In vitro efficacy of cyclooctadepsipepdtides and aminophenylamidines alone and in combination against third-stage larvae and adult worms of Nippostrongylus brasiliensis and first-stage larvae of Trichinella spiralis

Parasitology Research

Volumn 112, Issue 1, 2013, Pages 335-345

  Kulke, Daniel ^a   Krücken, Jürgen ^a   Demeler, Janina ^a   Harder, Achim ^b   Mehlhorn, Heinz ^b   Von Samson Himmelstjerna, Georg ^a  

^a FREIE UNIVERSITÄT BERLIN   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINESTERASE; AMIDANTEL; ANTHELMINTIC AGENT; ANTIPARASITIC AGENT; CYCLO(DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL DEXTRO LACTYL N METHYLLEUCYL DEXTRO 3 PHENYLLACTYL N METHYLLEUCYL); EMODEPSIDE; LEVAMISOLE; TRIBENDIMIDINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHELMINTIC ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; ENZYME RELEASE; FEMALE; HOST PARASITE INTERACTION; IN VITRO STUDY; LARVAL STAGE; NEMATODIASIS; NIPPOSTRONGYLUS BRASILIENSIS; NONHUMAN; PRIORITY JOURNAL; RAT; STRONGYLE INFECTION; STRONGYLOIDIASIS; TRICHINELLA SPIRALIS;

ANIMALS; ANTHELMINTICS; DEPSIPEPTIDES; DRUG SYNERGISM; LARVA; LOCOMOTION; NIPPOSTRONGYLUS; PHENYLENEDIAMINES; TRICHINELLA SPIRALIS;

ANCYLOSTOMA CEYLANICUM; NIPPOSTRONGYLUS BRASILIENSIS; TRICHINELLA SPIRALIS;

EID: 84872293388     PISSN: 09320113     EISSN: 14321955     Source Type: Journal    
DOI: 10.1007/s00436-012-3141-1     Document Type: Article

References (46)

1. Conder GA, Johnson SS, Nowakowski DS, Blake TE, Dutton FE, Nelson SJ, Thomas EM, Davis JP, Thompson DP (1995) Anthelmintic profile of the cyclodepsipeptide PF1022A in in vitro and in vivo models. J Antibiot 48(8):820-823
2. Crompton DWT, World Health Organization (2006) Preventive chemotherapy in human helminthiasis: coordinated use of anthelminthic drugs in control interventions: a manual for health professionals and programme managers. World Health Organization, Geneva
3. Crompton DWT, Savioli L (2007) Handbook of helminthiasis for public health. CRC/Taylor & Francis, Boca Raton
4. Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM (1961) A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95
5. Geary TG, Mackenzie CD (2011) Progress and challenges in the discovery of macrofilaricidal drugs. Expert Rev Anti Infect Ther 9(8):681-695
6. Guest M, Bull K, Walker RJ, Amliwala K, O'Connor V, Harder A, Holden-Dye L, Hopper NA (2007) The calcium-activated potassium channel, SLO-1, is required for the action of the novel cyclo-octadepsipeptide anthelmintic, emodepside, in Caenorhabditis elegans. Int J Parasitol 37(14):1577-1588
7. Gulick RM et al (1997) Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy. N Engl J Med 337(11):734-739
8. Harder A, von Samson-Himmelstjerna G (2002) Cyclooctadepsipeptides - a new class of anthelmintically active compounds. Parasitol Res 88(6):481-488
9. Harder A, Schmitt-Wrede HP, Krucken J, Marinovski P, Wunderlich F, Willson J, Amliwala K, Holden-Dye L, Walker R (2003) Cyclooctadepsipeptides - an anthelmintically active class of compounds exhibiting a novel mode of action. Int J Antimicrob Ag 22(3):318-331
10. Hu Y, Xiao SH, Aroian RV (2009) The new anthelmintic tribendimidine is an L-type (levamisole and pyrantel) nicotinic acetylcholine receptor agonist. PLoS Negl Trop Dis 3(8):e499
11. Knopp S et al (2010) Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. Clin Infect Dis 51(12):1420-1428
12. Kotze AC, Lowe A, O'Grady J, Kopp SR, Behnke JM (2009) Dose-response assay templates for in vitro assessment of resistance to benzimidazole and nicotinic acetylcholine receptor agonist drugs in human hookworms. AmJTrop Med Hyg 81(1):163-170
13. Krücken J, Harder A, Jeschke P, Holden-Dye L, O'Connor V, Welz C, von Samson-Himmelstjerna G (2012) Anthelmintic cyclcooctadepsipeptides: complex in structure and mode of action. Trends Parasitol 28:385-394. doi: 10.1016/j.pt.2012.06.005
14. Kulke D, Krucken J, Welz C, von Samson-Himmelstjerna G, Harder A (2012) In vivo efficacy of the anthelmintic tribendimidine against the cestode Hymenolepis microstoma in a controlled laboratory trial. Acta Trop 123(2):78-84
15. Leathwick DM, Hosking BC, Bisset SA, McKay CH (2009) Managing anthelmintic resistance: is it feasible in New Zealand to delay the emergence of resistance to a new anthelmintic class? New Zeal Vet J 57(4):181-192
16. Li RH, Gao JH, Wang SF, Pei YJ, Shen JY, Yan PM, Yin GR (2011) Effect of oral administration of tribendimidine at different dosages against Trichinella spiralis encapsulated larvae in mice. Chin J Parasitol Parasit Dis 29(2):117-121
17. Lumley AM, Lee DL (1981) Nippostrongylus brasiliensis and Nematodirus battus: changes in numbers and weight during the course of infection. Exp Parasitol 52(2):183-190
18. Lustigman S, Prichard RK, Gazzinelli A, Grant WN, Boatin BA, McCarthy JS, Basanez MG (2012) A research agenda for helminth diseases of humans: the problem of helminthiases. PLoS Negl Trop Dis 6(4):e1582
19. Martin RJ, Robertson AP, Buxton SK, Beech RN, Charvet CL, Neveu C (2012) Levamisole receptors: a second awakening. Trends Parasitol 28(7):289-296
20. Mehlhorn H, Schmahl G, Frese M, Mevissen I, Harder A, Krieger K (2005) Effects of a combinations of emodepside and praziquantel on parasites of reptiles and rodents. Parasitol Res 97(1):65-69
21. Nicolay F, Harder A, von Samson-Himmelstjerna G, Mehlhorn H (2000) Synergistic action of a cyclic depsipeptide and piperazine on nematodes. Parasitol Res 86(12):982-992
22. Ogilvie BM, Rothwell TL, Bremner KC, Schnitzerling HJ, Nolan J, Keith RK (1973) Acetylcholinesterase secretion by parasitic nematodes. I. Evidence for secretion of the enzyme by a number of species. Int J Parasitol 3(5):589-597
23. Olliaro P, Seiler J, Kuesel A, Horton J, Clark JN, Don R, Keiser J (2011) Potential drug development candidates for human soil-transmitted helminthiases. PLoS Negl Trop Dis 5(6):e1138
24. Olsen A (2007) Efficacy and safety of drug combinations in the treatment of schistosomiasis, soil-transmitted helminthiasis, lymphatic filariasis and onchocerciasis. T Roy Soc Trop Med H 101(8):747-758
25. Prichard RK, Basanez MG, Boatin BA, McCarthy JS, Garcia HH, Yang GJ, Sripa B, Lustigman S (2012) A research agenda for helminth diseases of humans: intervention for control and elimination. PLoS Negl Trop Dis 6(4):e1549
26. Rapson EB, Lee DL, Watts SD (1981) Changes in the acetylcholinesterase activity of the nematode Nippostrongylus brasiliensis following treatment with benzimidazoles in vivo. Mol Biochem Parasitol 4(1-2):9-15
27. Rothwell TL, Ogilvie BM, Love RJ (1973) Acetylcholinesterase secretion by parasitic nematodes. II. Trichostrongylus spp. Int J Parasitol 3(5):599-608
28. Speich B, Ame SM, Ali SM, Alles R, Hattendorf J, Utzinger J, Albonico M, Keiser J (2012) Efficacy and safety of nitazoxanide, albendazole, and nitazoxanide-albendazole against Trichuris trichiura infection: a randomized controlled trial. PLoS Negl Trop Dis 6(6):e1685
29. Steinmann P, Zhou XN, Du ZW, Jiang JY, Xiao SH, Wu ZX, Zhou H, Utzinger J (2008) Tribendimidine and albendazole for treating soil-transmitted helminths, Strongyloides stercoralis and Taenia spp.: open-label randomized trial. PLoS Negl Trop Dis 2(10):e322
30. Tomlinson G, Albuquerque CA, Woods RA (1985) The effects of amidantel (BAY d 8815) and its deacylated derivative (BAY d 9216) on Caenorhabditis elegans. Eur J Pharmacol 113(2):255-262
31. Tritten L, Nwosu U, Vargas M, Keiser J (2012) In vitro and in vivo efficacy of tribendimidine and its metabolites alone and in combination against the hookworms Heligmosomoides bakeri and Ancylostoma ceylanicum. Acta Trop 122(1):101-107
32. von Samson-Himmelstjerna G, Harder A, Schnieder T, Kalbe J, Mencke N (2000) In vivo activities of the new anthelmintic depsipeptide PF 1022A. Parasitol Res 86(3):194-199
33. Wang M, Watanabe N, Shomura T, Ohtomo H (1994) Effects of PF1022A from Mycelia sterilia on Trichinella spiralis in mice. Jpn J Parasitol 43(5):346-350
34. Wang M, Watanabe N, Shomura T, Ohtomo H (1995) Effects of PF1022A on Nippostrongylus brasiliensis in rats and Hymenolepis nana in mice. Jpn J Parasitol 44(4):306-310
35. Watts SD, Rapson EB, Atkins AM, Lee DL (1982) Inhibition of acetylcholinesterase secretion from Nippostrongylus brasiliensis by benzimidazole anthelmintics. Biochem Pharmacol 31(19):3035-3040
36. Weaver HJ, Hawdon JM, Hoberg EP (2010) Soil-transmitted helminthiases: implications of climate change and human behavior. Trends Parasitol 26(12):574-581
37. Welz C, Kruger N, Schniederjans M, Miltsch SM, Krucken J, Guest M, Holden-Dye L, Harder A, von Samson-Himmelstjerna G (2011) SLO-1-channels of parasitic nematodes reconstitute locomotor behaviour and emodepside sensitivity in Caenorhabditis elegans slo-1 loss of function mutants. PLoS Pathog 7(4):e1001330
38. Wollweber H, Niemers E, Flucke W, Andrews P, Schulz HP, Thomas H (1979) Amidantel, a potent anthelminthic from a new chemical class. Arzneim Forsch 29(1):31-32
39. Wolstenholme AJ, Fairweather I, Prichard R, von Samson-Himmelstjerna G, Sangster NC (2004) Drug resistance in veterinary helminths. Trends Parasitol 20(10):469-476
40. Woods RA, Malone KMB (1985) The effects of amidantel (BAY d 8815) and its deacylated derivative (BAY d 9216) on wild-type and resistant mutants of Caenorhabditis elegans. Can J Zool 64:1310-1316
41. World Health Organization (2011a) WHO model list of essential medicines: 17th list, March 2011. World Health Organization, Geneva
42. World Health Organization (2011b) WHO model list of essential medicines for children: 3rd list, March 2011. World Health Organization, Geneva
43. Xiao SH, Hui-Ming W, Tanner M, Utzinger J, Chong W (2005) Tribendimidine: a promising, safe and broad-spectrum anthelmintic agent from China. Acta Trop 94(1):1-14
44. Xue J, Xiao SH, Xu LL, Qiang HQ (2010a) The effect of tribendimidine and its metabolites against Necator americanus in golden hamsters and Nippostrongylus braziliensis in rats. Parasitol Res 106(4):775-781
45. Xue J, Xiao SH, Xu LL, Zhang YN, Qiang HQ (2010b) Efficacy of tribendimidine and albendazole in treating mice infected with Trichinella spiralis. Chin J Parasitol Parasit Dis 28(1):8-11
46. Yuan G, Xu J, Qu T, Wang B, Zhang R, Wei C, Guo R (2010) Metabolism and disposition of tribendimidine and its metabolites in healthy Chinese volunteers. Drugs R D 10(2):83-90