Synthesis and biological evaluation of analogues of the kinase inhibitor nilotinib as Abl and Kit inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 3, 2013, Pages 682-686

  Duveau, Damien Y ^a   Hu, Xin ^a   Walsh, Martin J ^a   Shukla, Suneet ^b   Skoumbourdis, Amanda P ^a   Boxer, Matthew B ^a   Ambudkar, Suresh V ^b   Shen, Min ^a   Thomas, Craig J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Abl; CML; Kinase; Kit; Molecular editing

Indexed keywords

ABELSON KINASE; BAFETINIB; FLUORINE; HG 78501; IMATINIB; METHYL GROUP; NILOTINIB; PROTEIN TYROSINE KINASE; PROTON; SORAFENIB; STEM CELL FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG DESIGN; DRUG SCREENING; DRUG STABILITY; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; MOLECULAR DYNAMICS;

CATALYTIC DOMAIN; DRUG DESIGN; ENZYME ACTIVATION; FLUORINE; METHANE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; ONCOGENE PROTEINS V-ABL; PROTEIN KINASE INHIBITORS; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-KIT; PYRIMIDINES;

EID: 84872287557     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.111     Document Type: Article

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