Is individual nasal sensitivity related to cellular metabolism of formaldehyde and susceptibility towards formaldehyde-induced genotoxicity?

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 723, Issue 1, 2011, Pages 11-17

  Zeller, Jasmin ^a   Ulrich, Alexandra ^a   Mueller, Joerg U ^b   Riegert, Clarissa ^a   Neuss, Simone ^a   Bruckner, Thomas ^b   Triebig, Gerhard ^b   Speit, Günter ^a  

^a UNIVERSITY OF ULM   (Germany)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

Author keywords

CO2 sensitivity; Comet assay; Formaldehyde dehydrogenase; Sister chromatid exchange

Indexed keywords

ALCOHOL DEHYDROGENASE; CARBON DIOXIDE; FORMALDEHYDE; FORMALDEHYDE DEHYDROGENASE; GLUTATHIONE; MESSENGER RNA; MUTAGENIC AGENT;

ADULT; ARTICLE; BLOOD CELL; BLOOD SAMPLING; CELL CULTURE; CELL METABOLISM; COMET ASSAY; CORRELATION ANALYSIS; DNA PROTEIN COMPLEX; GAMMA RADIATION; GENOTOXICITY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HYPERSENSITIVITY; LEUKOCYTE; LYMPHOCYTE; MALE; NORMAL HUMAN; NOSE IRRITATION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SISTER CHROMATID EXCHANGE;

EID: 79957825265     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2011.03.014     Document Type: Article

References (26)

1. Arts J.H., Rennen M.A., de Heer C. Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity. Regul. Toxicol. Pharmacol. 2006, 44:144-160.
2. Lang I., Bruckner T., Triebig G. Formaldehyde and chemosensory irritation in humans: a controlled human exposure study. Regul. Toxicol. Pharmacol. 2008, 50:23-36.
3. Casanova M., Morgan K.T., Gross E.A., Moss O.R., Heck H.A. DNA-protein cross-links and cell replication at specific sites in the nose of F344 rats exposed subchronically to formaldehyde. Fundam. Appl. Toxicol. 1994, 23:525-536.
4. Schmid O., Speit G. Genotoxic effects induced by formaldehyde in human blood and implications for the interpretation of biomonitoring studies. Mutagenesis 2007, 22:69-74.
5. Speit G., Schmid O., Neuss S., Schutz P. Genotoxic effects of formaldehyde in the human lung cell line A549 and in primary human nasal epithelial cells. Environ. Mol. Mutagen. 2008, 49:300-307.
6. Lu K., Collins L.B., Ru H., Bermudez E., Swenberg J.A. Distribution of DNA adducts caused by inhaled formaldehyde is consistent with induction of nasal carcinoma but not leukemia. Toxicol. Sci. 2010, 116:441-451.
7. Speit G., Zeller J., Schmid O., Elhajouji A., Ma-Hock L., Neuss S. Inhalation of formaldehyde does not induce systemic genotoxic effects in rats. Mutat. Res. 2009, 677:76-85.
8. Kligerman A.D., Phelps M.C., Erexson G.L. Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation. Toxicol. Lett. 1984, 21:241-246.
9. Formaldehyde I.A.R.C. 2-hydroxyethanol and 1-tert-butoxypropan-2-ol, IARC. Monogr. Eval. Carcinog. Risks Hum. 2006, 88:1-478.
10. McGregor D., Bolt H., Cogliano V., Richter-Reichhelm H.B. Formaldehyde and glutaraldehyde and nasal cytotoxicity: case study within the context of the 2006 IPCS human framework for the analysis of a cancer mode of action for humans. Crit Rev. Toxicol. 2006, 36:821-835.
11. SCOEL, Recommendation from the Scientific Committee on Occupational Exposure Limits for Formaldehyde, SUM/125, March 2008.
12. Shusterman D., Murphy M.A., Balmes J. The influence of sex, allergic rhinitis, and test system on nasal sensitivity to airborne irritants: a pilot study. Environ. Health Perspect. 2001, 109:15-19.
13. Cebulska-Wasilewska A., Pawlyk I., Panek A., Wiechec A., Kalina I., Popov T., Georgieva T., Farmer P.B. Exposure to environmental polycyclic aromatic hydrocarbons: influences on cellular susceptibility to DNA damage (sampling Kosice and Sofia). Mutat. Res. 2007, 620:145-154.
14. Cebulska-Wasilewska A., Binkova B., Sram R.J., Kalina I., Popov T., Farmer P.B. Repair competence assay in studies of the influence of environmental exposure to c-PAHs on individual susceptibility to induction of DNA damage. Mutat. Res. 2007, 620:155-164.
15. Trenz K., Lugowski S., Jahrsdorfer U., Jainta S., Vogel W., Speit G. Enhanced sensitivity of peripheral blood lymphocytes from women carrying a BRCA1 mutation towards the mutagenic effects of various cytostatics. Mutat. Res. 2003, 544:279-288.
16. Kosti O., Byrne C., Meeker K.L., Watkins K.M., Loffredo C.A., Shields P.G., Schwartz M.D., Willey S.C., Cocilovo C., Zheng Y.L. Mutagen sensitivity, tobacco smoking and breast cancer risk: a case-control study. Carcinogenesis 2010, 31:654-659.
17. Collins A.R The comet assay for DNA damage and repair: principles, applications, and limitations. Mol. Biotechnol. 2004, 26:249-261.
18. Speit G., Hartmann A. The comet assay: a sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol. Biol. 2006, 314:275-286.
19. Trzeciak A.R., Barnes J., Evans M.K. A modified alkaline comet assay for measuring DNA repair capacity in human populations. Radiat. Res. 2008, 169:110-121.
20. Gaivao I., Piasek A., Brevik A., Shaposhnikov S., Collins A.R. Comet assay-based methods for measuring DNA repair in vitro; estimates of inter- and intra-individual variation. Cell Biol. Toxicol. 2009, 25:45-52.
21. Merk O., Speit G. Significance of formaldehyde-induced DNA-protein crosslinks for mutagenesis. Environ. Mol. Mutagen. 1998, 32:260-268.
22. Hedberg J.J., Backlund M., Stromberg P., Lonn S., Dahl M.L., Ingelman-Sundberg M., Hoog J.O. Functional polymorphism in the alcohol dehydrogenase 3 (ADH3) promoter. Pharmacogenetics 2001, 11:815-824.
23. Speit G., Neuss S., Schmid O. The human lung cell line A549 does not develop adaptive protection against the DNA-damaging action of formaldehyde. Environ. Mol. Mutagen. 2010, 51:130-137.
24. Neuss S., Holzmann K., Speit G. Gene expression changes in primary human nasal epithelial cells exposed to formaldehyde in vitro. Toxicol. Lett. 2010, 198:289-295.
25. Neuss S., Moepps B., Speit G. Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation. Mutagenesis 2010, 25:359-364.
26. Speit G., Schutz P., Weber I., Ma-Hock L., Kaufmann W., Gelbke H.P., Durrer S. Analysis of micronuclei, histopathological changes and cell proliferation in nasal epithelium cells of rats after exposure to formaldehyde by inhalation. Mutat. Res. 2011, 721:127-135.