In vivo efficacy studies of layer-by-layer nano-matrix bearing kaempferol for the conditions of osteoporosis: A study in ovariectomized rat model

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 82, Issue 3, 2012, Pages 508-517

  Kumar, Avinash ^a   Gupta, Girish K ^b   Khedgikar, Vikram ^a   Gautam, Jyoti ^a   Kushwaha, Priyanka ^a   Changkija, Bendangla ^a   Nagar, Geet K ^a   Gupta, Varsha ^b   Verma, Ashwni ^b   Dwivedi, Anil Kumar ^b   Chattopadhyay, Naibedya ^a   Mishra, Prabhat Ranjan ^b   Trivedi, Ritu ^a  

^a Division of Endocrinology   (India)

^b CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Bioavailability; Bone marrow cells; Bone micro architecture; Kaempferol; LbL nano matrix; Osteoblast mineralization

Indexed keywords

CALCEIN; FLAVANOID; FLUOROCHROME; KAEMPFEROL; NANOCARRIER; OSTEOCALCIN; PARATHYROID HORMONE[1-34]; TETRACYCLINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BONE MARROW; BONE MARROW CELL; BONE MINERALIZATION; BONE STRUCTURE; BONE TURNOVER; CONTROLLED STUDY; CRYSTALLIZATION; DETERIORATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG RETENTION; FEMALE; GENE EXPRESSION; HISTOLOGY; IN VIVO STUDY; MAXIMUM PLASMA CONCENTRATION; MICRO-COMPUTED TOMOGRAPHY; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPENIA; OSTEOPOROSIS; OVARIECTOMY; RAT; RNA ISOLATION; TRABECULAR BONE; TREATMENT WITHDRAWAL;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BONE AND BONES; BONE DISEASES, METABOLIC; BONE MARROW CELLS; CALCIUM CARBONATE; DISEASE MODELS, ANIMAL; ELECTROLYTES; FEMALE; KAEMPFEROLS; NANOPARTICLES; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; OVARIECTOMY; PARATHYROID HORMONE; RATS; RATS, SPRAGUE-DAWLEY; TIME FACTORS; TISSUE DISTRIBUTION;

EID: 84870537129     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2012.08.001     Document Type: Article

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