-
1
-
-
78650890818
-
Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: A pilot study
-
Sathananthan A, Dalla Man C, Micheletto F, Zinsmeister AR, Camilleri M, Giesler PD, Laugen JM, Toffolo G, Rizza RA, Cobelli C, Vella A. Common genetic variation in GLP1R and insulin secretion in response to exogenous GLP-1 in nondiabetic subjects: a pilot study. Diabetes Care 2010;33:2074-2076
-
(2010)
Diabetes Care
, vol.33
, pp. 2074-2076
-
-
Sathananthan, A.1
Dalla Man, C.2
Micheletto, F.3
Zinsmeister, A.R.4
Camilleri, M.5
Giesler, P.D.6
Laugen, J.M.7
Toffolo, G.8
Rizza, R.A.9
Cobelli, C.10
Vella, A.11
-
2
-
-
57349160286
-
Medical management of hyperglycaemia in type 2 diabetes mellitus: A consensus algorithm for the initiation and adjustment of therapy: A consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes
-
American Diabetes Association, European Association for the Study of Diabetes
-
Nathan DM, Buse JB, Davidson MB, Ferrannini E, Holman RR, Sherwin R, Zinman B, American Diabetes Association, European Association for the Study of Diabetes. Medical management of hyperglycaemia in type 2 diabetes mellitus: a consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of Diabetes. Diabetologia 2009;52:17-30
-
(2009)
Diabetologia
, vol.52
, pp. 17-30
-
-
Nathan, D.M.1
Buse, J.B.2
Davidson, M.B.3
Ferrannini, E.4
Holman, R.R.5
Sherwin, R.6
Zinman, B.7
-
3
-
-
69849104533
-
Incretin-based therapy: How do incretin mimetics and DPP-4 inhibitors fit into treatment algorithms for type 2 diabetic patients?
-
Nauck M, Smith U. Incretin-based therapy: how do incretin mimetics and DPP-4 inhibitors fit into treatment algorithms for type 2 diabetic patients? Best Pract Res Clin Endocrinol Metab 2009;23:513-523
-
(2009)
Best Pract Res Clin Endocrinol Metab
, vol.23
, pp. 513-523
-
-
Nauck, M.1
Smith, U.2
-
4
-
-
15444352146
-
Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: Evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation
-
Hansen T, Eiberg H, Rouard M, Vaxillaire M, Møller AM, Rasmussen SK, Fridberg M, Urhammer SA, Holst JJ, Almind K, Echwald SM, Hansen L, Bell GI, Pedersen O. Novel MODY3 mutations in the hepatocyte nuclear factor-1alpha gene: evidence for a hyperexcitability of pancreatic beta-cells to intravenous secretagogues in a glucose-tolerant carrier of a P447L mutation. Diabetes 1997;46:726-730
-
(1997)
Diabetes
, vol.46
, pp. 726-730
-
-
Hansen, T.1
Eiberg, H.2
Rouard, M.3
Vaxillaire, M.4
Møller, A.M.5
Rasmussen, S.K.6
Fridberg, M.7
Urhammer, S.A.8
Holst, J.J.9
Almind, K.10
Echwald, S.M.11
Hansen, L.12
Bell, G.I.13
Pedersen, O.14
-
5
-
-
2342633204
-
Activating mutations in the gene encoding the ATP-sensitive potassium- Channel subunit Kir6.2 and permanent neonatal diabetes
-
Gloyn AL, Pearson ER, Antcliff JF, Proks P, Bruining GJ, Slingerland AS, Howard N, Srinivasan S, Silva JM, Molnes J, Edghill EL, Frayling TM, Temple IK, Mackay D, Shield JP, Sumnik Z, van Rhijn A, Wales JK, Clark P, Gorman S, Aisenberg J, Ellard S, Njølstad PR, Ashcroft FM, Hattersley AT. Activating mutations in the gene encoding the ATP-sensitive potassium- channel subunit Kir6.2 and permanent neonatal diabetes. N Engl J Med 2004;350:1838-1849
-
(2004)
N Engl J Med
, vol.350
, pp. 1838-1849
-
-
Gloyn, A.L.1
Pearson, E.R.2
Antcliff, J.F.3
Proks, P.4
Bruining, G.J.5
Slingerland, A.S.6
Howard, N.7
Srinivasan, S.8
Silva, J.M.9
Molnes, J.10
Edghill, E.L.11
Frayling, T.M.12
Temple, I.K.13
Mackay, D.14
Shield, J.P.15
Sumnik, Z.16
Van Rhijn, A.17
Wales, J.K.18
Clark, P.19
Gorman, S.20
Aisenberg, J.21
Ellard, S.22
Njølstad, P.R.23
Ashcroft, F.M.24
Hattersley, A.T.25
more..
-
6
-
-
44649186218
-
A case of new mutation in maturity-onset diabetes of the young type 3 (MODY 3) responsive to a low dose of sulphonylurea
-
Jesic MD, Sajic S, Jesic MM, Maringa M, Micic D, Necic S. A case of new mutation in maturity-onset diabetes of the young type 3 (MODY 3) responsive to a low dose of sulphonylurea. Diabetes Res Clin Pract 2008;81:e1-e3
-
(2008)
Diabetes Res Clin Pract
, vol.81
-
-
Jesic, M.D.1
Sajic, S.2
Jesic, M.M.3
Maringa, M.4
Micic, D.5
Necic, S.6
-
7
-
-
33746686369
-
Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations
-
Neonatal Diabetes International Collaborative Group
-
Pearson ER, Flechtner I, Njølstad PR, Malecki MT, Flanagan SE, Larkin B, Ashcroft FM, Klimes I, Codner E, Iotova V, Slingerland AS, Shield J, Robert JJ, Holst JJ, Clark PM, Ellard S, Søvik O, Polak M, Hattersley AT, Neonatal Diabetes International Collaborative Group. Switching from insulin to oral sulfonylureas in patients with diabetes due to Kir6.2 mutations. N Engl J Med 2006;355:467-477
-
(2006)
N Engl J Med
, vol.355
, pp. 467-477
-
-
Pearson, E.R.1
Flechtner, I.2
Njølstad, P.R.3
Malecki, M.T.4
Flanagan, S.E.5
Larkin, B.6
Ashcroft, F.M.7
Klimes, I.8
Codner, E.9
Iotova, V.10
Slingerland, A.S.11
Shield, J.12
Robert, J.J.13
Holst, J.J.14
Clark, P.M.15
Ellard, S.16
Søvik, O.17
Polak, M.18
Hattersley, A.T.19
-
8
-
-
41149084500
-
Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes
-
DOI 10.1038/ncpendmet0778, PII NCPENDMET0778
-
Murphy R, Ellard S, Hattersley AT. Clinical implications of a molecular genetic classification of monogenic beta-cell diabetes. Nat Clin Pract Endocrinol Metab 2008;4:200-213 (Pubitemid 351430925)
-
(2008)
Nature Clinical Practice Endocrinology and Metabolism
, vol.4
, Issue.4
, pp. 200-213
-
-
Murphy, R.1
Ellard, S.2
Hattersley, A.T.3
-
9
-
-
0033847575
-
Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: Evidence for pharmacogenetics in diabetes
-
DOI 10.1046/j.1464-5491.2000.00305.x
-
Pearson ER, Liddell WG, Shepherd M, Corrall RJ, Hattersley AT. Sensitivity to sulphonylureas in patients with hepatocyte nuclear factor-1alpha gene mutations: evidence for pharmacogenetics in diabetes. Diabet Med 2000;17:543-545 (Pubitemid 30660158)
-
(2000)
Diabetic Medicine
, vol.17
, Issue.7
, pp. 543-545
-
-
Pearson, E.R.1
Liddell, W.G.2
Shepherd, M.3
Corrall, R.J.4
Hattersley, A.T.5
-
10
-
-
21344451651
-
Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes
-
DOI 10.1007/s00125-005-1751-1
-
Charbonnel B, Schernthaner G, Brunetti P, Matthews DR, Urquhart R, Tan MH, Hanefeld M. Long-term efficacy and tolerability of add-on pioglitazone therapy to failing monotherapy compared with addition of gliclazide or metformin in patients with type 2 diabetes. Diabetologia 2005;48:1093-1104 (Pubitemid 40909644)
-
(2005)
Diabetologia
, vol.48
, Issue.6
, pp. 1093-1104
-
-
Charbonnel, B.1
Schernthaner, G.2
Brunetti, P.3
Matthews, D.R.4
Urquhart, R.5
Tan, M.H.6
Hanefeld, M.7
-
11
-
-
33846817233
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: A randomized, double-blind, non-inferiority trial
-
Sitagliptin Study 024 Group
-
Nauck MA, Meininger G, Sheng D, Terranella L, Stein PP, Sitagliptin Study 024 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor, sitagliptin, compared with the sulfonylurea, glipizide, in patients with type 2 diabetes inadequately controlled on metformin alone: a randomized, double-blind, non-inferiority trial. Diabetes Obes Metab 2007; 9:194-205
-
(2007)
Diabetes Obes Metab
, vol.9
, pp. 194-205
-
-
Nauck, M.A.1
Meininger, G.2
Sheng, D.3
Terranella, L.4
Stein, P.P.5
-
12
-
-
62449129181
-
Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU)
-
LEAD-1 SU study group
-
Marre M, Shaw J, Brändle M, Bebakar WM, Kamaruddin NA, Strand J, Zdravkovic M, Le Thi TD, Colagiuri S, LEAD-1 SU study group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with Type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-278
-
(2009)
Diabet Med
, vol.26
, pp. 268-278
-
-
Marre, M.1
Shaw, J.2
Brändle, M.3
Bebakar, W.M.4
Kamaruddin, N.A.5
Strand, J.6
Zdravkovic, M.7
Le Thi, T.D.8
Colagiuri, S.9
-
13
-
-
0030601059
-
Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling
-
DOI 10.1006/bbrc.1996.0945
-
Heller RS, Kieffer TJ, Habener JF. Point mutations in the first and third intracellular loops of the glucagon-like peptide-1 receptor alter intracellular signaling. Biochem Biophys Res Commun 1996;223:624-632 (Pubitemid 26246123)
-
(1996)
Biochemical and Biophysical Research Communications
, vol.223
, Issue.3
, pp. 624-632
-
-
Heller, R.S.1
Kieffer, T.J.2
Habener, J.F.3
-
14
-
-
0033304574
-
Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells
-
Salapatek AM, MacDonald PE, Gaisano HY, Wheeler MB. Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells. Mol Endocrinol 1999;13:1305-1317 (Pubitemid 30645288)
-
(1999)
Molecular Endocrinology
, vol.13
, Issue.8
, pp. 1305-1317
-
-
Salapatek, A.M.F.1
MacDonald, P.E.2
Gaisano, H.Y.3
Wheeler, M.B.4
-
15
-
-
4444281755
-
Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population
-
DOI 10.1016/j.diabres.2004.02.004, PII S016882270400049X
-
Tokuyama Y, Matsui K, Egashira T, Nozaki O, Ishizuka T, Kanatsuka A. Five missense mutations in glucagon-like peptide 1 receptor gene in Japanese population. Diabetes Res Clin Pract 2004; 66:63-69 (Pubitemid 39201373)
-
(2004)
Diabetes Research and Clinical Practice
, vol.66
, Issue.1
, pp. 63-69
-
-
Tokuyama, Y.1
Matsui, K.2
Egashira, T.3
Nozaki, O.4
Ishizuka, T.5
Kanatsuka, A.6
-
16
-
-
22044446844
-
A human glucagon-like peptide-1 receptor polymorphism results in reduced agonist responsiveness
-
DOI 10.1016/j.regpep.2005.05.001, PII S0167011505001229
-
Beinborn M, Worrall CI, McBride EW, Kopin AS. A human glucagon-like peptide- 1 receptor polymorphism results in reduced agonist responsiveness. Regul Pept 2005;130:1-6 (Pubitemid 40966015)
-
(2005)
Regulatory Peptides
, vol.130
, Issue.1-2
, pp. 1-6
-
-
Beinborn, M.1
Worrall, C.I.2
McBride, E.W.3
Kopin, A.S.4
-
17
-
-
2542479899
-
Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system
-
DOI 10.1210/en.2004-0015
-
Brubaker PL, Drucker DJ. Minireview: Glucagon-like peptides regulate cell proliferation and apoptosis in the pancreas, gut, and central nervous system. Endocrinology 2004;145:2653-2659 (Pubitemid 38686211)
-
(2004)
Endocrinology
, vol.145
, Issue.6
, pp. 2653-2659
-
-
Brubaker, P.L.1
Drucker, D.J.2
-
18
-
-
68049136013
-
Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF- 2/IGF-1 receptor autocrine loop
-
Cornu M, Yang JY, Jaccard E, Poussin C, Widmann C, Thorens B. Glucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF- 2/IGF-1 receptor autocrine loop. Diabetes 2009;58:1816-1825
-
(2009)
Diabetes
, vol.58
, pp. 1816-1825
-
-
Cornu, M.1
Yang, J.Y.2
Jaccard, E.3
Poussin, C.4
Widmann, C.5
Thorens, B.6
-
19
-
-
0035069103
-
Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice
-
DOI 10.1007/s004280000374
-
Ling Z, Wu D, Zambre Y, Flamez D, Drucker DJ, Pipeleers DG, Schuit FC. Glucagon-like peptide 1 receptor signaling influences topography of islet cells in mice. Virchows Arch 2001;438: 382-387 (Pubitemid 32285364)
-
(2001)
Virchows Archiv
, vol.438
, Issue.4
, pp. 382-387
-
-
Ling, Z.1
Wu, D.2
Zambre, Y.3
Flamez, D.4
Drucker, D.J.5
Pipeleers, D.G.6
Schuit, F.C.7
-
20
-
-
33846006173
-
The incretin system: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes
-
DOI 10.1016/S0140-6736(06)69705-5, PII S0140673606697055
-
Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368:1696-1705 (Pubitemid 46048557)
-
(2006)
Lancet
, vol.368
, Issue.9548
, pp. 1696-1705
-
-
Drucker, D.J.1
Nauck, M.A.2
-
21
-
-
35848942800
-
Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms
-
Schäfer SA, Tschritter O, Machicao F, Thamer C, Stefan N, Gallwitz B, Holst JJ, Dekker JM, 't Hart LM, t'Hart LM, Nijpels G, van Haeften TW, Häring HU, Fritsche A. Impaired glucagon-like peptide-1-induced insulin secretion in carriers of transcription factor 7-like 2 (TCF7L2) gene polymorphisms. Diabetologia 2007;50: 2443-2450
-
(2007)
Diabetologia
, vol.50
, pp. 2443-2450
-
-
Schäfer, S.A.1
Tschritter, O.2
Machicao, F.3
Thamer, C.4
Stefan, N.5
Gallwitz, B.6
Holst, J.J.7
Dekker, J.M.8
'T Hart, L.M.9
T'Hart, L.M.10
Nijpels, G.11
Van Haeften, T.W.12
Häring, H.U.13
Fritsche, A.14
-
22
-
-
67349102328
-
The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men
-
Pilgaard K, Jensen CB, Schou JH, Lyssenko V, Wegner L, Brøns C, Vilsbøll T, Hansen T, Madsbad S, Holst JJ, Vølund A, Poulsen P, Groop L, Pedersen O, Vaag AA. The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men. Diabetologia 2009; 52:1298-1307
-
(2009)
Diabetologia
, vol.52
, pp. 1298-1307
-
-
Pilgaard, K.1
Jensen, C.B.2
Schou, J.H.3
Lyssenko, V.4
Wegner, L.5
Brøns, C.6
Vilsbøll, T.7
Hansen, T.8
Madsbad, S.9
Holst, J.J.10
Vølund, A.11
Poulsen, P.12
Groop, L.13
Pedersen, O.14
Vaag, A.A.15
-
23
-
-
77449099615
-
TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action
-
Villareal DT, Robertson H, Bell GI, Patterson BW, Tran H, Wice B, Polonsky KS. TCF7L2 variant rs7903146 affects the risk of type 2 diabetes by modulating incretin action. Diabetes 2010;59:479-485
-
(2010)
Diabetes
, vol.59
, pp. 479-485
-
-
Villareal, D.T.1
Robertson, H.2
Bell, G.I.3
Patterson, B.W.4
Tran, H.5
Wice, B.6
Polonsky, K.S.7
-
24
-
-
64649105053
-
TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells
-
da Silva Xavier G, Loder MK, McDonald A, Tarasov AI, Carzaniga R, Kronenberger K, Barg S, Rutter GA. TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. Diabetes 2009;58: 894-905
-
(2009)
Diabetes
, vol.58
, pp. 894-905
-
-
Da Silva Xavier, G.1
Loder, M.K.2
McDonald, A.3
Tarasov, A.I.4
Carzaniga, R.5
Kronenberger, K.6
Barg, S.7
Rutter, G.A.8
-
25
-
-
65249159171
-
Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes
-
Müssig K, Staiger H, Machicao F, Stancáková A, Kuusisto J, Laakso M, Thamer C, Machann J, Schick F, Claussen CD, Stefan N, Fritsche A, Häring HU. Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. J Clin Endocrinol Metab 2009;94:1353-1360
-
(2009)
J Clin Endocrinol Metab
, vol.94
, pp. 1353-1360
-
-
Müssig, K.1
Staiger, H.2
Machicao, F.3
Stancáková, A.4
Kuusisto, J.5
Laakso, M.6
Thamer, C.7
Machann, J.8
Schick, F.9
Claussen, C.D.10
Stefan, N.11
Fritsche, A.12
Häring, H.U.13
-
26
-
-
67349190497
-
A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion
-
Schäfer SA, Müssig K, Staiger H, Machicao F, Stefan N, Gallwitz B, Häring HU, Fritsche A. A common genetic variant in WFS1 determines impaired glucagon-like peptide-1-induced insulin secretion. Diabetologia 2009;52:1075-1082
-
(2009)
Diabetologia
, vol.52
, pp. 1075-1082
-
-
Schäfer, S.A.1
Müssig, K.2
Staiger, H.3
Machicao, F.4
Stefan, N.5
Gallwitz, B.6
Häring, H.U.7
Fritsche, A.8
-
27
-
-
39749147092
-
Managing diabetes in the elderly: Go easy, individualize
-
Hornick T, Aron DC. Managing diabetes in the elderly: go easy, individualize. Cleve Clin J Med 2008;75:70-78
-
(2008)
Cleve Clin J Med
, vol.75
, pp. 70-78
-
-
Hornick, T.1
Aron, D.C.2
|