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Volumn 18, Issue SUPPL.3, 2012, Pages 6-26

Current issues in GLP-1 receptor agonist therapy for type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ADIPONECTIN; C REACTIVE PROTEIN; CALCITONIN; DIPEPTIDYL PEPTIDASE IV INHIBITOR; EXENDIN 4; GLIMEPIRIDE; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCAGON LIKE PEPTIDE 1 RECEPTOR; GLUCAGON LIKE PEPTIDE 1 RECEPTOR AGONIST; GLUCOSE; INSULIN; INSULIN DETEMIR; INSULIN GLARGINE; LIRAGLUTIDE; METFORMIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PIOGLITAZONE; SITAGLIPTIN; SULFONYLUREA; TETRAHYDROLIPSTATIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84872335789     PISSN: 1530891X     EISSN: 19342403     Source Type: Journal    
DOI: 10.4158/EP12300.RA     Document Type: Article
Times cited : (4)

References (212)
  • 1
    • 34248223285 scopus 로고    scopus 로고
    • Biology of incretins: GLP-1 and GIP
    • Baggio LL, Drucker DJ. Biology of incretins: GLP-1 and GIP. Gastroenterology. 2007;132:2131-2157.
    • (2007) Gastroenterology , vol.132 , pp. 2131-2157
    • Baggio, L.L.1    Drucker, D.J.2
  • 2
    • 75149143476 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: New advances
    • Asmar M, Holst JJ. Glucagon-like peptide 1 and glucose-dependent insulinotropic polypeptide: new advances. Curr Opin Endocrinol Diabetes Obes. 2010;17:57-62.
    • (2010) Curr Opin Endocrinol Diabetes Obes , vol.17 , pp. 57-62
    • Asmar, M.1    Holst, J.J.2
  • 3
    • 0027391607 scopus 로고
    • Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
    • Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest. 1993;91:301-307.
    • (1993) J Clin Invest , vol.91 , pp. 301-307
    • Nauck, M.A.1    Heimesaat, M.M.2    Orskov, C.3    Holst, J.J.4    Ebert, R.5    Creutzfeldt, W.6
  • 4
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 1993;36:741-744.
    • (1993) Diabetologia , vol.36 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 5
    • 0031033531 scopus 로고    scopus 로고
    • Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM
    • Rachman J, Barrow BA, Levy JC, Turner RC. Near-normalisation of diurnal glucose concentrations by continuous administration of glucagon-like peptide-1 (GLP-1) in subjects with NIDDM. Diabetologia. 1997;40:205-211.
    • (1997) Diabetologia , vol.40 , pp. 205-211
    • Rachman, J.1    Barrow, B.A.2    Levy, J.C.3    Turner, R.C.4
  • 6
    • 0029907680 scopus 로고    scopus 로고
    • Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 Amide]) in patients with NIDDM
    • Nauck MA, Wollschlager D, Werner J, et al. Effects of subcutaneous glucagon-like peptide 1 (GLP-1 [7-36 amide]) in patients with NIDDM. Diabetologia. 1996;39:1546-1553.
    • (1996) Diabetologia , vol.39 , pp. 1546-1553
    • Nauck, M.A.1    Wollschlager, D.2    Werner, J.3
  • 7
  • 8
    • 85205841684 scopus 로고    scopus 로고
    • Januvia (sitagliptin) [prescribing information] Whitehouse Station NJ: Merck Co. Inc. Accessed for verification October 25, 2012
    • Januvia (sitagliptin) [prescribing information]. Whitehouse Station, NJ: Merck & Co., Inc.; 2010. http://www.merck.com/product/usa/pi-circulars/j/ januvia/januvia-pi.pdf. Accessed for verification October 25, 2012.
    • (2010)
  • 9
    • 85205888979 scopus 로고    scopus 로고
    • Onglyza (saxagliptin) [prescribing information] Princeton NJ and Wilmington DE: Bristol-Myers Squibb Company and AstraZeneca Pharmaceuticals LP Accessed for verification October 25 2012
    • Onglyza (saxagliptin) [prescribing information]. Princeton, NJ, and Wilmington, DE: Bristol-Myers Squibb Company and AstraZeneca Pharmaceuticals LP; 2011. http://packageinserts.bms.com/pi/pi-onglyza. pdf. Accessed for verification October 25, 2012.
    • (2011)
  • 10
    • 85205841096 scopus 로고    scopus 로고
    • Tradjenta (linaglip) [prescribing information] Ridgefield CT: Boehringer Ingelheim Pharmaceuticals Inc.. Accessed for verification October 25, 2012
    • Tradjenta (linaglip) [prescribing information]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2011. http://hcp. tradjenta.com/prescribinginformation.jsp. Accessed for verification October 25, 2012.
    • (2011)
  • 11
    • 72449177017 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Accessed for verification October 25 2012
    • U.S. Food and Drug Administration. Sitagliptin (marketed as Januvia and Janumet) information. http://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafety InformationforPatientsandProviders/ucm183768.htm. Accessed for verification October 25, 2012.
    • Sitagliptin (Marketed As Januvia and Janumet) Information
  • 12
    • 85205835340 scopus 로고    scopus 로고
    • China Two Innovative Therapies That Support Public Health Goals [press Release]. Basel Switzerland: Novartis; January 18. Accessed for verification October 25, 2012
    • Novartis receives approval for Lucentis® and launches Galvus® in China, two innovative therapies that support public health goals [press release]. Basel, Switzerland: Novartis; January 18, 2012. http://www.novartis. com/newsroom/media-releases/en/2012/1578311.shtml. Accessed for verification October 25, 2012.
    • (2012) Novartis Receives Approval for Lucentis® and Launches Galvus
  • 14
    • 85205876098 scopus 로고    scopus 로고
    • LG'sgemiglo' wins KFDA approval
    • June 28. Accessed for verification October 25, 2012
    • LG's 'gemiglo' wins KFDA approval. The Korean Herald. June 28, 2012. http://view.koreaherald.com/kh/view. php?ud=20120628001086. Accessed for verification October 25, 2012.
    • (2012) The Korean Herald
  • 16
    • 84871405156 scopus 로고    scopus 로고
    • San Diego CA: Amylin Pharmaceuticals Inc. Accessed for verification October 25 2012
    • Byetta (exenatide) [prescribing information]. San Diego, CA: Amylin Pharmaceuticals Inc.; 2011. http://documents.byetta.com/Byetta-PI.pdf. Accessed for verification October 25, 2012.
    • (2011) Byetta (Exenatide) [Prescribing Information]
  • 17
    • 84880259985 scopus 로고    scopus 로고
    • Princeton NJ: Novo Nordisk Inc. Accessed for verification October 25 2012
    • Victoza (liraglutide [rDNA] injection) [prescribing information]. Princeton, NJ: Novo Nordisk Inc.; 2012. http://www.novo-pi. com/victoza.pdf. Accessed for verification October 25, 2012.
    • (2012) Victoza (Liraglutide [RDNA] Injection) [Prescribing Information]
  • 20
    • 55549136417 scopus 로고    scopus 로고
    • Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: A randomized, cross-over study
    • DeFronzo RA, Okerson T, Viswanathan P, Guan X, Holcombe JH, MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin. 2008;24:2943-2952.
    • (2008) Curr Med Res Opin , vol.24 , pp. 2943-2952
    • Defronzo, R.A.1    Okerson, T.2    Viswanathan, P.3    Guan, X.4    Holcombe, J.H.5    MacConell, L.6
  • 21
    • 77952309372 scopus 로고    scopus 로고
    • Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
    • Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet. 2010;375:1447-1456.
    • (2010) Lancet , vol.375 , pp. 1447-1456
    • Pratley, R.E.1    Nauck, M.2    Bailey, T.3
  • 22
    • 84859013614 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): A 26-week double-blind study
    • Russell-Jones D, Cuddihy RM, Hanefeld M, et al. Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): a 26-week double-blind study. Diabetes Care. 2012;35:252-258.
    • (2012) Diabetes Care , vol.35 , pp. 252-258
    • Russell-Jones, D.1    Cuddihy, R.M.2    Hanefeld, M.3
  • 23
    • 80053390364 scopus 로고    scopus 로고
    • Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: A randomized, double-blind, crossover study
    • Berg JK, Shenouda SK, Heilmann CR, Gray AL, Holcombe JH. Effects of exenatide twice daily versus sitagliptin on 24-h glucose, glucoregulatory and hormonal measures: a randomized, double-blind, crossover study. Diabetes Obes Metab. 2011;13:982-989.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 982-989
    • Berg, J.K.1    Shenouda, S.K.2    Heilmann, C.R.3    Gray, A.L.4    Holcombe, J.H.5
  • 24
    • 79952755181 scopus 로고    scopus 로고
    • One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: A randomised, parallel-group, open-label trial
    • Pratley R, Nauck M, Bailey T, et al. One year of liraglutide treatment offers sustained and more effective glycaemic control and weight reduction compared with sitagliptin, both in combination with metformin, in patients with type 2 diabetes: a randomised, parallel-group, open-label trial. Int J Clin Pract. 2011;65:397-407.
    • (2011) Int J Clin Pract , vol.65 , pp. 397-407
    • Pratley, R.1    Nauck, M.2    Bailey, T.3
  • 25
    • 77955573674 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
    • Bergenstal RM, Wysham C, Macconell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet. 2010;376:431-439.
    • (2010) Lancet , vol.376 , pp. 431-439
    • Bergenstal, R.M.1    Wysham, C.2    MacConell, L.3
  • 26
    • 70350475695 scopus 로고    scopus 로고
    • Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors
    • Neumiller JJ. Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. J Am Pharm Assoc (2003). 2009;49(Suppl 1):S16-S29.
    • (2003) J Am Pharm Assoc , vol.49 , Issue.SUPPL. 1
    • Neumiller, J.J.1
  • 27
    • 34249891874 scopus 로고    scopus 로고
    • Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
    • Kim D, MacConell L, Zhuang D, et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care. 2007;30:1487-1493.
    • (2007) Diabetes Care , vol.30 , pp. 1487-1493
    • Kim, D.1    MacConell, L.2    Zhuang, D.3
  • 28
    • 79960952161 scopus 로고    scopus 로고
    • American Association of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan
    • Handelsman Y, Mechanick JI, Blonde L, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan. Endocr Pract. 2011;17(Suppl 2):1-53.
    • (2011) Endocr Pract , vol.17 , Issue.SUPPL. 2 , pp. 1-53
    • Handelsman, Y.1    Mechanick, J.I.2    Blonde, L.3
  • 29
    • 84855185039 scopus 로고    scopus 로고
    • Standards of medical care in diabetes - 2012
    • American Diabetes Association
    • American Diabetes Association. Standards of medical care in diabetes - 2012. Diabetes Care. 2012;35(Suppl 1):S11-S63.
    • (2012) Diabetes Care , vol.35 , Issue.SUPPL. 1
  • 30
    • 84866268783 scopus 로고    scopus 로고
    • Management of hyperglycemia in type 2 diabetes: A patient-centered approach: Position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
    • Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of hyperglycemia in type 2 diabetes: A patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2012;35:1364-1379.
    • (2012) Diabetes Care , vol.35 , pp. 1364-1379
    • Inzucchi, S.E.1    Bergenstal, R.M.2    Buse, J.B.3
  • 31
    • 75549091263 scopus 로고    scopus 로고
    • Statement by the American Association of Clinical Endocrinologists/ American College of Endocrinology (AACE/ACE) consensus panel on type 2 diabetes mellitus: An algorithm for glycemic control
    • Rodbard HW, Jellinger PS, Bloomgarden ZT, et al. Statement by the American Association of Clinical Endocrinologists/American College of Endocrinology (AACE/ACE) consensus panel on type 2 diabetes mellitus: an algorithm for glycemic control. Endocr Pract. 2009;15:540-559.
    • (2009) Endocr Pract , vol.15 , pp. 540-559
    • Rodbard, H.W.1    Jellinger, P.S.2    Bloomgarden, Z.T.3
  • 32
    • 67649666737 scopus 로고    scopus 로고
    • Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
    • Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet. 2009;374:39-47.
    • (2009) Lancet , vol.374 , pp. 39-47
    • Buse, J.B.1    Rosenstock, J.2    Sesti, G.3
  • 33
    • 53249142132 scopus 로고    scopus 로고
    • Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: A randomised, open-label, non-inferiority study
    • Drucker DJ, Buse JB, Taylor K, et al. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomised, open-label, non-inferiority study. Lancet. 2008;372:1240-1250.
    • (2008) Lancet , vol.372 , pp. 1240-1250
    • Drucker, D.J.1    Buse, J.B.2    Taylor, K.3
  • 34
    • 79955661908 scopus 로고    scopus 로고
    • DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
    • Blevins T, Pullman J, Malloy J, et al. DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinol Metab. 2011;96:1301-1310.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1301-1310
    • Blevins, T.1    Pullman, J.2    Malloy, J.3
  • 36
    • 84863689753 scopus 로고    scopus 로고
    • Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION-6): A randomised, open-label study
    • September 12-16; Lisbon, Portugal [abstract 75]
    • Buse J, Nauck M, Forst T, et al. Efficacy and safety of exenatide once weekly versus liraglutide in subjects with type 2 diabetes (DURATION-6): a randomised, open-label study. 47th Annual Meeting of the European Association for the Study of Diabetes; September 12-16, 2011; Lisbon, Portugal [abstract 75].
    • (2011) 47th Annual Meeting of the European Association for the Study of Diabetes
    • Buse, J.1    Nauck, M.2    Forst, T.3
  • 37
    • 77956076972 scopus 로고    scopus 로고
    • Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
    • Buse JB, Sesti G, Schmidt WE, et al. Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care. 2010;33:1300-1303.
    • (2010) Diabetes Care , vol.33 , pp. 1300-1303
    • Buse, J.B.1    Sesti, G.2    Schmidt, W.E.3
  • 38
    • 77953828230 scopus 로고    scopus 로고
    • DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks
    • Buse JB, Drucker DJ, Taylor KL, et al. DURATION-1: Exenatide once weekly produces sustained glycemic control and weight loss over 52 weeks. Diabetes Care. 2010;33:1255-1261.
    • (2010) Diabetes Care , vol.33 , pp. 1255-1261
    • Buse, J.B.1    Drucker, D.J.2    Taylor, K.L.3
  • 39
    • 37349008890 scopus 로고    scopus 로고
    • Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: A multinational, randomized, open-label, two-period, crossover noninferiority trial
    • Barnett AH, Burger J, Johns D, et al. Tolerability and efficacy of exenatide and titrated insulin glargine in adult patients with type 2 diabetes previously uncontrolled with metformin or a sulfonylurea: a multinational, randomized, open-label, two-period, crossover noninferiority trial. Clin Ther. 2007;29:2333-2348.
    • (2007) Clin Ther , vol.29 , pp. 2333-2348
    • Barnett, A.H.1    Burger, J.2    Johns, D.3
  • 40
    • 7444228521 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
    • Buse JB, Henry RR, Han J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care. 2004;27:2628-2635.
    • (2004) Diabetes Care , vol.27 , pp. 2628-2635
    • Buse, J.B.1    Henry, R.R.2    Han, J.3
  • 41
    • 70450199755 scopus 로고    scopus 로고
    • Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: Results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study
    • Davies MJ, Donnelly R, Barnett AH, Jones S, Nicolay C, Kilcoyne A. Exenatide compared with long-acting insulin to achieve glycaemic control with minimal weight gain in patients with type 2 diabetes: results of the Helping Evaluate Exenatide in patients with diabetes compared with Long-Acting insulin (HEELA) study. Diabetes Obes Metab. 2009;11(12):1153-1162.
    • (2009) Diabetes Obes Metab , vol.11 , Issue.12 , pp. 1153-1162
    • Davies, M.J.1    Donnelly, R.2    Barnett, A.H.3    Jones, S.4    Nicolay, C.5    Kilcoyne, A.6
  • 42
    • 18144401971 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
    • DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care. 2005;28:1092-1100.
    • (2005) Diabetes Care , vol.28 , pp. 1092-1100
    • Defronzo, R.A.1    Ratner, R.E.2    Han, J.3    Kim, D.D.4    Fineman, M.S.5    Baron, A.D.6
  • 43
    • 26944477362 scopus 로고    scopus 로고
    • Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: A randomized trial
    • Heine RJ, Van Gaal LF, Johns D, et al. Exenatide versus insulin glargine in patients with suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med. 2005;143:559-569.
    • (2005) Ann Intern Med , vol.143 , pp. 559-569
    • Heine, R.J.1    Van Gaal, L.F.2    Johns, D.3
  • 44
    • 17144371646 scopus 로고    scopus 로고
    • Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
    • Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care. 2005;28:1083-1091.
    • (2005) Diabetes Care , vol.28 , pp. 1083-1091
    • Kendall, D.M.1    Riddle, M.C.2    Rosenstock, J.3
  • 45
    • 51549095571 scopus 로고    scopus 로고
    • Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: A randomized, double-blind, placebo-controlled, parallel-group study
    • Moretto TJ, Milton DR, Ridge TD, et al. Efficacy and tolerability of exenatide monotherapy over 24 weeks in antidiabetic drug-naive patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther. 2008;30:1448-1460.
    • (2008) Clin Ther , vol.30 , pp. 1448-1460
    • Moretto, T.J.1    Milton, D.R.2    Ridge, T.D.3
  • 46
    • 34247195226 scopus 로고    scopus 로고
    • A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: A non-inferiority study
    • Nauck MA, Duran S, Kim D, et al. A comparison of twice-daily exenatide and biphasic insulin aspart in patients with type 2 diabetes who were suboptimally controlled with sulfonylurea and metformin: a non-inferiority study. Diabetologia. 2007;50:259-267.
    • (2007) Diabetologia , vol.50 , pp. 259-267
    • Nauck, M.A.1    Duran, S.2    Kim, D.3
  • 47
    • 34247259577 scopus 로고    scopus 로고
    • The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: A randomized trial
    • Zinman B, Hoogwerf BJ, Durán García S, et al. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med. 2007;146:477-485.
    • (2007) Ann Intern Med , vol.146 , pp. 477-485
    • Zinman, B.1    Hoogwerf, B.J.2    Durán García, S.3
  • 48
    • 59449101432 scopus 로고    scopus 로고
    • Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
    • Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet. 2009;373:473-481.
    • (2009) Lancet , vol.373 , pp. 473-481
    • Garber, A.1    Henry, R.2    Ratner, R.3
  • 49
    • 62449129181 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
    • Marre M, Shaw J, Brandle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med. 2009;26:268-278.
    • (2009) Diabet Med , vol.26 , pp. 268-278
    • Marre, M.1    Shaw, J.2    Brandle, M.3
  • 50
    • 62449169287 scopus 로고    scopus 로고
    • Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study
    • Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (Liraglutide Effect and Action in Diabetes)-2 study. Diabetes Care. 2009;32:84-90.
    • (2009) Diabetes Care , vol.32 , pp. 84-90
    • Nauck, M.1    Frid, A.2    Hermansen, K.3
  • 51
    • 69949117621 scopus 로고    scopus 로고
    • Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): A randomised controlled trial
    • Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus (LEAD-5 met+SU): a randomised controlled trial. Diabetologia. 2009;52:2046-2055.
    • (2009) Diabetologia , vol.52 , pp. 2046-2055
    • Russell-Jones, D.1    Vaag, A.2    Schmitz, O.3
  • 52
    • 67650066860 scopus 로고    scopus 로고
    • Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
    • Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care. 2009;32:1224-1230.
    • (2009) Diabetes Care , vol.32 , pp. 1224-1230
    • Zinman, B.1    Gerich, J.2    Buse, J.B.3
  • 54
    • 77953859640 scopus 로고    scopus 로고
    • Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): An open-label randomised trial
    • Diamant M, Van Gaal L, Stranks S, et al. Once weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes (DURATION-3): an open-label randomised trial. Lancet. 2010;375:2234-2243.
    • (2010) Lancet , vol.375 , pp. 2234-2243
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3
  • 55
    • 38549162147 scopus 로고    scopus 로고
    • Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
    • Klonoff DC, Buse JB, Nielsen LL, et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin. 2008;24:275-286.
    • (2008) Curr Med Res Opin , vol.24 , pp. 275-286
    • Klonoff, D.C.1    Buse, J.B.2    Nielsen, L.L.3
  • 56
    • 79951906623 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes
    • Garber A, Henry RR, Ratner R, et al. Liraglutide, a once-daily human glucagon-like peptide 1 analogue, provides sustained improvements in glycaemic control and weight for 2 years as monotherapy compared with glimepiride in patients with type 2 diabetes. Diabetes Obes Metab. 2011;13:348-356.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 348-356
    • Garber, A.1    Henry, R.R.2    Ratner, R.3
  • 58
    • 77953103244 scopus 로고    scopus 로고
    • Exenatide is non-inferior to insulin in reducing HbA1c: An integrated analysis of 1423 patients with type 2 diabetes
    • Blevins T, Han J, Nicewarner D, Chen S, Oliveira JH, Aronoff S. Exenatide is non-inferior to insulin in reducing HbA1c: an integrated analysis of 1423 patients with type 2 diabetes. Postgrad Med. 2010;122:118-128.
    • (2010) Postgrad Med , vol.122 , pp. 118-128
    • Blevins, T.1    Han, J.2    Nicewarner, D.3    Chen, S.4    Oliveira, J.H.5    Aronoff, S.6
  • 59
    • 84860618430 scopus 로고    scopus 로고
    • Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks
    • Diamant M, Van Gaal L, Stranks S, et al. Safety and efficacy of once-weekly exenatide compared with insulin glargine titrated to target in patients with type 2 diabetes over 84 weeks. Diabetes Care. 2012;35:683-689.
    • (2012) Diabetes Care , vol.35 , pp. 683-689
    • Diamant, M.1    Van Gaal, L.2    Stranks, S.3
  • 60
    • 84867191797 scopus 로고    scopus 로고
    • A randomized non-inferiority study comparing the addition of exenatide twice daily to sitagliptin or switching from sitagliptin to exenatide twice daily in patients with type 2 diabetes experiencing inadequate glycaemic control on metformin and sitagliptin
    • Feb 29. [Epub ahead of print]
    • Violante R, Oliveira JH, Yoon KH, et al. A randomized non-inferiority study comparing the addition of exenatide twice daily to sitagliptin or switching from sitagliptin to exenatide twice daily in patients with type 2 diabetes experiencing inadequate glycaemic control on metformin and sitagliptin. Diabet Med. 2012 Feb 29. [Epub ahead of print].
    • (2012) Diabet Med.
    • Violante, R.1    Oliveira, J.H.2    Yoon, K.H.3
  • 61
    • 79953165707 scopus 로고    scopus 로고
    • GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes
    • Mentis N, Vardarli I, Kothe LD, et al. GIP does not potentiate the antidiabetic effects of GLP-1 in hyperglycemic patients with type 2 diabetes. Diabetes. 2011;60:1270-1276.
    • (2011) Diabetes , vol.60 , pp. 1270-1276
    • Mentis, N.1    Vardarli, I.2    Kothe, L.D.3
  • 62
    • 58149467276 scopus 로고    scopus 로고
    • Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes
    • Højberg PV, Vilsbøll T, Rabøl R, et al. Four weeks of near-normalisation of blood glucose improves the insulin response to glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in patients with type 2 diabetes. Diabetologia. 2009;52:199-207.
    • (2009) Diabetologia , vol.52 , pp. 199-207
    • Højberg, P.V.1    Vilsbøll, T.2    Rabøl, R.3
  • 63
    • 84871710499 scopus 로고    scopus 로고
    • Exenatide twice daily: Analysis of effectiveness and safety data stratified by age, sex, race, duration of diabetes, and body mass index
    • Pencek R, Blickensderfer A, Li Y, Brunell SC, Anderson PW. Exenatide twice daily: Analysis of effectiveness and safety data stratified by age, sex, race, duration of diabetes, and body mass index. Postgrad Med. 2012;124:21-32.
    • (2012) Postgrad Med , vol.124 , pp. 21-32
    • Pencek, R.1    Blickensderfer, A.2    Li, Y.3    Brunell, S.C.4    Anderson, P.W.5
  • 64
    • 84867580368 scopus 로고    scopus 로고
    • Exenatide once weekly for the treatment of type 2 diabetes: Effectiveness and tolerability in patient subpopulations
    • Aug 24. [Epub ahead of print]
    • Pencek R, Blickensderfer A, Li Y, Brunell SC, Chen S. Exenatide once weekly for the treatment of type 2 diabetes: effectiveness and tolerability in patient subpopulations. Int J Clin Pract. 2012 Aug 24. [Epub ahead of print]
    • (2012) Int J Clin Pract.
    • Pencek, R.1    Blickensderfer, A.2    Li, Y.3    Brunell, S.C.4    Chen, S.5
  • 65
    • 84859879074 scopus 로고    scopus 로고
    • Use of concomitant glucose-lowering therapies and associated treatment results observed in clinical trials of twice-daily exenatide
    • Pencek R, Brunell SC, Li Y, Hoogwerf BJ, Malone J. Use of concomitant glucose-lowering therapies and associated treatment results observed in clinical trials of twice-daily exenatide. Endocr Pract. 2012;18:227-237.
    • (2012) Endocr Pract , vol.18 , pp. 227-237
    • Pencek, R.1    Brunell, S.C.2    Li, Y.3    Hoogwerf, B.J.4    Malone, J.5
  • 66
    • 84871697848 scopus 로고    scopus 로고
    • Exenatide once weekly for the treatment of type 2 diabetes mellitus: Clinical results in subgroups of patients using different concomitant medications
    • Pencek R, Brunell SC, Li Y, Hoogwerf BJ, Malone J. Exenatide once weekly for the treatment of type 2 diabetes mellitus: clinical results in subgroups of patients using different concomitant medications. Postgrad Med. 2012;124:33-40.
    • (2012) Postgrad Med , vol.124 , pp. 33-40
    • Pencek, R.1    Brunell, S.C.2    Li, Y.3    Hoogwerf, B.J.4    Malone, J.5
  • 67
    • 80053582714 scopus 로고    scopus 로고
    • The effect of disease stage, indicated by number of previous oral antidiabetic agents, on the response to liraglutide in type 2 diabetes
    • Garber A, Matthews D, Zinman B, Thomsen A, Flalhati A, Guerci B. The effect of disease stage, indicated by number of previous oral antidiabetic agents, on the response to liraglutide in type 2 diabetes. Diabetes. 2011;60(Suppl 1):0967-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Garber, A.1    Matthews, D.2    Zinman, B.3    Thomsen, A.4    Flalhati, A.5    Guerci, B.6
  • 68
    • 67049132386 scopus 로고    scopus 로고
    • Clinical application of incretin-based therapy: Therapeutic potential, patient selection and clinical use
    • Kendall DM, Cuddihy RM, Bergenstal RM. Clinical application of incretin-based therapy: therapeutic potential, patient selection and clinical use. Am J Med. 2009;122(6 Suppl):S37-50.
    • (2009) Am J Med , vol.122 , Issue.6 SUPPL.
    • Kendall, D.M.1    Cuddihy, R.M.2    Bergenstal, R.M.3
  • 69
    • 0032983666 scopus 로고    scopus 로고
    • Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: Progressive requirement for multiple therapies (UKPDS 49)
    • United Kingdom Prospective Diabetes Study (UKPDS) Group
    • Turner RC, Cull CA, Frighi V, Holman RR, United Kingdom Prospective Diabetes Study (UKPDS) Group. Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA. 1999;281:2005-2012.
    • (1999) JAMA , vol.281 , pp. 2005-2012
    • Turner, R.C.1    Cull, C.A.2    Frighi, V.3    Holman, R.R.4
  • 70
    • 0032511566 scopus 로고    scopus 로고
    • Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34)
    • UK Prospective Diabetes Study (UKPDS) Group
    • UK Prospective Diabetes Study (UKPDS) Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854-865.
    • (1998) Lancet , vol.352 , pp. 854-865
  • 71
    • 33845405222 scopus 로고    scopus 로고
    • Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy
    • Kahn SE, Haffner SM, Heise MA, et al. Glycemic durability of rosiglitazone, metformin, or glyburide monotherapy. N Engl J Med. 2006;355:2427-2443.
    • (2006) N Engl J Med , vol.355 , pp. 2427-2443
    • Kahn, S.E.1    Haffner, S.M.2    Heise, M.A.3
  • 74
    • 85205866549 scopus 로고    scopus 로고
    • Postprandial serum C-peptide is a useful parameter in the prediction of successful switching to liraglutide monotherapy from complex insulin therapy in Japanese patients with type 2 diabetes
    • Aug 2. [Epub ahead of print]
    • Iwao T, Sakai K, Sata M. Postprandial serum C-peptide is a useful parameter in the prediction of successful switching to liraglutide monotherapy from complex insulin therapy in Japanese patients with type 2 diabetes. J Diabetes Complications. 2012 Aug 2. [Epub ahead of print].
    • (2012) J Diabetes Complications
    • Iwao, T.1    Sakai, K.2    Sata, M.3
  • 75
    • 79551615182 scopus 로고    scopus 로고
    • Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: A randomized, controlled trial
    • Buse JB, Bergenstal RM, Glass LC, et al. Use of twice-daily exenatide in basal insulin-treated patients with type 2 diabetes: a randomized, controlled trial. Ann Intern Med. 2011;154:103-112.
    • (2011) Ann Intern Med , vol.154 , pp. 103-112
    • Buse, J.B.1    Bergenstal, R.M.2    Glass, L.C.3
  • 76
    • 84862903186 scopus 로고    scopus 로고
    • Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets
    • DeVries JH, Bain SC, Rodbard HW, et al. Sequential intensification of metformin treatment in type 2 diabetes with liraglutide followed by randomized addition of basal insulin prompted by A1C targets. Diabetes Care. 2012;35:1446-1454.
    • (2012) Diabetes Care , vol.35 , pp. 1446-1454
    • Devries, J.H.1    Bain, S.C.2    Rodbard, H.W.3
  • 77
    • 84861787873 scopus 로고    scopus 로고
    • Adding insulin detemir (IDet) to liraglutide and metformin improves glycaemic control with sustained weight reduction and low hypoglycaemia rate: 52 week results
    • Bain SC, DeVries JH, Seufert J, et al. Adding insulin detemir (IDet) to liraglutide and metformin improves glycaemic control with sustained weight reduction and low hypoglycaemia rate: 52 week results. Diabetologia. 2011;54(Suppl 1):73.
    • (2011) Diabetologia , vol.54 , Issue.SUPPL. 1 , pp. 73
    • Bain, S.C.1    Devries, J.H.2    Seufert, J.3
  • 78
    • 79955556781 scopus 로고    scopus 로고
    • The effect of liraglutide added to U-500 insulin in patients with type 2 diabetes and high insulin requirements
    • Lane W, Weinrib S, Rappaport J. The effect of liraglutide added to U-500 insulin in patients with type 2 diabetes and high insulin requirements. Diabetes Technol Ther. 2011;13:592-595.
    • (2011) Diabetes Technol Ther , vol.13 , pp. 592-595
    • Lane, W.1    Weinrib, S.2    Rappaport, J.3
  • 79
    • 3242664057 scopus 로고    scopus 로고
    • Exendin-4 normalized postcibal glycemic excursions in type 1 diabetes
    • Dupre J, Behme MT, McDonald TJ. Exendin-4 normalized postcibal glycemic excursions in type 1 diabetes. J Clin Endocrinol Metab. 2004;89:3469-3473.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3469-3473
    • Dupre, J.1    Behme, M.T.2    McDonald, T.J.3
  • 80
    • 77956074558 scopus 로고    scopus 로고
    • The role of adjunctive exenatide therapy in pediatric type 1 diabetes
    • Raman VS, Mason KJ, Rodriguez LM, et al. The role of adjunctive exenatide therapy in pediatric type 1 diabetes. Diabetes Care. 2010;33:1294-1296.
    • (2010) Diabetes Care , vol.33 , pp. 1294-1296
    • Raman, V.S.1    Mason, K.J.2    Rodriguez, L.M.3
  • 82
    • 80054690193 scopus 로고    scopus 로고
    • Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual {beta}-cell function
    • Kielgast U, Krarup T, Holst JJ, Madsbad S. Four weeks of treatment with liraglutide reduces insulin dose without loss of glycemic control in type 1 diabetic patients with and without residual {beta}-cell function. Diabetes Care. 2011;34:1463-1468.
    • (2011) Diabetes Care , vol.34 , pp. 1463-1468
    • Kielgast, U.1    Krarup, T.2    Holst, J.J.3    Madsbad, S.4
  • 83
    • 79959392262 scopus 로고    scopus 로고
    • Liraglutide as additional treatment for type 1 diabetes
    • Varanasi A, Bellini N, Rawal D, et al. Liraglutide as additional treatment for type 1 diabetes. Eur J Endocrinol. 2011;165:77-84.
    • (2011) Eur J Endocrinol , vol.165 , pp. 77-84
    • Varanasi, A.1    Bellini, N.2    Rawal, D.3
  • 84
    • 85205886351 scopus 로고    scopus 로고
    • Long-term follow-up of patients with type 1 diabetes on lirglutide and the effect of liraglutide as additional treatment in obese patients with type 1 diabetes
    • Kuhadiya N, Malik R, Bellini N, et al. Long-term follow-up of patients with type 1 diabetes on lirglutide and the effect of liraglutide as additional treatment in obese patients with type 1 diabetes. Endocr Rev. 2012;33:OR17-1.
    • (2012) Endocr Rev , vol.33
    • Kuhadiya, N.1    Malik, R.2    Bellini, N.3
  • 85
    • 79951619351 scopus 로고    scopus 로고
    • Genetic determinants predicting efficacy of glucose-lowering drugs?: A long way to go
    • Nauck MA, Vardarli I. Genetic determinants predicting efficacy of glucose-lowering drugs?: a long way to go Diabetes Care. 2010;33:2123-2125.
    • (2010) Diabetes Care , vol.33 , pp. 2123-2125
    • Nauck, M.A.1    Vardarli, I.2
  • 86
    • 84860250733 scopus 로고    scopus 로고
    • Clinical relevance of anti-exenatide antibodies: Safety, efficacy and cross-reactivity with long-term treatment
    • Fineman MS, Mace KF, Diamant M, et al. Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment. Diabetes Obes Metab. 2012;14:546-554.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 546-554
    • Fineman, M.S.1    MacE, K.F.2    Diamant, M.3
  • 87
    • 79956328908 scopus 로고    scopus 로고
    • Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: Results from the Liraglutide Effect and Action in Diabetes (LEAD) trials
    • Buse JB, Garber A, Rosenstock J, et al. Liraglutide treatment is associated with a low frequency and magnitude of antibody formation with no apparent impact on glycemic response or increased frequency of adverse events: results from the Liraglutide Effect and Action in Diabetes (LEAD) trials. J Clin Endocrinol Metab. 2011;96:1695-1702.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 1695-1702
    • Buse, J.B.1    Garber, A.2    Rosenstock, J.3
  • 88
    • 78649911161 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of exenatide extended-release after single and multiple dosing
    • Fineman M, Flanagan S, Taylor K, et al. Pharmacokinetics and pharmacodynamics of exenatide extended-release after single and multiple dosing. Clin Pharmacokinet. 2011;50:65-74.
    • (2011) Clin Pharmacokinet , vol.50 , pp. 65-74
    • Fineman, M.1    Flanagan, S.2    Taylor, K.3
  • 89
    • 84860250733 scopus 로고    scopus 로고
    • Clinical relevance of anti-exenatide antibodies: Safety, efficacy and cross-reactivity with long-term treatment
    • Fineman MS, Mace KF, Diamant M, et al. Clinical relevance of anti-exenatide antibodies: safety, efficacy and cross-reactivity with long-term treatment. Diabetes Obes Metab. 2012;14:546-554.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 546-554
    • Fineman, M.S.1    MacE, K.F.2    Diamant, M.3
  • 90
    • 0010477738 scopus 로고    scopus 로고
    • Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima Indians
    • Norman RA, Permana P, Tanizawa Y, Ravussin E. Absence of genetic variation in some obesity candidate genes (GLP1R, ASIP, MC4R, MC5R) among Pima Indians. Int J Obes Relat Metab Disord. 1999;23:163-165.
    • (1999) Int J Obes Relat Metab Disord , vol.23 , pp. 163-165
    • Norman, R.A.1    Permana, P.2    Tanizawa, Y.3    Ravussin, E.4
  • 91
    • 0028282950 scopus 로고
    • Human glucagon-like peptide-1 receptor gene in NIDDM. Identification and use of simple sequence repeat polymorphisms in genetic analysis
    • Tanizawa Y, Riggs AC, Elbein SC, Whelan A, Donis-Keller H, Permutt MA. Human glucagon-like peptide-1 receptor gene in NIDDM. Identification and use of simple sequence repeat polymorphisms in genetic analysis. Diabetes. 1994;43:752-757.
    • (1994) Diabetes , vol.43 , pp. 752-757
    • Tanizawa, Y.1    Riggs, A.C.2    Elbein, S.C.3    Whelan, A.4    Donis-Keller, H.5    Permutt, M.A.6
  • 92
    • 0029848580 scopus 로고    scopus 로고
    • A population association study of four candidate genes (hexokinase II, glucagon-like peptide-1 receptor, fatty acid binding protein-2, and apolipoprotein C-II) with type 2 diabetes and impaired glucose tolerance in Japanese subjects
    • Yagi T, Nishi S, Hinata S, Murakami M, Yoshimi T. A population association study of four candidate genes (hexokinase II, glucagon-like peptide-1 receptor, fatty acid binding protein-2, and apolipoprotein C-II) with type 2 diabetes and impaired glucose tolerance in Japanese subjects. Diabet Med. 1996;13:902-907.
    • (1996) Diabet Med , vol.13 , pp. 902-907
    • Yagi, T.1    Nishi, S.2    Hinata, S.3    Murakami, M.4    Yoshimi, T.5
  • 93
    • 22044446844 scopus 로고    scopus 로고
    • A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness
    • Beinborn M, Worrall CI, McBride EW, Kopin AS. A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness. Regul Pept. 2005;130:1-6.
    • (2005) Regul Pept , vol.130 , pp. 1-6
    • Beinborn, M.1    Worrall, C.I.2    McBride, E.W.3    Kopin, A.S.4
  • 94
    • 78650890818 scopus 로고    scopus 로고
    • Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: A pilot study
    • Sathananthan A, Man CD, Micheletto F, et al. Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study. Diabetes Care. 2010;33:2074-2076.
    • (2010) Diabetes Care , vol.33 , pp. 2074-2076
    • Sathananthan, A.1    Man, C.D.2    Micheletto, F.3
  • 95
    • 80051958802 scopus 로고    scopus 로고
    • Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: Allosteric rescue of loss of function mutation
    • Koole C, Wootten D, Simms J, et al. Polymorphism and ligand dependent changes in human glucagon-like peptide-1 receptor (GLP-1R) function: Allosteric rescue of loss of function mutation. Mol Pharmacol. 2011;80:486-497.
    • (2011) Mol Pharmacol , vol.80 , pp. 486-497
    • Koole, C.1    Wootten, D.2    Simms, J.3
  • 96
    • 77649294607 scopus 로고    scopus 로고
    • Weighing risks and benefits of liraglutide - The FDA's review of a new antidiabetic therapy
    • Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide - The FDA's review of a new antidiabetic therapy. N Engl J Med. 2010;362:774-777.
    • (2010) N Engl J Med , vol.362 , pp. 774-777
    • Parks, M.1    Rosebraugh, C.2
  • 97
    • 77951700065 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Accessed August 19 2012
    • U.S. Food and Drug Administration. Drugs@FDA: FDA approved drug products. http://www.accessdata.fda.gov/Scripts/cder/DrugsatFDA/. Accessed August 19, 2012.
    • Drugs@FDA: FDA Approved Drug Products
  • 98
    • 77950228684 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
    • Knudsen LB, Madsen LW, Andersen S, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology. 2010;151:1473-1486.
    • (2010) Endocrinology , vol.151 , pp. 1473-1486
    • Knudsen, L.B.1    Madsen, L.W.2    Andersen, S.3
  • 99
    • 84857422717 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation
    • Madsen LW, Knauf JA, Gotfredsen C, et al. GLP-1 receptor agonists and the thyroid: C-cell effects in mice are mediated via the GLP-1 receptor and not associated with RET activation. Endocrinology. 2012;153:1538-1547.
    • (2012) Endocrinology , vol.153 , pp. 1538-1547
    • Madsen, L.W.1    Knauf, J.A.2    Gotfredsen, C.3
  • 101
    • 83655191987 scopus 로고    scopus 로고
    • Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: Relevance for incretin-based diabetes therapy
    • Waser B, Beetschen K, Pellegata NS, Reubi JC. Incretin receptors in non-neoplastic and neoplastic thyroid C cells in rodents and humans: Relevance for incretin-based diabetes therapy. Neuroendocrinology. 2011;94(4):291-301.
    • (2011) Neuroendocrinology , vol.94 , Issue.4 , pp. 291-301
    • Waser, B.1    Beetschen, K.2    Pellegata, N.S.3    Reubi, J.C.4
  • 102
    • 85205891814 scopus 로고    scopus 로고
    • National Cancer Institute, Accessed for verification October 25 2012
    • National Cancer Institute. Thyroid cancer treatment (PDQ): general information about thyroid cancer. http://www.cancer.gov/cancertopics/pdq/ treatment/thyroid/HealthProfessional. Accessed for verification October 25, 2012.
    • Thyroid Cancer Treatment (PDQ): General Information about Thyroid Cancer
  • 103
    • 84872291610 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. FDA Briefing Materials-Liraglutide. Accessed for verification October 25, 2012
    • U.S. Food and Drug Administration. Endocrinologic and Metabolic Drugs Advisory Committee. FDA briefing materials- liraglutide. http://www.fda.gov/ ohrms/dockets/ac/09/briefing/2009-4422b2-01-FDA.pdf. Accessed for verification October 25, 2012.
    • Endocrinologic and Metabolic Drugs Advisory Committee
  • 104
    • 85205870373 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. FDA Briefing Document: NDA 202293: Dapagliflozin Tablets 5 And 10 Mg. Accessed for verification October 25, 2012
    • U.S. Food and Drug Administration. Endocrine and Metabolics Drugs Advisory Committee Panel. FDA briefing document: NDA 202293: Dapagliflozin tablets, 5 and 10 mg. http://www.fda.gov/downloads/AdvisoryCommittees/ CommitteesMeeting Materials/Drugs/EndocrinologicandMetabolic DrugsAdvisoryCommittee/UCM262994.pdf. Accessed for verification October 25, 2012.
    • Endocrine and Metabolics Drugs Advisory Committee Panel
  • 105
    • 79952284556 scopus 로고    scopus 로고
    • GLP-1 and calcitonin concentration in humans: Lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide
    • Hegedus L, Moses AC, Zdravkovic M, Le Thi T, Daniels GH. GLP-1 and calcitonin concentration in humans: lack of evidence of calcitonin release from sequential screening in over 5000 subjects with type 2 diabetes or nondiabetic obese subjects treated with the human GLP-1 analog, liraglutide. J Clin Endocrinol Metab. 2011;96:853-860.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 853-860
    • Hegedus, L.1    Moses, A.C.2    Zdravkovic, M.3    Le Thi, T.4    Daniels, G.H.5
  • 106
    • 79959559653 scopus 로고    scopus 로고
    • Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies
    • Elashoff M, Matveyenko AV, Gier B, Elashoff R, Butler PC. Pancreatitis, pancreatic, and thyroid cancer with glucagon-like peptide-1-based therapies. Gastroenterology. 2011;141:150-156.
    • (2011) Gastroenterology , vol.141 , pp. 150-156
    • Elashoff, M.1    Matveyenko, A.V.2    Gier, B.3    Elashoff, R.4    Butler, P.C.5
  • 107
    • 84872331521 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration, Accessed for verification October 25 2012
    • U.S. Food and Drug Administration. FDA adverse event reporting system (FAERS) (formerly AERS). http://www.fda.gov/Drugs/ GuidanceComplianceRegulatoryInformation/Surveillance/AdverseDrugEffects/default. htm. Accessed for verification October 25, 2012.
    • FDA Adverse Event Reporting System (FAERS) (Formerly AERS)
  • 108
    • 85205852209 scopus 로고    scopus 로고
    • European Association For The Study Of Diabetes Published Online In Gastroenterology February, Increased Incidence Of Pancreatitis And Cancer Among Patients Given Glucagon-like Peptide-1- Based Therapy. Accessed for verification October 25, 2012
    • European Association for the Study of Diabetes. EASD commentary on the publication by Elashoff et al., published online in gastroenterology, February 2011: increased incidence of pancreatitis and cancer among patients given glucagon-like peptide-1- based therapy. http://87.234.226.93/easd-intranet/ easdwebfiles/statements/Elashoff-Commentary.pdf. Accessed for verification October 25, 2012.
    • (2011) EASD Commentary on the Publication
    • Elashoff1
  • 109
    • 85205844093 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Accessed for verification October 25 2012
    • U.S. Food and Drug Administration. Victoza NDA approval letter. http://www.accessdata.fda.gov/drugsatfda-docs/appletter/2010/022341s000ltr. pdf. Accessed for verification October 25, 2012.
    • Victoza NDA Approval Letter
  • 110
    • 85205862890 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration. Accessed for verification October 25 2012
    • U.S. Food and Drug Administration. Bydureon NDA approval letter. http://www.accessdata.fda.gov/drugsatfda-docs/appletter/2012/022200s000ltr.pdf. Accessed for verification October 25, 2012.
    • Bydureon NDA Approval Letter
  • 111
    • 85205860058 scopus 로고    scopus 로고
    • Novo Nordisk. Accessed for verification October 25 2012
    • Novo Nordisk. Important drug warning concerning Victoza®. http://www.fda.gov/downloads/Safety/MedWatch/SafetyInformation/ SafetyAlertsforHuman MedicalProducts/UCM258828.pdf. Accessed for verification October 25, 2012.
    • Important Drug Warning Concerning Victoza®
  • 112
    • 33646458182 scopus 로고    scopus 로고
    • Amylin Pharmaceuticals Inc,. Accessed for verification October 25 2012
    • Amylin Pharmaceuticals Inc. Important drug warning. http://bydureonhcp. com/Content/pdf/Dear-HCP-Letter.pdf. Accessed for verification October 25, 2012.
    • Important Drug Warning
  • 113
    • 65949111736 scopus 로고    scopus 로고
    • Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
    • Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care. 2009;32:834-838.
    • (2009) Diabetes Care , vol.32 , pp. 834-838
    • Noel, R.A.1    Braun, D.K.2    Patterson, R.E.3    Bloomgren, G.L.4
  • 114
    • 77955016889 scopus 로고    scopus 로고
    • Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes
    • Girman CJ, Kou TD, Cai B, et al. Patients with type 2 diabetes mellitus have higher risk for acute pancreatitis compared with those without diabetes. Diabetes Obes Metab. 2010;12:766-771.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 766-771
    • Girman, C.J.1    Kou, T.D.2    Cai, B.3
  • 115
    • 79951704452 scopus 로고    scopus 로고
    • Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: A retrospective observational pharmacy claims analysis
    • Garg R, Chen W, Pendergrass M. Acute pancreatitis in type 2 diabetes treated with exenatide or sitagliptin: a retrospective observational pharmacy claims analysis. Diabetes Care. 2010;33:2349- 2354.
    • (2010) Diabetes Care , vol.33 , pp. 2349-2354
    • Garg, R.1    Chen, W.2    Pendergrass, M.3
  • 116
    • 67649304917 scopus 로고    scopus 로고
    • Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
    • Dore DD, Seeger JD, Arnold Chan K. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin. 2009;25:1019-1027.
    • (2009) Curr Med Res Opin , vol.25 , pp. 1019-1027
    • Dore, D.D.1    Seeger, J.D.2    Arnold Chan, K.3
  • 117
    • 79952696926 scopus 로고    scopus 로고
    • A retrospective cohort study to assess the relative risk of acute pancreatitis among initiators of exenatide compared to initiators of other antidiabetic medication: A follow-up study
    • Wenten M, Gaebler J, Hussein M, et al. A retrospective cohort study to assess the relative risk of acute pancreatitis among initiators of exenatide compared to initiators of other antidiabetic medication: A follow-up study. Diabetes. 2010;59(Suppl 1):A163.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Wenten, M.1    Gaebler, J.2    Hussein, M.3
  • 118
    • 79954994764 scopus 로고    scopus 로고
    • A cohort study of acute pancreatitis in relation to exenatide use
    • Dore DD, Bloomgren GL, Wenten M, et al. A cohort study of acute pancreatitis in relation to exenatide use. Diabetes Obes Metab. 2011;13:559-566.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 559-566
    • Dore, D.D.1    Bloomgren, G.L.2    Wenten, M.3
  • 119
    • 84867212961 scopus 로고    scopus 로고
    • Relative risk of acute pancreatitis in initiators of exenatide twice daily compared with other anti-diabetic medication: A follow-up study
    • Mar 14. [Epub ahead of print]
    • Wenten M, Gaebler JA, Hussein M, et al. Relative risk of acute pancreatitis in initiators of exenatide twice daily compared with other anti-diabetic medication: a follow-up study. Diabet Med. 2012 Mar 14. [Epub ahead of print].
    • (2012) Diabet Med.
    • Wenten, M.1    Gaebler, J.A.2    Hussein, M.3
  • 120
    • 84867053241 scopus 로고    scopus 로고
    • Exenatide therapy and the risk of pancreatitis and pancreatic cancer in a privately insured population
    • Jul 30. [Epub ahead of print]
    • Romley JA, Goldman DP, Solomon M, McFadden D, Peters AL. Exenatide therapy and the risk of pancreatitis and pancreatic cancer in a privately insured population. Diabetes Technol Ther. 2012 Jul 30. [Epub ahead of print].
    • (2012) Diabetes Technol Ther.
    • Romley, J.A.1    Goldman, D.P.2    Solomon, M.3    McFadden, D.4    Peters, A.L.5
  • 121
    • 84884904575 scopus 로고    scopus 로고
    • The association of pancreatitis with antidiabetic drug use: Gaining insight through the FDA pharmacovigilance database
    • Oct 19. [Epub ahead of print]
    • Raschi E, Piccinni C, Poluzzi E, Marchesini G, De Ponti F. The association of pancreatitis with antidiabetic drug use: gaining insight through the FDA pharmacovigilance database. Acta Diabetol. 2011 Oct 19. [Epub ahead of print].
    • (2011) Acta Diabetol.
    • Raschi, E.1    Piccinni, C.2    Poluzzi, E.3    Marchesini, G.4    De Ponti, F.5
  • 124
    • 84860567470 scopus 로고    scopus 로고
    • Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the kras (G12D) mouse model
    • Gier B, Matveyenko AV, Kirakossian D, Dawson D, Dry SM, Butler PC. Chronic GLP-1 receptor activation by exendin-4 induces expansion of pancreatic duct glands in rats and accelerates formation of dysplastic lesions and chronic pancreatitis in the kras (G12D) mouse model. Diabetes. 2012;61:1250-1262.
    • (2012) Diabetes , vol.61 , pp. 1250-1262
    • Gier, B.1    Matveyenko, A.V.2    Kirakossian, D.3    Dawson, D.4    Dry, S.M.5    Butler, P.C.6
  • 125
    • 84860577431 scopus 로고    scopus 로고
    • The human GLP-1 analog liraglutide and the pancreas: Evidence for the absence of structural pancreatic changes in three species
    • Nyborg NC, Molck AM, Madsen LW, Knudsen LB. The human GLP-1 analog liraglutide and the pancreas: evidence for the absence of structural pancreatic changes in three species. Diabetes. 2012;61:1243-1249.
    • (2012) Diabetes , vol.61 , pp. 1243-1249
    • Nyborg, N.C.1    Molck, A.M.2    Madsen, L.W.3    Knudsen, L.B.4
  • 126
    • 81155155431 scopus 로고    scopus 로고
    • Effect of exenatide BID on kidney function and adverse events in clinical trials
    • Tuttle K, Brown C, Lee D, et al. Effect of exenatide BID on kidney function and adverse events in clinical trials. Diabetes. 2011;60(Suppl 1):971-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Tuttle, K.1    Brown, C.2    Lee, D.3
  • 127
    • 84862777558 scopus 로고    scopus 로고
    • Exenatide and sitagliptin are not associated with increased risk of acute renal failure: A retrospective claims analysis
    • Pendergrass M, Fenton C, Haffner SM, Chen W. Exenatide and sitagliptin are not associated with increased risk of acute renal failure: a retrospective claims analysis. Diabetes Obes Metab. 2012;14:596-600.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 596-600
    • Pendergrass, M.1    Fenton, C.2    Haffner, S.M.3    Chen, W.4
  • 128
    • 79959692519 scopus 로고    scopus 로고
    • Mild renal impairment and the efficacy and safety of liraglutide
    • Davidson JA, Brett J, Falahati A, Scott D. Mild renal impairment and the efficacy and safety of liraglutide. Endocr Pract. 2011;17:345-355.
    • (2011) Endocr Pract , vol.17 , pp. 345-355
    • Davidson, J.A.1    Brett, J.2    Falahati, A.3    Scott, D.4
  • 129
    • 84859735520 scopus 로고    scopus 로고
    • Safety and tolerability of exenatide twice daily in patients with type 2 diabetes: Integrated analysis of 5594 patients from 19 placebo-controlled and comparator-controlled clinical trials
    • Macconell L, Brown C, Gurney K, Han J. Safety and tolerability of exenatide twice daily in patients with type 2 diabetes: integrated analysis of 5594 patients from 19 placebo-controlled and comparator-controlled clinical trials. Diabetes Metab Syndr Obes. 2012;5:29-41.
    • (2012) Diabetes Metab Syndr Obes , vol.5 , pp. 29-41
    • MacConell, L.1    Brown, C.2    Gurney, K.3    Han, J.4
  • 131
    • 51649107392 scopus 로고    scopus 로고
    • Exenatide
    • may aggravate moderate diabetic renal impairment: a case report
    • Johansen OE, Whitfield R. Exenatide may aggravate moderate diabetic renal impairment: a case report. Br J Clin Pharmacol. 2008;66:568-569.
    • (2008) Br J Clin Pharmacol , vol.66 , pp. 568-569
    • Johansen, O.E.1    Whitfield, R.2
  • 134
    • 78349307376 scopus 로고    scopus 로고
    • Acute renal failure when exenatide is co-administered with diuretics and angiotensin II blockers
    • Lopez-Ruiz A, del Peso-Gilsanz C, Meoro- Aviles A, et al. Acute renal failure when exenatide is co-administered with diuretics and angiotensin II blockers. Pharm World Sci. 2010;32:559-561.
    • (2010) Pharm World Sci , vol.32 , pp. 559-561
    • Lopez-Ruiz, A.1    Del Peso-Gilsanz, C.2    Meoro-Aviles, A.3
  • 136
    • 85205867283 scopus 로고    scopus 로고
    • Acute tubulointerstitial nephritis following treatment with exenatide
    • Jul 4. [Epub ahead of print]
    • Nandakoban H, Furlong TJ, Flack Jr. Acute tubulointerstitial nephritis following treatment with exenatide. Diabet Med. 2012 Jul 4. [Epub ahead of print].
    • (2012) Diabet Med.
    • Nandakoban, H.1    Furlong, T.J.2    Flack, J.R.3
  • 138
    • 34548034895 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of exenatide
    • Linnebjerg H, Kothare PA, Park S, et al. Effect of renal impairment on the pharmacokinetics of exenatide. Br J Clin Pharmacol. 2007;64:317-327.
    • (2007) Br J Clin Pharmacol , vol.64 , pp. 317-327
    • Linnebjerg, H.1    Kothare, P.A.2    Park, S.3
  • 139
    • 70849096647 scopus 로고    scopus 로고
    • Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide
    • Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol. 2009;68:898-905.
    • (2009) Br J Clin Pharmacol , vol.68 , pp. 898-905
    • Jacobsen, L.V.1    Hindsberger, C.2    Robson, R.3    Zdravkovic, M.4
  • 140
    • 79952694840 scopus 로고    scopus 로고
    • Cardiovascular safety of exenatide BID: An integrated analysis from controlled clinical trials in participants with type 2 diabetes
    • Ratner R, Han J, Nicewarner D, Yushmanova I, Hoogwerf BJ, Shen L. Cardiovascular safety of exenatide BID: An integrated analysis from controlled clinical trials in participants with type 2 diabetes. Cardiovasc Diabetol. 2011;10:22.
    • (2011) Cardiovasc Diabetol , vol.10 , pp. 22
    • Ratner, R.1    Han, J.2    Nicewarner, D.3    Yushmanova, I.4    Hoogwerf, B.J.5    Shen, L.6
  • 141
    • 80052039077 scopus 로고    scopus 로고
    • Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2-3 liraglutide clinical development studies
    • Marso SP, Lindsey JB, Stolker JM, et al. Cardiovascular safety of liraglutide assessed in a patient-level pooled analysis of phase 2-3 liraglutide clinical development studies. Diab Vasc Dis Res. 2011;8:237-240.
    • (2011) Diab Vasc Dis Res , vol.8 , pp. 237-240
    • Marso, S.P.1    Lindsey, J.B.2    Stolker, J.M.3
  • 142
    • 79951702236 scopus 로고    scopus 로고
    • Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: A retrospective analysis of the LifeLink database
    • Best JH, Hoogwerf BJ, Herman WH, et al. Risk of cardiovascular disease
    • (2011) Diabetes Care , vol.34 , pp. 90-95
    • Best, J.H.1    Hoogwerf, B.J.2    Herman, W.H.3
  • 143
    • 84858207420 scopus 로고    scopus 로고
    • The risk of heart failure among patients receiving exenatide versus other glucose-lowering medications for type 2 diabetes: A matched retrospective cohort analysis of the GE healthcare electronic medical record database
    • Best JH, Little W, Chiquette E, Saunders WB, Maggs D. The risk of heart failure among patients receiving exenatide versus other glucose-lowering medications for type 2 diabetes: a matched retrospective cohort analysis of the GE healthcare electronic medical record database. Diabetes. 2011;60(Suppl 1):1133-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Best, J.H.1    Little, W.2    Chiquette, E.3    Saunders, W.B.4    Maggs, D.5
  • 144
    • 70350430650 scopus 로고    scopus 로고
    • Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP-1 analog for treatment of type 2 diabetes
    • Chatterjee DJ, Khutoryansky N, Zdravkovic M, Sprenger CR, Litwin JS. Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP-1 analog for treatment of type 2 diabetes. J Clin Pharmacol. 2009;49:1353-1362.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1353-1362
    • Chatterjee, D.J.1    Khutoryansky, N.2    Zdravkovic, M.3    Sprenger, C.R.4    Litwin, J.S.5
  • 145
    • 80053606722 scopus 로고    scopus 로고
    • A thorough QT study to evaluate the effects of single dose exenatide 10 mug on cardiac repolarization in healthy subjects
    • Linnebjerg H, Seger M, Kothare PA, Hunt T, Wolka AM, Mitchell MI. A thorough QT study to evaluate the effects of single dose exenatide 10 mug on cardiac repolarization in healthy subjects. Int J Clin Pharmacol Ther. 2011;49:594-604.
    • (2011) Int J Clin Pharmacol Ther , vol.49 , pp. 594-604
    • Linnebjerg, H.1    Seger, M.2    Kothare, P.A.3    Hunt, T.4    Wolka, A.M.5    Mitchell, M.I.6
  • 146
    • 80052729324 scopus 로고    scopus 로고
    • Exenatide once weekly did not affect corrected QT interval in patients with type 2 diabetes
    • Sager P, Darpö B, Han J, et al. Exenatide once weekly did not affect corrected QT interval in patients with type 2 diabetes. Diabetes. 2011;60(Suppl 1):1070-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Sager, P.1    Darpö, B.2    Han, J.3
  • 147
    • 84872320453 scopus 로고    scopus 로고
    • Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects
    • Aug 10. [Epub ahead of print]
    • Darpo B, Sager P, Macconell L, et al. Exenatide at therapeutic and supratherapeutic concentrations does not prolong the QTc interval in healthy subjects. Br J Clin Pharmacol. 2012 Aug 10. [Epub ahead of print].
    • (2012) Br J Clin Pharmacol
    • Darpo, B.1    Sager, P.2    MacConell, L.3
  • 148
    • 84859003663 scopus 로고    scopus 로고
    • Effects of glucagon-like peptide-1 receptor agonists on weight loss: Systematic review and meta-analyses of randomised controlled trials
    • Vilsboll T, Christensen M, Junker AE, Knop FK, Gluud LL. Effects of glucagon-like peptide-1 receptor agonists on weight loss: systematic review and meta-analyses of randomised controlled trials. BMJ. 2012;344:d7771.
    • (2012) BMJ , vol.344
    • Vilsboll, T.1    Christensen, M.2    Junker, A.E.3    Knop, F.K.4    Gluud, L.L.5
  • 149
    • 84860112822 scopus 로고    scopus 로고
    • Liraglutide, a once-daily human GLP-1 analog, lowers systolic blood pressure (SBP) independently of concomitant antihypertensive treatment
    • Fonseca V, Plutzky J, Montanya E, et al. Liraglutide, a once-daily human GLP-1 analog, lowers systolic blood pressure (SBP) independently of concomitant antihypertensive treatment. Diabetes. 2010;59(Suppl 1):A79.
    • (2010) Diabetes , vol.59 , Issue.SUPPL. 1
    • Fonseca, V.1    Plutzky, J.2    Montanya, E.3
  • 152
    • 76749161358 scopus 로고    scopus 로고
    • Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes
    • Okerson T, Yan P, Stonehouse A, Brodows R. Effects of exenatide on systolic blood pressure in subjects with type 2 diabetes. Am J Hypertens. 2010;23:334-339.
    • (2010) Am J Hypertens , vol.23 , pp. 334-339
    • Okerson, T.1    Yan, P.2    Stonehouse, A.3    Brodows, R.4
  • 153
    • 84864360856 scopus 로고    scopus 로고
    • Effects of HbA(1c) and weight reduction on blood pressure in patients with type 2 diabetes mellitus treated with exenatide
    • Paul S, Best J, Klein K, Han J, Maggs D. Effects of HbA(1c) and weight reduction on blood pressure in patients with type 2 diabetes mellitus treated with exenatide. Diabetes Obes Metab. 2012;14:826-834.
    • (2012) Diabetes Obes Metab , vol.14 , pp. 826-834
    • Paul, S.1    Best, J.2    Klein, K.3    Han, J.4    Maggs, D.5
  • 155
    • 85205846829 scopus 로고    scopus 로고
    • Liraglutide suppresses postprandial triglyceride (TG) and apolipoprotein B48 (ApoB48) responses to a fat-rich meal in subjects with type 2 diabetes
    • Hermansen K, Baekdal T, During M, et al. Liraglutide suppresses postprandial triglyceride (TG) and apolipoprotein B48 (ApoB48) responses to a fat-rich meal in subjects with type 2 diabetes. Canadian J Diabetes. 2012;36(5):S35.
    • (2012) Canadian J Diabetes , vol.36 , Issue.5
    • Hermansen, K.1    Baekdal, T.2    During, M.3
  • 156
    • 78449281377 scopus 로고    scopus 로고
    • Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170,000 participants in 26 randomised trials
    • Cholesterol Treatment Trialists' (CTT) Collaboration
    • Cholesterol Treatment Trialists' (CTT) Collaboration, Baigent C, Blackwell L, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376:1670-1681.
    • (2010) Lancet , vol.376 , pp. 1670-1681
    • Baigent, C.1    Blackwell, L.2
  • 157
    • 77952708442 scopus 로고    scopus 로고
    • Effects of fibrates on cardiovascular outcomes: A systematic review and meta-analysis
    • Jun M, Foote C, Lv J, et al. Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis Lancet. 2010;375:1875-1884.
    • (2010) Lancet , vol.375 , pp. 1875-1884
    • Jun, M.1    Foote, C.2    Lv, J.3
  • 158
    • 72549104133 scopus 로고    scopus 로고
    • Are you targeting non-high-density lipoprotein cholesterol?
    • Robinson JG. Are you targeting non-high-density lipoprotein cholesterol? J Am Coll Cardiol. 2009;55:42-44.
    • (2009) J Am Coll Cardiol , vol.55 , pp. 42-44
    • Robinson, J.G.1
  • 159
    • 77951704587 scopus 로고    scopus 로고
    • Effects of combination lipid therapy in type 2 diabetes mellitus
    • ACCORD Study Group, Ginsberg HN, Elam MB, et al. Effects of combination lipid therapy in type 2 diabetes mellitus. N Engl J Med. 2010;362:1563-1574.
    • (2010) N Engl J Med , vol.362 , pp. 1563-1574
    • Study Group, A.1    Ginsberg, H.N.2    Elam, M.B.3
  • 160
    • 84855171302 scopus 로고    scopus 로고
    • Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy
    • AIM-HIGH Investigators, Boden WE, Probstfield JL, et al. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy N Engl J Med. 2011;365:2255-2267.
    • (2011) N Engl J Med , vol.365 , pp. 2255-2267
    • Boden, W.E.1    Probstfield, J.L.2
  • 161
    • 79751506305 scopus 로고    scopus 로고
    • Triglycerides and atherogenic dyslipidaemia: Extending treatment beyond statins in the high-risk cardiovascular patient
    • Watts GF, Karpe F. Triglycerides and atherogenic dyslipidaemia: Extending treatment beyond statins in the high-risk cardiovascular patient. Heart. 2011;9:350-356.
    • (2011) Heart , vol.9 , pp. 350-356
    • Watts, G.F.1    Karpe, F.2
  • 162
    • 84872316241 scopus 로고    scopus 로고
    • VADT investigators
    • Accessed for verification October 25 2012
    • Duckworth WC, Abraira C, Moritz T, VADT Investigators. VA diabetes trial (VADT) update. http://webcasts.prous.com/netadmin/webcast-viewer/Preview.aspx: type=0&lid=9473&pv=2&preview=False&id cl=0. Accessed for verification October 25, 2012.
    • VA Diabetes Trial (VADT) Update
    • Duckworth, W.C.1    Abraira, C.2    Moritz, T.3
  • 163
    • 77957742069 scopus 로고    scopus 로고
    • Severe hypoglycemia and risks of vascular events and death
    • Zoungas S, Patel A, Chalmers J, et al. Severe hypoglycemia and risks of vascular events and death. N Engl J Med. 2010;363:1410-1418.
    • (2010) N Engl J Med , vol.363 , pp. 1410-1418
    • Zoungas, S.1    Patel, A.2    Chalmers, J.3
  • 164
    • 70449360911 scopus 로고    scopus 로고
    • Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: New results from the ADVANCE trial
    • Zoungas S, de Galan BE, Ninomiya T, et al. Combined effects of routine blood pressure lowering and intensive glucose control on macrovascular and microvascular outcomes in patients with type 2 diabetes: new results from the ADVANCE trial. Diabetes Care. 2009;32:2068-2074.
    • (2009) Diabetes Care , vol.32 , pp. 2068-2074
    • Zoungas, S.1    De Galan, B.E.2    Ninomiya, T.3
  • 165
    • 84862302997 scopus 로고    scopus 로고
    • Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): An open-label, randomised controlled trial
    • Gallwitz B, Guzman J, Dotta F, et al. Exenatide twice daily versus glimepiride for prevention of glycaemic deterioration in patients with type 2 diabetes with metformin failure (EUREXA): an open-label, randomised controlled trial. Lancet. 2012;379:2270-2278.
    • (2012) Lancet , vol.379 , pp. 2270-2278
    • Gallwitz, B.1    Guzman, J.2    Dotta, F.3
  • 166
    • 77958184434 scopus 로고    scopus 로고
    • Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition
    • Bunck MC, Diamant M, Eliasson B, et al. Exenatide affects circulating cardiovascular risk biomarkers independently of changes in body composition. Diabetes Care. 2010;33:1734-1737.
    • (2010) Diabetes Care , vol.33 , pp. 1734-1737
    • Bunck, M.C.1    Diamant, M.2    Eliasson, B.3
  • 167
    • 79959975635 scopus 로고    scopus 로고
    • Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients
    • Derosa G, Putignano P, Bossi AC, et al. Exenatide or glimepiride added to metformin on metabolic control and on insulin resistance in type 2 diabetic patients. Eur J Pharmacol. 2011;666:251-256.
    • (2011) Eur J Pharmacol , vol.666 , pp. 251-256
    • Derosa, G.1    Putignano, P.2    Bossi, A.C.3
  • 168
    • 84855483249 scopus 로고    scopus 로고
    • Exenatide exerts a potent anti-inflammatory effect
    • Chaudhuri A, Ghanim H, Vora M, et al. Exenatide exerts a potent anti-inflammatory effect J Clin Endocrinol Metab. 2012;97:198-207.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 198-207
    • Chaudhuri, A.1    Ghanim, H.2    Vora, M.3
  • 169
    • 84861944029 scopus 로고    scopus 로고
    • Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: A randomized trial
    • Kelly AS, Bergenstal RM, Gonzalez-Campoy JM, Katz H, Bank AJ. Effects of exenatide vs. metformin on endothelial function in obese patients with pre-diabetes: a randomized trial. Cardiovasc Diabetol. 2012;11:64.
    • (2012) Cardiovasc Diabetol , vol.11 , pp. 64
    • Kelly, A.S.1    Bergenstal, R.M.2    Gonzalez-Campoy, J.M.3    Katz, H.4    Bank, A.J.5
  • 170
    • 82955198030 scopus 로고    scopus 로고
    • Exenatide as a weight-loss therapy in extremely obese youth without diabetes
    • Kelly A, Metzig A, Rudser K, et al. Exenatide as a weight-loss therapy in extremely obese youth without diabetes. Diabetes. 2011;60(Suppl 1):420-PP.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1 , pp. 420
    • Kelly, A.1    Metzig, A.2    Rudser, K.3
  • 171
    • 50649110233 scopus 로고    scopus 로고
    • Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with type 2 diabetes
    • Courreges JP, Vilsboll T, Zdravkovic M, et al. Beneficial effects of once-daily liraglutide, a human glucagon-like peptide-1 analogue, on cardiovascular risk biomarkers in patients with type 2 diabetes. Diabet Med. 2008;25:1129-1131.
    • (2008) Diabet Med , vol.25 , pp. 1129-1131
    • Courreges, J.P.1    Vilsboll, T.2    Zdravkovic, M.3
  • 172
    • 84865130603 scopus 로고    scopus 로고
    • Addition of liraglutide in patients with type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function
    • Sep
    • Forst T, Michelson G, Ratter F, et al. Addition of liraglutide in patients with type 2 diabetes well controlled on metformin monotherapy improves several markers of vascular function. Diabet Med. 2012. Sep;29:1115-1118.
    • (2012) Diabet Med , vol.29 , pp. 1115-1118
    • Forst, T.1    Michelson, G.2    Ratter, F.3
  • 173
    • 77954948794 scopus 로고    scopus 로고
    • Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes
    • Koska J, Schwartz EA, Mullin MP, Schwenke DC, Reaven PD. Improvement of postprandial endothelial function after a single dose of exenatide in individuals with impaired glucose tolerance and recent-onset type 2 diabetes. Diabetes Care. 2010;33:1028-1030.
    • (2010) Diabetes Care , vol.33 , pp. 1028-1030
    • Koska, J.1    Schwartz, E.A.2    Mullin, M.P.3    Schwenke, D.C.4    Reaven, P.D.5
  • 174
    • 85205864879 scopus 로고    scopus 로고
    • Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: Results from an observational research
    • Jun 25. [Epub ahead of print]
    • Irace C, De Luca S, Shehaj E, et al. Exenatide improves endothelial function assessed by flow mediated dilation technique in subjects with type 2 diabetes: results from an observational research. Diab Vasc Dis Res. 2012 Jun 25. [Epub ahead of print].
    • (2012) Diab Vasc Dis Res.
    • Irace, C.1    De Luca, S.2    Shehaj, E.3
  • 176
    • 84863560602 scopus 로고    scopus 로고
    • Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction
    • Lonborg J, Vejlstrup N, Kelbaek H, et al. Exenatide reduces reperfusion injury in patients with ST-segment elevation myocardial infarction. Eur Heart J. 2011;33:1491-1499.
    • (2011) Eur Heart J , vol.33 , pp. 1491-1499
    • Lonborg, J.1    Vejlstrup, N.2    Kelbaek, H.3
  • 177
    • 84860807487 scopus 로고    scopus 로고
    • Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia
    • Lonborg J, Kelbaek H, Vejlstrup N, et al. Exenatide reduces final infarct size in patients with ST-segment-elevation myocardial infarction and short-duration of ischemia Circ Cardiovasc Interv. 2012;5:288-295.
    • (2012) Circ Cardiovasc Interv , vol.5 , pp. 288-295
    • Lonborg, J.1    Kelbaek, H.2    Vejlstrup, N.3
  • 178
    • 84862521094 scopus 로고    scopus 로고
    • Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: A double-blind, randomised controlled clinical trial of efficacy and safety
    • Nathanson D, Ullman B, Lofstrom U, et al. Effects of intravenous exenatide in type 2 diabetic patients with congestive heart failure: a double-blind, randomised controlled clinical trial of efficacy and safety. Diabetologia. 2012;55:926-935.
    • (2012) Diabetologia , vol.55 , pp. 926-935
    • Nathanson, D.1    Ullman, B.2    Lofstrom, U.3
  • 181
    • 70350621095 scopus 로고    scopus 로고
    • Monotherapy with liraglutide, a once-daily human GLP-1 analog, provides sustained reductions in A1C, FPG, and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results
    • Garber AJ, Henry R, Ratner R, Hale P, Chang CT, Bode B. Monotherapy with liraglutide, a once-daily human GLP-1 analog, provides sustained reductions in A1C, FPG, and weight compared with glimepiride in type 2 diabetes: LEAD-3 mono 2-year results. Diabetes. 2009;58(Suppl 1):162-OR.
    • (2009) Diabetes , vol.58 , Issue.SUPPL. 1
    • Garber, A.J.1    Henry, R.2    Ratner, R.3    Hale, P.4    Chang, C.T.5    Bode, B.6
  • 182
    • 84872286271 scopus 로고    scopus 로고
    • Weight change with liraglutide and comparator therapies: An analysis of seven phase 3 trials from the liraglutide diabetes development programme
    • Aug 3. [Epub ahead of print]
    • Niswender K, Pi-Sunyer X, Buse J, et al. Weight change with liraglutide and comparator therapies: an analysis of seven phase 3 trials from the liraglutide diabetes development programme. Diabetes Obes Metab. 2012 Aug 3. [Epub ahead of print].
    • (2012) Diabetes Obes Metab.
    • Niswender, K.1    Pi-Sunyer, X.2    Buse, J.3
  • 183
    • 33748442464 scopus 로고    scopus 로고
    • Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
    • Blonde L, Klein EJ, Han J, et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab. 2006;8:436-447.
    • (2006) Diabetes Obes Metab , vol.8 , pp. 436-447
    • Blonde, L.1    Klein, E.J.2    Han, J.3
  • 184
    • 84858079439 scopus 로고    scopus 로고
    • Glucagon-like peptide 1 (GLP-1) analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction
    • Lind M, Jendle J, Torffvit O, Lager I. Glucagon-like peptide 1 (GLP-1) analogue combined with insulin reduces HbA1c and weight with low risk of hypoglycemia and high treatment satisfaction. Prim Care Diabetes. 2011;6:41-6.
    • (2011) Prim Care Diabetes , vol.6 , pp. 41-46
    • Lind, M.1    Jendle, J.2    Torffvit, O.3    Lager, I.4
  • 185
    • 84857531976 scopus 로고    scopus 로고
    • Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus
    • Levin PA, Mersey JH, Zhou S, Bromberger LA. Clinical outcomes using long-term combination therapy with insulin glargine and exenatide in patients with type 2 diabetes mellitus. Endocr Pract. 2012;18:17-25.
    • (2012) Endocr Pract , vol.18 , pp. 17-25
    • Levin, P.A.1    Mersey, J.H.2    Zhou, S.3    Bromberger, L.A.4
  • 186
    • 33847629709 scopus 로고    scopus 로고
    • Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease
    • Tolman KG, Fonseca V, Dalpiaz A, Tan MH. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care. 2007;30:734-743.
    • (2007) Diabetes Care , vol.30 , pp. 734-743
    • Tolman, K.G.1    Fonseca, V.2    Dalpiaz, A.3    Tan, M.H.4
  • 187
    • 11144351102 scopus 로고    scopus 로고
    • The histological course of nonalcoholic fatty liver disease: A longitudinal study of 103 patients with sequential liver biopsies
    • Adams LA, Sanderson S, Lindor KD, Angulo P. The histological course of nonalcoholic fatty liver disease: a longitudinal study of 103 patients with sequential liver biopsies. J Hepatol. 2005;42:132-138.
    • (2005) J Hepatol , vol.42 , pp. 132-138
    • Adams, L.A.1    Sanderson, S.2    Lindor, K.D.3    Angulo, P.4
  • 188
    • 34547732002 scopus 로고    scopus 로고
    • GI epidemiology: Nonalcoholic fatty liver disease
    • Angulo P. GI epidemiology: nonalcoholic fatty liver disease. Aliment Pharmacol Ther. 2007;25:883-889.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 883-889
    • Angulo, P.1
  • 189
    • 70450190143 scopus 로고    scopus 로고
    • Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
    • Jendle J, Nauck MA, Matthews DR, et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab. 2009;11:1163-1172.
    • (2009) Diabetes Obes Metab , vol.11 , pp. 1163-1172
    • Jendle, J.1    Nauck, M.A.2    Matthews, D.R.3
  • 191
    • 77956090389 scopus 로고    scopus 로고
    • Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without prediabetes
    • Rosenstock J, Klaff LJ, Schwartz S, et al. Effects of exenatide and lifestyle modification on body weight and glucose tolerance in obese subjects with and without prediabetes. Diabetes Care. 2010;33:1173-1175.
    • (2010) Diabetes Care , vol.33 , pp. 1173-1175
    • Rosenstock, J.1    Klaff, L.J.2    Schwartz, S.3
  • 192
    • 84862207266 scopus 로고    scopus 로고
    • Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analogue, liraglutide
    • Astrup A, Carraro R, Finer N, et al. Safety, tolerability and sustained weight loss over 2 years with the once-daily human GLP-1 analogue, liraglutide. Int J Obes (Lond). 2012;36:890.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 890
    • Astrup, A.1    Carraro, R.2    Finer, N.3
  • 193
    • 84890563594 scopus 로고    scopus 로고
    • Liraglutide provides weight maintenance and additional weight loss after low calorie diet-induced weight loss in obese subjects without diabetes: The SCALETM maintenance study
    • Wadden T, Hollander P, Klein S, et al. Liraglutide provides weight maintenance and additional weight loss after low calorie diet-induced weight loss in obese subjects without diabetes: the SCALETM maintenance study. Diabetes. 2011;60(Suppl 1):1859-P.
    • (2011) Diabetes , vol.60 , Issue.SUPPL. 1
    • Wadden, T.1    Hollander, P.2    Klein, S.3
  • 195
    • 84859046364 scopus 로고    scopus 로고
    • Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes
    • Dushay J, Gao C, Gopalakrishnan GS, et al. Short-term exenatide treatment leads to significant weight loss in a subset of obese women without diabetes Diabetes Care. 2012;35:4-11.
    • (2012) Diabetes Care , vol.35 , pp. 4-11
    • Dushay, J.1    Gao, C.2    Gopalakrishnan, G.S.3
  • 196
    • 84856242456 scopus 로고    scopus 로고
    • Exenatide as a weight-loss therapy in extreme pediatric obesity: A randomized, controlled pilot study
    • Kelly AS, Metzig AM, Rudser KD, et al. Exenatide as a weight-loss therapy in extreme pediatric obesity: a randomized, controlled pilot study. Obesity (Silver Spring). 2012;20:364-370.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 364-370
    • Kelly, A.S.1    Metzig, A.M.2    Rudser, K.D.3
  • 197
    • 80053005298 scopus 로고    scopus 로고
    • A systematic review of patient-reported and economic outcomes: Value to stakeholders in the decision-making process in patients with type 2 diabetes mellitus
    • Vieta A, Badia X, Sacristan JA. A systematic review of patient-reported and economic outcomes: value to stakeholders in the decision-making process in patients with type 2 diabetes mellitus. Clin Ther. 2011;33:1225-1245.
    • (2011) Clin Ther , vol.33 , pp. 1225-1245
    • Vieta, A.1    Badia, X.2    Sacristan, J.A.3
  • 199
    • 0036059959 scopus 로고    scopus 로고
    • The DAWN (diabetes attitude, wishes and needs) study
    • Alberti G. The DAWN (diabetes attitude, wishes and needs) study. Pract Diabetes Int. 2002;19:22-24.
    • (2002) Pract Diabetes Int , vol.19 , pp. 22-24
    • Alberti, G.1
  • 200
    • 27944467231 scopus 로고    scopus 로고
    • The diabetes attitudes, wishes, and needs program: A new approach to improving outcomes of diabetes care
    • Skovlund S, Peyrot M, DAWN International Advisory Panel. The diabetes attitudes, wishes, and needs program: a new approach to improving outcomes of diabetes care. Diabetes Spectrum. 2005;18:136-142.
    • (2005) Diabetes Spectrum , vol.18 , pp. 136-142
    • Skovlund, S.1    Peyrot, M.2
  • 201
    • 20444493790 scopus 로고    scopus 로고
    • Psychosocial problems and barriers to improved diabetes management: Results of the cross-national diabetes attitudes, wishes and needs (DAWN) study
    • Peyrot M, Rubin RR, Lauritzen T, Snoek FJ, Matthews DR, Skovlund SE. Psychosocial problems and barriers to improved diabetes management: results of the cross-national Diabetes Attitudes, Wishes and Needs (DAWN) study Diabet Med. 2005;22:1379-1385.
    • (2005) Diabet Med , vol.22 , pp. 1379-1385
    • Peyrot, M.1    Rubin, R.R.2    Lauritzen, T.3    Snoek, F.J.4    Matthews, D.R.5    Skovlund, S.E.6
  • 202
    • 33746426239 scopus 로고    scopus 로고
    • Health care and patient-reported outcomes: Results of the cross-national diabetes attitudes wishes and needs (DAWN) study
    • Rubin RR, Peyrot M, Siminerio LM. Health care and patient-reported outcomes: Results of the cross-national Diabetes Attitudes, Wishes and Needs (DAWN) study. Diabetes Care. 2006;29:1249-1255.
    • (2006) Diabetes Care , vol.29 , pp. 1249-1255
    • Rubin, R.R.1    Peyrot, M.2    Siminerio, L.M.3
  • 203
    • 77949524816 scopus 로고    scopus 로고
    • Willingness to pay for health improvements associated with anti-diabetes treatments for people with type 2 diabetes
    • Jendle J, Torffvit O, Ridderstrale M, Lammert M, Ericsson A, Bogelund M. Willingness to pay for health improvements associated with anti-diabetes treatments for people with type 2 diabetes. Curr Med Res Opin. 2010;26:917-923.
    • (2010) Curr Med Res Opin , vol.26 , pp. 917-923
    • Jendle, J.1    Torffvit, O.2    Ridderstrale, M.3    Lammert, M.4    Ericsson, A.5    Bogelund, M.6
  • 204
    • 84867939081 scopus 로고    scopus 로고
    • Willingness to pay for diabetes drug therapy in type 2 diabetes patients: Based on LEAD clinical programme results
    • Aug 1. [Epub ahead of print]
    • Jendle J, Torffvit O, Ridderstrale M, Ericsson A, Nilsen B, Bogelund M. Willingness to pay for diabetes drug therapy in type 2 diabetes patients: based on LEAD clinical programme results. J Med Econ. 2012 Aug 1. [Epub ahead of print].
    • (2012) J Med Econ.
    • Jendle, J.1    Torffvit, O.2    Ridderstrale, M.3    Ericsson, A.4    Nilsen, B.5    Bogelund, M.6
  • 205
    • 77958497881 scopus 로고    scopus 로고
    • Understanding GLP-1 analogs and enhancing patients success
    • (Suppl 3):72S; quiz 73S-74S
    • Kruger DF, Bode B, Spollett GR. Understanding GLP-1 analogs and enhancing patients success. Diabetes Educ. 2010;36(Suppl 3):44S-72S; quiz 73S-74S.
    • (2010) Diabetes Educ , vol.36 , Issue.SUPPL. 3
    • Kruger, D.F.1    Bode, B.2    Spollett, G.R.3
  • 206
    • 77955833026 scopus 로고    scopus 로고
    • The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes
    • Russell-Jones D. The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes. Int J Clin Pract. 2010;64:1402-1414.
    • (2010) Int J Clin Pract , vol.64 , pp. 1402-1414
    • Russell-Jones, D.1
  • 207
    • 4644300651 scopus 로고    scopus 로고
    • Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes
    • Fineman MS, Shen LZ, Taylor K, Kim DD, Baron AD. Effectiveness of progressive dose-escalation of exenatide (exendin-4) in reducing dose-limiting side effects in subjects with type 2 diabetes. Diabetes Metab Res Rev. 2004;20:411-417.
    • (2004) Diabetes Metab Res Rev , vol.20 , pp. 411-417
    • Fineman, M.S.1    Shen, L.Z.2    Taylor, K.3    Kim, D.D.4    Baron, A.D.5
  • 208
    • 33750726976 scopus 로고    scopus 로고
    • Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes
    • Secnik Boye K, Matza LS, Oglesby A, et al. Patient-reported outcomes in a trial of exenatide and insulin glargine for the treatment of type 2 diabetes. Health Qual Life Outcomes. 2006;4:80.
    • (2006) Health Qual Life Outcomes , vol.4 , pp. 80
    • Secnik Boye, K.1    Matza, L.S.2    Oglesby, A.3
  • 209
    • 77954184211 scopus 로고    scopus 로고
    • Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: Results from a randomized controlled trial in patients with type 2 diabetes
    • Bode BW, Testa MA, Magwire M, et al. Patient-reported outcomes following treatment with the human GLP-1 analogue liraglutide or glimepiride in monotherapy: results from a randomized controlled trial in patients with type 2 diabetes. Diabetes Obes Metab. 2010;12:604-612.
    • (2010) Diabetes Obes Metab , vol.12 , pp. 604-612
    • Bode, B.W.1    Testa, M.A.2    Magwire, M.3
  • 210
    • 79951689950 scopus 로고    scopus 로고
    • Weight-related quality of life, health utility, psychological well-being, and satisfaction with exenatide once weekly compared with sitagliptin or pioglitazone after 26 weeks of treatment
    • Best JH, Rubin RR, Peyrot M, et al. Weight-related quality of life, health utility, psychological well-being, and satisfaction with exenatide once weekly compared with sitagliptin or pioglitazone after 26 weeks of treatment. Diabetes Care. 2011;34:314-319.
    • (2011) Diabetes Care , vol.34 , pp. 314-319
    • Best, J.H.1    Rubin, R.R.2    Peyrot, M.3
  • 211
    • 67649774247 scopus 로고    scopus 로고
    • Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily
    • Best JH, Boye KS, Rubin RR, Cao D, Kim TH, Peyrot M. Improved treatment satisfaction and weight-related quality of life with exenatide once weekly or twice daily. Diabet Med. 2009;26:722-728.
    • (2009) Diabet Med , vol.26 , pp. 722-728
    • Best, J.H.1    Boye, K.S.2    Rubin, R.R.3    Cao, D.4    Kim, T.H.5    Peyrot, M.6
  • 212
    • 79955950106 scopus 로고    scopus 로고
    • Patient-reported outcomes are superior in patients with type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: Results from a randomized, open-label study
    • Schmidt WE, Christiansen JS, Hammer M, Zychma MJ, Buse JB. Patient-reported outcomes are superior in patients with type 2 diabetes treated with liraglutide as compared with exenatide, when added to metformin, sulphonylurea or both: results from a randomized, open-label study. Diabet Med. 2011;28:715-723.
    • (2011) Diabet Med , vol.28 , pp. 715-723
    • Schmidt, W.E.1    Christiansen, J.S.2    Hammer, M.3    Zychma, M.J.4    Buse, J.B.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.