Sensory and pulmonary effects of acute exposure to sulfur dioxide (SO2)

Toxicology Letters

Volumn 196, Issue 1, 2010, Pages 42-50

  van Thriel, Christoph ^a   Schäper, Michael ^a   Kleinbeck, Stefan ^a   Kiesswetter, Ernst ^a   Blaszkewicz, Meinolf ^a   Golka, Klaus ^a   Nies, Eberhard ^b   Raulf Heimsoth, Monika ^c   Brüning, Thomas ^c  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

^b INSTITUT FÜR ARBEITSSCHUTZ DER DEUTSCHEN GESETZLICHEN UNFALLVERSICHERUNG IFA   (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

Eye irritation; Odor annoyance; Pulmonary function; Upper airways

Indexed keywords

SULFUR DIOXIDE;

ADULT; ANNOYANCE; ARTICLE; BICYCLE ERGOMETRY; ENVIRONMENTAL EXPOSURE; EYE IRRITATION; EYELID REFLEX; FEMALE; FORCED EXPIRATORY VOLUME; GENDER; HUMAN; HUMAN EXPERIMENT; LUNG FUNCTION; MALE; NAUSEA; NORMAL HUMAN; NOSE AIRFLOW; ODOR; PRIORITY JOURNAL; RATING SCALE; RHINOMANOMETRY; SENSATION; SNEEZING; SPIROMETRY; SYMPTOM;

ACUTE TOXICITY TESTS; ADULT; AIR POLLUTANTS; BLINKING; FEMALE; HUMANS; INHALATION EXPOSURE; LUNG; MALE; OLFACTORY PERCEPTION; PULMONARY VENTILATION; SULFUR DIOXIDE;

EID: 77952742841     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2010.03.013     Document Type: Article

References (62)

1. ACGIH 2008 TLVs® and BEIs® 2008, ACGIH, Cincinnati.
2. ACGIH 2009 TLVs® and BEIs® 2009, ACGIH, Cincinnati.
3. Arts J.H., de Heer C., Woutersen R.A. Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits. Int. Arch. Occup. Environ. Health 2006, 79:283-298.
4. Bedi J.F., Folinsbee L.J., Horvath S.M. Pulmonary function effects of 1.0 and 2.0ppm sulfur dioxide exposure in active young male non-smokers. J. Air Pollut. Control. Assoc. 1984, 34:1117-1121.
5. Bedi J.F., Horvath S.M. Inhalation route effects on exposure to 2.0 parts per million sulfur dioxide in normal subjects. JAPCA 1989, 39:1448-1452.
6. Bernstein J.A., Alexis N., Barnes C., Bernstein I.L., Bernstein J.A., Nel A., Peden D., Diaz-Sanchez D., Tarlo S.M., Williams P.B. Health effects of air pollution. J. Allergy Clin. Immunol. 2004, 114:1116-1123.
7. Bessac B.F., Jordt S.E. Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. Physiology (Bethesda) 2008, 23:360-370.
8. BGIA International Limit Values 2009 2009, vol. 2009. BGIA, Institute for Occupational Safety and Health, St. Augustin.
9. Boulet L.P., Turcotte H. Lung hyperinflation, perception of bronchoconstriction and airway hyperresponsiveness. Clin. Invest. Med. 2007, 30:2-11.
10. Broder I., Smith J.W., Corey P., Holness L. Health status and sulfur dioxide exposure of nickel smelter workers and civic laborers. J. Occup. Med. 1989, 31:347-353.
11. Currie G.P., Ayres J.G. Assessment of bronchial responsiveness following exposure to inhaled occupational and environmental agents. Toxicol. Rev. 2004, 23:75-81.
12. Dalton P. Odor, irritation and perception of health risk. Int. Arch. Occup. Environ. Health 2002, 75:283-290.
13. Doty R.L., Cometto-Muniz J.E., Jalowayski A.A., Dalton P., Kendal-Reed M., Hodgson M. Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit. Rev. Toxicol. 2004, 34:85-142.
14. Ernstgard L., Iregren A., Sjogren B., Johanson G. Acute effects of exposure to vapours of acetic acid in humans. Toxicol. Lett. 2006, 165:22-30.
15. Faul F., Erdfelder E., Lang A.G., Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav. Res. Methods 2007, 39:175-191.
16. Green B.G., Dalton P., Cowart B., Shaffer G., Rankin K., Higgins J. Evaluating the 'Labeled Magnitude Scale' for measuring sensations of taste and smell. Chem. Senses 1996, 21:323-334.
17. Green B.G., Shaffer G.S. The sensory response to capsaicin during repeated topical exposures: differential effects on sensations of itching and pungency. Pain 1993, 53:323-334.
18. Holzer P. Acid-sensitive ion channels and receptors. Handb. Exp. Pharmacol. 2009, 283-332.
19. Inoue T., Bryant B.P. Multiple types of sensory neurons respond to irritating volatile organic compounds (VOCs): calcium fluorimetry of trigeminal ganglion neurons. Pain 2005, 117:193-203.
20. Iregren A. Computer-assisted testing. Occupational Neurotoxicology 1998, 213-231. CRC Press LLC, Boca Raton. L.G. Costa, L. Manzo (Eds.).
21. Iregren A., Gamberale F. Human behavioral toxicology. Central nervous effects of low-dose exposure to neurotoxic substances in the work environment. Scand. J. Work Environ. Health 1990, 16(Suppl. 1):17-25.
22. 2 on respiratory system of adult Miyakejima resident 2 years after returning to the island. J. Occup. Health 2009, 51:38-47.
23. Kamat S.R., Patil J.D., Gregart J., Dalal N., Deshpande J.M., Hardikar P. Air pollution related respiratory morbidity in central and north-eastern Bombay. J. Assoc. Physicians India 1992, 40:588-593.
24. Kiesswetter E., van Thriel C., Schaper M., Blaszkewicz M., Seeber A. Eye blinks as indicator for sensory irritation during constant and peak exposures to 2-ethylhexanol. Environ. Toxicol. Pharmacol. 2005, 19:531-541.
25. Kilic D. The effects of ageing and sulfur dioxide inhalation exposure on visual-evoked potentials, antioxidant enzyme systems, and lipid-peroxidation levels of the brain and eye. Neurotoxicol. Teratol. 2003, 25:587-598.
26. Kleinbeck S., Juran S.A., Kiesswetter E., Schaper M., Blaszkewicz M., Bruning T., van Thriel C. Evaluation of ethyl acetate on three dimensions: investigation of behavioral, physiological and psychological indicators of adverse chemosensory effects. Toxicol. Lett. 2008, 182:102-109.
27. Kleinbeck S., Michael S., Meinolf B., van Thriel C. Odor thresholds and respiratory effects of sulphur dioxide. Chem. Senses 2008, 33:S106-S1106.
28. Kulle T.J., Sauder L.R., Hebel J.R., Miller W.R., Green D.J., Shanty F. Pulmonary effects of sulfur dioxide and respirable carbon aerosol. Environ. Res. 1986, 41:239-250.
29. Kuwabara Y., Alexeeff G.V., Broadwin R., Salmon A.G. Evaluation and application of the RD50 for determining acceptable exposure levels of airborne sensory irritants for the general public. Environ. Health Perspect. 2007, 115:1609-1616.
30. Lang I., Bruckner T., Triebig G. Formaldehyde and chemosensory irritation in humans: a controlled human exposure study. Regul. Toxicol. Pharmacol. 2008, 50:23-36.
31. Lingueglia E. Acid-sensing ion channels in sensory perception. J. Biol. Chem. 2007, 282:17325-17329.
32. Liote H., Zahm J.M., Pierrot D., Puchelle E. Role of mucus and cilia in nasal mucociliary clearance in healthy subjects. Am. Rev. Respir. Dis. 1989, 140:132-136.
33. McLeod R.L., Jia Y., McHugh N.A., Fernandez X., Mingo G.G., Wang X., Parra L.E., Chen J., Brown D., Bolser D.C., Kreutner W., Hey J.A. Sulfur-dioxide exposure increases TRPV1-mediated responses in nodose ganglia cells and augments cough in guinea pigs. Pulm. Pharmacol. Ther. 2007, 20:750-757.
34. Nagata Y. Odor intensity and odor threshold value. J. Jpn. Air Clean. Assoc. 2003, 41:17-25.
35. Nielsen G.D., Wolkoff P., Alarie Y. Sensory irritation: risk assessment approaches. Regul. Toxicol. Pharmacol. 2007, 48:6-18.
36. Nowak D., Jorres R., Berger J., Claussen M., Magnussen H. Airway responsiveness to sulfur dioxide in an adult population sample. Am. J. Respir. Crit. Care Med. 1997, 156:1151-1156.
37. Page E.B. Ordered hypotheses for multiple treatments-a significance test for linear ranks. J. Am. Stat. Assoc. 1963, 58:216-230.
38. Peters A., Goldstein I.F., Beyer U., Franke K., Heinrich J., Dockery D.W., Spengler J.D., Wichmann H.E. Acute health effects of exposure to high levels of air pollution in eastern Europe. Am. J. Epidemiol. 1996, 144:570-581.
39. Peters J.M., Smith T.J., Bernstein L., Wright W.E., Hammond S.K. Pulmonary effects of exposures in silicon carbide manufacturing. Br. J. Ind. Med. 1984, 41:109-115.
40. Purslow C., Wolffsohn J. The relation between physical properties of the anterior eye and ocular surface temperature. Optom. Vis. Sci. 2007, 84:197-201.
41. Quanjer P.H., Tammeling G.J., Cotes J.E., Pedersen O.F., Peslin R., Yernault J.C. Lung volumes and forced ventilatory flows. Report working party standardization of lung function tests, european community for steel and coal. official statement of the European respiratory society. Eur. Respir. J. Suppl. 1993, 16:5-40.
42. Raulf-Heimsoth M., Hoffmeyer F., van Thriel C., Blaszkewicz M., Bunger J., Bruning T. Assessment of low dose effects of acute sulphur dioxide exposure on the airways using non-invasive methods. Arch. Toxicol. 2009.
43. Roger L.J., Kehrl H.R., Hazucha M., Horstman D.H. Bronchoconstriction in asthmatics exposed to sulfur dioxide during repeated exercise. J. Appl. Physiol. 1985, 59:784-791.
44. Rohlman D.S., Lucchini R., Anger W.K., Bellinger D.C., van Thriel C. Neurobehavioral testing in human risk assessment. Neurotoxicology 2008, 29:555-566.
45. Sandstrom T., Kolmodin-Hedman B., Stjernberg N., Andersson M.C., Lofvenius G. Challenge test for sulfur dioxide-symptom and lung function measurements. Scand. J. Work Environ. Health 1988, 14(Suppl. 1):77-79.
46. Schaper M. Development of a database for sensory irritants and its use in establishing occupational exposure limits. Am. Ind. Hyg. Assoc. J. 1993, 54:488-544.
47. Schneider A., Tilemann L., Schermer T., Gindner L., Laux G., Szecsenyi J., Meyer F.J. Diagnosing asthma in general practice with portable exhaled nitric oxide measurement-results of a prospective diagnostic study: FENO < or =16 ppb better than FENO< or =12 ppb to rule out mild and moderate to severe asthma [added]. Respir. Res. 2009, 10:15.
48. Seeber A., van Thriel C., Haumann K., Kiesswetter E., Blaszkewicz M., Golka K. Psychological reactions related to chemosensory irritation. Int. Arch. Occup. Environ. Health 2002, 75:314-325.
49. Shusterman D. Individual factors in nasal chemesthesis. Chem. Senses 2002, 27:551-564.
50. Shusterman D. Environmental nonallergic rhinitis. Clin. Allergy Immunol. 2007, 19:249-266.
51. Shusterman D. Trigeminally-mediated health effects of air pollutants: sources of inter-individual variability. Hum. Exp. Toxicol. 2007, 26:149-157.
52. Shusterman D., Hummel T. Symposium overview: nasal trigeminal function: qualitative, quantitative, and temporal effects. Ann. N.Y. Acad. Sci. 2009, 1170:181-183.
53. Silver W.L., Clapp T.R., Stone L.M., Kinnamon S.C. TRPV1 receptors and nasal trigeminal chemesthesis. Chem. Senses 2006, 31:807-812.
54. Smeets M., Dalton P. Evaluating the human response to chemicals: odor, irritation and non-sensory factors. Environ. Toxicol. Pharmacol. 2005, 19:581-588.
55. 2 by the human nose. Arch. Environ. Health 1966, 12:725-728.
56. Story G.M. The emerging role of TRP channels in mechanisms of temperature and pain sensation. Curr. Neuropharmacol. 2006, 4:183-196.
57. U.S.EPA Integrated Science Assessment (ISA) for Sulfur Oxides - Health Criteria (Final Report) 2008, U.S. Environmental Protection Agency, Washington, DC, EPA/600/R-08/047F.
58. van Thriel C., Schaper M., Kiesswetter E., Kleinbeck S., Juran S., Blaszkewicz M., Fricke H.H., Altmann L., Berresheim H., Bruning T. From chemosensory thresholds to whole body exposures-experimental approaches evaluating chemosensory effects of chemicals. Int. Arch. Occup. Environ. Health 2006, 79:308-321.
59. van Thriel C., Blaszkewicz M., Schaper M., Juran S.A., Kleinbeck S., Kiesswetter E., Wrbitzky R., Stache J., Golka K., Bader M. Chemosensory effects during acute exposure to N-methyl-2-pyrrolidone (NMP). Toxicol. Lett. 2007, 175:44-56.
60. Winterton D.L., Kaufman J., Keener C.V., Quigley S., Farin F.M., Williams P.V., Koenig J.Q. Genetic polymorphisms as biomarkers of sensitivity to inhaled sulfur dioxide in subjects with asthma. Ann. Allergy Asthma Immunol. 2001, 86:232-238.
61. Wolkoff P., Skov P., Franck C., Petersen L.N. Eye irritation and environmental factors in the office environment-hypotheses, causes and a physiological model. Scand. J. Work Environ. Health 2003, 29:411-430.
62. Wolkoff P. Healthy" eye in office-like environments. Environ. Int. 2008, 34:1204-1214.