerontol 51A:M260-M265
45. Harkins SW, Price DD, Katz MA (1983) Are cerebral evoked potentials reliable indices of first or second pain? In: Bonica JJ, Lindblom U, Iggo A (eds) Advances in Pain Research and Therapy, vol. 5 Raven Press, New York, pp 185-191
46. Henton WW, Smith JC, Tucker D (1969) Odor discrimination in pigeons following section of the olfactory nerves. J Comp Physiol Psychol 69:317-323
47. Holley A, Bouvet JF, Delaleu JC (1991) Evidence for interactions between trigeminal afferents and olfactory receptor cells in the amphibian olfactory mucosa. In: Green BG, Mason JR, Kare MR (eds) Chemical Senses, vol 2, Irritation. Marcell Dekker, New York, pp 61-67
48. Hoshino T, Usui N (1987) Objective olfactometry by the method of recordings of respiratory resistances. Jibiinkoka 90:516-522
49. Hummel T, Barz S, Lötsch J, Roscher S, Kettenmann B, Kobal G (1996) Loss of olfactory function leads to a decrease of trigeminal sensitivity. Chem Senses 21:75-79
50. Hummel T, Barz S, Pauli E, Kobal G (1998) Chemosensory event-related potentials change as a function of age. Electroencephalogr Clin Neurophysiol 108:208-217
51. Hummel T, Dalton P, Dilks DD (1999) Effects of exposure to irritants. Soc Neurosci Abstr 25:2187
52. Hummel T, Gruber M, Pauli E, Kobal G (1994) Event-related potentials in response to repetitive painful stimulation. Electroencephalogr Clin Neurophysiol 92:426-432
53. Hummel T, Kobal G (1999) Chemosensory event-related potentials to trigeminal stimuli change in relation to the interval between repetitive stimulation of the nasal mucosa. Eur Arch Otorhinolaryngol 256:16-21
54. Hummel T, Kraetsch H-G, Pauli E, Kobal G (1998) Responses to nasal irritation obtained from the human nasal mucosa. Rhinology 36:168-172
55. Hummel T, Livermore A, Hummel C, Kobal G (1992) Chemosensory event-related potentials in man: Relation to olfactory and painful elicited by nicotine. Electroencephalogr Clin Neurophysiol 84:192-195
56. Hummel T, Pauli E, Stefan H, Kettenmann B, Schüler P, Kobal G (1995) Chemosensory event-related potentials in patients with temporal lobe epilepsy. Epilepsia 36:79-85
57. Hummel T, Rothbauer C, Pauli E, Kobal G (1998) Effects of the decongestant oxymetazoline on human olfactory and intranasal trigeminal function in acute rhinitis. Eur J Clin Pharmacol 54:521-528
58. Hummel T, Schiessl C, Wendler J, Kobal G (1996) Peripheral electrophysiological responses decrease in response to repetitive painful stimulation of the human nasal mucosa. Neurosci Lett 212:37-40
59. Hummel T, Sekinger B, Wolf SR, Pauli E, Kobal G (1997) "Sniffin' sticks": Olfactory performance assessed by the combined testing of odor identification, odor discrimination and olfactory threshold. Chem Senses 22:39-52
60. Hummel T, Yousem DM, Alsop DC, Geckle RJ, Doty RL (1997) Functional MRI of olfactory and intranasal chemosensory trigeminal nerve activation. Soc Neurosci Abstr 23:2076
61. 2 stimulation of nasal mucosa: A magnetoencephalographic study in man. Electroencephalogr Clin Neurophysiol 64:347-349
62. Inokuchi A, Kimmelmann CP, Snow JB (1993) Convergence of olfactory and nasotrigeminal inputs on possible trigeminal contributions to olfactory responses in rat thalamus. Eur Arch Otorhinolarygnol 249:473-477
63. Jones-Gotman M, Zatorre RJ (1993) Odor recognition memory in humans: Role of right temporal and orbitofrontal regions. Brain Cogn 22:182-198
64. Kelly JP, Dodd J (1991) Trigeminal system. In: Kandel ER, Schwartz JH, Jessell TM (eds) Principles of Neural Science. Elsevier, New York, pp 701-710
65. Kendall-Reed M, Walker JC (1996) Human respiratory responses to odorants. Chem Senses 21:486
66. Kendall-Reed M, Walker JC (1998) Human respiratory responses to irritants. Talk presented at the "Workshop on Sensory Irritation", 8-9 May 1998, Center for Indoor Air Research, Sea Lodge, La Jolla, California, USA
67. Kenshalo DR (1986) Somesthetic sensitivity in young and elderly humans. J Gerontol 41:732-742
68. Kettenmann B, Hummel C, Stefan H, Kobal G (1996) Magnetoencephalographical recordings: Separation of cortical responses to different chemical stimulation in man. Funct Neurosci (EEG Suppl) 46:287-290
69. Kirk-Smith MD, Booth DA (1987) Chemoreception in human behaviour: An experimental analysis of the social effects of fragrances. Chem Senses 12:159-166
70. Kobal G (1981) Elektrophysiologische Untersuchungen des Menschlichen Geruchssinns. Thieme, Stuttgart
71. Kobal G, Hummel C (1988) Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroencephalogr Clin Neurophysiol 71:241-250
72. Kobal G, Hummel T (1988) Effects of flupirtine on the pain-related evoked potential and the spontaneous EEG. Agents Actions 23 1/2:117-119
73. Kobal G, Hummel T (1989) Brain responses to chemical stimulation of the trigeminal nerve in man. In: Green BG, Mason JR, Kare MR (eds) Chemical Senses, vol 2, Irritation Marcel-Dekker, New York, pp 123-139
74. Koelega HS, Köster EP (1974) Some experiments on sex differences in odor perception. Ann N Y Acad Sci 237:234-246
75. Komai M, Bryant BP (1993) Acetazolamide specifically inhibits lingual trigeminal nerve responses to carbon dioxide. Brain Res 612:122-129
76. Konnerth A, Lux HD, Morad M (1987) Proton-induced transformation of calcium channels in chick dorsal root ganglion cells. J Physiol 386:603-633
77. Kratskin I, Hummel T, Hastings L, Doty R (2000) 3-Methylindole alters both olfactory and trigeminal nasal mucosal potentials in rats. Neuroreport 11:2195-2197
78. Laing DG, Wilcox ME (1987) An investigation of the mechanisms of odor suppression using physical and dichorhinic mixtures. Behav Brain Res 26:79-87
79. Lang J (1989) Clinical Anatomy of the Nose, Nasal Cavity and Paranasal Sinuses. Thieme, Stuttgart
80. Laska M, Distel H, Hudson R (1997) Trigeminal perception of odorant quality in congenitally anosmic subjects. Chem Senses 22:447-456
81. Lewis T (1937) The nocifensor system of nerves and its reactions. Br Med J 431-435
82. Lingueglia E, De Weille JR, Bassilana F, Heurteaux C, Sakai H, Waldmann R, Lazdunski M (1997) A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cells. J Biol Chem 272:29778-29783
83. Livermore A, Hummel T, Kobal G (1992) Chemosensory event-related potentials in the investigation of interactions between the olfactory and the somatosensory (trigeminal) systems. Electroencephalogr Clin Neurophysiol 83:201-210
84. 2. Eur J Pain 1:207-213
85. Mackenzie RA, Burke D, Skuse NF, Lethlean AK (1975) Fiber function and perception during cutaneous nerve block. J Neurol Neurosurg Psychiatry 38:865-873
86. Minz AI (1968) Condition of the nervous system in old men. Z Altersforsch 21:271-277
87. Murphy C (1983) Age-related effects on the threshold, psychophysical function, and pleasantness of menthol. J Gerontol 38:217-222
88. Ochoa J, Mair WGP (1969) The normal sural nerve in man. I. Ultrastructure and numbers of fibres and cells. Acta Neuropathol (Berl) 13:197-216
89. Olsson MJ, Cain WS (1996) 21:650
90. Parker GH (1922) The common chemical sense. In: Parker GH (ed) Smell, Taste, and Allied Senses in the Vertebrates. Lippincott, Philadelphia, pp 102-109
91. Price DD (1972) Characteristics of second pain and flexion reflexes indicative of prolonged central summation. Exp Neurol 37:371-387
92. Price DD, Hu JW. Dubner R, Gracely R (1977) Peripheral suppression of first pain and central summation of second pain evoked by noxious heat pulses. Pain 3:57-68
93. Raja SN, Meyer RA, Ringkamp M, Campbell JN (1999) Peripheral neural mechanisms of nociception. In: Wall PD, Melzack R (eds) Textbook of Pain. Churchill Livingstone, Edinburgh, pp 11-57
94. Raymond SA, Thalhammer JG, Popitz-Bergez F, Strichartz GR (1990) Changes in axonal impulse conduction correlate with sensory modality in primary afferent fibers in the rat. Brain Res 526:318-321
95. Renner B, Meindorfner F, Kägler M, Thürauf N, Barocka A, Kobal G (1998) Discrimination of R- and S-nicotine by the trigeminal nerve. Chem Senses 23:302
96. Sekizawa SI, Tsubone H (1994) Nasal receptors responding to noxious chemical irritants. Resp Physiol 96:37-48
97. Silver WL (1991) Physiological factors in nasal trigeminal chemoreception. In: Green BG, Mason JR, Kare MR (eds) Chemical Senses, vol 2, Irritation, Marcel Dekker, New York, pp 21-37
98. Silver WL, Fraley LG, Finger TE (1991) The effects of neonatal capsaicin administration on trigeminal nerve chemoreceptors in the rat nasal cavity Brain Res 561:211-216
99. Sinclair DC, Hinshaw JR (1950) A comparison of the sensory dissociation produced by procaine and by limb compression. Brain 73:480-498
100. Snow PJ, Lumb BM, Cervero F (1992) The representation of prolonged and in intense, noxious somatic and visceral stimuli in the ventrolateral orbital cortex of the cat. Pain 48:89-99
101. Steen KH, Reeh PW (1993) Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin. Neuroscience Lett 154:113-116
102. Steen KH, Reeh PW, Anton F, Handwerker HO (1991) Protons selectively induce lasting excitation and sensitization of nociceptors in rat skin. J Neurosci 12:86-95
103. +] and is increaed under amiloride, in vitro. Soc Neurosci 21:648
104. Stevens JC, Cain WS (1986) Aging and the perception of nasal irritation. Physiol Behav 37:323-328
105. Stevens JC, Plantinga A, Cain WS (1982) Reduction of odor and nasal pungency associated with aging. Neurobiol Aging 3:125-132
106. Stone H (1969) Effect of ethmoidal nerve stimulation on olfactory bulbar electrical activity. In: Pfaffmann C (ed) Olfaction and Taste. Rockefeller University Press, New York, pp 216-220
107. Stone H, Rebert CS (1970) Observations on trigeminal olfactory interactions. Brain Res 21:138-142
108. Tateyama T, Hummel T, Roscher S, Post H, Kobal G (1998) Relation of olfactory event-related potentials to changes in stimulus concentrations. Electroencephalogr Clin Neurophysiol 108:449-455
109. 2, tooth pulp event-related potentials, and acoustic event-related potentials to the tranquilizer diazepam. Br J Clin Pharmacol 38:545-555
110. Thürauf N, Friedel I, Hummel C, Kobal G (1991) The mucosal potential elicited by noxious chemical stimuli: Is it a peripheral nociceptive event. Neurosci Lett 128:297-300
111. Torebjörk HE, Hallin RG (1970) C-fibre units recorded from human sensory nerve fascicles in situ. Acta Soc Med Upsala 75:81-84
112. Van Toller S (1999) Assessing the impact of anosmia: Review of a questionnaire's findings. Chem Senses 24:705-712
113. Von Skramlik E (1926) Handbuch der Physiologie der Niedren Sinne. Thieme, Leipzig
114. Walker JC, Jennings RA (1991) Comparison of odor perception in humans and animals. In: Laing DG, Doty RL, Breipohl W (eds) The Human Sense of Smell. Springer, Berlin, pp 261-280
115. Walker JC, Tucker D, Smith JC (1979) Odor sensitivity mediated by the trigeminal nerve in the pigeon. Chem Senses Flav 4:107-116
116. Wysocki CJ, Cowart BJ, Varga E (1997) Nasal-trigeminal sensitivity in normal aging and clinical populations. Chem Senses 22:826
117. Yousem DM, Maldjian JA. Siddiqi F, Hummel T, Alsop DC, Geckle RJ, Bilker WB, Doty RL (1999) Gender effects on odor-stimulated functional magnetic resonance imaging. Brain Res 818:480-487
118. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E (1992) Functional localization and lateralization of human olfactory cortex. Nature 360:339-340