Discovery of coumarin-dihydropyridine hybrids as bone anabolic agents

Journal of Medicinal Chemistry

Volumn 56, Issue 1, 2013, Pages 109-122

  Sashidhara, Koneni V ^a   Kumar, Manoj ^a   Khedgikar, Vikram ^a   Kushwaha, Priyanka ^a   Modukuri, Ram K ^a   Kumar, Abdhesh ^a   Gautam, Jyoti ^a   Singh, Divya ^a   Sridhar, Balasubramaniam ^b   Trivedi, Ritu ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

^b INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; ANABOLIC AGENT; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN TYPE 1; COUMARIN; DIETHYL 4 (8 TERT BUTYL 3 (METHOXYCARBONYL) 2 OXO 2H CHROMEN 6 YL) 2,6 DIMETHYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; DIHYDROPYRIDINE; DIMETHYL 4 (8SEC BUTYL 3 (METHOXYCARBONYL) 2 OXO 2H CHROMEN 6 YL) 2,6 DIMETHYL 1,4 DIHYDROPYRIDINE 3,5 DICARBOXYLATE; ETHYL 4 (8 SEC BUTYL 3 (METHOXYCARBONYL) 2 OXO 2H CHROMEN 6 YL) 2 METHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; ETHYL 4 (8 SEC BUTYL 3 (METHOXYCARBONYL) 2 OXO 2H CHROMEN 6 YL) 2,7,7 TRIMETHYL 5 OXO 1,4,5,6,7,8 HEXAHYDROQUINOLINE 3 CARBOXYLATE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE; BONE DENSITY; BONE MASS; BONE MINERAL; BONE TURNOVER; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; OSSIFICATION; OSTEOLYSIS; TRABECULAR BONE;

ADMINISTRATION, ORAL; ANABOLIC AGENTS; ANIMALS; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; COUMARINS; CRYSTALLOGRAPHY, X-RAY; DIHYDROPYRIDINES; FEMALE; GENE EXPRESSION; HUMANS; MICE; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS, POSTMENOPAUSAL; OVARIECTOMY; QUINOLONES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84872312161     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm301281e     Document Type: Article

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