FoxP3 inhibits proliferation and induces apoptosis of gastric cancer cells by activating the apoptotic signaling pathway

Biochemical and Biophysical Research Communications

Volumn 430, Issue 2, 2013, Pages 804-809

  Ma, Gui Fen ^a   Chen, Shi Yao ^a   Sun, Zhi Rong ^b   Miao, Qing ^a   Liu, Yi Mei ^a   Zeng, Xiao Qing ^a   Luo, Tian Cheng ^a   Ma, Li Li ^a   Lian, Jing Jing ^a   Song, Dong Li ^a  

^a FUDAN UNIVERSITY   (China)

^b FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

Author keywords

Apoptotic pathway; Cell apoptosis; Cell proliferation; FoxP3; Gastric cancer

Indexed keywords

CASPASE 3; CASPASE 9; CELLULAR INHIBITOR OF APOPTOSIS 1; CHOLECYSTOKININ OCTAPEPTIDE; MESSENGER RNA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN; PROTEIN BCL 2; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR FOXP3; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL NUCLEUS; CELL PROLIFERATION; CLONOGENESIS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOPLASM; FLOW CYTOMETRY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOASSAY; IMMUNOFLUORESCENCE; MOLECULAR MECHANICS; NICK END LABELING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; STOMACH CANCER; UPREGULATION;

APOPTOSIS; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; MITOCHONDRIAL PROTEINS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; UP-REGULATION;

EID: 84872333498     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.11.065     Document Type: Article

References (34)

1. Hori S., Sakaguchi S. Foxp3: a critical regulator of the development and function of regulatory T cells. Microbes Infect. 2004, 6:745-751.
2. Salama P., Phillips M., Grieu F., et al. Tumor-infiltrating FOXP3+ T regulatory cells show strong prognostic significance in colorectal cancer. J. Clin. Oncol. 2009, 27:186-192.
3. Kim W.Y., Jeon Y.K., Kim T.M., et al. Increased quantity of tumor-infiltrating FOXP3-positive regulatory T cells is an independent predictor for improved clinical outcome in extranodal NK/T-cell lymphoma. Ann. Oncol. 2009, 20:1688-1696.
4. Yuan X.L., Chen L., Li M.X., et al. Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner. Clin. Immunol. 2010, 134:277-288.
5. Shen Z., Zhou S., Wang Y., et al. Higher intratumoral infiltrated Foxp3+ Treg numbers and Foxp3+/CD8+ ratio are associated with adverse prognosis in resectable gastric cancer. J. Cancer Res. Clin. Oncol. 2010, 136:1585-1595.
6. Ebert L.M., Tan B.S., Browning J., et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res. 2008, 68:3001-3009.
7. Karanikas V., Speletas M., Zamanakou M., et al. Foxp3 expression in human cancer cells. J. Trans. Med. 2008, 6.
8. Dimitrakopoulos F.I., Papadaki H., Antonacopoulou A.G., et al. Association of FOXP3 expression with non-small cell lung cancer. Anticancer Res. 2011, 31:1677-1683.
9. Wang W.H., Jiang C.L., Yan W., et al. FOXP3 expression and clinical characteristics of hepatocellular carcinoma. World J. Gastroenterol. 2010, 16:5502-5509.
10. Martin F., Ladoire S., Mignot G., Apetoh L., Ghiringhelli F. Human FOXP3 and cancer. Oncogene 2010, 29:4121-4129.
11. Zuo T., Wang L.Z., Morrison C. FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene. Cell 2007, 129:1275-1286.
12. Zuo T., Liu R.H., Zhang H.M., et al. FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2. J. Clin. Invest. 2007, 117:3765-3773.
13. Hinz S., Pagerols-Raluy L., Oberg H.H., et al. Foxp3 expression in pancreatic carcinoma cells as a novel mechanism of immune evasion in cancer. Cancer Res. 2007, 67:8344-8350.
14. Bang Y.J., Van Cutsem E., Feyereislova A., et al. Trastuzumab in combination with chemotherapy versus chemotherapy alone for treatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled trial. Lancet 2010, 376:687-697.
15. Vanderhaegen J., Paridaens R., Neven P. Adjuvant trastuzumab in HER2-positive breast cancer. N. Engl. J. Med. 2012, 366: 664:664-666.
16. Ladoire S., Arnould L., Mignot G., et al. Presence of Foxp3 expression in tumor cells predicts better survival in HER2-overexpressing breast cancer patients treated with neoadjuvant chemotherapy. Breast Cancer Res. Treat. 2011, 125:65-72.
17. Wang L.Z., Liu R.H., Li W.Q. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 2009, 16:336-346.
18. Liang Y.J., Liu H.C., Su Y.X., et al. Foxp3 expressed by tongue squamous cell carcinoma cells correlates with clinicopathologic features and overall survival in tongue squamous cell carcinoma patients. Oral Oncol. 2011, 47:566-570.
19. Yoshii M., Tanaka H., Ohira M., et al. Expression of forkhead box P3 in tumour cells causes immunoregulatory function of signet ring cell carcinoma of the stomach. Br. J. Cancer 2012, 106:1668-1674.
20. Wang L., Liu R., Li W., et al. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell 2009, 16:336-346.
21. Liu R., Wang L., Chen G., et al. FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus. Cancer Res. 2009, 69:2252-2259.
22. Chen L., Lan B., Chen X.H., et al. Cell cycle dependent genes from the gastric cancer cell MKN45 can affect tumorigenesis. Hepatogastroenterology 2011, 58:674-681.
23. Karube K., Aoki R., Sugita Y., et al. The relationship of FOXP3 expression and clinicopathological characteristics in adult T-cell leukemia/lymphoma. Modern Pathol. 2008, 21:617-625.
24. Satoh M.S., Lindahl T. Role of poly (ADP-ribose) formation in DNA repair. Nature 1992, 356:356-358.
25. Lazebnik Y.A., Kaufmann S.H., Desnoyers S., Poirier G.G., Earnshaw W.C. Cleavage of poly (ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994, 371:346-347.
26. Nimmanapalli R., Bhalla K. Targets in apoptosis signaling: promise of selective anticancer therapy. Meth. Mol. Biol. 2003, 223:465-483.
27. Ebert L.M., Tan B.S., Browning J., et al. The regulatory T cell-associated transcription factor FoxP3 is expressed by tumor cells. Cancer Res 2008, 68:3001-3009.
28. Wang L., Liu R., Ribick M., Zheng P., Liu Y. FOXP3 as an X-linked tumor suppressor. Discov. Med. 2010, 10:322-328.
29. Liu Y., Wang Y., Li W., et al. Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse. Cancer Res 2009, 69:5954-5960.
30. Zhang H.Y., Sun H. Up-regulation of Foxp3 inhibits cell proliferation, migration and invasion in epithelial ovarian cancer. Cancer Lett 2010, 287:91-97.
31. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev. 2001, 15:2922-2933.
32. Pramanik K.C., Boreddy S.R., Srivastava S.K. Role of mitochondrial electron transport chain complexes in capsaicin mediated oxidative stress leading to apoptosis in pancreatic cancer cells. PLoS One 2011, 6:e20151.
33. Jung D.J., Jin D.H., Hong S.W., et al. Foxp3 expression in p53-dependent DNA damage responses. J. Biol. Chem. 2010, 285:7995-8002.
34. Tischner D., Gaggl I., Peschel I., et al. Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice. J. Autoimmun. 2012, 38:59-69.