Biodegradable intraoperative system for bone infection treatment II. In vivo evaluation

International Journal of Pharmaceutics

Volumn 143, Issue 2, 1996, Pages 187-194

  Iannuccelli, V ^a   Coppi, G ^a   Bondi, M ^a   Pinelli, M ^a   Mingione, A ^a   Cameroni, R ^a  

^a UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

alginate; biodegradability; calcium; gentamicin; implant; osteomyelitis

Indexed keywords

ALGINIC ACID; GENTAMICIN; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; BIODEGRADATION; BONE INFECTION; COMPLEX FORMATION; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG TISSUE LEVEL; IMPLANT; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030575740     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(96)04711-4     Document Type: Article

References (24)

1. Casals, J.B., A new simplified MIC-test for aerobes and anaerobes using three tablets on an agar medium. Chemioterapia, 2 (1983) 135-6.
2. Firsov, A.A., Nazarov, A.D. and Fomina, I.P., Biodegradable implants containing gentamicin: drug release and pharmacokinetics. Drug Dev. Ind. Pharm., 13 (1987) 1651-1674.
3. Fox, K.E., Total extraction of aminoglycosides from guinea pig and bullfrog tissues with sodium hydroxide or trichloroacetic acid. Anitmicrob. Agents Chemother., 33 (1989) 448-451.
4. Gerhart, T.N., Roux, R.D., Hanff, P.A., Horowitz, G.L., Renshaw, A.A. and Hayes, W.C., Antibiotic-loaded biodegradable bone cement for prophylaxis and treatment of experimental osteomyelitis in rats. J. Orthop. Res., 11 (1993) 250-255.
5. Glover, S.C. and Geddes, A.M., Treatment of pyogenic osteomyelitis. J. Anitmicrob. Ther., 8 (1981) 347-354.
6. Handbook of Pharmaceutical Excipients, American Pharmaceutical Association, Washington, and The Pharmaceutical Society of Great Britain, London, 1986, pp. 5.
7. Haug, A., Larsen, B. and Smidsröd, O., The degradation of alginates at different pH values. Acta Chem. Scand., 17 (1963) 1466-1468.
8. Iannuccelli, V., Coppi, G. and Cameroni, R., Biodegradable intraoperative system for bone infection treatment. I. The drug/polymer interaction. Int. J. Pharm., in press.
9. Kahn, D.S. and Pritzker, K.P.H., The pathophysiology of bone infection. Clin. Orthop., 96 (1973) 12-19.
10. Kronenthal, R.L., Biodegradable polymers in medicine and surgery. In Kronenthal, R.L., Oser, Z. and Martin, E. (Eds), Polymers in Medicine and Surgery, Plenum Press, New York, 1975, pp. 119-133.
11. Reynolds, J.E.F. (Ed.), Martindale, The Extra Pharmacopoeia, The Pharmaceutical Press, London, 1993. pp. 169-172.
12. Mauduit, J., Bukh, N. and Vert, M., Gentamycin/poly(lactic acid) blends aimed at sustained release local antibiotic therapy administered per-operatively. I. The case of gentamycin base and gentamycin sulphate in poly(DL-lactic acid) oligomers. J. Controlled Release, 23 (1993) 209-220.
13. McDowell, R.H., Properties of Alginates, Alginate Industries Limited, London, 1986, pp. 41-48.
14. Norden, C. and Keleti, E., Experimental osteomyelitis caused by Pseudomonas aeruginosa. J. Infect. Dis., 141 (1980) 71-75.
15. Norden, C.W., Experimental osteomyelitis. II. Therapeutic trials and measurement of antibiotic levels in bone. J. Infect. Dis., 124 (1971) 565-571.
16. Norden, C.W., Experimental osteomyelitis. IV. Therapeutic trials with rifampin alone and in combination with gentamicin, sisomicin, and cephalothin. J. Infect. Dis., 132 (1975) 493-499.
17. Robinson, D.H. and Sampath, S., Release kinetics of tobramycin sulphate from polymethylmethacrylate implants. Drug Dev. Ind. Pharm., 15 (1989) 2339-2357.
18. Rosenkrantz, B.E., Greco, J.R., Hoogerheide, J.G. and Oden, E.M., Gentamicin sulphate. In Florey, K. (Ed.), Analytical Profiles of Drug Substances, Academic Press, New York, 1980, Vol. 9, pp. 295-340.
19. Sampath, S.S., Garvin, K. and Robinson D.H., Preparation and characterization of biodegradable poly(L-lactic acid) gentamicin delivery systems. Int. J. Pharm., 78 (1992). 165-174.
20. Thoma, K., Rainer, A. and Randzio, J., Biodegradable controlled release implants based on β-tricalcium phosphate ceramic. 2. Testing of gentamicin controlled release pellets in vitro and in vivo. Eur. J. Pharm. Biopharm., 38 (1992) 107-112.
21. Wahlig, H., Gentamicin-PMMA beads: a drug delivery system in the treatment of chronic bone and soft tissue infections. J. Antimicrob. Chemother., 10 (1982) 463-465.
22. Wei, G., Kotoura Y., Oka, M., Yamamuro, T., Wada, R., Hyon, S.-H. and Ikada Y., A bioabsorbable delivery system for antibiotic treatment of osteomyelitis. J. Bone Joint Surg., 73B (1991) 246-252.
23. Weinstein, M.J., Luedemann, G.M., Oden, E.M. and Wagman, G.H., Gentamicin, a new broad-spectrum antibiotic complex. Antimicrob. Agents Chemother., (1963) 1-7.
24. Zhang, X., Wyss, U.P., Pichora, D. and Goosen, M.F.A., Biodegradable controlled antibiotic release devices for osteomyelitis: optimization of release properties. J. Pharm. Pharmacol., 46 (1994) 718-724.