Completely N 1-selective palladium-catalyzed arylation of unsymmetric imidazoles: Application to the synthesis of nilotinib

Journal of the American Chemical Society

Volumn 134, Issue 1, 2012, Pages 700-706

  Ueda, Satoshi ^a   Su, Mingjuan ^a   Buchwald, Stephen L ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARYL HALIDES; ARYLATIONS; CATALYTIC SYSTEM; HETEROCYCLES; IN-SITU FORMATIONS; INHIBITORY EFFECT; LIGAND COMPLEXES; N-ARYLATION REACTIONS; PALLADIUM-CATALYZED ARYLATION; REGIOSELECTIVE SYNTHESIS; TRIFLATES; TYROSINE KINASE INHIBITOR;

AMINO ACIDS; AROMATIC COMPOUNDS; CATALYSIS; CHELATION; COMPLEXATION; ENZYME INHIBITION; LIGANDS; PALLADIUM COMPOUNDS; REGIOSELECTIVITY; SYNTHESIS (CHEMICAL);

PALLADIUM;

IMIDAZOLE DERIVATIVE; METAL; NILOTINIB; PALLADIUM; 4 METHYL N (3 (4 METHYLIMIDAZOL 1 YL) 5 (TRIFLUOROMETHYL)PHENYL) 3 ((4 PYRIDIN 3 YLPYRIMIDIN 2 YL)AMINO)BENZAMIDE; 4 METHYLIMIDAZOLE; 4-METHYL-N-(3-(4-METHYLIMIDAZOL-1-YL)-5-(TRIFLUOROMETHYL)PHENYL)-3-((4-PYRIDIN-3-YLPYRIMIDIN-2-YL)AMINO)BENZAMIDE; 4-METHYLIMIDAZOLE; NITROGEN; PYRIMIDINE DERIVATIVE;

ARTICLE; ARYLATION; CATALYSIS; CHEMICAL BINDING; DRUG SYNTHESIS; INHIBITION KINETICS; STEREOCHEMISTRY; CHEMISTRY; DRUG DESIGN; ENZYME SPECIFICITY; STEREOISOMERISM; SYNTHESIS;

CATALYSIS; DRUG DESIGN; IMIDAZOLES; NITROGEN; PALLADIUM; PYRIMIDINES; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 84855716644     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja2102373     Document Type: Article

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